journal
Journals Proceedings of the National Ac...

Proceedings of the National Academy of Sciences of the United States of America

https://read.qxmd.com/read/38889126/psychosocial-experiences-are-associated-with-human-brain-mitochondrial-biology
#1
JOURNAL ARTICLE
Caroline Trumpff, Anna S Monzel, Carmen Sandi, Vilas Menon, Hans-Ulrich Klein, Masashi Fujita, Annie Lee, Vladislav A Petyuk, Cheyenne Hurst, Duc M Duong, Nicholas T Seyfried, Aliza P Wingo, Thomas S Wingo, Yanling Wang, Madhav Thambisetty, Luigi Ferrucci, David A Bennett, Philip L De Jager, Martin Picard
Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain function relies on energy transformation by mitochondria oxidative phosphorylation (OxPhos). Two main lines of evidence position mitochondria both as targets and drivers of psychosocial experiences. On the one hand, chronic stress exposure and mood states may alter multiple aspects of mitochondrial biology; on the other hand, functional variations in mitochondrial OxPhos capacity may alter social behavior, stress reactivity, and mood...
July 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905242/community-assembly-influences-plant-trait-economic-spectra-and-functional-trade-offs-at-ecosystem-scales
#2
JOURNAL ARTICLE
William R L Anderegg, Jordi Martinez-Vilalta, Maurizio Mencuccini, Rafael Poyatos
Plant functional traits hold the potential to greatly improve the understanding and prediction of climate impacts on ecosystems and carbon cycle feedback to climate change. Traits are commonly used to place species along a global conservative-acquisitive trade-off, yet how and if functional traits and conservative-acquisitive trade-offs scale up to mediate community and ecosystem fluxes is largely unknown. Here, we combine functional trait datasets and multibiome datasets of forest water and carbon fluxes at the species, community, and ecosystem-levels to quantify the scaling of the tradeoff between maximum flux and sensitivity to vapor pressure deficit...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905241/near-infrared-nanosensors-enable-optical-imaging-of-oxytocin-with-selectivity-over-vasopressin-in-acute-mouse-brain-slices
#3
JOURNAL ARTICLE
Jaewan Mun, Nicole Navarro, Sanghwa Jeong, Nicholas Ouassil, Esther Leem, Abraham G Beyene, Markita P Landry
Oxytocin plays a critical role in regulating social behaviors, yet our understanding of its function in both neurological health and disease remains incomplete. Real-time oxytocin imaging probes with spatiotemporal resolution relevant to its endogenous signaling are required to fully elucidate oxytocin's role in the brain. Herein, we describe a near-infrared oxytocin nanosensor (nIROXT), a synthetic probe capable of imaging oxytocin in the brain without interference from its structural analogue, vasopressin...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905240/phd2-enzyme-is-an-intracellular-manganese-sensor-that-initiates-the-homeostatic-response-against-elevated-manganese
#4
JOURNAL ARTICLE
Kerem C Gurol, Thomas Jursa, Eun Jeong Cho, Walter Fast, Kevin N Dalby, Donald R Smith, Somshuvra Mukhopadhyay
Intracellular sensors detect changes in levels of essential metals to initiate homeostatic responses. But, a mammalian manganese (Mn) sensor is unknown, representing a major gap in understanding of Mn homeostasis. Using human-relevant models, we recently reported that: 1) the primary homeostatic response to elevated Mn is upregulation of hypoxia-inducible factors (HIFs), which increases expression of the Mn efflux transporter SLC30A10; and 2) elevated Mn blocks the prolyl hydroxylation of HIFs by prolyl hydroxylase domain (PHD) enzymes, which otherwise targets HIFs for degradation...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905239/a-cuc1-auxin-genetic-module-links-cell-polarity-to-patterned-tissue-growth-and-leaf-shape-diversity-in-crucifer-plants
#5
JOURNAL ARTICLE
Zi-Liang Hu, David Wilson-Sánchez, Neha Bhatia, Madlen I Rast-Somssich, Anhui Wu, Daniela Vlad, Liam McGuire, Lachezar A Nikolov, Patrick Laufs, Xiangchao Gan, Stefan Laurent, Adam Runions, Miltos Tsiantis
How tissue-level information encoded by fields of regulatory gene activity is translated into the patterns of cell polarity and growth that generate the diverse shapes of different species remains poorly understood. Here, we investigate this problem in the case of leaf shape differences between Arabidopsis thaliana , which has simple leaves, and its relative Cardamine hirsuta that has complex leaves divided into leaflets. We show that patterned expression of the transcription factor CUP-SHAPED COTYLEDON1 in C...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905238/hydrogen-isotope-fractionation-is-controlled-by-co-2-in-coccolithophore-lipids
#6
JOURNAL ARTICLE
Ismael Torres-Romero, Hongrui Zhang, Reto S Wijker, Alexander J Clark, Rachel E McLeod, Madalina Jaggi, Heather M Stoll
Hydrogen isotope ratios (δ2 H) represent an important natural tracer of metabolic processes, but quantitative models of processes controlling H-fractionation in aquatic photosynthetic organisms are lacking. Here, we elucidate the underlying physiological controls of 2 H/1 H fractionation in algal lipids by systematically manipulating temperature, light, and CO2 (aq) in continuous cultures of the haptophyte Gephyrocapsa oceanica . We analyze the hydrogen isotope fractionation in alkenones (αalkenone ), a class of acyl lipids specific to this species and other haptophyte algae...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38905237/insights-into-stereoselective-ring-formation-in-canonical-strigolactone-identification-of-a-dirigent-domain-containing-enzyme-catalyzing-orobanchol-synthesis
#7
JOURNAL ARTICLE
Masato Homma, Takatoshi Wakabayashi, Yoshitaka Moriwaki, Nanami Shiotani, Takumi Shigeta, Kazuki Isobe, Atsushi Okazawa, Daisaku Ohta, Tohru Terada, Kentaro Shimizu, Masaharu Mizutani, Hirosato Takikawa, Yukihiro Sugimoto
Strigolactones (SLs) are plant apocarotenoids with diverse roles and structures. Canonical SLs, widespread and characterized by structural variations in their tricyclic lactone (ABC-ring), are classified into two types based on C-ring configurations. The steric C-ring configuration emerges during the BC-ring closure, downstream of the biosynthetic intermediate, carlactonoic acid (CLA). Most plants produce either type of canonical SLs stereoselectively, e.g., tomato ( Solanum lycopersicum ) yields orobanchol with an α-oriented C-ring...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900803/correction-for-kim-et-al-mdga1-negatively-regulates-amyloid-precursor-protein-mediated-synapse-inhibition-in-the-hippocampus
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900802/correction-for-breznau-et-al-observing-many-researchers-using-the-same-data-and-hypothesis-reveals-a-hidden-universe-of-uncertainty
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900801/ultrafast-terahertz-stark-spectroscopy-reveals-the-excited-state-dipole-moments-of-retinal-in-bacteriorhodopsin
#10
JOURNAL ARTICLE
Jia Zhang, Poonam Singh, Dieter Engel, Benjamin P Fingerhut, Matthias Broser, Peter Hegemann, Thomas Elsaesser
The photoinduced all-trans to 13-cis isomerization of the retinal Schiff base represents the ultrafast first step in the reaction cycle of bacteriorhodopsin (BR). Extensive experimental and theoretical work has addressed excited-state dynamics and isomerization via a conical intersection with the ground state. In conflicting molecular pictures, the excited state potential energy surface has been modeled as a pure S[Formula: see text] state that intersects with the ground state, or in a 3-state picture involving the S[Formula: see text] and S[Formula: see text] states...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900800/dynamics-of-multicellular-swirling-on-micropatterned-substrates
#11
JOURNAL ARTICLE
Xi Li, Bin Chen
Chirality plays a crucial role in biology, as it is highly conserved and fundamentally important in the developmental process. To better understand the relationship between the chirality of individual cells and that of tissues and organisms, we develop a generalized mechanics model of chiral polarized particles to investigate the swirling dynamics of cell populations on substrates. Our analysis reveals that cells with the same chirality can form distinct chiral patterns on ring-shaped or rectangular substrates...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900799/ultrafast-generation-of-hidden-phases-via-energy-tuned-electronic-photoexcitation-in-magnetite
#12
JOURNAL ARTICLE
B Truc, P Usai, F Pennacchio, G Berruto, R Claude, I Madan, V Sala, T LaGrange, G M Vanacore, S Benhabib, F Carbone
Phase transitions occurring in nonequilibrium conditions can evolve through high-energy intermediate states inaccessible via equilibrium adiabatic conditions. Because of the subtle nature of such hidden phases, their direct observation is extremely challenging and requires simultaneous visualization of matter at subpicoseconds and subpicometer scales. Here, we show that a magnetite crystal in the vicinity of its metal-to-insulator transition evolves through different hidden states when controlled via energy-tuned ultrashort laser pulses...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900798/democratizing-protein-language-models-with-parameter-efficient-fine-tuning
#13
JOURNAL ARTICLE
Samuel Sledzieski, Meghana Kshirsagar, Minkyung Baek, Rahul Dodhia, Juan Lavista Ferres, Bonnie Berger
Proteomics has been revolutionized by large protein language models (PLMs), which learn unsupervised representations from large corpora of sequences. These models are typically fine-tuned in a supervised setting to adapt the model to specific downstream tasks. However, the computational and memory footprint of fine-tuning (FT) large PLMs presents a barrier for many research groups with limited computational resources. Natural language processing has seen a similar explosion in the size of models, where these challenges have been addressed by methods for parameter-efficient fine-tuning (PEFT)...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900797/a-druggable-cascade-links-methionine-metabolism-to-epigenomic-reprogramming-in-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Chehyun Nam, Li-Yan Li, Qian Yang, Benjamin Ziman, Hua Zhao, Boyan Hu, Casey Collet, Pei Jing, Qifang Lei, Li-Yan Xu, En-Min Li, H Phillip Koeffler, Uttam K Sinha, De-Chen Lin
Upper aerodigestive squamous cell carcinoma (UASCC) is a common and aggressive malignancy with few effective therapeutic options. Here, we investigate amino acid metabolism in this cancer, surprisingly noting that UASCC exhibits the highest methionine level across all human cancers, driven by its transporter LAT1. We show that LAT1 is also expressed at the highest level in UASCC, transcriptionally activated by UASCC-specific promoter and enhancers, which are directly coregulated by SCC master regulators TP63/KLF5/SREBF1...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900796/sediment-dna-can-revolutionize-archaeology-if-it-is-used-the-right-way
#15
JOURNAL ARTICLE
Vera Aldeias, Mareike C Stahlschmidt
No abstract text is available yet for this article.
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900795/membrane-nanotubes-transform-into-double-membrane-sheets-at-condensate-droplets
#16
JOURNAL ARTICLE
Ziliang Zhao, Vahid Satarifard, Reinhard Lipowsky, Rumiana Dimova
Cellular membranes exhibit a multitude of highly curved morphologies such as buds, nanotubes, cisterna-like sheets defining the outlines of organelles. Here, we mimic cell compartmentation using an aqueous two-phase system of dextran and poly(ethylene glycol) encapsulated in giant vesicles. Upon osmotic deflation, the vesicle membrane forms nanotubes, which undergo surprising morphological transformations at the liquid-liquid interfaces inside the vesicles. At these interfaces, the nanotubes transform into cisterna-like double-membrane sheets (DMS) connected to the mother vesicle via short membrane necks...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900794/frost-free-zone-on-leaves-revisited
#17
JOURNAL ARTICLE
Annika Einbock, Franz Conen
Particular frost patterns on natural leaves had prompted Yao et al. [Y. Yao et al ., Proc. Natl. Acad. Sci. U.S.A. 117 , 6323-6329 (2020)] to investigate the underlying physics. Their work revealed why on corrugated surfaces ice forms on crests and dries out adjacent grooves. In the absence of frost, in contrast, grooves tend to constitute niches on a leaf where microorganisms are less limited by moisture than in other locations. Here, we show that microorganisms able to nucleate ice before it forms on crests can modify the frosting pattern to their advantage...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900793/predicted-hot-superconductivity-in-lasc-2-h-24-under-pressure
#18
JOURNAL ARTICLE
Xin-Ling He, Wenbo Zhao, Yu Xie, Andreas Hermann, Russell J Hemley, Hanyu Liu, Yanming Ma
The recent theory-driven discovery of a class of clathrate hydrides (e.g., CaH6 , YH6 , YH9 , and LaH10 ) with superconducting critical temperatures ( T c ) well above 200 K has opened the prospects for "hot" superconductivity above room temperature under pressure. Recent efforts focus on the search for superconductors among ternary hydrides that accommodate more diverse material types and configurations compared to binary hydrides. Through extensive computational searches, we report the prediction of a unique class of thermodynamically stable clathrate hydrides structures consisting of two previously unreported H24 and H30 hydrogen clathrate cages at megabar pressures...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900792/physical-modeling-of-nucleosome-clustering-in-euchromatin-resulting-from-interactions-between-epigenetic-reader-proteins
#19
JOURNAL ARTICLE
Joseph G Wakim, Andrew J Spakowitz
Euchromatin is an accessible phase of genetic material containing genes that encode proteins with increased expression levels. The structure of euchromatin in vitro has been described as a 30-nm fiber formed from ordered nucleosome arrays. However, recent advances in microscopy have revealed an in vivo euchromatin architecture that is much more disordered, characterized by variable-length linker DNA and sporadic nucleosome clusters. In this work, we develop a theoretical model to elucidate factors contributing to the disordered in vivo architecture of euchromatin...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38900791/mdgas-perform-activity-dependent-synapse-type-specific-suppression-via-distinct-extracellular-mechanisms
#20
JOURNAL ARTICLE
Seungjoon Kim, Gyubin Jang, Hyeonho Kim, Dongseok Lim, Kyung Ah Han, Ji Won Um, Jaewon Ko
MDGA (MAM domain containing glycosylphosphatidylinositol anchor) family proteins were previously identified as synaptic suppressive factors. However, various genetic manipulations have yielded often irreconcilable results, precluding precise evaluation of MDGA functions. Here, we found that, in cultured hippocampal neurons, conditional deletion of MDGA1 and MDGA2 causes specific alterations in synapse numbers, basal synaptic transmission, and synaptic strength at GABAergic and glutamatergic synapses, respectively...
June 25, 2024: Proceedings of the National Academy of Sciences of the United States of America
journal
journal
20328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.