Natalie Strange, Laurence Luu, Vanissa Ong, Bryan A Wee, Matthew J A Phillips, Laura McCaughey, Joel R Steele, Christopher K Barlow, Charles G Cranfield, Garry Myers, Rami Mazraani, Charles Rock, Peter Timms, Wilhelmina M Huston
UNLABELLED: Chlamydia trachomatis is an intracellular bacterial pathogen that undergoes a biphasic developmental cycle, consisting of intracellular reticulate bodies and extracellular infectious elementary bodies. A conserved bacterial protease, HtrA, was shown previously to be essential for Chlamydia during the reticulate body phase, using a novel inhibitor (JO146). In this study, isolates selected for the survival of JO146 treatment were found to have polymorphisms in the acyl-acyl carrier protein synthetase gene ( aasC ) ...
March 6, 2024: Journal of Bacteriology