Jennifer Carlisle Michel, Margaret M B Grivette, Amber T Harshfield, Lisa Huynh, Ava P Komons, Bradley Loomis, Kaitlan McKinnis, Brennen T Miller, Ethan Q Nguyen, Tiffany W Huang, Sophia Lauf, Elias S Michel, Mia E Michel, Jane S Kissinger, Audrey J Marsh, William E Crow, Lila E Kaye, Abagael M Lasseigne, Rachel M Lukowicz-Bedford, Dylan R Farnsworth, E Anne Martin, Adam C Miller
Electrical synapses are neuronal gap junction (GJ) channels associated with a macromolecular complex called the electrical synapse density (ESD), which regulates development and dynamically modifies electrical transmission. However, the proteomic makeup and molecular mechanisms utilized by the ESD that direct electrical synapse formation are not well understood. Using the Mauthner cell of zebrafish as a model, we previously found that the intracellular scaffolding protein ZO1b is a member of the ESD, localizing postsynaptically, where it is required for GJ channel localization, electrical communication, neural network function, and behavior...
November 27, 2023: PLoS Genetics