journal
https://read.qxmd.com/read/37733487/communication-and-activation-in-pain-to-enhance-relationships-and-treat-pain-with-equity-cooperate-a-randomized-clinical-trial
#1
JOURNAL ARTICLE
Marianne S Matthias, Joanne K Daggy, Anthony J Perkins, Jasma Adams, Matthew J Bair, Diana J Burgess, Johanne Eliacin, Perla Flores, Laura J Myers, Tetla Menen, Philip Procento, Kevin L Rand, Michelle P Salyers, Mackenzie L Shanahan, Adam T Hirsh
Racialized disparities in chronic pain care are well-documented and persist despite national priorities focused on health equity. Similar disparities have been observed in patient activation (ie, having the knowledge, confidence, and skills to manage one's health). As such, interventions targeting patient activation represent a novel approach to addressing and reducing disparities in pain care. Communication and Activation in Pain to Enhance Relationships and Treat Pain with Equity is a randomized controlled trial of a 6-session telephone-delivered intervention to increase patient activation for Black patients with chronic pain...
September 21, 2023: Pain
https://read.qxmd.com/read/37733484/acid-sensing-ion-channel-3-mediates-pain-hypersensitivity-associated-with-high-fat-diet-consumption-in-mice
#2
JOURNAL ARTICLE
Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel
Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population. Obesity is a major risk factor for metabolic syndrome that includes hyperlipidemia and diabetes mellitus. The early phases of metabolic syndrome are often associated with hyperexcitability of peripheral small diameter sensory fibers and painful diabetic neuropathy. Here, we investigated the effect of high-fat diet-induced obesity on the activity of dorsal root ganglion (DRG) sensory neurons and pain perception. We deciphered the underlying cellular mechanisms involving the acid-sensing ion channel 3 (ASIC3)...
September 21, 2023: Pain
https://read.qxmd.com/read/37733479/a-cognitive-behavioral-digital-health-intervention-for-sickle-cell-disease-pain-in-adolescents-a-randomized-controlled-multicenter-trial
#3
JOURNAL ARTICLE
Tonya M Palermo, Chitra Lalloo, Chuan Zhou, Carlton Dampier, William Zempsky, Sherif M Badawy, Nitya Bakshi, Yeon Joo Ko, Fareha Nishat, Jennifer N Stinson
Severe acute and chronic pain are the most common complications of sickle cell disease (SCD). Pain results in disability, psychosocial distress, repeated clinic visits/hospitalizations, and significant healthcare costs. Psychosocial pain interventions that teach cognitive and behavioral strategies for managing pain have been effective in other adolescent populations when delivered in person or through digital technologies. Our aim was to conduct a multisite, randomized, controlled trial to improve pain and coping in youth aged 12 to 18 years with SCD using a digital cognitive-behavioral therapy program (iCanCope with Sickle Cell Disease; iCC-SCD) vs Education control...
September 21, 2023: Pain
https://read.qxmd.com/read/37733476/gut-microbiota-dysbiosis-alters-chronic-pain-behaviors-in-a-humanized-transgenic-mouse-model-of-sickle-cell-disease
#4
JOURNAL ARTICLE
Yavnika Kashyap, Zaijie Jim Wang
Pain is the most common symptom experienced by patients with sickle cell disease (SCD) throughout their lives and is the main cause of hospitalization. Despite the progress that has been made towards understanding the disease pathophysiology, major gaps remain in the knowledge of SCD pain, the transition to chronic pain, and effective pain management. Recent evidence has demonstrated a vital role of gut microbiota in pathophysiological features of SCD. However, the role of gut microbiota in SCD pain is yet to be explored...
September 21, 2023: Pain
https://read.qxmd.com/read/37733475/co-occurrence-of-chronic-pain-and-anxiety-depression-symptoms-in-u-s-adults-prevalence-functional-impacts-and-opportunities
#5
JOURNAL ARTICLE
Jennifer S De La Rosa, Benjamin R Brady, Mohab M Ibrahim, Katherine E Herder, Jessica S Wallace, Alyssa R Padilla, Todd W Vanderah
Co-occurrence of chronic pain and clinically significant symptoms of anxiety and/or depression is regularly noted in the literature. Yet, little is known empirically about population prevalence of co-occurring symptoms, nor whether people with co-occurring symptoms constitute a distinct subpopulation within US adults living with chronic pain or US adults living with anxiety and/or depression symptoms (A/D). To address this gap, this study analyzes data from the 2019 National Health Interview Survey, a representative annual survey of self-reported health status and treatment use in the United States (n = 31,997)...
September 21, 2023: Pain
https://read.qxmd.com/read/37703430/the-genetic-variant-slc2a1-rs1105297-is-associated-with-the-differential-analgesic-response-to-a-glucose-based-treatment-in-newborns
#6
JOURNAL ARTICLE
Riccardo Farinella, Fabio Falchi, Arianna Tavanti, Cristina Tuoni, Maria Grazia Di Nino, Luca Filippi, Massimiliano Ciantelli, Cosmeri Rizzato, Daniele Campa
Neonatal pain is a critical issue in clinical practice. The oral administration of glucose-based solutions is currently one of the most common and effective nonpharmacologic strategies for neonatal pain relief in daily minor procedures. However, a varying degree of analgesic efficacy has been reported for this treatment. Environmental, maternal, and genetic factors may explain this variability and potentially allow for a personalized analgesic approach, maximizing therapeutic efficacy and preventing side effects...
September 13, 2023: Pain
https://read.qxmd.com/read/37703419/bradykinin-receptor-expression-and-bradykinin-mediated-sensitization-of-human-sensory-neurons
#7
JOURNAL ARTICLE
Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J Widman, Richard A Slivicki, Maria Payne, Henry M Susser, Bryan A Copits, Robert W Gereau
Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root ganglia (DRG), which contain the cell bodies of sensory neurons, differ in the expression and function of key GPCRs and ion channels; whether bradykinin receptor expression and function are conserved across species has not been studied in depth. In this study, we used human DRG tissue from organ donors to provide a detailed characterization of bradykinin receptor expression and bradykinin-induced changes in the excitability of human sensory neurons...
September 13, 2023: Pain
https://read.qxmd.com/read/37703404/expectations-underlie-the-effects-of-unpredictable-pain-a-behavioral-and-electroencephalogram-study
#8
JOURNAL ARTICLE
Fabien Pavy, Jonas Zaman, Andreas Von Leupoldt, Diana M Torta
Previous studies on the potential effects of unpredictability on pain perception and its neural correlates yielded divergent results. This study examined whether this may be explained by differences in acquired expectations. We presented 41 healthy volunteers with laser heat stimuli of different intensities. The stimuli were preceded either by predictable low, medium, or high cues or by unpredictable low-medium, medium-high, or low-high cues. We recorded self-reports of pain intensity and unpleasantness and laser-evoked potentials (LEPs)...
September 13, 2023: Pain
https://read.qxmd.com/read/37703400/searching-for-the-rainbow-biomarkers-relevant-for-chronic-postsurgical-pain
#9
JOURNAL ARTICLE
Esther M Pogatzki-Zahn, Daniel Segelcke
No abstract text is available yet for this article.
September 13, 2023: Pain
https://read.qxmd.com/read/37703398/alzheimer-disease-may-compromise-patients-ability-for-expectancy-based-pain-modulation-now-what
#10
JOURNAL ARTICLE
Katja Wiech, Ulrike Bingel
No abstract text is available yet for this article.
September 13, 2023: Pain
https://read.qxmd.com/read/37703402/-the-mere-imagination-scares-me-evidence-for-fear-responses-during-mental-imagery-of-pain-associated-interoceptive-sensations-in-adolescents-with-chronic-pain
#11
JOURNAL ARTICLE
Kim D Opdensteinen, Hannah Rach, Piotr Gruszka, Luca Schaan, Dirk Adolph, Christiane A Pané-Farré, Christoph Benke, Angelika M Dierolf, Silvia Schneider, Tanja Hechler
According to the bio-informational theory of emotion by Lang, mental imagery of fearful stimuli activates physiological and behavioural response systems, even in the absence of sensory input. We investigated whether instructed mental imagery of pain-associated (not painful) interoceptive sensations entails a threat value and elicits increased startle response, skin conductance level (SCL), and heart rate (HR) indicative of defensive mobilization in adolescents with chronic pain. Additionally, self-reported measures (fear, fear of pain, desire to avoid) were assessed...
September 8, 2023: Pain
https://read.qxmd.com/read/37703397/placebo-analgesia-and-nocebo-hyperalgesia-in-patients-with-alzheimer-disease-and-healthy-participants
#12
JOURNAL ARTICLE
Susan Tomczak Matthiesen, Mette Sieg, Stephanie Skøtt Andersen, Martina Amanzio, Nanna Brix Finnerup, Troels Staehelin Jensen, Hanne Gottrup, Lene Vase
The role of placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease (AD) is largely unknown, with only few studies in the area. Therefore, this study aims to investigate to which extent placebo analgesia and nocebo hyperalgesia effects are present in patients experiencing mild-to-moderate AD. Twenty-one patients with AD (test population) and 26 healthy participants (HP; design validation) were exposed to thermal pain stimulation on 3 test days: Lidocaine condition (open/hidden lidocaine administration), capsaicin condition (open/hidden capsaicin administration), and natural history (no treatment), in a randomized, within-subject design...
September 8, 2023: Pain
https://read.qxmd.com/read/37678556/randomized-double-blind-controlled-trial-of-a-combination-of-alpha-lipoic-acid-and-pregabalin-for-neuropathic-pain-the-pain-care-trial
#13
JOURNAL ARTICLE
Ian Gilron, Sylvia Robb, Dongsheng Tu, Ronald R Holden, Alan C Jackson, Scott Duggan, Roumen Milev
We compared a combination of the nonsedating antioxidant, alpha-lipoic acid (ALA), with the sedating anticonvulsant, pregabalin, vs each monotherapy to treat neuropathic pain due to peripheral neuropathies. In this randomized, double-blind, 3-period crossover trial, participants received oral ALA, pregabalin, and their combination-each for 6 weeks. The primary outcome was mean daily pain intensity at maximal tolerated doses (MTD); secondary outcomes included quality of life (SF-36), sleep (Medical Outcomes Study-Sleep Scale), adverse effects, drug doses, and other measures...
September 7, 2023: Pain
https://read.qxmd.com/read/37733488/improving-the-art-and-science-of-communication-in-people-living-with-chronic-pain
#14
JOURNAL ARTICLE
Carmen Renee Green
No abstract text is available yet for this article.
September 6, 2023: Pain
https://read.qxmd.com/read/37703399/inflammatory-biomarkers-in-patients-with-painful-knee-osteoarthritis-exploring-the-potential-link-to-chronic-postoperative-pain-after-total-knee-arthroplasty-a-secondary-analysis
#15
JOURNAL ARTICLE
Rocco Giordano, Bijar Ghafouri, Lars Arendt-Nielsen, Kristian Kjær-Staal Petersen
Total knee arthroplasty (TKA) is the end-stage treatment of knee osteoarthritis (OA), and approximately 20% of patients experience chronic postoperative pain. Studies indicate that inflammatory biomarkers might be associated with pain in OA and potentially linked to the development of chronic postoperative pain after TKA. This study aimed to (1) evaluate preoperative serum levels of inflammatory biomarkers in patients with OA and healthy control subjects, (2) investigate preoperative differences of inflammatory biomarker profiles in subgroups of patients, and (3) compare subgroups of patients with and without postoperative pain 12 months after surgery...
September 6, 2023: Pain
https://read.qxmd.com/read/37678566/hpv-head-and-neck-cancer-derived-small-extracellular-vesicles-communicate-with-trpv1-neurons-to-mediate-cancer-pain
#16
JOURNAL ARTICLE
Kufreobong E Inyang, Christine M Evans, Matthew Heussner, Margaret Petroff, Mark Reimers, Paola D Vermeer, Nathan Tykocki, Joseph K Folger, Geoffroy Laumet
Severe pain is often experienced by patients with head and neck cancer and is associated with a poor prognosis. Despite its frequency and severity, current treatments fail to adequately control cancer-associated pain because of our lack of mechanistic understanding. Although recent works have shed some light of the biology underlying pain in HPV-negative oral cancers, the mechanisms mediating pain in HPV+ cancers remain unknown. Cancer-derived small extracellular vesicles (cancer-sEVs) are well positioned to function as mediators of communication between cancer cells and neurons...
September 6, 2023: Pain
https://read.qxmd.com/read/37678245/bodily-maps-of-emotions-and-pain-tactile-and-hedonic-sensitivity-in-healthy-controls-and-patients-experiencing-chronic-pain
#17
JOURNAL ARTICLE
Juhani Ojala, Juulia T Suvilehto, Lauri Nummenmaa, Eija Kalso
Pain is an unpleasant sensory and emotional experience. Both pain and emotions are warning signals against outside harm. Interoception, bodily sensations of emotions can be assessed with the emBODY tool where participants colour the body parts where they feel different emotions. Bodily maps of emotions (BMoE) have been shown to be similar between healthy individuals independent of age, sex, cultural background, and language. We used this tool to analyze how these body maps may differ between healthy controls and patients with persistent pain...
September 6, 2023: Pain
https://read.qxmd.com/read/37638836/-seeing-the-light-in-the-shade-of-it-primary-caregiver-and-youth-perspectives-on-using-an-inpatient-portal-for-pain-care-during-hospitalization
#18
JOURNAL ARTICLE
Nicole Pope, Sophie Jones, Dianne Crellin, Greta Palmer, Mike South, Denise Harrison
Studies from multiple countries report that most hospitalized children, especially the youngest and sickest, experience pain that is often severe yet inadequately treated. Evidence suggests this can lead to immediate and lifelong consequences affecting children, families, and communities. Partnership and shared decision-making by children, families, and clinicians is the ideal pediatric healthcare model and can improve care quality and safety, including pain care. A growing evidence base demonstrates that inpatient portals (electronic personal health record applications linked to hospital electronic medical or health records) can improve child and family engagement, outcomes, and satisfaction during hospitalization...
August 25, 2023: Pain
https://read.qxmd.com/read/37625188/information-is-power-a-qualitative-study-exploring-the-lived-experiences-of-patients-with-degenerative-cervical-radiculopathy
#19
JOURNAL ARTICLE
Joshua Plener, Silvano Mior, Melissa Atkinson-Graham, Sheilah Hogg-Johnson, Pierre Côté, Carlo Ammendolia
Degenerative cervical radiculopathy (DCR) can lead to severe pain, paraesthesia, and/or motor weakness, resulting in significant morbidity, disability, and reduced quality of life. Typically, individuals suffer from prolonged symptoms, with time to complete recovery spanning months to years. Little is known about the impact DCR has on peoples' lives. Therefore, this study aimed to explore the everyday experiences of individuals living with DCR. A qualitative study was conducted through an interpretivist lens exploring the experiences of participants...
August 25, 2023: Pain
https://read.qxmd.com/read/37624912/associations-between-patient-reported-functional-disability-and-measures-of-physical-ability-in-juvenile-fibromyalgia
#20
JOURNAL ARTICLE
Robert C Gibler, James L Peugh, Megan Pfeiffer, Staci Thomas, Sara E Williams, Katie Beasley, Scott Bonnette, Sara Collins, Sarah E Beals-Erickson, Sylvia Ounpuu, Matthew Briggs, Jennifer N Stinson, Gregory D Myer, Susmita Kashikar-Zuck
Juvenile fibromyalgia (JFM) is a chronic condition characterized by symptoms of pain and fatigue and is associated with sedentary behavior and functional disability. Adults with fibromyalgia exhibit deficits in physical fitness as evidenced by lower aerobic capacity and physical endurance, but it is unknown whether these impairments are apparent in adolescents with JFM. Furthermore, the extent to which functional disability and pain interference relate to measures of physical fitness has not been investigated in a pediatric pain population...
August 25, 2023: Pain
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