Nadia Soliman, Simon Haroutounian, Andrea G Hohmann, Elliot Krane, Jing Liao, Malcolm Macleod, Daniel Segelcke, Christopher Sena, James Thomas, Jan Vollert, Kimberley Wever, Harutyun Alaverdyan, Ahmed Barakat, Tyler Barthlow, Amber L Harris Bozer, Alexander Davidson, Marta Diaz-delCastillo, Antonina Dolgorukova, Mehnaz I Ferdousi, Catherine Healy, Simon Hong, Mary Hopkins, Arul James, Hayley B Leake, Nathalie M Malewicz, Michael Mansfield, Amelia K Mardon, Darragh Mattimoe, Daniel P McLoone, Gith Noes-Holt, Esther M Pogatzki-Zahn, Emer Power, Bruno Pradier, Eleny Romanos-Sirakis, Astra Segelcke, Rafael Vinagre, Julio A Yanes, Jingwen Zhang, Xue Ying Zhang, David P Finn, Andrew S C Rice
We report a systematic review and meta-analysis of studies which assessed the antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators on pain-associated behavioural outcomes in animal models of pathological or injury-related persistent pain. In April 2019, we systematically searched 3 online databases and used crowd science and machine learning to identify studies for inclusion. We calculated a standardised mean difference (SMD) effect size for each comparison and performed a random effects meta-analysis...
March 15, 2021: Pain