Vishruth Girish, Asad A Lakhani, Sarah L Thompson, Christine M Scaduto, Leanne M Brown, Ryan A Hagenson, Erin L Sausville, Brianna E Mendelson, Pranav K Kandikuppa, Devon A Lukow, Monet Lou Yuan, Eric C Stevens, Sophia N Lee, Klaske M Schukken, Saron M Akalu, Anand Vasudevan, Charles Zou, Barbora Salovska, Wenxue Li, Joan C Smith, Alison M Taylor, Robert A Martienssen, Yansheng Liu, Ruping Sun, Jason M Sheltzer
Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (<u>Re</u>storing <u>D</u>isomy in <u>A</u>neuploid cells using <u>C</u>RISPR <u>T</u>argeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, we created a panel of isogenic cells that have or lack common aneuploidies, and we demonstrate that trisomy of chromosome 1q is required for malignant growth in cancers harboring this alteration...
July 6, 2023: Science