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American Journal of Health-system Pharmacy: AJHP

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https://read.qxmd.com/read/30698654/comparison-of-real-world-outcomes-in-patients-with-nonvalvular-atrial-fibrillation-treated-with-direct-oral-anticoagulant-agents-or-warfarin
#1
Manasi Datar, Concetta Crivera, Heather Rozjabek, Ibrahim M Abbass, Yihua Xu, Margaret K Pasquale, Jeff R Schein, George A Andrews
Purpose: To compare patients with atrial fibrillation (AF) initiating direct oral anticoagulants (DOACs) versus warfarin on clinical outcomes including stroke, systemic embolism (SE), bleeding events, and cost of care. Methods: This retrospective observational study used Medicare Advantage Prescription Drug and fully insured commercial claims from the Humana Research Database. Patients with AF who initiated a DOAC or warfarin from January 1, 2012 through September 30, 2015 were included...
January 29, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30698653/developing-and-evaluating-a-pharmacy-technician-home-visit-program
#2
Katherine Fuller, Patrick Gregory, Beiyu Liu, Eugenie Komives, Benjamin Smith
No abstract text is available yet for this article.
January 29, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30698650/development-and-validation-of-a-dynamic-inpatient-risk-prediction-model-for-clinically-significant-hypokalemia-using-electronic-health-record-data
#3
Yan Li, Benjamin Staley, Carl Henriksen, Dandan Xu, Gloria Lipori, Almut G Winterstein
Purpose: The purpose of this study was to develop a dynamic risk prediction model for inpatient hypokalemia and evaluate its predictive performance. Methods: A retrospective cohort included all admissions aged 18 years and above from 2 large tertiary hospitals in Florida over a 22-month period. Hypokalemia was defined as a potassium value of less than 3 mmol/L, and subsequent initiation of potassium supplements. Twenty-five risk factors (RF) identified from literature were operationalized using discrete electronic health record (EHR) data elements...
January 29, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30689729/medication-review-in-older-adults-importance-of-time-to-benefit
#4
Lorenz Van der Linden, Julie Hias, Isabel Spriet, Karolien Walgraeve, Johan Flamaing, Jos Tournoy
No abstract text is available yet for this article.
January 22, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30689699/musculoskeletal-toxicities-in-patients-receiving-concomitant-statin-and-daptomycin-therapy
#5
Kazuhiko Kido, Austin A Oyen, Morgan A Beckmann, Sara D Brouse
Purpose: This article evaluates the musculoskeletal safety of concomitant therapy with daptomycin and Hydroxymethylglutaryl-coenzyme A (HMG CoA) reductase inhibitors (statins). Summary: Often indicated for severe gram-positive infections, daptomycin is commonly administered with statins but there is limited guidance on the appropriate management of concomitant therapy with daptomycin and statins. A narrative review was conducted to review contemporary clinical evidence of the safety of concomitant therapy with daptomycin and statins...
January 21, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30689698/hemorrhagic-conversion-after-alteplase-administration-in-a-patient-with-vasculitis-and-acute-ischemic-stroke
#6
Brian W Gilbert, Laxmi Dhakal, Alison Lacy, Joel B Huffman
Purpose: A case of alteplase administration to a patient with vasculitis and acute ischemic stroke (AIS) is reported. Summary: A 38-year-old woman with a recent diagnosis of granulomatosis with polyangiitis (GPA) received alteplase for AIS and developed symptomatic hemorrhagic conversion. Published reports regarding the safety of thrombolytic therapy in patients with a high inflammatory burden are inconsistent. The current case adds to the literature on the topic...
January 19, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30689696/development-and-implementation-of-a-strategy-to-ensure-outpatient-access-to-medications-started-in-the-inpatient-setting
#7
Anthony Trovato, Kavish Choudhary, Erin R Fox
No abstract text is available yet for this article.
January 18, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753296/new-drugs-and-dosage-forms
#8
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753294/stakeholders-describe-drug-shortage-challenges
#9
Kate Traynor
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753293/hopes-are-high-for-collaborative-practice-in-florida
#10
Kate Traynor
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753292/safety-of-high-dose-intravenous-labetalol-in-hypertensive-crisis
#11
Jason P Hecht, Syeda M Mahmood, Mary-Margaret Brandt
Purpose: The study assesses the safety of high-dose intravenous (i.v.) labetalol in adults. Methods: This is a retrospective administrative record review of 28 hospitals in one health care system, from October 2010 through October 2015. Patients were included if they received 300 mg of i.v. labetalol within a 24-hour period. Vital signs, adverse events and cumulative medication doses were obtained for up to 24 hours while on labetalol. Adverse events were defined as any systolic blood pressure measurement less than 90 mm Hg or heart rate less than 60 beats per minute...
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753291/using-a-spare-medication-vial-to-store-multiple-medications-a-potentially-fatal-in-home-medication-error
#12
James B Leonard, Wendy Klein-Schwartz
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753290/adverse-drug-reactions-in-the-veterans-affairs-healthcare-system-frequency-severity-and-causative-medications-analyzed-by-patient-age
#13
Von R Moore, Peter A Glassman, Anthony Au, Chester B Good, Thomas C Leadholm, Francesca E Cunningham
Purpose: Adverse drug events (ADEs) in the U.S. Department of Veterans Affairs (VA) were evaluated, and differences in age group report rates and reported medications in different age groups were assessed. Methods: We utilized the VA Adverse Drug Event Reporting System (ADERS) to assess 10-year age groups regarding ADE reporting rates, event severity, and associated reported medications. Data were derived from 484,351 ADE reports from 395,703 patients included in VA ADERS from 2009 through 2016...
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753289/midostaurin-for-the-management-of-flt3-mutated-acute-myeloid-leukemia-and-advanced-systemic-mastocytosis
#14
Nichole Sly, Katie Gaspar
Purpose: This article reviews the pharmacology, efficacy, safety, cost, and future directions of midostaurin for the treatment of acute myeloid leukemia (AML), aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm, and mast cell leukemia, collectively known as advanced systemic mastocytosis (SM). Summary: Midostaurin was approved by the U.S. Food and Drug Administration for the treatment of FMS-like tyrosine kinase-3 (FLT3)- mutated AML...
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753288/advancing-pharmacy-practice-by-reducing-gaps-in-pharmacogenetic-education
#15
Annie Chang, Ryan Nelson, Diana Brixner
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753287/use-of-a-tablet-computer-application-to-engage-patients-in-updating-their-medication-list
#16
Sunil Kripalani, Kimberly Hart, Caitlin Schaninger, Stuart Bracken, Christopher Lindsell, Dane R Boyington
Purpose: Failure to obtain an accurate medication history can adversely affect patient care in the emergency department (ED) and propagate errors into the inpatient and outpatient settings. Obtaining an accurate medication history in the ED is challenging, however, due to limited time, a suboptimal environment for patient interaction, and inadequate information in the electronic health record (EHR). This article describes the development and initial evaluation of the PictureRx Medication History Application, a tablet computer-based program that queries patients' prescription fill data from the Surescripts Medication History service and renders it graphically for review and editing at the point of care...
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753286/administration-of-crushed-maraviroc-via-percutaneous-gastrostomy-tube-in-a-patient-with-human-immunodeficiency-virus-and-progressive-multifocal-leukoencephalopathy
#17
Patricia Pecora Fulco, Travis L Gatesman
No abstract text is available yet for this article.
February 9, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753317/use-of-economic-predictions-to-make-formulary-decisions
#18
Mary Frances Picone, Christopher S Wisniewski, Genevieve Luehrs Hayes
Purpose: The accuracy of cost savings and reimbursement predictions for medications added to an academic medical center formulary was assessed. Methods: Formulary changes over a 5-year period were reviewed by the investigators. Medications were included if the medication was added to formulary and the monograph included cost savings or reimbursement data that indicated a positive net margin. The primary endpoints were percent predicted cost savings and net margin per medication based on medication cost only...
February 8, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753316/effect-of-modifying-dose-alerts-in-an-electronic-health-record-on-frequency-of-alerts
#19
Rachel Muhlenkamp, Nathan Ash, Kristi Ziegenbusch, Nancy Rampe, Bryan Bishop, Eyob Adane
Purpose: Results of a study to reduce the number of medication order-entry alerts and perceived alert fatigue by optimizing alert logic are reported. Methods: Data on dosage alerts registered throughout a health system over 2 days per study phase (preintervention and postintervention) were collected from the electronic health record. The 5 medications most frequently associated with dosage alerts during computerized prescriber order entry (CPOE) were evaluated for appropriateness in relation to patient-specific characteristics...
February 8, 2019: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/30753315/impact-of-clinical-pharmacy-specialists-on-glycemic-control-in-veterans-with-type-2-diabetes
#20
Kathryn Schmidt, Jo-Ann Caudill, Tina Hamilton
Purpose: The results of a study to determine the impact that Patient Aligned Care Team clinical pharmacy specialists (CPSs) have in improving glycemic control among veterans with type 2 diabetes are reported. Methods: Reductions in glycosylated hemoglobin (HbA1c) values in diabetic patients are associated with improved outcomes related to vascular complications. Current diabetes management strategies at the Cincinnati Veteran Affairs Medical Center (VAMC) involve a multidisciplinary approach that includes visits with a CPS by veterans referred by a primary care provider...
February 8, 2019: American Journal of Health-system Pharmacy: AJHP
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