journal
https://read.qxmd.com/read/37740600/anticoagulant-drug-drug-interactions-with-cannabinoids-a-systematic-review
#1
REVIEW
Maureen A Smythe, Wendy Wu, Candice L Garwood
INTRODUCTION: This systematic review evaluates the extent to which the effect of anticoagulants may be altered in the presence of cannabinoids. METHODS: The following databases were searched: EMBASE, PubMed, Web of Science, Scopus, PscycINFO, and CINAHL from database inception through May 2023. Search terms included cannabis AND anticoagulant AND drug interactions, and related key words. The major outcome was hemorrhage or thrombosis and if available, the relative change in quantitative intensity of anticoagulation after cannabinoid exposure...
September 23, 2023: Pharmacotherapy
https://read.qxmd.com/read/37728179/fluid-resuscitation-and-relation-to-respiratory-support-escalation-in-patients-with-and-without-pulmonary-hypertension-with-sepsis
#2
JOURNAL ARTICLE
Mary J Fronrath, Laura Hencken, Carolyn R Martz, Bryan Kelly, Zachary R Smith
PURPOSE: To compare guideline-based fluid resuscitation and need for respiratory support escalation in septic patients with pulmonary hypertension (PH) to those without PH. METHODS: This was a single center, retrospective cohort study (November 2013-December 2019) of patients with or without PH hospitalized and diagnosed with sepsis. Patients with sepsis were included into two groups based on a previous PH diagnosis or no PH diagnosis. The primary outcome was incidence of respiratory support escalation within 72 hours from sepsis time zero...
September 20, 2023: Pharmacotherapy
https://read.qxmd.com/read/37728152/morphomics-informed-population-pharmacokinetic-and-physiologically-based-pharmacokinetic-modeling-to-optimize-cefazolin-surgical-prophylaxis
#3
JOURNAL ARTICLE
Shuhan Liu, Aleksas Matvekas, Tamara Naimi, Aws Ghanem, Ruiting Li, Krishani Rajanayake, Brian Derstine, Brian Ross, June Sullivan, Hyun Gi Yun, Scott Regenbogen, John Byrn, Grace Su, Stewart Wang, Manjunath P Pai
INTRODUCTION: Cefazolin is the leading antibiotic used to prevent surgical site infections worldwide. Consensus guidelines recommend adjustment of the cefazolin dose above and below 120 kg without regard to body composition. Algorithms exist to repurpose radiologic data into body composition (morphomics) and inform dosing decisions in obesity. OBJECTIVES: To compare the current standard of body weight to morphomic measurements as covariates of cefazolin pharmacokinetics and aid dose stratification of cefazolin in patients with obesity undergoing colorectal surgery...
September 20, 2023: Pharmacotherapy
https://read.qxmd.com/read/37724631/standards-of-practice-to-advance-the-quality-of-health-care
#4
EDITORIAL
C Lindsay DeVane, Jerry L Bauman
No abstract text is available yet for this article.
September 19, 2023: Pharmacotherapy
https://read.qxmd.com/read/37724038/erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
September 19, 2023: Pharmacotherapy
https://read.qxmd.com/read/37699580/fluoroquinolone-associated-adverse-events-of-interest-among-hospitalized-veterans-affairs-patients-with-community-acquired-pneumonia-who-were-treated-with-a-fluoroquinolone-a-focus-on-tendonitis-clostridioides-difficile-infection-and-aortic-aneurysm
#6
JOURNAL ARTICLE
Nimish Patel, Allison Gorseth, Gina Belfiore, Nicholas Stornelli, Colleen Lowry, Thomas Lodise
INTRODUCTION: An understanding of how frequently individual fluoroquinolone (FQ) adverse events of interest (FQAEIs) occur within specific infection types is imperative to coordinate appropriate use of FQ and potential avoidance in certain disease states and/or patient populations. OBJECTIVES: Study objectives were to i) quantify the incidence of three concerning FQAEI (i.e., adverse tendon event (TE), Clostridioides difficile infection (CDI), and aortic aneurysm/dissection (AAD)), ii) identify the patient-level factors that predict these events, and iii) develop clinical risk scores to estimate the predicted probabilities of each FQAEI based on patient-level covariates available on clinical presentation...
September 12, 2023: Pharmacotherapy
https://read.qxmd.com/read/37698371/cyp2d6-guided-opioid-therapy-for-adults-with-cancer-pain-a-randomized-implementation-clinical-trial
#7
JOURNAL ARTICLE
Scott A Mosley, Emily Cicali, Alex Del Cueto, Diane G Portman, Kristine A Donovan, Yan Gong, Taimour Langaee, Priya Gopalan, Jessica Schmit, Jason S Starr, Natalie Silver, Young D Chang, Sahana Rajasekhara, Joshua E Smith, Heloisa P Soares, Mike Clare-Salzler, Petr Starostik, Thomas J George, Howard L McLeod, Roger B Fillingim, J Kevin Hicks, Larisa H Cavallari
INTRODUCTION: The CYP2D6 enzyme metabolizes opioids commonly prescribed for cancer-related pain, and CYP2D6 polymorphisms may contribute to variability in opioid response. We evaluated the feasibility of implementing CYP2D6-guided opioid prescribing for patients with cancer and report pilot outcome data. METHODS: Adult patients from two cancer centers were prospectively enrolled into a hybrid implementation-effectiveness clinical trial and randomized to CYP2D6-genotype guided opioid selection, with clinical recommendations, or usual care...
September 12, 2023: Pharmacotherapy
https://read.qxmd.com/read/37688422/transitioning-disopyramide-to-mavacamten-in-obstructive-hypertrophic-cardiomyopathy-a-case-series-and-clinical-guide
#8
Andrew Willeford, Jorge Silva Enciso
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a genetic disorder for which first-line treatments for obstructive HCM (oHCM) include beta-blockers, non-dihydropyridine calcium-channel blockers, and disopyramide for refractory cases. Mavacamten, a selective cardiac myosin inhibitor, is indicated for symptomatic oHCM to improve functional capacity and symptoms. Use of disopyramide and mavacamten together is not recommended due to concerns of additive negative inotropic effects. Transitioning from disopyramide to mavacamten may be preferred to avoid adverse effects and frequent administration, however, the best approach for making the transition has not been established...
September 9, 2023: Pharmacotherapy
https://read.qxmd.com/read/37681344/switching-from-intravenous-vancomycin-to-oral-antibiotics-reduces-adverse-events-in-a-retrospective-cohort-of-outpatients-with-orthopedic-infections
#9
JOURNAL ARTICLE
Chanah K Gallagher, Heather Cummins, Russell J Benefield, Laura K Certain
INTRODUCTION: Vancomycin is frequently used for prolonged courses in treating osteoarticular infections despite a high rate of adverse drug events (ADE). The objective of this study was to evaluate the safety and effectiveness of transitioning to oral therapy compared to continuing parenteral vancomycin in patients with orthopedic infections. METHODS: We conducted a single-center, retrospective cohort study of patients with orthopedic infections discharged on parenteral vancomycin with a planned duration of at least four weeks...
September 8, 2023: Pharmacotherapy
https://read.qxmd.com/read/37604646/approaches-to-precision-based-anticoagulation-management-in-the-critically-ill
#10
JOURNAL ARTICLE
William E Dager, Toby C Trujillo, Brian W Gilbert
Anticoagulant therapy is commonly associated with a high incidence of avoidable adverse events, especially in the acute care setting. This has led to several initiatives by key national health care stakeholders, including specific attention in The Joint Commission's National Patient Safety Goals, to improve anticoagulation management. The subject of special populations has long been identified as challenging by clinicians with the use of anticoagulants. This is driven in part by numerous variables that can contribute to hard outcomes such as bleeding, thrombosis, length of stay, hospital re-admission, morbidity, and mortality...
August 21, 2023: Pharmacotherapy
https://read.qxmd.com/read/37602980/correction-to-comparative-adherence-trajectories-of-oral-disease-modifying-agents-in-multiple-sclerosis
#11
(no author information available yet)
No abstract text is available yet for this article.
August 21, 2023: Pharmacotherapy
https://read.qxmd.com/read/37596844/antimicrobial-pharmacokinetics-and-dosing-in-critically-ill-adults-receiving-prolonged-intermittent-renal-replacement-therapy-a-systematic-review
#12
REVIEW
Arvind Grewal, Pierre Thabet, Samuel Dubinsky, Debanjali Purkayastha, Kristy Wong, Ryan Marko, Swapnil Hiremath, Brian Hutton, Salmaan Kanji
INTRODUCTION: Prolonged intermittent renal replacement therapy (PIRRT) is gaining popularity as a renal replacement modality in intensive care units, but there is a relative lack of guidance regarding antimicrobial clearance and dosing when compared with other modalities. OBJECTIVES: The objectives of this systematic review were to: 1) identify and describe the pharmacokinetics (PK) of relevant antimicrobials used in critically ill adults receiving PIRRT, 2) evaluate the quality of evidence supporting this data, and 3) propose dosing recommendations based on the synthesis of this data...
August 19, 2023: Pharmacotherapy
https://read.qxmd.com/read/37593883/baricitinib-versus-tocilizumab-in-critically-ill-covid-19-patients-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Grace M Conroy, Seth R Bauer, Andrea M Pallotta, Abhijit Duggal, Lu Wang, Gretchen L Sacha
BACKGROUND: Tocilizumab and baricitinib improve outcomes in severely ill patients with coronavirus disease 2019 (COVID-19), however, comparative analyses of clinical outcomes related to these agents is lacking. A tocilizumab national shortage shifted treatment to baricitinib in critically ill patients, allowing for an outcome comparison in a similar population. The purpose of this study is to compare clinical outcomes in critically ill COVID-19 patients who received tocilizumab and those who received baricitinib...
August 18, 2023: Pharmacotherapy
https://read.qxmd.com/read/37574774/using-population-pharmacokinetics-to-optimize-initial-vancomycin-dosing-guidelines-for-neonates-to-treat-sepsis-caused-by-coagulase-negative-staphylococcus
#14
JOURNAL ARTICLE
Erin Chung, Winnie Seto
INTRODUCTION: Vancomycin dosing tailored for newborns is challenging due to the significant influence of maturation and organ function on pharmacokinetics. Population pharmacokinetic (popPK) models can be used to improve target attainment in neonates. OBJECTIVES: The primary objective was to derive and evaluate a popPK model of intravenous vancomycin for neonates. Secondly, the predictive performance of this popPK model was compared with published popPK models. METHODS: This is a retrospective cohort study of neonates admitted to the neonatal intensive care unit receiving intravenous vancomycin...
August 13, 2023: Pharmacotherapy
https://read.qxmd.com/read/37574770/efficacy-of-risdiplam-in-spinal-muscular-atrophy-a-systematic-review-and-meta-analysis
#15
REVIEW
Carlos Pascual-Morena, Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Irene Martínez-García, Nerea Moreno-Herráiz, Celia Álvarez-Bueno, Alicia Saz-Lara
OBJECTIVES: This systematic review and meta-analysis aimed to assess the efficacy and safety of risdiplam on motor and respiratory function in spinal muscular atrophy (SMA). METHODS: We systematically searched Medline, Scopus, Web of Science, and the Cochrane Library from inception to March 2023. We included pre-post studies that determined the effect of risdiplam on the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND), the 32-item Motor Function Measure (MFM32), the Revised upper limb module (RULM), the Hammersmith Functional Motor Scale - Expanded (HFMSE), respiratory function, and the proportion of risdiplam-related adverse events in a population with SMA (phenotypes 1 and 2/3)...
August 13, 2023: Pharmacotherapy
https://read.qxmd.com/read/37574548/transplacental-methadone-exposure-and-risk-of-neonatal-opioid-withdrawal-syndrome
#16
JOURNAL ARTICLE
Varsha Bhatt-Mehta, Xinyue Jing, Xinwen Wang, Hao-Jie Zhu
STUDY OBJECTIVE: Neonatal opioid withdrawal syndrome (NOWS) is a condition that often occurs in neonates born to mothers who received methadone treatment for opioid use disorder during pregnancy. Early identification and treatment of infants at risk of NOWS may improve clinical outcomes. The purpose of this study was to evaluate whether maternal and umbilical cord plasma concentrations of methadone and its metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), could predict the need for NOWS treatment...
August 13, 2023: Pharmacotherapy
https://read.qxmd.com/read/37539477/potential-drug-drug-interactions-among-u-s-adults-treated-with-nirmatrelvir-ritonavir-a-cross-sectional-study-of-the-national-covid-cohort-collaborative-n3c
#17
JOURNAL ARTICLE
Xuya Xiao, Hemalkumar B Mehta, Jill Curran, Brian T Garibaldi, G Caleb Alexander
IMPORTANCE: Nirmatrelvir/ritonavir has potential to interact with many drugs. OBJECTIVE: To estimate the prevalence of potential moderate to severe drug-drug interactions (DDIs) involving nirmatrelvir/ritonavir, identify interacting medications, and evaluate risk factors associated with potential DDIs. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional study using electronic health records from the National COVID Cohort Collaborative Enclave, one of the largest COVID-19 data resources in the United States...
August 4, 2023: Pharmacotherapy
https://read.qxmd.com/read/37538041/anticoagulation-strategies-in-patients-with-extracorporeal-membrane-oxygenation-a-network-meta-analysis-and-systematic-review
#18
REVIEW
Jiale Chen, Guoquan Chen, Wenyi Zhao, Wenxing Peng
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) plays an important role in providing temporary life support for patients with severe cardiac or pulmonary failure, but requires strict anticoagulation and monitoring. This network meta-analysis systematically explored the most effective anticoagulation and monitoring strategies for patients receiving ECMO. METHODS: MEDLINE, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched up to January 31, 2023, for studies comparing unfractionated heparin (UFH), argatroban (Arg), bivalirudin (Biv), and/or nafamostat mesylate (NM) in patients receiving ECMO...
August 4, 2023: Pharmacotherapy
https://read.qxmd.com/read/37519116/review-of-anticoagulation-considerations-in-extracorporeal-membrane-oxygenation-support
#19
REVIEW
Sydney D T Graboyes, Phillip S Owen, Rickey A Evans, Theodore J Berei, Katarzyna M Hryniewicz, Ian B Hollis
Since its first success in 1975, extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency for pulmonary and cardiopulmonary bypass. Use in adults has increased exponentially since the early 2000s, but despite thousands of international cannulations using both veno-arterial (VA) and veno-venous (VV) ECMO, there are still significant hemocompatibility-related adverse events. Current management of anticoagulation has been based on the Extracorporeal Life Support Organization guidance published in 2014 with recent updates published in 2022...
July 30, 2023: Pharmacotherapy
https://read.qxmd.com/read/37491976/practical-considerations-for-individualizing-drug-dosing-in-critically-ill-adults-receiving-renal-replacement-therapy
#20
REVIEW
Salmaan Kanji, Claire Roger, Fabio Silvio Taccone, Laurent Muller
Critically ill patients with sepsis admitted to the intensive care unit (ICU) often present with or develop renal dysfunction requiring renal replacement therapy (RRT) in addition to antimicrobial therapy. While early and appropriate antimicrobials for sepsis have been associated with an increased probability of survival, adequate dosing is also required in these patients. Adequate dosing of antimicrobials refers to dosing strategies that achieve serum drug levels at the site of infection that are able to provide a microbiological and/or clinical response while avoiding toxicity from excessive antibiotic exposure...
July 26, 2023: Pharmacotherapy
journal
journal
20313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.