Samantha J Wala, Mecklin V Ragan, Nitin Sajankila, Samuel G Volpe, Nanditha Purayil, Zachary Dumbauld, Gail E Besner
Necrotizing enterocolitis (NEC) is an infectious and inflammatory intestinal disease that is the most common surgical emergency in the premature patient population. Although the etiology of the disease is multifactorial, intestinal dysbiosis is a hallmark of this disease. Based on this, probiotics may play a therapeutic role in NEC by introducing beneficial bacteria with immunomodulating, antimicrobial, and anti-inflammatory functions into the gastrointestinal tract. Currently, there is no Food and Drug Administration (FDA)-approved probiotic for the prevention and treatment of NEC...
June 2023: Seminars in Pediatric Surgery