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JOURNAL ARTICLE
Shawn S Jackson, Jennifer J Lee, William M Jackson, Jerri C Price, Sue R Beers, John W Berkenbosch, Katherine V Biagas, Robert H Dworkin, Constance S Houck, Guohua Li, Heidi A B Smith, Denham S Ward, Kanecia O Zimmerman, Martha A Q Curley, Christopher M Horvat, David T Huang, Neethi P Pinto, Cynthia F Salorio, Rebeccah Slater, Beth S Slomine, Leanne L West, David Wypij, Keith O Yeates, Lena S Sun
OBJECTIVES: Sedation and analgesia for infants and children requiring mechanical ventilation in the PICU is uniquely challenging due to the wide spectrum of ages, developmental stages, and pathophysiological processes encountered. Studies evaluating the safety and efficacy of sedative and analgesic management in pediatric patients have used heterogeneous methodologies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) IV hosted a series of multidisciplinary meetings to establish consensus statements for future clinical study design and implementation as a guide for investigators studying PICU sedation and analgesia...
December 7, 2023: Pediatric Critical Care Medicine
#2
JOURNAL ARTICLE
Eric J Wilsterman, Marianne E Nellis, Josep Panisello, Awni Al-Subu, Ryan Breuer, Dai Kimura, Conrad Krawiec, Palen P Mallory, Sholeen Nett, Erin Owen, Simon J Parsons, Ronald C Sanders, Annery Garcia-Marcinkiewicz, Natalie Napolitano, Justine Shults, Vinay Nadkarni, Akira Nishisaki
OBJECTIVES: Children with trisomy 21 often have anatomic and physiologic features that may complicate tracheal intubation (TI). TI in critically ill children with trisomy 21 is not well described. We hypothesize that in children with trisomy 21, TI is associated with greater odds of adverse airway outcomes (AAOs), including TI-associated events (TIAEs), and peri-intubation hypoxemia (defined as > 20% decrease in pulse oximetry saturation [Spo2]). DESIGN: Retrospective database study using the National Emergency Airway Registry for Children (NEAR4KIDS)...
December 7, 2023: Pediatric Critical Care Medicine
#3
JOURNAL ARTICLE
Julia A Heneghan, Sarah B Walker, Andrea Fawcett, Tellen D Bennett, Adam C Dziorny, L Nelson Sanchez-Pinto, Reid W D Farris, Meredith C Winter, Colleen Badke, Blake Martin, Stephanie R Brown, Michael C McCrory, Manette Ness-Cochinwala, Colin Rogerson, Orkun Baloglu, Ilana Harwayne-Gidansky, Matthew R Hudkins, Rishikesan Kamaleswaran, Sandeep Gangadharan, Sandeep Tripathi, Eneida A Mendonca, Barry P Markovitz, Anoop Mayampurath, Michael C Spaeder
OBJECTIVE: Perform a scoping review of supervised machine learning in pediatric critical care to identify published applications, methodologies, and implementation frequency to inform best practices for the development, validation, and reporting of predictive models in pediatric critical care. DESIGN: Scoping review and expert opinion. SETTING: We queried CINAHL Plus with Full Text (EBSCO), Cochrane Library (Wiley), Embase (Elsevier), Ovid Medline, and PubMed for articles published between 2000 and 2022 related to machine learning concepts and pediatric critical illness...
December 7, 2023: Pediatric Critical Care Medicine
#4
JOURNAL ARTICLE
Meredith Fischer, David K Ngendahimana, R Scott Watson, Adam J Schwarz, Steven L Shein
OBJECTIVES: To describe rates and associated risk factors for functional decline 6 months after critical bronchiolitis in a large, multicenter dataset. DESIGN: Nonprespecified secondary analysis of existing 6-month follow-up data of patients in the Randomized Evaluation of Sedation Titration for Respiratory Failure trial (RESTORE, NCT00814099). SETTING: Patients recruited to RESTORE in any of 31 PICUs in the United States, 2009-2013. PATIENTS: Mechanically ventilated PICU patients under 2 years at admission with a primary diagnosis of bronchiolitis...
December 1, 2023: Pediatric Critical Care Medicine
#5
JOURNAL ARTICLE
Alex Lepage-Farrell, Laurence Tabone, Virginie Plante, Atsushi Kawaguchi, Joshua Feder, Sally Al Omar, Guillaume Emeriaud
OBJECTIVES: To describe our experience of using noninvasive neurally adjusted ventilatory assist (NIV-NAVA) in infants with bronchiolitis, its association with the evolution of respiratory effort, and PICU outcomes. DESIGN: Retrospective analysis of a prospectively curated, high-frequency electronic database. SETTING: A PICU in a university-affiliated maternal-child health center in Canada. PATIENTS: Patients younger than 2 years old who were admitted with a diagnosis of acute bronchiolitis and treated with NIV-NAVA from October 2016 to June 2018...
November 21, 2023: Pediatric Critical Care Medicine
#6
JOURNAL ARTICLE
Raphael Joye, Vladimir L Cousin, Julie Wacker, Aparna Hoskote, Fabienne Gebistorf, Joseph E Tonna, Peter T Rycus, Ravi R Thiagarajan, Angelo Polito
OBJECTIVES: To determine factors associated with brain death in children treated with extracorporeal cardiopulmonary resuscitation (E-cardiopulmonary resuscitation). DESIGN: Retrospective database study. SETTINGS: Data reported to the Extracorporeal Life Support Organization (ELSO), 2017-2021. PATIENTS: Children supported with venoarterial extracorporeal membrane oxygenation (ECMO) for E-cardiopulmonary resuscitation...
November 20, 2023: Pediatric Critical Care Medicine
#7
JOURNAL ARTICLE
Rachel Vassar, Nehali Mehta, Lane Epps, Fei Jiang, Edilberto Amorim, Sharon Wietstock
OBJECTIVES: Pediatric out-of-hospital cardiac arrest (OHCA) is associated with substantial morbidity and mortality. Limited data exist to guide timing and method of neurologic prognostication after pediatric OHCA, making counseling on withdrawal of life-sustaining therapies (WLSTs) challenging. This study investigates the timing and mode of death after pediatric OHCA and factors associated with mortality. Additionally, this study explores delayed recovery after comatose examination on day 3 postarrest...
November 20, 2023: Pediatric Critical Care Medicine
#8
JOURNAL ARTICLE
Katherine R Schlosser Metitiri, Adler Perotte
OBJECTIVES: Patient vital sign data charted in the electronic health record (EHR) are used for time-sensitive decisions, yet little is known about when these data become nominally available compared with when the vital sign was actually measured. The objective of this study was to determine the magnitude of any delay between when a vital sign was actually measured in a patient and when it nominally appears in the EHR. DESIGN: We performed a single-center retrospective cohort study...
November 15, 2023: Pediatric Critical Care Medicine
#9
JOURNAL ARTICLE
Luan Thanh Vo, Dat Tat Nguyen, Thinh Ngoc Tran, Hang Hoang-Thanh Tran, Trang Thi-Hoai Đoan, Tram Ngoc Pham, Thanh Thi-Hoai Mai, Quynh Xuan-Thuy Nguyen, Thuan Khac Nguyen, Thuong Thi-Kim Nguyen, Sakib Burza, Thanh Tat Nguyen
OBJECTIVES: Profound dengue shock syndrome (DSS) complicated by severe respiratory failure necessitating mechanical ventilation (MV) accounts for high case fatality rates among PICU-admitted patients. A major challenge to management is the assessment of intravascular volume, which can be hampered by severe plasma leakage and the use of MV. DESIGN: Retrospective cohort, from 2013 to 2021. PATIENTS: Sixty-seven children with profound DSS supported by MV, some of whom underwent bedside point-of-care ultrasound (POCUS) for assessment and monitoring of hemodynamics and fluid administration...
November 15, 2023: Pediatric Critical Care Medicine
#10
JOURNAL ARTICLE
Marianne E Nellis, Oliver Karam, Guillermo Aldave, Brandon G Rocque, David F Bauer
OBJECTIVES: To report pediatric intensivists' and pediatric neurosurgeons' responses to case-based scenarios about plasma and platelet transfusions before intracranial pressure (ICP) monitor placement in children with severe traumatic brain injury (TBI). DESIGN: Cross-sectional, electronic survey to evaluate reported plasma and platelet transfusion decisions in eight scenarios of TBI in which ICP monitor placement was indicated. SETTING: Survey administered through the Pediatric Acute Lung Injury and Sepsis Investigators and the American Association of Neurologic Surgeons...
November 15, 2023: Pediatric Critical Care Medicine
#11
JOURNAL ARTICLE
Laurie A Lee, Dori-Ann Martin, Meagan Mahoney, Lee James, Yaron Avitzur, Allison Carroll, Bailey Piggott, Christopher Tomlinson, Simon Urschel, Lorraine Hamiwka
OBJECTIVES: To understand contemporary pediatric organ donation programs in Canadian PICUs, including: policies and practices, data collection and reporting, and system and process barriers. DESIGN: A cross-sectional survey carried out 2021-2022. SETTING: Canadian PICUs affiliated with a donor physician network. SUBJECTS: Pediatric intensivists identified as the donation program lead, or most knowledgeable about donation for their institution...
November 15, 2023: Pediatric Critical Care Medicine
#12
JOURNAL ARTICLE
Daniela Chanci, Jocelyn R Grunwell, Alireza Rafiei, Ronald Moore, Natalie R Bishop, Prakadeshwari Rajapreyar, Lisa M Lima, Mark Mai, Rishikesan Kamaleswaran
OBJECTIVES: To develop and externally validate an intubation prediction model for children admitted to a PICU using objective and routinely available data from the electronic medical records (EMRs). DESIGN: Retrospective observational cohort study. SETTING: Two PICUs within the same healthcare system: an academic, quaternary care center (36 beds) and a community, tertiary care center (56 beds). PATIENTS: Children younger than 18 years old admitted to a PICU between 2010 and 2022...
November 13, 2023: Pediatric Critical Care Medicine
#13
JOURNAL ARTICLE
Arjun Chandna, Suy Keang, Meas Vorlark, Bran Sambou, Chhay Chhingsrean, Heav Sina, Pav Vichet, Kaajal Patel, Eang Habsreng, Arthur Riedel, Lazaro Mwandigha, Constantinos Koshiaris, Rafael Perera-Salazar, Paul Turner, Ngoun Chanpheaktra, Claudia Turner
OBJECTIVES: To develop a clinical prediction model to risk stratify children admitted to PICUs in locations with limited resources, and compare performance of the model to nine existing pediatric severity scores. DESIGN: Retrospective, single-center, cohort study. SETTING: PICU of a pediatric hospital in Siem Reap, northern Cambodia. PATIENTS: Children between 28 days and 16 years old admitted nonelectively to the PICU...
November 10, 2023: Pediatric Critical Care Medicine
#14
JOURNAL ARTICLE
Kelsey M Gladen, David Tellez, Natalie Napolitano, Lauren R Edwards, Ronald C Sanders, Taiki Kojima, Matthew P Malone, Justine Shults, Conrad Krawiec, Shashikanth Ambati, Riley McCarthy, Aline Branca, Lee A Polikoff, Philipp Jung, Simon J Parsons, Palen Mallory, Kavipriya Komeswaran, Christopher Page-Goertz, Megan C Toal, G Kris Bysani, Keith Meyer, Fabrizio Chiusolo, Lily B Glater-Welt, Awni Al-Subu, Katherine Biagas, Jan Hau Lee, Michael Miksa, John S Giuliano, Krista L Kierys, Andrea M Talukdar, Michelle DeRusso, Laurence Cucharme-Crevier, Michelle Adu-Arko, Asha Shenoi, Dai Kimura, Molly Flottman, Shantaveer Gangu, Ashley D Freeman, Mark D Piehl, G A Nuthall, Keiko M Tarquinio, Ilana Harwayne-Gidansky, Tatsuya Hasegawa, Erin S Rescoe, Ryan K Breuer, Mioko Kasagi, Vinay M Nadkarni, Akira Nishisaki
OBJECTIVES: Extremes of patient body mass index are associated with difficult intubation and increased morbidity in adults. We aimed to determine the association between being underweight or obese with adverse airway outcomes, including adverse tracheal intubation (TI)-associated events (TIAEs) and/or severe peri-intubation hypoxemia (pulse oximetry oxygen saturation < 80%) in critically ill children. DESIGN/SETTING: Retrospective cohort using the National Emergency Airway for Children registry dataset of 2013-2020...
November 1, 2023: Pediatric Critical Care Medicine
#15
JOURNAL ARTICLE
Julia B Tager, Jessica T Hinojosa, Brynn M LiaBraaten, Kathryn A Balistreri, Danica Aniciete, Elizabeth Charleston, Joel E Frader, Douglas B White, Marla L Clayman, Lauren R Sorce, W Hobart Davies, Charles B Rothschild, Kelly N Michelson
OBJECTIVES: To describe challenges experienced by parents of children hospitalized in the PICU during PICU admission as reported by family navigators. DESIGN: A preplanned secondary analysis of open-response data coded via inductive qualitative approach from the Navigate randomized controlled trial (RCT) dataset (ID NCT02333396). SETTING: Two university-affiliated PICUs in the Midwestern United States as part of an RCT. PATIENTS: Two hundred twenty-four parents of 190 PICU patients...
October 27, 2023: Pediatric Critical Care Medicine
#16
JOURNAL ARTICLE
Roberta Esteves Vieira de Castro, Juliana Patrícia Chaves de Almeida, Daniela Nasu Monteiro Medeiros, Elie Cheniaux, José Colleti Júnior, Maria Clara de Magalhães-Barbosa, Arnaldo Prata-Barbosa, Erwin Ista
No abstract text is available yet for this article.
October 27, 2023: Pediatric Critical Care Medicine
#17
JOURNAL ARTICLE
Anthony A Sochet, Julie Jaffray, Brian R Branchford, Elizabeth E Havlicek, Maua Mosha, Ernest K Amankwah, Vera Ignjatovic, E Vincent S Faustino, Neil A Goldenberg
OBJECTIVES: To determine if the duration of invasive mechanical ventilation (IMV) was associated with hospital-acquired venous thromboembolism (HA-VTE) among critically ill children. DESIGN: A multicenter, matched case-control study as a secondary analysis of Children's Hospital Acquired Thrombosis (CHAT) Consortium registry. SETTING: PICUs within U.S. CHAT Consortium participating centers. PATIENTS: Children younger than 21 years old admitted to a PICU receiving IMV for greater than or equal to 1 day duration from January 2012 to March 2022 were included for study...
October 26, 2023: Pediatric Critical Care Medicine
#18
JOURNAL ARTICLE
Aikaterini Volanaki, George Briassoulis, George Gerostergios, George Samiotakis, Evgenia Soumaki, Chani Traube, Stavroula Ilia
No abstract text is available yet for this article.
October 26, 2023: Pediatric Critical Care Medicine
#19
JOURNAL ARTICLE
Danielle M Van Damme, Emily M McRae, Sharon Y Irving, Serena P Kelly, Keiko M Tarquinio, John S Giuliano, Michael D Ruppe, Krista L Kierys, Ryan K Breuer, Simon J Parsons, Palen P Mallory, Asha N Shenoi, Kelly A Swain, Lee A Polikoff, Anthony Lee, Michelle A Adu-Darko, Natalie Napolitano, Justine Shults, Akira Nishisaki, John W Berkenbosch
OBJECTIVES: To describe tracheal intubation (TI) practice by Advanced Practice Registered Nurses (APRNs) in North American PICUs, including rates of TI-associated events (TIAEs) from 2015 to 2019. DESIGN/SETTING: Retrospective study using the National Emergency Airway Registry for Children with all TIs performed in PICU and pediatric cardiac ICU between January 2015 and December 2019. The primary outcome was first attempt TI success rate. Secondary outcomes were TIAEs, severe TIAEs, and hypoxemia...
October 26, 2023: Pediatric Critical Care Medicine
#20
JOURNAL ARTICLE
Luregn J Schlapbach, Sabrina Goertz, Niels Hagenbuch, Blandine Aubert, Sebastien Papis, Eric Giannoni, Klara M Posfay-Barbe, Martin Stocker, Ulrich Heininger, Sara Bernhard-Stirnemann, Anita Niederer-Loher, Christian R Kahlert, Giancarlo Natalucci, Christa Relly, Thomas Riedel, Christoph Aebi, Christoph Berger, Philipp K A Agyeman
OBJECTIVES: Previous studies applying Sepsis-3 criteria to children were based on retrospective analyses of PICU cohorts. We aimed to compare organ dysfunction criteria in children with blood culture-proven sepsis, including emergency department, PICU, and ward patients, and to assess relevance of organ dysfunctions for mortality prediction. DESIGN: We have carried out a nonprespecified, secondary analysis of a prospective dataset collected from September 2011 to December 2015...
October 25, 2023: Pediatric Critical Care Medicine
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