journal
https://read.qxmd.com/read/36995039/nonpublication-and-selective-outcome-reporting-of-oral-health-trials
#1
JOURNAL ARTICLE
H Diakonoff, G Khalil, S Jungo, J M Treluyer, H Fron-Chabouis, V Smaïl-Faugeron
Less than one-quarter of oral health trials are registered in a public registry. However, no study has assessed the extent of study publication and selective outcome reporting bias in the field of oral health. We identified oral health trials registered between 2006 and 2016 in ClinicalTrials.gov. We assessed whether results of early discontinued trials, trials having an unknown status, and completed trials had been published and, among published trials, whether outcomes differed between the registered record and the corresponding publication...
March 30, 2023: Journal of Dental Research
https://read.qxmd.com/read/36951356/unequal-impact-of-col1a1-and-col1a2-variants-on-dentinogenesis-imperfecta
#2
JOURNAL ARTICLE
P M Yamaguti, M de La Dure-Molla, S Monnot, Y J Cardozo-Amaya, G Baujat, C Michot, B P J Fournier, M C Riou, E C C Caldas Rosa, Y Soares de Lima, P A C Dos Santos, G Alcaraz, E N S Guerra, L C Castro, S F de Oliveira, R Pogue, A Berdal, L M de Paula, J F Mazzeu, V Cormier-Daire, A C Acevedo
Dentinogenesis imperfecta (DI) is the main orodental manifestation of osteogenesis imperfecta (OI) caused by COL1A1 or COL1A2 heterozygous pathogenic variants. Its prevalence varies according to the studied population. Here, we report the molecular analysis of 81 patients with OI followed at reference centers in Brazil and France presenting COL1A1 or COL1A2 variants. Patients were submitted to clinical and radiographic dental examinations to diagnose the presence of DI. In addition, a systematic literature search and a descriptive statistical analysis were performed to investigate OI/DI phenotype-genotype correlation in a worldwide sample...
March 23, 2023: Journal of Dental Research
https://read.qxmd.com/read/36942967/ligature-induced-periodontitis-drives-colorectal-cancer-an-experimental-model-in-mice
#3
JOURNAL ARTICLE
Y T Shi, J M He, Z A Tong, Y J Qian, Q W Wang, D J C Jia, W J Zhu, Y X Zhao, B B Cai, S J Chen, M S Si
Periodontitis is a prevalent inflammatory oral disease associated with an increased risk of colorectal cancer. Experimental animal models are critical tools to investigate the effects and mechanisms of periodontitis on colorectal cancer. Several murine periodontitis models have been used in research, including oral gavage, periodontal pathogen injection, and ligature models. The role of experimental periodontitis caused by silk ligation in colorectal cancer remains unclear. In this study, we used an experimental periodontitis model on a colitis-associated colorectal cancer model and a spontaneous model, respectively...
March 21, 2023: Journal of Dental Research
https://read.qxmd.com/read/36942423/efficacy-of-a-mouthwash-containing-chx-and-cpc-in-sars-cov-2-positive-patients-a-randomized-controlled-clinical-trial
#4
JOURNAL ARTICLE
E L Bonn, A Rohrhofer, F X Audebert, H Lang, D L Auer, K J Scholz, P Schuster, J J Wenzel, K-A Hiller, W Buchalla, J M Gottsauner, V Vielsmeier, B Schmidt, F Cieplik
Soon after the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, preprocedural mouthwashes were recommended for temporarily reducing intraoral viral load and infectivity of individuals potentially infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to protect medical personnel. Particularly, the antiseptic cetylpyridinium chloride (CPC) has shown virucidal effects against SARS-CoV-2 in vitro. Therefore, the aim of this randomized controlled clinical trial was to investigate the efficacy of a commercially available mouthwash containing CPC and chlorhexidine digluconate (CHX) at 0...
March 21, 2023: Journal of Dental Research
https://read.qxmd.com/read/36919905/chronological-and-replicative-aging-of-cd51-pdgfr-%C3%AE-pulp-stromal-cells
#5
JOURNAL ARTICLE
L Yao, F Li, C Yu, H Wang, Y Wang, L Ye, F Yu
As a crucial source of mesenchymal stromal cells, CD51+ /PDGFR-α+ human dental pulp stromal cells (hDPSCs) are promising seeding cells for regenerative medicine. Cellular senescence hinders the translational application of hDPSCs. However, it remains unclear whether chronological and replicative senescence results in distinct outcomes for hDPSCs. To investigate the influence of senescence on DPSCs, we used transgenic lineage tracking, immunofluorescence, flow cytometry, and various molecular experiments to depict the dynamic pattern of hDPSCs in mice and humans during chronological and replicative senescence...
March 15, 2023: Journal of Dental Research
https://read.qxmd.com/read/36919900/international-delphi-study-to-optimize-the-oral-health-section-in-interrai
#6
JOURNAL ARTICLE
E Schoebrechts, J de Almeida Mello, P Vandenbulcke, E Palmers, A Declercq, D Declerck, J Duyck
Introduction: The oral health (OH) of care-dependent older people is generally poor. Since caregivers are mainly responsible for older people's daily care, they can be considered important intermediaries to improve their OH by performing regular OH assessments. The interRAI instruments are introduced in 37 countries to assess care needs and facilitate care planning across different health care settings. The oral health section (OHS) within the interRAI instrument used in long-term care facilities was optimized for the Belgian context to identify residents who need assistance with daily oral care and/or need to be referred to a dentist...
March 15, 2023: Journal of Dental Research
https://read.qxmd.com/read/36919893/reduced-autophagy-in-aged-trigeminal-neurons-causes-amyloid-%C3%AE-diffusion
#7
JOURNAL ARTICLE
R Sonoda, E Kuramoto, S Minami, S E Matsumoto, Y Ohyagi, T Saito, T Saido, K Noguchi, T Goto
The relationship between oral health and the development of Alzheimer's disease (AD) in the elderly is not yet well understood. In this regard, the association between aging or neurodegeneration of the trigeminal nervous system and the accumulation of amyloid-β(1-42) (Aβ42 ) oligomers in the pathogenesis of AD is unknown. We focused on selective autophagy in the trigeminal mesencephalic nucleus (Vmes) and the diffusion of Aβ42 oligomers with respect to aging of the trigeminal nervous system and whether the degeneration of Vmes neurons affects the diffusion of Aβ42 oligomers...
March 15, 2023: Journal of Dental Research
https://read.qxmd.com/read/36919874/prediction-of-future-caries-in-1-year-old-children-via-the-salivary-microbiome
#8
JOURNAL ARTICLE
R Raksakmanut, P Thanyasrisung, S Sritangsirikul, K Kitsahawong, A L Seminario, W Pitiphat, O Matangkasombut
Dental caries is the most common chronic disease in children that causes negative effects on their health, development, and well-being. Early preventive interventions are key to reduce early childhood caries prevalence. An efficient strategy is to provide risk-based targeted prevention; however, this requires an accurate caries risk predictor, which is still lacking for infants before caries onset. We aimed to develop a caries prediction model based on the salivary microbiome of caries-free 1-y-old children...
March 15, 2023: Journal of Dental Research
https://read.qxmd.com/read/36919873/plasticity-of-dental-cell-types-in-development-regeneration-and-evolution
#9
REVIEW
J Krivanek, M Buchtova, K Fried, I Adameyko
Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single-cell transcriptomics, which helped to define not only cell states with mathematical precision but also transitions between them. This includes new aspects of dental epithelial and mesenchymal stem cell niches and beyond. These recent efforts revealed continuous and fluid trajectories connecting cell states during dental development and exposed the natural plasticity of tooth-building progenitors...
March 15, 2023: Journal of Dental Research
https://read.qxmd.com/read/36913545/development-of-rat-caries-induced-pulpitis-model-for-vital-pulp-therapy
#10
JOURNAL ARTICLE
H Huang, M Okamoto, M Watanabe, S Matsumoto, K Moriyama, S Komichi, M Ali, S Matayoshi, R Nomura, K Nakano, Y Takahashi, M Hayashi
Rodent animal models for vital pulp therapy are commonly used in dental research because their tooth anatomy and cellular processes are similar to the anatomy and processes in humans. However, most studies have been conducted using uninfected sound teeth, which makes it difficult to adequately assess the inflammatory shift after vital pulp therapy. In the present study, we aimed to establish a caries-induced pulpitis model based on the conventional rat caries model and then evaluate inflammatory changes during the wound-healing process after pulp capping in a model of reversible pulpitis induced by carious infection...
March 13, 2023: Journal of Dental Research
https://read.qxmd.com/read/36908187/the-emerging-role-of-accelerated-cellular-senescence-in-periodontitis
#11
REVIEW
R Aquino-Martinez
Accelerated cellular senescence may be a crucial process for periodontitis progression because it integrates the damaging effects of major periodontitis risk factors. Cellular senescence is a manifestation of aging at the cellular level. However, recent technological advances have shown that healthy young cells continuously exposed to sublethal oxidative stress undergo accelerated senescence. Although accumulation of senescent cells is normal in aged tissues, persistent bacterial infection, chronic inflammation, diabetes, and smoking promote the early onset of senescence by causing DNA damage...
March 12, 2023: Journal of Dental Research
https://read.qxmd.com/read/36908186/diabetes-edentulism-and-cognitive-decline-a-12-year-prospective-analysis
#12
JOURNAL ARTICLE
B Wu, H Luo, C Tan, X Qi, F A Sloan, A R Kamer, M D Schwartz, M Martinez, B L Plassman
Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-occurrence of DM and edentulism on cognitive decline is understudied. This 12-y cohort study aimed to assess the effect of the co-occurrence of DM and edentulism on cognitive decline and examine whether the effect differs by age group. Data were drawn from the 2006 to 2018 Health and Retirement Study. The study sample included 5,440 older adults aged 65 to 74 y, 3,300 aged 75 to 84 y, and 1,208 aged 85 y or older...
March 12, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883660/the-role-of-gingival-fibroblasts-in-the-pathogenesis-of-periodontitis
#13
REVIEW
A Wielento, K B Lagosz-Cwik, J Potempa, A M Grabiec
Gingival fibroblasts (GFs) are essential components of the periodontium, which are responsible for the maintenance of tissue structure and integrity. However, the physiological role of GFs is not restricted to the production and remodeling of the extracellular matrix. GFs also act as sentinel cells that modulate the immune response to oral pathogens invading the gingival tissue. As an important "nonclassical" component of the innate immune system, GFs respond to bacteria and damage-related signals by producing cytokines, chemokines, and other inflammatory mediators...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883653/tough-adhesive-hydrogel-for-intraoral-adhesion-and-drug-delivery
#14
JOURNAL ARTICLE
D T Wu, B R Freedman, K H Vining, D L Cuylear, F P S Guastaldi, Y Levin, D J Mooney
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are common chronic inflammatory conditions, manifesting as painful oral lesions that negatively affect patients' quality of life. Current treatment approaches are mainly palliative and often ineffective due to inadequate contact time of the therapeutic agent with the lesions. Here, we developed the Dental Tough Adhesive (DenTAl), a bioinspired adhesive patch with robust mechanical properties, capable of strong adhesion against diverse wet and dynamically moving intraoral tissues, and extended drug delivery of clobetasol-17-propionate, a first-line drug for treating OLP and RAS...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883651/promotional-effect-and-molecular-mechanism-of-synthesized-zinc-oxide-nanocrystal-on-zirconia-abutment-surface-for-soft-tissue-sealing
#15
JOURNAL ARTICLE
J Hu, I Atsuta, Y Luo, X Wang, Q Jiang
Studies have confirmed that tooth loss is closely related to systemic diseases, such as obesity, diabetes, cardiovascular diseases, some types of tumors, and Alzheimer's disease. Among many methods for tooth restoration, implant restoration is the most commonly used method. After implantation, long-term stability of implants requires not only good bone bonding but also good soft tissue sealing between implants and surrounding soft tissues. The zirconia abutment is used in clinical implant restoration treatment, but due to the strong biological inertia of zirconia, it is difficult to form stable chemical or biological bonds with surrounding tissues...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883649/a-salivary-gland-resident-macrophage-subset-regulating-radiation-responses
#16
JOURNAL ARTICLE
Q Zhao, S Pan, L Zhang, Y Zhang, A Shahsavari, P Lotey, C L Baetge, M A Deveau, C A Gregory, G M Kapler, F Liu
Radiotherapy of head and neck cancers frequently leads to irreversible hypofunction of salivary glands, which severely compromises the quality of life and is extremely difficult to treat. We found recently that salivary gland resident macrophages are sensitive to radiation and interact with epithelial progenitors and endothelial cells through homeostatic paracrine factors. Heterogeneous subpopulations of resident macrophages are present in other organs with distinct functions, whereas subpopulations of salivary gland resident macrophages with distinct functions or transcriptional profiles have not been reported yet...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883648/the-murine-oral-metatranscriptome-reveals-microbial-and-host-signatures-of-periodontal-disease
#17
JOURNAL ARTICLE
S Joseph, M Carda-Diéguez, J Aduse-Opoku, A Alsam, A Mira, M A Curtis
Periodontal disease is accompanied by alterations to cellular profiles and biological activities of both the subgingival microbiome and host tissues. Although significant progress has been made in describing the molecular basis of the homeostatic balance of host-commensal microbe interactions in health compared to the destructive imbalance in disease, particularly with respect to immune and inflammatory systems, few studies have attempted a comprehensive analysis in diverse host models. Here, we describe the development and application of a metatranscriptomic approach to analysis of host-microbe gene transcription in a murine periodontal disease model, based on oral gavage infection using Porphyromonas gingivalis in C57BL6/J mice...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883630/tertiary-lymphoid-structure-raises-survival-and-immunotherapy-in-hpv-hnscc
#18
JOURNAL ARTICLE
H Li, S-W Zhu, J-J Zhou, D-R Chen, J Liu, Z-Z Wu, W-Y Wang, M-J Zhang, Z-J Sun
Immune checkpoint blockade (ICB) targeting PD-1/PD-L1 has been used for the treatment of head and neck squamous cell carcinoma (HNSCC). However, the overall response rate to ICB therapy for HNSCC remains less than 20%. It has recently been reported that the appearance of tertiary lymphoid structures (TLSs) in tumor tissue is correlated with better prognosis and response to ICB treatment. Here, we demonstrated an immune classification for the tumor microenvironment (TME) of HNSCC by analyzing The Cancer Genome Atlas (TCGA)-HNSCC data set and found that immunotype D with TLS enrichment had a better prognosis and response to ICB treatment...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36883625/nlrp3-disturbs-treg-th17-cell-balance-to-aggravate-apical-periodontitis
#19
JOURNAL ARTICLE
S Leng, W Xu, L Wu, L Liu, J Du, F Yang, D Huang, L Zhang
Apical periodontitis is an inflammatory condition that is considered an immunological reaction of the periapical tissue to invading bacteria and their pathogenic components. Recent research has revealed that NLR family pyrin domain containing 3 (NLRP3) is crucial to the pathogenesis of apical periodontitis and serves as a link between innate and adaptive immunity. The balance between regulatory T-cell (Treg) and T helper cell 17 (Th17 cell) determines the direction of the inflammatory response. Therefore, this study aimed to investigate whether NLRP3 exacerbated periapical inflammation by disturbing Treg/Th17 balance and the underlying regulatory mechanisms...
March 8, 2023: Journal of Dental Research
https://read.qxmd.com/read/36803061/impact-of-treatment-on-host-responses-in-young-individuals-with-periodontitis
#20
REVIEW
L S Branco-de-Almeida, I M Velsko, I C V de Oliveira, R C G de Oliveira, L M Shaddox
Grade C periodontitis in young individuals is characterized by severe/rapid periodontal destruction, usually early onset, in systemically healthy individuals. An individual's host response, triggered by a dysbiotic subgingival biofilm, has been reported as a contributor to the tissue destruction, although mechanisms of this response and contributions to such disease remain poorly understood. Nonsurgical treatment has resulted in positive clinical responses for both localized (now molar-incisor pattern) and generalized forms of grade C periodontitis, especially when adjunctive systemic antibiotics are used...
February 18, 2023: Journal of Dental Research
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