Ira Winkler, Maria Sappler, Elke Ruth Gizewski, Ursula Kiechl-Kohlendorfer, Vera Neubauer, Elke Griesmaier
INTRODUCTION: Preterm infants are at risk for impairment in brain maturation at term equivalent age (TEA). Diffusion tensor imaging (DTI) is a powerful magnetic resonance imaging (MRI) technique, quantitatively reflecting microstructural brain development of white matter regions with parameters such as fractional anisotropy (FA) and apparent diffusion coefficient (ADC). Amplitude-integrated electroencephalography (aEEG) assesses electrocortical activity and brain function. METHODS: Aim of this study was to investigate a possible correlation between functional and microstructural brain maturation using neonatal aEEG and DTI-MRI at TEA...
December 5, 2023: Neonatology
Judith Rittenschober-Boehm, Renate Fuiko, Alex Farr, Birgit Willinger, Angelika Berger, Katharina Goeral
INTRODUCTION: Intrauterine infection with Ureaplasma species (U.spp.) is mostly a result of vaginal colonization with subsequent ascending infection and is associated with adverse pregnancy outcome. Little is known about rates and risk factors for ascending infection. Aim of the current study was to analyse the frequency of ascending U.spp. infection in vaginally colonized pregnant women delivering preterm and subsequent short- and long-term outcome of infants. METHODS: Women delivering ≤32 weeks of gestation with available data on vaginal U...
December 5, 2023: Neonatology
Nora Switchenko, Vivek Shukla, Musaku Mwenechanya, Elwyn Chomba, Archana Patel, Patricia L Hibberd, Namasivayam Ambalavanan, Lester Figueroa, Manolo Mazariegos, Nancy F Krebs, Shivaprasad S Goudar, Richard Derman, Fabian Esamai, Edward A Liechty, Sheri Bucher, Sarah Saleem, Robert L Goldenberg, Adrien Lokangaka, Antoinette Tshefu, Carl L Bose, Marion Koso-Thomas, Sylvia Tan, Tracy Nolen, Elizabeth M McClure, Waldemar A Carlo
BACKGROUND: Newborns with hypoxemia often require life-saving respiratory support. In low-resource settings, it is unknown if respiratory support is delivered more frequently to term infants or preterm infants. We hypothesized that in a registry-based birth cohort in 105 geographic areas in seven low- and middle-income countries, more term newborns received respiratory support than preterm newborns. METHODS: This is a hypothesis-driven observational study based on prospectively collected data from the Maternal and Newborn Health Registry of the NICHD Global Network for Women's and Children's Health Research...
December 4, 2023: Neonatology
Benedikt Stephan Biesinger, Christoph Male, Veronika Kranebitter, Julia Binder, Martin B Niederle, Andrea Reinprecht, Christoph Binder
INTRODUCTION: Here we present the case of a newborn baby boy with severe plasminogen deficiency causing occlusive hydrocephalus and ligneous conjunctivitis. CASE PRESENTATION: Shortly after birth, the hydrocephalus was treated with a ventriculoperitoneal shunt implantation. However, the child had to be readmitted soon afterward because of shunt obstruction. Subglottic microtrauma caused by the necessary intubations then led to another life-threatening complication - subglottic stenosis with pseudomembrane formation...
December 1, 2023: Neonatology
Zhelan Huang, Bo Liu, Tiantian Xiao, Yaqiong Wang, Yulan Lu, Liyuan Hu, Guoqiang Cheng, Zhihua Li, Laishuan Wang, Rong Zhang, Jin Wang, Yun Cao, Xinran Dong, Lin Yang, Wenhao Zhou
INTRODUCTION: Pathogenic variant in the KCNQ2 gene is a common genetic etiology of neonatal convulsion. However, it remains a question in KCNQ2-related disorders that who will develop into atypical developmental outcomes. METHODS: We established a prediction model for the neurodevelopmental outcomes of newborns with seizures caused by KCNQ2 gene defects based on the Gradient Boosting Machine (GBM) model with a training set obtained from the Human Gene Mutation Database (HGMD, public training dataset)...
December 1, 2023: Neonatology
Akinobu Taniguchi, Kazuki Nishida, Toshihiko Suzuki, Erina Kataoka, Naozumi Fujishiro, Eiko Kato, Hikaru Yamamoto, Koji Takemoto, Miharu Ito, Seiji Hayashi, Yuichiro Sugiyama, Takashi Maeda, Yoshiyuki Takahashi, Yoshiaki Sato
INTRODUCTION: The effects of hydrocortisone (HDC) administration to extremely low birth weight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants. METHODS: This study was a retrospective cohort study conducted in eight centers in Japan. The subjects of this study were ELBW infants born between April 2015 and March 2017. The association between postnatal total HDC dosage up to 36 weeks postmenstrual age and the developmental quotient (DQ) at 3 years of age was examined...
December 1, 2023: Neonatology
Yohan Soreze, Nadia Nathan, Julien Jegard, Erik Hervieux, Pauline Clermidi, Chiara Sileo, Camille Louvrier, Marie Legendre, Aurore Coulomb L'Herminé
Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory failure with pulmonary hypertension requiring venoarterial extracorporeal membrane oxygenation. Histological examination of the lung biopsy specimen was consistent with the diagnosis of AcDys...
November 30, 2023: Neonatology
Leena Kassem, Abed Athamna, Rami Abu Fanne, Yana Tal, Adi Klein, Sarit Freimann, David Haim, Maanit Shapira, Wasef Na'amnih, Eias Kassem
INTRODUCTION: High-sensitivity cardiac troponin T (hs-cTnT) is not used routinely as a diagnostic biomarker in newborns. The high precision of hs-cTnT assays increases the ability to determine small differences in cTnT over time and to detect troponin T elevation; thus, we believe that hs-cTnT assays might improve clinical care. We explored the plausible association between hs-cTnT levels (ng/L) in healthy newborns and prolonged second stage of labor, neonatal, and maternal factors. METHODS: A prospective study was performed among healthy newborns in the Obstetrics and Gynecology Department at Hillel Yaffe Medical Center in Israel in January-June 2021...
November 28, 2023: Neonatology
Yujiao Zhou, Kun Zhu, Xiayi Zhang, Zheyi Zhu, Li Jiang, Linlin Xing, Binyue Xu, TingTing Ai, Quanbo Liu, Ruiqiu Zhao, Ximing Xu, Juan Chen, Zhenzhen Zhang
INTRODUCTION: Limited studies have explored the clinical features, treatment, and prognosis of neonatal tuberculosis (TB). Here, we attempted to delineate the clinical characteristics of neonatal TB, which may help clinicians further understand this disease. METHODS: A retrospective analysis of neonates diagnosed with congenital and/or neonatal TB disease from January 2010 to December 2020 was performed. Information on the demographic and epidemiological features, clinical symptoms, laboratory and imaging examinations, therapeutic regimens, and outcomes was collected...
November 27, 2023: Neonatology
Vanessa Karlinski Vizentin, Isabela Madeira de Sá Pacheco, Thalita Fahel Vilas Bôas Azevêdo, Cynthia Florêncio de Mesquita, Rafael Alvim Pereira
BACKGROUND: Caffeine is commonly used as therapy for apnea of prematurity and has shown potential in preventing other conditions in preterm neonates. However, the optimal timing for caffeine therapy remains uncertain. OBJECTIVE: This study aimed to compare the outcomes of early versus late administration of caffeine in preterm neonates. METHODS: PubMed, Embase, and Cochrane Library were searched for studies comparing 0-2 days to ≥3 days caffeine introduction in preterm neonates...
November 21, 2023: Neonatology
Simone Schwarz, Francisco Brevis Nuñez, Nikola R Dürr, Martin Schlunz-Hendann, Friedhelm Brassel, Ursula Felderhoff-Müser, Christian Dohna-Schwake, Nora Bruns
INTRODUCTION: Vein of Galen aneurysmal malformation (VGAM) is a rare, congenital cerebrovascular malformation with high morbidity and mortality. Parameters to foresee clinical progression and allow individualized parent counseling are lacking. The aim of this study was to evaluate aortic steal measured by Doppler ultrasound as a prognostic parameter in these neonates. METHODS: A retrospective monocentric analysis of cardiac ultrasound exams before embolization in neonates with VGAM was conducted...
October 31, 2023: Neonatology
Hoi Ying Sharon Lau, Xuelian Wang, Ho Tsun Michelia Wong, Ka Hei Catherine Lam, Hugh Simon Lam
INTRODUCTION: Compared with multivariate risk assessment, traditional category-based risk assessment (CRA) approaches for neonatal early-onset sepsis (EOS) screening are usually straightforward to use, do not require electronic devices, but are associated with higher rates of antibiotic use. This study aims to evaluate the performance of a novel enhanced CRA (eCRA) framework on EOS admissions and antibiotic use and to investigate whether a modified version with adjustments in risk factor weighting can allow its performance to match the EOS calculator while remaining easy to implement...
October 31, 2023: Neonatology
Srirupa Hari Gopal, Ganga Gokulakrishnan, Madhulika Kulkarni, Caraciolo J Fernandes, Mohan Pammi
BACKGROUND: Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel and is not readily available. Urinary biomarkers can be used as an adjunct. OBJECTIVE: The objective of this study was to systematically review the diagnostic accuracy of urinary N terminal pro-B type natriuretic peptides (NT-proBNP) for hs-PDA in preterm neonates. METHODS: We included studies that evaluated urinary NT-proBNP and urinary NT-proBNP/creatinine ratio (index tests) in preterm neonates with hs-PDA (participants) in comparison with echocardiogram (reference standard)...
October 27, 2023: Neonatology
Pratima Anand, Suman Chaurasia, Akash Sharma, Ramesh Agarwal, M Jeeva Sankar
No abstract text is available yet for this article.
October 26, 2023: Neonatology
Francesco Raimondi, Pasquale Dolce, Claudio Veropalumbo, Enrico Sierchio, Rebeca Gregorio Hernandez, Javier Rodriguez Fanjul, Fabio Meneghin, Roberto Raschetti, Luca Bonadies, Iuri Corsini, Almudena Alonso Ojembarrena, Serena Salomè, Lorena Rodeño Fernandez, Manuel Sanchez Luna, Gianluca Lista, Fabio Mosca, Carlo Dani, Eugenio Baraldi, Lucio Giordano, Peter G Davis, Letizia Capasso
INTRODUCTION: Early targeted surfactant therapy for preterm infants is recommended but the best criteria to personalize treatment are unclear. We validate a previously published multivariate prognostic model based on gestational age (GA), lung ultrasound score (LUS), and oxygen saturation to inspire oxygen fraction ratio (SatO2/FiO2) using an independent data set. METHODS: Pragmatic, observational study in 10 Italian and Spanish NICUs, including preterm babies (250 and 336 weeks divided into 3 GA intervals) with clinical signs of respiratory distress syndrome and stabilized on CPAP...
October 26, 2023: Neonatology
Soo Hyun Kim, Euiseok Jung, Ha Na Lee, Jeong Min Lee, Sung Hyeon Park, Jiyoon Jeong, Byong Sop Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim
INTRODUCTION: This study aimed to investigate the outcomes of infants at 18-24 months born in the Korean Neonatal Network with a birth weight <500 g. METHODS: The anthropometric and neurodevelopmental data of infants with a birth weight <500 g at a gestational age of ≥22 weeks who were registered in the Korean Neonatal Network 2013-2017 and followed up at a corrected age of 18-24 months were reviewed. Neurodevelopmental impairment was defined as the presence of any of the following: (1) cerebral palsy; (2) severe visual impairment; (3) hearing impairment; or (4) cognitive impairment...
October 20, 2023: Neonatology
Qi Zhou, Melissa Ong, Xiang Y Ye, Joseph Y Ting, Prakesh S Shah, Anne Synnes, Thuy Mai Luu, Shoo Lee
INTRODUCTION: Sepsis and intraventricular hemorrhage (IVH) are associated with poorer long-term neurodevelopmental outcomes in very preterm infants (VPIs), but less is known about the long-term effect of meningitis and the combined impact of both meningitis and IVH. Our objective was to examine the long-term neurodevelopmental outcomes of VPIs with late onset sepsis and meningitis, with and without IVH, in Canada. METHODS: We conducted a retrospective cohort study of all infants <29 weeks GA who were admitted to 26 tertiary-level neonatal intensive care units in the Canadian Neonatal Network (CNN) and Canadian Neonatal Follow-Up Network (CNFUN) databases, from January 1, 2010, to December 31, 2016...
October 20, 2023: Neonatology
Julia Buchmayer, Gregor Kasprian, Raphaela Jernej, Sophie Stummer, Victor Schmidbauer, Vito Giordano, Katrin Klebermass-Schrehof, Angelika Berger, Katharina Goeral
INTRODUCTION: Cerebral magnetic resonance imaging (cMRI) is an important diagnostic tool in neonatology. In addition to qualitative analysis, quantitative measurements may help identify infants with impaired brain growth. This study aimed to create reference values for brain metrics of various brain areas in neonates without major brain injuries born before 28 weeks of gestation. METHODS: This retrospective study analyzes cMRI imaging data of high-risk patients without severe brain pathologies at term-equivalent age, collected over 4 years since November 2017...
October 20, 2023: Neonatology
Trixie A Katz, Anton H van Kaam, Suzanne M Mugie, Cornelieke S H Aarnoudse-Moens, Femke de Groof, Anne A M W van Kempen, Maria E N van den Heuvel, Judith Vogelzang, Maarten Rijpert, Irene A Schiering, Irene Koomen-Botman, Fenna Visser, Aleid G Leemhuis, Wes Onland
INTRODUCTION: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). METHODS: This single-center retrospective cohort study included infants born between 2009 and 2016 at a gestational age (GA) <30 weeks with moderate or severe BPD at 36 weeks' postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities were collected from the electronic patient records...
October 18, 2023: Neonatology
Steven C Mehl, Jorge I Portuondo, Yao Tian, Mehul V Raval, Alice King, Kristy L Rialon, Adam M Vogel, David E Wesson, Sohail R Shah, Nader N Massarweh
INTRODUCTION: A large proportion of postoperative mortality after pediatric surgery occurs among neonates with specific high-risk diagnoses. The extent to which there is hospital-level mortality variation among patients with these diagnoses and whether this variation is associated with differences in failure to rescue (FTR) is unclear. METHODS: The Pediatric Health Information System® database (2012-2020) was used to identify patients who underwent surgery for eight high-risk neonatal diagnoses: gastroschisis; volvulus; necrotizing enterocolitis; intestinal atresia; meconium peritonitis; tracheoesophageal fistula; congenital diaphragmatic hernia; and perinatal intestinal perforation...
October 16, 2023: Neonatology
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