Klaus Ferdinand Gärditz
Apparently, there is a broad scope of legal issues affecting the work with embryonic stem cells. I cannot address them all. I would like to focus on two fields of law and discuss, rather in the overview, some salient issues of German constitutional and administrative law framing the scientific research process. Compared to the sophisticated scientific work we discuss here, legal arguments and operations remain blunt and awkward, addressing rather the identity of a society than the fluid frontiers of science and technology...
March 20, 2023: Journal of Perinatal Medicine
Brigitte Strizek
Perinatal brain damage is still one of the leading contributors to perinatal death and postnatal disability worldwide. However, the term perinatal brain damage encompasses very different aetiological entities that result in an insult to the developing brain and does not differentiate between the onset, cause and severity of this insult. Hypoxic-ischemic encephalopathy (HIE), intraventricular haemorrhage, periventricular leukomalacia and perinatal stroke are often listed as the major aetiologies of perinatal brain damage...
March 1, 2023: Journal of Perinatal Medicine
Roberto Romero, Heike Jahnke, Thorsten Braun, Frank Chervenak, Vincenzo D'Addario, Marty Ellington, Mehmet R Genc, Anne Greenough, Amos Grunebaum, Asim Kurjak, Daniel W Skupski, Ivica Zalud
No abstract text is available yet for this article.
February 28, 2023: Journal of Perinatal Medicine
Bashayer Saeed, Asma Tulbah, Marwah Bintalib, Edward Bentz De Vol, Samar Almogbel, Mawadah BaAli, Hanifa Bukhari, Meshayel Foudaneel, Jawaher Almutairi, Maram Bin Mahfodh, Maha Tulbah, Maha Alnemer, Wesam Kurdi
OBJECTIVES: Chorioangioma represents a challenge due to the rarity of the condition, paucity of sufficient management guidelines, and controversies regarding the best invasive fetal therapy option; most of the scientific evidence for clinical treatment has been limited to case reports. The aim of this retrospective study was to review the natural antenatal history, maternal and fetal complications, and therapeutic modalities used in pregnancies complicated with placental chorioangioma at a single Center...
February 23, 2023: Journal of Perinatal Medicine
Lea J Berg, Oliver Brüstle
Recreating human cell and organ systems in vitro has tremendous potential for disease modeling, drug discovery and regenerative medicine. The aim of this short overview is to recapitulate the impressive progress that has been made in the fast-developing field of cell programming during the past years, to illuminate the advantages and limitations of the various cell programming technologies for addressing nervous system disorders and to gauge their impact for perinatal medicine.
February 22, 2023: Journal of Perinatal Medicine
Shannon Gunawardana, Fahad M S Arattu Thodika, Vadivelam Murthy, Prashanth Bhat, Emma E Williams, Theodore Dassios, Anthony D Milner, Anne Greenough
OBJECTIVES: Over the last decade, there has been increased use of end-tidal carbon dioxide (ETCO2 ) and oxygen saturation (SpO2 ) monitoring during resuscitation of prematurely born infants in the delivery suite. Our objectives were to test the hypotheses that low end-tidal carbon dioxide (ETCO2 ) levels, low oxygen saturations (SpO2 ) and high expiratory tidal volumes (VTE ) during the early stages of resuscitation would be associated with adverse outcomes in preterm infants. METHODS: Respiratory recordings made in the first 10 min of resuscitation in the delivery suite of 60 infants, median GA 27 (interquartile range 25-29) weeks were analysed...
February 20, 2023: Journal of Perinatal Medicine
Christos-Georgios Kontovazainitis, Georgios N Katsaras, Dimitra Gialamprinou, Georgios Mitsiakos
OBJECTIVES: Although the vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS Cov-2) is considered safe during pregnancy, vaccine hesitancy among pregnant women is high. The results of published observational studies addressing the issue of Covid-19 vaccination's efficacy and safety during pregnancy need to be summarized. CONTENT: This systematic review compares the incidence of major maternal and neonatal outcomes between SARS Cov-2 vaccinated and unvaccinated pregnant women...
February 17, 2023: Journal of Perinatal Medicine
Ichchha Madan, Frank I Jackson, Reinaldo Figueroa, Ray Bahado-Singh
OBJECTIVES: To determine the effect of gestational age at delivery on maternal and neonatal outcomes in preterm prelabor rupture of membranes (PPROM) and assess various predictors of neonatal and infant mortality in these pregnancies. METHODS: United States birth data from CDC-National Center for Health Statistics natality database for years 2004-2008 was used to identify singleton pregnancies with PPROM and delivery from 32 0/7 to 36 6/7 weeks. Controls were singletons at 37-40 weeks, without PPROM...
February 6, 2023: Journal of Perinatal Medicine
Cara S Wetcher, Moti Gulersen, Burton Rochelson, Weiwei Shan, Eran Bornstein, Matthew J Blitz
OBJECTIVES: We aimed to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with an increased risk of hypertensive disorders of pregnancy (HDP). METHODS: A multicenter retrospective cohort study of all pregnant patients who had SARS-CoV-2 testing and delivered in a large health system between March 2020 and March 2021. Cases were stratified into two groups: patients who tested positive for SARS-CoV-2 during pregnancy vs...
February 2, 2023: Journal of Perinatal Medicine
Toshiyuki Hata, Tomomi Kawahara, Miyu Konishi, Saori Bouno, Tomomi Yamanishi, Aya Koyanagi, Takahito Miyake
OBJECTIVES: To describe prevalence, outcome, color Doppler, and HDlive Flow (Silhouette) with spatiotemporal image correlation (STIC) features of isolated tortuous ductus arteriosus in Japanese fetuses at 28-31 + 6 weeks of gestation. METHODS: During a 37-month period, 3,150 fetal screenings were performed at 28-31 + 6 weeks of gestation. Isolated tortuous ductus arteriosus was evaluated using color Doppler and HDlive Flow (Silhouette) with STIC...
January 30, 2023: Journal of Perinatal Medicine
Amos Grünebaum, Eran Bornstein, Joachim W Dudenhausen, Erez Lenchner, Monique De Four Jones, Aneesha Varrey, Dawnette Lewis, Frank A Chervenak
OBJECTIVES: The objective of this study was to compare the maximum 5-min Apgar score of 10 among different U.S. races and Hispanic ethnicity. METHODS: Retrospective population-based cohort study from the National Center for Health Statistics (NCHS), and Division of Vital Statistics natality online database. We included only deliveries where the race and Hispanic ethnicity of the father and mother were listed as either Black, White, Chinese, or Asian Indian and as Hispanic or Latino origin or other...
January 30, 2023: Journal of Perinatal Medicine
Mohammad Aadil Khan, Mohd Jahid
OBJECTIVES: Sub-Saharan African countries account for nearly half of maternal deaths, and Southern Asian countries are second in the 85% of deaths that occur worldwide. Despite this fact, there is a rapid enhancement in the number of skilled health workers. There has been a sharp increase of 53% in 1990 and 61% in 2007 in trained birth attendant utilization shows that attention is being paid to the management of labor services. But surprisingly, still, the births take place without the assistance of trained health personnel in Southern Asian countries and Sub-Saharan Africa...
January 23, 2023: Journal of Perinatal Medicine
Phillip Connell, Mark Turrentine, Leah Antoniewicz
OBJECTIVES: To estimate the correlation of cervical dilation between pocket-device point-of-care transperineal ultrasound (TPUS) and digital cervical examination (DCE). METHODS: Laboring pregnant individuals ≥37 weeks of gestation presenting were prospectively evaluated for cervical dilation with a handheld pocket-sized ultrasound (Butterfly iQ+® ) applied to the perineum, with a blinded DCE directly following. Subjects completed a survey to rate pain and for any preference from the examinations...
January 6, 2023: Journal of Perinatal Medicine
Sabahattin Anil Ari, Asli Suner, Ayse Rabia Senkaya, Firat Okmen, Ali Akdemir, Ahmet Mete Ergenoglu
OBJECTIVES: To define and compare the diagnostic accuracy of ultrasonography (USG) and magnetic resonance imaging (MRI) for the placental adhesive disorder (PAD). METHODS: A prospective study was conducted between January 2019 and February 2020 in a tertiary referral university hospital. A total of 115 placenta previa cases were included in the study during the third trimester of gestation. USG examination was performed, and the placenta was scanned in a systematic manner using gray-scale ultrasound, color Doppler flow mapping, and 3-D imaging for each participant...
January 6, 2023: Journal of Perinatal Medicine
Tiina Kantomaa, Marja Vääräsmäki, Mika Gissler, Mikko Sairanen, Jaana Nevalainen
No abstract text is available yet for this article.
January 6, 2023: Journal of Perinatal Medicine
Selen Yaman, Meryem Ceyhan, Necati Hancerliogullari, Esin Merve Koc, Tuba Candar, Aytekin Tokmak
OBJECTIVES: Kynurinine (KYN) and its metabolites, which are released during the metabolism of tryptophan, an essential amino acid, have many important functions, such as cellular energy production, regulation of vascular tone, and regulation of the immune system. In this study, we aimed to detect serum KYN levels, which may be an indicator of KYN pathway activity, in idiopathic fetal growth restriction (FGR) and oligohydramnios cases whose pathophysiology is known to be affected by multiple factors, such as placental hypoperfusion, immune dysregulation, and maternal nutrition disorder, and to investigate their relationship with these common obstetric complications...
January 2, 2023: Journal of Perinatal Medicine
Laurence Caron, Louise Ghesquiere, Emmanuel Bujold
No abstract text is available yet for this article.
January 2, 2023: Journal of Perinatal Medicine
Caroline Cervante Chagas, Ana Letícia Siqueira Pontes, Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Ilenia Mappa, Clementina Viscardi, Giuseppe Rizzo, Edward Araujo Júnior
OBJECTIVES: To determine reference curves for fetal aortic and pulmonary valve annulus area by three-dimensional ultrasonography using the spatio-temporal image correlation (STIC) in the rendering mode, and to ascertain its applicability in congenital heart disease (CHD). METHODS: We performed a retrospective cross-sectional study of 328 normal fetuses and 42 fetuses with CHD between 20 and 33 weeks 6 days of gestation. The outflow plane view of the great vessels was used to measure the areas of the valvar annuli, and the measurements were performed in systole...
January 2, 2023: Journal of Perinatal Medicine
Esin Koç, Dilek Dilli
OBJECTIVES: In this article, we aimed to evaluate the most recent information on the impact of the COVID-19 pandemic on the health of mothers and their babies. METHODS: We conducted a literature search by utilizing online sources. Scientific papers that were written in English on the effects of COVID-19 on both mother and their newborn were assessed. RESULTS: COVID-19 can be fatal, especially in pregnant women with accompanying chronic diseases...
December 29, 2022: Journal of Perinatal Medicine
Jerzy Stanek
OBJECTIVES: Fetal blood circulation may be modified in congenital heart disease (CHD). This retrospective analysis was performed to study whether the type of CHD is associated with specific placental pathology. METHODS: 3 types of CHD based on presumed proportion of placental and systemic blood distribution in fetal circulation were analyzed: Group 1: 89 cases with low placental blood content (hypoplastic left heart syndrome, transposition of great arteries, coarctation of aorta), Group 2: 71 placentas with intermediate placental and systemic blood content due to increased intracardiac blood mixing (tetralogy of Fallot, truncus arteriosus, double inlet/outlet ventricle), and Group 3: 24 placentas with high placental blood content (tricuspid or pulmonary atresia, Ebstein anomaly)...
December 28, 2022: Journal of Perinatal Medicine
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