Yan Shen, Qingyu Cui, Li Xiao, Lifeng Wang, Qianqian Li, Ruihong Zhang, Zhaowen Chen, Jianmin Niu
OBJECTIVES: Preeclampsia (PE) is a disease specific to pregnancy that causes 9-10 % of maternal deaths. Early-onset PE (<34 weeks' gestation) is the most dangerous category of PE. Wnt7a and GPR124 (G protein-coupled receptor 124) are widely expressed in the human reproductive process. Especially during embryogenesis and tumorigenesis, Wnt7a plays a crucial role. However, few studies have examined the association between Wnt7a-GPR124 and early-onset PE. The aim of this study was to examine the significance of Wnt7a and GPR124 in early-onset PE as well as Wnt7a's role in trophoblast cells...
September 12, 2023: Journal of Perinatal Medicine
Uri Amikam, Ahmad Badeghiesh, Haitham Baghlaf, Richard Brown, Michael H Dahan
OBJECTIVES: Gastrointestinal system (GIS) cancer in pregnancy is a rare disease. Our aim was to evaluate the association between this type of cancer and pregnancy, delivery and neonatal outcomes. METHODS: We conducted a retrospective population-based cohort study using the Healthcare Cost and Utilization Project, Nation-wide Inpatient Sample (HCUP-NIS). We included all women who delivered or had a maternal death in the US between 2004 and 2014. We compared women with an ICD-9 diagnosis of GIS cancer to those without...
September 8, 2023: Journal of Perinatal Medicine
Rebecca Karkia, Tara Giacchino, Helen Watson, Andrew Gough, Ghada Ramadan, Ranjit Akolekar
OBJECTIVES: To compare pregnancy complications in pregnancies with and without pre-gestational diabetes mellitus (DM) managed in a multidisciplinary high-risk diabetes antenatal clinic. METHODS: This screening cohort study was undertaken at a large maternity unit in the United Kingdom between January 2010 and December 2022. We included singleton pregnancies that booked at our unit at 11-13 weeks' gestation. Univariate and multivariate logistic regression analysis was carried out to determine risks of complications in pregnancies with type 1 and type 2 DM after adjusting for maternal and pregnancy characteristics...
September 7, 2023: Journal of Perinatal Medicine
Allan Jenkinson, Sarah Zaidi, Ravindra Bhat, Anne Greenough, Theodore Dassios
OBJECTIVES: Hypoxic ischaemic encephalopathy (HIE) is associated with oxidative stress. A potential marker of oxidative damage is carboxyhaemoglobin (COHb) which is the product of the reaction between carbon monoxide and haemoglobin and is routinely assessed on blood gas analysis. Our objective was to test the hypothesis that higher COHb levels would be associated with worse outcomes in infants treated for HIE. METHODS: A retrospective, observational study was performed of all infants who received whole body hypothermia for HIE at a tertiary neonatal intensive care unit between January 2018 and August 2021...
August 29, 2023: Journal of Perinatal Medicine
Ghinwa Lawand, Fathima Minisha, Salwa Abu Yaqoub, Nader Al Dewik, Hilal Al Rifai, Thomas Farrell
OBJECTIVES: Abnormal body mass index (BMI) during pregnancy, a growing public health concern, increases maternal and neonatal complications. This study aimed to investigate the impact of abnormal BMI on perinatal outcomes compared to normal BMI. METHODS: A total of 14,624 women having singleton births were categorized as underweight (BMI<18.5 kg/m2 ), overweight (25.0-29.9 kg/m2 ), obesity class I (30.0-34.9 kg/m2 ), obesity class II (35...
August 24, 2023: Journal of Perinatal Medicine
Jessica A Meyer, Suzanne Alton, Hyunuk Seung, Autusa Pahlavan, Ariel R Trilling, Martha Coghlan, Katherine R Goetzinger, Liviu Cojocaru
OBJECTIVES: To evaluate the impact of an Enhanced Recovery After Cesarean (ERAC) protocol on the post-cesarean recovery experience using a validated ten-item questionnaire (ERAC-Q). METHODS: This is a prospective cohort study of patients completing ERAC quality-of-life questionnaires (ERAC-Q) during inpatient recovery after cesarean delivery (CD) between October 2019 and September 2020, before and after the implementation of our ERAC protocol. Patients with non-Pfannenstiel incision, ICU admission, massive transfusion, bowel injury, existing chronic pain disorders, acute postpartum depression, or neonatal demise were excluded...
August 23, 2023: Journal of Perinatal Medicine
Allan C Jenkinson, Ourania Kaltsogianni, Theodore Dassios, Anne Greenough
OBJECTIVES: Dexamethasone administration can reduce bronchopulmonary dysplasia, our objective was to identify long term adverse effects. CONTENT: A systematic review was performed to determine the childhood and adolescent cardiopulmonary and cognitive effects of dexamethasone systemically administered to preterm infants during neonatal intensive care. Relevant studies were identified by searching two electronic health databases and the grey literature. Spirometry assessments were used as respiratory outcomes, blood pressure and echocardiography assessments as cardiovascular outcomes and cognitive and motor function as cognitive outcomes...
August 23, 2023: Journal of Perinatal Medicine
Weissmann-Brenner Alina, Castel Elias, Kassif Eran, Friedrich Lior, Mor Nizan, Levin Gabriel, Lahav Ezra Hila, Meyer Raanan
OBJECTIVES: To compare delivery outcomes of pregnancies diagnosed with placenta-accreta-syndrome (PAS) who underwent conservative treatment to patients who underwent cesarean hysterectomy. METHODS: A retrospective study of all women diagnosed with PAS treated in one tertiary medical center between 03/2011 and 11/2020 was performed. Comparison was made between conservative management during cesarean delivery and cesarean hysterectomy. Conservative management included leaving uterus in situ with/without placenta and with/without myometrial resection...
August 21, 2023: Journal of Perinatal Medicine
Maria Chiara Marra, Maria Elena Pietrolucci, Ilenia Mappa, Ja Li Angela Lu, Daniele Di Mascio, Francesco D'Antonio, Giuseppe Rizzo
OBJECTIVES: To develop charts for fetal brain cortical structures following a proposed standardized methodology and using quantile regression. METHODS: Prospective cross-sectional study including 344 low-risk singleton pregnancies between 19 and 34 weeks of gestation. The depth of Sylvian (SF), Parieto-occipital (POF) and calcarine fissures (CF) were measured on ultrasound images using a standardized technique and their changes were evaluated by quantile regression as a function of gestational age (GA) interval or head circumference (HC)...
August 21, 2023: Journal of Perinatal Medicine
Liviu Cojocaru, Myint Noe, Autusa Pahlavan, Alissa Werzen, Hyunuk Seung, Young Chae Jessica Yoo, Patricia Tyson, Shivakumar Narayanan, Shifa Turan, Ozhan M Turan, Joel V Chua
OBJECTIVES: To explore the association between COVID-19 severity and pregnancy using measures such as COVID-19 ordinal scale severity score, hospitalization, intensive care unit (ICU) admission, oxygen supplementation, invasive mechanical ventilation, and death. METHODS: We conducted a retrospective, multicenter cohort study to understand the association between COVID-19 severity and pregnancy. We reviewed consecutive charts of adult females, ages 18-45, with laboratory testing for SARS-CoV-2 infection between March 1, 2020, and August 31, 2020...
August 21, 2023: Journal of Perinatal Medicine
Anjeza Xholli, Ambrogio P Londero, Elena Magnetti, Sabrina Vadrucci, Isabella Neri, Gaia Marcantognini, Anna Luna Tramontano, Francesca Monari, Angelo Cagnacci
OBJECTIVES: The study's primary aim was to examine the relationship between paternal age and perinatal outcomes. METHODS: This study used data from two hospital birth registries to examine the association between paternal age and adverse perinatal outcomes. The sample included all live singleton births between 2010 and 2022. The primary exposure was paternal age, and the following perinatal outcomes were considered: mode of conception, mode of delivery, pregnancy complications, and neonatal outcomes...
August 21, 2023: Journal of Perinatal Medicine
Celeste R S De Groot, Esther J C Konings, Willem P de Boode, Anke J M Oerlemans, Esther Sikkel, Sanne M B I Botden, Peter J Merkus, Robin van der Lee, Rosa Geurtzen
OBJECTIVES: Congenital diaphragmatic hernia (CDH) is a congenital malformation in which the diaphragm and lungs are underdeveloped, leading to cardiorespiratory and other problems. This study aimed to explore professionals' views regarding prenatal counselling in CDH. METHODS: A qualitative study was performed among healthcare professionals involved in the care of CDH patients in Radboud university medical center Amalia Children's Hospital. Semi-structured interviews were conducted until saturation was achieved...
August 11, 2023: Journal of Perinatal Medicine
Sonia Giouleka, Antonios Siargkas, Ioannis Tsakiridis, Apostolos Mamopoulos, Apostolos Athanasiadis, Themistoklis Dagklis
OBJECTIVES: To investigate the incidence and risk factors of bilobate placenta, as well as to assess its impact on preeclampsia (PE), preterm delivery (PTD) and small-for-gestational age (SGA) neonates. METHODS: A prospective study of singleton pregnancies, undergoing routine anomaly scan at 20+0 -23+6 gestational weeks, was conducted, between 2018 and 2022. The impact of prenatally diagnosed bilobate placenta on PE, PTD and SGA was assessed. Multivariate logistic regression models were employed to assess the independent association between bilobate placenta and the main pregnancy outcomes, using specific confounders...
August 8, 2023: Journal of Perinatal Medicine
Charlotte Kalinka Metz, Anna Sophie Skof, Wolfgang Henrich, Jalid Sehouli, Andreas M Kaufmann, Irena Rohr
OBJECTIVES: Studies already pointed out the increased risk of human papillomavirus (HPV) positivity and the implied risk of cervical dysplasia and even cervical carcinoma in pregnant women with human immunodeficiency virus (HIV) infection. Nevertheless, due to less data there is still no standardised and expanded screening for this high-risk group. CONTENT: Two online databases (PubMed, EMBASE) were used to identify eligible studies. Results are shown in percentages...
August 7, 2023: Journal of Perinatal Medicine
Muradiye Yildirim, Deniz Oluklu, Dilek Menekse Beser, Derya Uyan Hendem, Betul Akgun Aktas, Esra Gulen Yildiz, Ozgur Kara, Dilek Sahin
OBJECTIVES: This study aimed to assess the effect of the inflammatory process on fetal cardiac functions in pregnant women with autoimmune diseases (AID). METHODS: This prospective study included 36 pregnant women with diagnosed AID. Nineteen systemic lupus erythematosus, 12 antiphospholipid syndrome, 5 Sjögren's syndrome, and 72 healthy pregnancies were included. Fetal cardiac functions were evaluated with pulsed-wave, tissue Doppler, and M-mode echocardiography...
August 3, 2023: Journal of Perinatal Medicine
Işıl Ayhan, Oya Demirci, Lütfiye Uygur, Şahap Odacilar, Olga Devrim Özbay Ayvaz, Ali Karaman, Ayşenur Celayir
OBJECTIVES: To estimate factors affecting survival in prenatally diagnosed omphalocele, factors predicting genetic abnormalities, and association of omphalocele and specific groups of anomalies. METHODS: A retrospective observational study was performed, analyzing data of all omphalocele cases diagnosed prenatally in the perinatology clinic of a referral center. Demographic data, characteristics of the omphalocele (size, content, associated anomalies), results of genetic testing, pregnancy outcomes and postnatal outcomes were analyzed...
August 3, 2023: Journal of Perinatal Medicine
Amos Grünebaum, Frank A Chervenak, Joachim Dudenhausen
No abstract text is available yet for this article.
August 3, 2023: Journal of Perinatal Medicine
Seyma Banu Arslanca, Ali Turhan Caglar
OBJECTIVES: Investigating the relationship between liver enzymes, uric acid (UA), and macrosomia will benefit physicians in the early detection of complications that may emerge during/after pregnancy. The study analyzed liver enzyme activity and UA levels in first-trimester pregnant for the risk of macrosomia. METHODS: This retrospective cross-sectional research analyzed the data of pregnant women who gave birth between Jan 2021-2023. All data were extracted from medical records, and UA and AST-ALT were examined in all the participants...
July 26, 2023: Journal of Perinatal Medicine
Sofia Roero, Silvana Arduino, Arianna Arese, Teresa Fea, Isabella Ferrando, Gabriella Scaltrito, Viola Casula, Alice Ronco, Carlotta Bossotti, Roberto Zizzo, Roberto Scali, Alberto Revelli
OBJECTIVES: To compare outcomes of monochorionic diamniotic (MCDA) twin pregnancies by in vitro fertilization (IVF) vs. spontaneously conceived counterparts. METHODS: Retrospective comparison. Data about MCDA twin pregnancies, conceived spontaneously or by IVF, attending the Twin Pregnancy Care Unit of Sant'Anna Hospital in Turin (Italy) between January 1st 2010 and March 31st 2022, were collected retrospectively. Obstetric, fetal, and neonatal outcomes of MCDA twin pregnancies by IVF were compared to those of spontaneously conceived counterparts...
July 26, 2023: Journal of Perinatal Medicine
Ying Chan, Xinhua Tang, Dongling Cai, Yize Liu, Dongmei Li, Jie Su, Guowei Neng, Yifei Yin, Zibiao Geng, Shu Zhu, Jinman Zhang, Lihong Jiang, Baosheng Zhu
OBJECTIVES: To evaluate the association between maternal polymorphisms of NANOS3 rs2016163, HELQ rs4693089, PRIM 1 rs2277339, TLK 1 rs10183486, ERCC6 rs2228526, EXO 1 rs1635501, DMC 1 rs5757133, and MSH 5 rs2075789 and fetal chromosomal abnormality. METHODS: This retrospective case-control study included 571 women with fetal chromosome abnormalities (330 pregnant women diagnosed with fetal aneuploidy, 241 with fetal de novo structural chromosome pregnancy) and 811 healthy pregnant women between January 2018 and April 2022...
July 25, 2023: Journal of Perinatal Medicine
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