Edward Simpson, Jill L Reiter, Jie Ren, Zhiqi Zhang, Kelly N Nudelman, Larry D Riggen, Michael D Menser, Jaroslaw Harezlak, Tatiana M Foroud, Andrew J Saykin, Alison Brooks, Kenneth L Cameron, Stefan M Duma, Gerald McGinty, Steven Rowson, Steven J Svoboda, Steven P Broglio, Michael A McCrea, Paul F Pasquina, Thomas W McAllister, Yunlong Liu
BACKGROUND: Molecular-based approaches to understanding concussion pathophysiology provide complex biological information that can advance concussion research and identify potential diagnostic and/or prognostic biomarkers of injury. OBJECTIVE: The aim of this study was to identify gene expression changes in peripheral blood that are initiated following concussion and are relevant to concussion response and recovery. METHODS: We analyzed whole blood transcriptomes in a large cohort of concussed and control collegiate athletes who were participating in the multicenter prospective cohort Concussion Assessment, Research, and Education (CARE) Consortium study...
November 8, 2023: Sports Medicine