journal
https://read.qxmd.com/read/38605676/pathogenesis-of-sleep-disordered-breathing-in-the-setting-of-opioid-use-a-multiple-mediation-analysis-using-physiology
#1
JOURNAL ARTICLE
Jeremy E Orr, Atul Malhotra, Eli Gruenberg, Traci Marin, Scott A Sands, Raichel M Alex, Robert L Owens, Christopher N Schmickl
STUDY OBJECTIVES: Opioid medications are commonly used and are known to impact both breathing and sleep, and are linked with adverse health outcomes including death. Clinical data indicate that chronic opioid use causes central sleep apnea, and might also worsen obstructive sleep apnea. The mechanisms by which opioids influence sleep-disordered breathing pathogenesis are not established. METHODS: Patients who underwent clinically-indicated polysomnography confirming sleep-disordered breathing (SDB) (AHI≥5/hr) were included...
April 12, 2024: Sleep
https://read.qxmd.com/read/38602244/longer-sleep-duration-in-alzheimer-s-disease-progression-a-compensatory-response
#2
EDITORIAL
Peng Li, Lei Gao, Brendan P Lucey, Yo-El S Ju, Erik S Musiek, Kun Hu
No abstract text is available yet for this article.
April 11, 2024: Sleep
https://read.qxmd.com/read/38602131/the-dynamic-responses-of-mood-and-sleep-physiology-to-chronic-sleep-restriction-and-subsequent-recovery-sleep
#3
JOURNAL ARTICLE
Christopher W Jones, Olivia Larson, Mathias Basner, David F Dinges
Healthy sleep of sufficient duration preserves mood and disturbed sleep is a risk factor for a range of psychiatric disorders. As adults commonly experience chronic sleep restriction (SR), an enhanced understanding of the dynamic relationship between sleep and mood is needed, including whether susceptibility to SR-induced mood disturbance differs between sexes. To address these gaps, data from N=221 healthy adults who completed one of two multi-day laboratory studies with identical 9-day SR protocols were analyzed...
April 11, 2024: Sleep
https://read.qxmd.com/read/38597884/insomnia-gone-in-one-week-without-medication-too-good-to-be-true
#4
JOURNAL ARTICLE
Célyne H Bastien, Ellemarije Altena
No abstract text is available yet for this article.
April 10, 2024: Sleep
https://read.qxmd.com/read/38587464/daily-associations-between-salivary-cortisol-and-eeg-assessed-sleep-a-15-day-intensive-longitudinal-study
#5
JOURNAL ARTICLE
Yang Yap, Natasha Yan Chi Tung, Lin Shen, Bei Bei, Andrew Phillips, Joshua F Wiley
STUDY OBJECTIVES: Current evidence suggests that cortisol levels are bi-directionally associated with sleep. However, the daily, naturalistic cortisol-sleep associations remain unclear, as current evidence is mostly cross-sectional. This study tested whether pre-sleep cortisol predicts sleep duration and quality, and whether these sleep parameters predict the following day's diurnal cortisol slope using a 15-day intensive longitudinal design with electroencephalographic measures and saliva sampling...
April 8, 2024: Sleep
https://read.qxmd.com/read/38581363/effects-of-a-work-schedule-with-abated-quick-returns-on-insomnia-sleepiness-and-work-related-fatigue-results-from-a-large-scale-cluster-randomized-controlled-trial
#6
JOURNAL ARTICLE
Ingebjørg Louise Rockwell Djupedal, Anette Harris, Erling Svensen, Ståle Pallesen, Siri Waage, Morten Birkeland Nielsen, Erlend Sunde, Bjørn Bjorvatn, Øystein Holmelid, Øystein Vedaa
STUDY OBJECTIVES: To investigate the effect of a work schedule with abated quick returns (i.e., >11 hours between two shifts) on insomnia, daytime sleepiness, and work-related fatigue compared to a shift schedule maintaining the usual number of quick returns. METHODS: A two-armed cluster randomized controlled trial including 66 units was conducted at a university hospital in Norway. Units with healthcare workers on rotating shift schedules were randomly assigned to a shift schedule with abated quick returns (intervention) or to continue with a schedule including quick returns as usual (control) for six months...
April 6, 2024: Sleep
https://read.qxmd.com/read/38571402/perturbation-of-the-insomnia-wdr90-gwas-locus-pinpoints-rs3752495-as-a-causal-variant-influencing-distal-expression-of-neighboring-gene-pig-q
#7
JOURNAL ARTICLE
Shilpa Sonti, Sheridan H Littleton, Matthew C Pahl, Amber J Zimmerman, Alessandra Chesi, Justin Palermo, Chiara Lasconi, Elizabeth B Brown, James A Pippin, Andrew D Wells, Fusun Doldur-Balli, Allan I Pack, Phillip R Gehrman, Alex C Keene, Struan F A Grant
Although genome wide association studies (GWAS) have identified loci for sleep-related traits, they do not directly uncover the underlying causal variants and corresponding effector genes. The majority of such variants reside in non-coding regions and are therefore presumed to impact cis-regulatory elements. Our previously reported 'variant-to-gene mapping' effort in human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs), combined with validation in both Drosophila and zebrafish, implicated PIG-Q as a functionally relevant gene at the insomnia 'WDR90' GWAS locus...
April 4, 2024: Sleep
https://read.qxmd.com/read/38552004/correction-to-sleepmat-a-new-behavioral-analysis-software-program-for-sleep-and-circadian-rhythms
#8
(no author information available yet)
No abstract text is available yet for this article.
March 29, 2024: Sleep
https://read.qxmd.com/read/38551123/sphyncs-feasibility-of-long-term-monitoring-with-fitbit-smartwatches-in-central-disorders-of-hypersomnolence-and-extraction-of-digital-biomarkers-in-narcolepsy
#9
JOURNAL ARTICLE
Oriella Gnarra, Julia van der Meer, Jan D Warncke, Livia G Fregolente, Elena Wenz, Kseniia Zub, Uchendu Nwachukwu, Zhongxing Zhang, Ramin Khatami, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Robert Riener, Claudio L A Bassetti, Markus H Schmidt
The Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (SPHYNCS) is a multicenter research initiative to identify new biomarkers in central disorders of hypersomnolence (CDH). Whereas narcolepsy type 1 (NT1) is well characterized, other CDH disorders lack precise biomarkers. In SPHYNCS, we utilized Fitbit smartwatches to monitor physical activity, heart rate, and sleep parameters over one year. We examined the feasibility of long-term ambulatory monitoring using the wearable device. We then explored digital biomarkers differentiating patients with NT1 from healthy controls (HC)...
March 29, 2024: Sleep
https://read.qxmd.com/read/38531670/heart-rate-variability-analysis-in-obstructive-sleep-apnoea-patients-with-daytime-sleepiness
#10
JOURNAL ARTICLE
Seren Ucak, Hasthi U Dissanayake, Philip de Chazal, Yu Sun Bin, Kate Sutherland, Bianca Setionago, Benjamin Tong, Brendon J Yee, Kristina Kairaitis, John R Wheatley, Amanda J Piper, Peter A Cistulli
STUDY OBJECTIVES: Recent studies suggest sleepy patients with OSA are at higher risk for incident cardiovascular disease. This study assessed cardiac autonomic function in sleepy versus non-sleepy patients with obstructive sleep apnoea (OSA) using heart rate variability (HRV) analysis. We hypothesised that HRV profiles of sleepy patients would indicate higher cardiovascular risk. METHODS: Electrocardiograms (ECG) derived from polysomnograms (PSG) collected by the Sydney Sleep Biobank were used to study HRV in groups of sleepy (ESS≥10) and non-sleepy OSA patients (ESS<10)...
March 26, 2024: Sleep
https://read.qxmd.com/read/38526098/longer-sleep-duration-and-neuroinflammation-in-at-risk-elderly-with-a-parental-history-of-alzheimer-s-disease
#11
JOURNAL ARTICLE
Andrée-Ann Baril, Cynthia Picard, Anne Labonté, Erlan Sanchez, Catherine Duclos, Béry Mohammediyan, John C S Breitner, Sylvia Villeneuve, Judes Poirier
STUDY OBJECTIVES: While short sleep could promote neurodegeneration, long sleep may be a marker of ongoing neurodegeneration, potentially as a result of neuroinflammation. The objective was to evaluate sleep patterns with age of expected Alzheimer's disease (AD) onset and neuroinflammation. METHODS: We tested 203 dementia-free participants (68.5±5.4y/o, 78M). The PREVENT-AD cohort includes older persons with a parental history of AD whose age was nearing their expected AD onset...
March 25, 2024: Sleep
https://read.qxmd.com/read/38520362/electroencephalography-connectome-changes-in-chronic-insomnia-disorder-are-correlated-with-neurochemical-signatures
#12
JOURNAL ARTICLE
Liyong Yu, Wei Peng, Wenting Lin, Yucai Luo, Daijie Hu, Guangli Zhao, Hao Xu, Zeyang Dou, Qi Zhang, Xiaojuan Hong, Siyi Yu
STUDY OBJECTIVES: This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) in patients with chronic insomnia disorder (CID) and to explore the correlation between macroscale connectomic variances and microscale neurotransmitter distributions. METHODS: We acquired 64-channel EEG from 35 female CID patients and 34 healthy females. EEG signals were source-localized using individual brain anatomy and orthogonalized to mitigate volume conduction...
March 23, 2024: Sleep
https://read.qxmd.com/read/38513693/cognitive-behavioral-therapy-for-insomnia%C3%A2-works-but-do-we-have-product-market-fit
#13
JOURNAL ARTICLE
Hailey Meaklim, Moira F Junge, David Cunnington
No abstract text is available yet for this article.
March 21, 2024: Sleep
https://read.qxmd.com/read/38513056/increased-flow-limitation-during-sleep-is-associated-with-decreased-psychomotor-vigilance-task-performance-in-individuals-with-suspected-obstructive-sleep-apnea-a-multi-cohort-study
#14
JOURNAL ARTICLE
Eric Staykov, Dwayne L Mann, Timo Leppänen, Juha Töyräs, Samu Kainulainen, Ali Azarbarzin, Brett Duce, Scott A Sands, Philip I Terrill
No abstract text is available yet for this article.
March 21, 2024: Sleep
https://read.qxmd.com/read/38512801/thermoneutral-temperature-exposure-enhances-slow-wave-sleep-with-a-correlated-improvement-in-amyloid-pathology-in-a-triple-transgenic-mouse-model-of-alzheimer-s-disease
#15
JOURNAL ARTICLE
J Wang, D Huffman, A Ajwad, C J McLouth, A Bachstetter, K Kohler, M P Murphy, B F O'Hara, M J Duncan, S Sunderam
Accumulation of amyloid-β (Aβ) plays an important role in Alzheimer's disease (AD) pathology. There is growing evidence that disordered sleep may accelerate AD pathology by impeding the physiological clearance of Aβ from the brain that occurs in normal sleep. Therapeutic strategies for improving sleep quality may therefore help slow disease progression. It is well documented that the composition and dynamics of sleep are sensitive to ambient temperature. We therefore compared Aβ pathology and sleep metrics derived from polysomnography in 12-month-old female 3xTg-AD mice (n = 8) exposed to thermoneutral temperatures during the light period over four weeks to those of age- and sex-matched controls (n = 8) that remained at normal housing temperature (22⁰C) during the same period...
March 21, 2024: Sleep
https://read.qxmd.com/read/38507644/correction-to-the-effect-of-total-sleep-deprivation-on-working-memory-evidence-from-diffusion-model
#16
(no author information available yet)
No abstract text is available yet for this article.
March 20, 2024: Sleep
https://read.qxmd.com/read/38506147/the-unique-vulnerabilities-of-nighttime-smartphone-use-a-commentary-on-tracked-and-self-reported-nighttime-smartphone-use-general-health-and-healthcare-utilization-results-from-the-smartsleep-study-by-drews-et-al
#17
EDITORIAL
https://read.qxmd.com/read/38497896/eeg-rhythmic-and-arrhythmic-spectral-components-and-functional-connectivity-at-resting-state-may-predict-the-development-of-synucleinopathies-in-idiopathic-rem-sleep-behavior-disorder
#18
JOURNAL ARTICLE
J Hernandez, J-M Lina, J Dubé, A Lafrenière, J-F Gagnon, J-Y Montplaisir, R B Postuma, J Carrier
STUDY OBJECTIVES: Idiopathic/isolated REM-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we investigated whether baseline resting-state EEG advanced spectral power and functional connectivity differ between iRBD patients who converted towards a synucleinopathy at follow-up and those who did not. METHODS: Eighty-one participants with iRBD (66.89±6.91 years) underwent a baseline resting-state EEG recording, a neuropsychological assessment and a neurological examination...
March 18, 2024: Sleep
https://read.qxmd.com/read/38497688/the-role-of-actigraphy-in-detecting-and-characterizing-the-early-phases-of-alzheimer-s-disease
#19
JOURNAL ARTICLE
Joseph R Winer
No abstract text is available yet for this article.
March 18, 2024: Sleep
https://read.qxmd.com/read/38482885/eeg-spectro-spatial-covariance-patterns-related-to-phenoconversion-in-isolated-rem-sleep-behavior-disorder-and-their-longitudinal-trajectories-in-%C3%AE-synucleinopathies
#20
JOURNAL ARTICLE
Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. METHODS: We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed resting EEGs. iRBD patients underwent follow-up EEG assessments and 18 iRBD patients converted (12 to Parkinson's disease (PD), 6 to dementia with Lewy bodies (DLB)) during follow-up...
March 14, 2024: Sleep
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