Ziyang Liang, Guoyang Zhang, GuangTing Gan, Duolan Naren, Xiaoyan Liu, Hongyun Liu, Jiani Mo, Shengqin Lu, Danian Nie, Liping Ma
Mesenchymal stem cells (MSCs) have become a promising therapeutic method. More safety data are needed to support clinical studies in more diseases. The aim of this study was to investigate the short- and long-term safety of human bone marrow-derived MSCs (hBMMSCs) in mice. In the present study, we injected control (saline infusion only), low (1.0 × 106 /kg), medium (1.0 × 107 /kg), and high (1.0 × 108 /kg) concentrations of hBMMSCs into BALB/c mice. The safety of the treatment was evaluated by observing changes in the general condition, hematology, biochemical indices, pathology of vital organs, lymphocyte subsets, and immune factor levels on days 14 and 150...
2023: Cell Transplantation