journal
https://read.qxmd.com/read/38887494/systemic-inflammation-differences-in-brain-vs-circulatory-dead-donors-impact-on-lung-transplant-recipients
#1
MULTICENTER STUDY
Alberto Sandiumenge, Irene Bello, Elisabeth Coll-Torres, Aroa Gomez-Brey, Clara Franco-Jarava, Eduardo Miñambres, Marina Pérez-Redondo, Fernando Mosteiro, Laura Sánchez-Moreno, Silvana Crowley, Eva Fieira, Borja Suberviola, Cristopher Alan Mazo, Alvar Agustí, Teresa Pont
Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients...
2024: Transplant International
https://read.qxmd.com/read/38881802/transplant-trial-watch
#2
EDITORIAL
John M O'Callaghan, Keno Mentor
No abstract text is available yet for this article.
2024: Transplant International
https://read.qxmd.com/read/38881801/simultaneous-heart-and-kidney-transplantation-a-systematic-review-and-proportional-meta-analysis-of-its-characteristics-and-long-term-variables
#3
REVIEW
Natália Zaneti Sampaio, Matheus Daniel Faleiro, Laynara Vitória da Silva Vieira, Gabriele Eckerdt Lech, Sofia Wagemaker Viana, Clara Pereira Oliveira Tavares, Adela D Mattiazzi, George W Burke
Patients with end-stage heart disease who undergo a heart transplant frequently have simultaneous kidney insufficiency, therefore simultaneous heart and kidney transplantation is an option and it is necessary to understand its characteristics and long-term variables. The recipient characteristics and operative and long-term variables were assessed in a meta-analysis. A total of 781 studies were screened, and 33 were thoroughly reviewed. 15 retrospective cohort studies and 376 patients were included. The recipient's mean age was 51...
2024: Transplant International
https://read.qxmd.com/read/38868358/pre-transplant-frequencies-of-foxp3-cd25-in-cd3-cd8-t-cells-as-potential-predictors-for-cmv-in-cmv-intermediate-risk-kidney-transplant-recipients
#4
JOURNAL ARTICLE
Agnes A Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A Klötzer, Barbara Prietl, Alexander H Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R Rosenkranz, Kathrin Eller
Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8+ T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8+ T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2)...
2024: Transplant International
https://read.qxmd.com/read/38855426/elements-of-weight-management-among-pre-kidney-transplant-candidates-the-patient-perspective
#5
JOURNAL ARTICLE
Ariana Chirban, Diana D Del Valle, Taylor Coe, Maria P Cote, Maggie Chen, Jennie Cataldo, Nahel Elias, Anushi Shah, Leigh Anne Dageforde
Obesity and related comorbidities heighten risks for complications in kidney transplant settings. While pre-transplant patients often have access to nutrition counseling and health support, literature is limited on patients' perceptions of weight and motivation to lose weight prior to transplantation. We conducted a survey among ≥18-year-old patients on the kidney transplant waitlist at a single center. Questions addressed weight perception, motivation for weight loss, available resources, and engagement in physical activity...
2024: Transplant International
https://read.qxmd.com/read/38845758/assessment-of-mitochondrial-respiration-during-hypothermic-storage-of-liver-biopsies-following-normothermic-machine-perfusion
#6
JOURNAL ARTICLE
Julia Hofmann, Alexander Kofler, Melanie Schartner, Madita L Buch, Martin Hermann, Bettina Zelger, Dietmar Öfner, Rupert Oberhuber, Theresa Hautz, Stefan Schneeberger, Andras T Meszaros
Organ quality can be assessed prior to transplantation, during normothermic machine perfusion (NMP) of the liver. Evaluation of mitochondrial function by high-resolution respirometry (HRR) may serve as a viability assessment concept in this setting. Freshly collected tissue is considered as optimal sample for HRR, but due to technical and personnel requirements, more flexible and schedulable measurements are needed. However, the impact of cold storage following NMP before processing biopsy samples for mitochondrial analysis remains unknown...
2024: Transplant International
https://read.qxmd.com/read/38845757/outcomes-of-lung-transplantation-in-patients-with-right-ventricular-dysfunction-a-single-center-retrospective-analysis-comparing-ecmo-configurations-in-a-bridge-to-transplant-setting
#7
COMPARATIVE STUDY
Su Yeon Lee, Jee Hwan Ahn, Ho Cheol Kim, Tae Sun Shim, Pil-Je Kang, Geun Dong Lee, Se Hoon Choi, Sung-Ho Jung, Seung-Il Park, Sang-Bum Hong
This study aimed to assess the lung transplantation (LT) outcomes of patients with right ventricular dysfunction (RVD), focusing on the impact of various extracorporeal membrane oxygenation (ECMO) configurations. We included adult patients who underwent LT with ECMO as a bridge-to-transplant from 2011 to 2021 at a single center. Among patients with RVD ( n = 67), veno-venous (V-V) ECMO was initially applied in 79% (53/67) and maintained until LT in 52% (35/67). Due to the worsening of RVD, the configuration was changed from V-V ECMO to veno-arterial (V-A) ECMO or a right ventricular assist device with an oxygenator (Oxy-RVAD) in 34% (18/67)...
2024: Transplant International
https://read.qxmd.com/read/38835886/minimizing-incision-in-living-donor-liver-transplantation-initial-experience-and-comparative-analysis-of-upper-midline-incision-in-115-recipients
#8
COMPARATIVE STUDY
Amit Rastogi, Ankur A Gupta, Raghav Bansal, Fysal Kollanta Valappil, Kamal S Yadav, Suchet Chaudhary, Prashant Bhangui, Swapnil Dhampalvar, Narendra S Choudhary, Neeraj Saraf, Arvinder S Soin
Living donor liver transplantation (LDLT) needs "Mercedes Benz" or "J-shaped" incision, causing short and long-term complications. An upper midline incision (UMI) is less invasive alternative but technically challenging. Reporting UMI for recipients in LDLT vs. conventional J-shaped incision. Retrospective analysis, July 2021 to December 2022. Peri-operative details and post-transplant outcomes of 115 consecutive adult LDLT recipients transplanted with UMI compared with 140 recipients with J-shaped incision...
2024: Transplant International
https://read.qxmd.com/read/38832357/donor-blood-tests-do-not-predict-pancreas-graft-survival-after-simultaneous-pancreas-kidney-transplantation-a-national-cohort-study
#9
JOURNAL ARTICLE
Ning Xuan Ho, Samuel J Tingle, Abdullah K Malik, Emily R Thompson, Georgios Kourounis, Aimen Amer, Sanjay Pandanaboyana, Colin Wilson, Steve White
Simultaneous pancreas-kidney (SPK) transplantation improves quality of life and limits progression of diabetic complications. There is reluctance to accept pancreata from donors with abnormal blood tests, due to concern of inferior outcomes. We investigated whether donor amylase and liver blood tests (markers of visceral ischaemic injury) predict pancreas graft outcome using the UK Transplant Registry (2016-2021). 857 SPK recipients were included (619 following brainstem death, 238 following circulatory death)...
2024: Transplant International
https://read.qxmd.com/read/38813393/machine-perfusion-enables-24-h-preservation-of-vascularized-composite-allografts-in-a-swine-model-of-allotransplantation
#10
JOURNAL ARTICLE
Marion Goutard, Pierre Tawa, Yanis Berkane, Alec R Andrews, Casie A Pendexter, Reinier J de Vries, Victor Pozzo, Golda Romano, Hyshem H Lancia, Irina Filz von Reiterdank, Nicolas Bertheuil, Ivy A Rosales, Ira Doressa Anne L How, Mark A Randolph, Alexandre G Lellouch, Curtis L Cetrulo, Korkut Uygun
The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP) is growing in the world of organ preservation. Herein, we investigated the outcomes of oxygenated acellular subnormothermic machine perfusion (SNMP) for 24-h VCA preservation before allotransplantation in a swine model. Six partial hindlimbs were procured on adult pigs and preserved ex vivo for 24 h with either SNMP ( n = 3) or SCS ( n = 3) before heterotopic allotransplantation...
2024: Transplant International
https://read.qxmd.com/read/38800671/risk-factors-incidence-and-outcomes-associated-with-clinically-significant-airway-ischemia
#11
JOURNAL ARTICLE
Gloria Li, Zejian Liu, Marcelo Salan-Gomez, Emma Keeney, Ethan D'Silva, Babith Mankidy, Andres Leon, Aladdein Mattar, Abdusallam Elsennousi, Jennalee Coster, Anupam Kumar, Bruno Rodrigues, Meng Li, Alexis Shafii, Puneet Garcha, Gabriel Loor
Airway complications following lung transplantation remain an important cause of morbidity and mortality. We aimed to identify the incidence, risk factors and outcomes associated with clinically significant airway ischemia (CSAI) in our center. We reviewed 217 lung transplants (386 airway anastomoses) performed at our institution between February 2016 and December 2020. Airway images were graded using the 2018 ISHLT grading guidelines modified slightly for retrospective analysis. Airways were considered to have CSAI if they developed ischemia severity >B2, stenosis >50%, and/or any degree of dehiscence within 6-months of transplant...
2024: Transplant International
https://read.qxmd.com/read/38784442/pitfalls-in-valganciclovir-prophylaxis-dose-adjustment-based-on-renal-function-in-kidney-transplant-recipients
#12
JOURNAL ARTICLE
Nathalie Hammer, Linard Hoessly, Fadi Haidar, Cédric Hirzel, Sophie de Seigneux, Christian van Delden, Bruno Vogt, Daniel Sidler, Dionysios Neofytos
Valganciclovir (VGC) is administered as prophylaxis to kidney transplant recipients (KTR) CMV donor (D)+/recipient (R)- and CMV R+ after thymoglobulin-induction (R+/TG). Although VGC dose adjustments based on renal function are recommended, there is paucity of real-life data on VGC dosing and associations with clinical outcomes. This is a retrospective Swiss Transplant Cohort Study-embedded observational study, including all adult D+/R- and R+/TG KTR between 2010 and 2020, who received prophylaxis with VGC...
2024: Transplant International
https://read.qxmd.com/read/38779355/impact-of-transient-and-persistent-donor-specific-antibodies-in-lung-transplantation
#13
JOURNAL ARTICLE
S Auner, C Hillebrand, P M Boehm, J Boecker, D Koren, S Schwarz, Z Kovacs, G Murakoezy, G Fischer, C Aigner, K Hoetzenecker, P Jaksch, A Benazzo
Lung transplantation (LuTx) is an established treatment for patients with end-stage lung diseases, however, outcomes are limited by acute and chronic rejection. One aspect that has received increasing attention is the role of the host's humoral alloresponse, particularly the formation of de novo donor-specific antibodies (dnDSAs). The aim of this study was to investigate the clinical significance of transient and persistent dnDSAs and to understand their impact on outcomes after LuTx. A retrospective analysis was conducted using DSA screening data from LuTx recipients obtained at the Medical University of Vienna between February 2016 and March 2021...
2024: Transplant International
https://read.qxmd.com/read/38773987/women-are-also-disadvantaged-in-accessing-transplant-outside-the-united-states-analysis-of-the-spanish-liver-transplantation-registry
#14
JOURNAL ARTICLE
Marta Tejedor, Fernando Neria, Gloria De La Rosa, Carolina Almohalla Álvarez, María Padilla, Andrea Boscà Robledo, Yiliam Fundora Suárez, Francisco Sánchez-Bueno, Miguel Angel Gómez-Bravo, Marina Berenguer
Sex inequities in liver transplantation (LT) have been documented in several, mostly US-based, studies. Our aim was to describe sex-related differences in access to LT in a system with short waiting times. All adult patients registered in the RETH-Spanish Liver Transplant Registry (2000-2022) for LT were included. Baseline demographics, presence of hepatocellular carcinoma, cause and severity of liver disease, time on the waiting list (WL), access to transplantation, and reasons for removal from the WL were assessed...
2024: Transplant International
https://read.qxmd.com/read/38751772/pre-transplant-calcimimetic-use-and-dose-information-improves-the-accuracy-of-prediction-of-tertiary-hyperparathyroidism-after-kidney-transplantation-a-retrospective-cohort-study
#15
JOURNAL ARTICLE
Manabu Okada, Tetsuhiko Sato, Tomoki Himeno, Yuki Hasegawa, Kenta Futamura, Takahisa Hiramitsu, Toshihiro Ichimori, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai
Tertiary hyperparathyroidism (THPT) is characterized by elevated parathyroid hormone and serum calcium levels after kidney transplantation (KTx). To ascertain whether pre-transplant calcimimetic use and dose information would improve THPT prediction accuracy, this retrospective cohort study evaluated patients who underwent KTx between 2010 and 2022. The primary outcome was the development of clinically relevant THPT. Logistic regression analysis was used to evaluate pre-transplant calcimimetic use as a determinant of THPT development...
2024: Transplant International
https://read.qxmd.com/read/38751771/lung-transplantation-in-controlled-donation-after-circulatory-determination-of-death-using-normothermic-abdominal-perfusion
#16
REVIEW
Paula Moreno, Javier González-García, Eloísa Ruíz-López, Antonio Alvarez
The main limitation to increased rates of lung transplantation (LT) continues to be the availability of suitable donors. At present, the largest source of lung allografts is still donation after the neurologic determination of death (brain-death donors, DBD). However, only 20% of these donors provide acceptable lung allografts for transplantation. One of the proposed strategies to increase the lung donor pool is the use of donors after circulatory-determination-of-death (DCD), which has the potential to significantly alleviate the shortage of transplantable lungs...
2024: Transplant International
https://read.qxmd.com/read/38751770/solid-organ-transplant-litigation-at-one-of-europe-s-largest-university-hospitals
#17
JOURNAL ARTICLE
Jacques Belghiti, François Cauchy, Corinne Antoine, Gérard Cheron, Marie Matignon
Due to its intrinsic complexity and the principle of collective solidarity that governs it, solid organ transplantation (SOT) seems to have been spared from the increase in litigation related to medical activity. Litigation relating to solid organ transplantation that took place in the 29 units of the Assistance Publique-Hôpitaux de Paris and was the subject of a judicial decision between 2015 and 2022 was studied. A total of 52 cases of SOT were recorded, all in adults, representing 1.1% of all cases and increasing from 0...
2024: Transplant International
https://read.qxmd.com/read/38751769/meeting-the-shortage-of-human-cells-and-tissues-the-andalusian-quality-assurance-programme-for-tissue-donation
#18
JOURNAL ARTICLE
Antonia José Alvarez-Marquez, Jesus Huet, José Miguel Pérez-Villares, Domingo Daga-Ruiz, Concepción Diaz-Aunión, Pablo Castro de la Nuez, Natividad Cuende
Background A quality assurance programme for the tissue donation process was launched in Andalusia in 2020 to facilitate the integration of tissue donation into end-of-life care, and to respond to the growing need for human tissue for therapeutic purposes. The results of this programme are presented here. Methods After identifying the hospital departments in which to intensify the detection of tissue donors, expanding training activities and designing a specific data collection system for possible tissue donors who do not donate their tissues, the results of the donation activity were quantified and the causes of non-donation were analysed by applying the critical pathway for deceased tissue donation methodology...
2024: Transplant International
https://read.qxmd.com/read/38741700/proteomic-analysis-of-primary-graft-dysfunction-in-porcine-lung-transplantation-reveals-alveolar-capillary-barrier-changes-underlying-the-high-particle-flow-rate-in-exhaled-breath
#19
JOURNAL ARTICLE
Anna Niroomand, Gabriel Hirdman, Nicholas Bèchet, Haider Ghaidan, Martin Stenlo, Sven Kjellström, Marc Isaksson, Ellen Broberg, Leif Pierre, Snejana Hyllén, Franziska Olm, Sandra Lindstedt
Primary graft dysfunction (PGD) remains a challenge for lung transplantation (LTx) recipients as a leading cause of poor early outcomes. New methods are needed for more detailed monitoring and understanding of the pathophysiology of PGD. The measurement of particle flow rate (PFR) in exhaled breath is a novel tool to monitor and understand the disease at the proteomic level. In total, 22 recipient pigs underwent orthotopic left LTx and were evaluated for PGD on postoperative day 3. Exhaled breath particles (EBPs) were evaluated by mass spectrometry and the proteome was compared to tissue biopsies and bronchoalveolar lavage fluid (BALF)...
2024: Transplant International
https://read.qxmd.com/read/38736987/transplant-trial-watch
#20
EDITORIAL
Simon R Knight, John M O'Callaghan
No abstract text is available yet for this article.
2024: Transplant International
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