journal
https://read.qxmd.com/read/37752016/liver-transplant-outcomes-in-young-adults-with-cirrhosis-related-to-nonalcoholic-fatty-liver-disease
#1
JOURNAL ARTICLE
Dmitri Bezinover, Naim Alhkouri, Roman Schumann, Nathaniel Geyer, Vernon Chinchilli, Jonathan G Stine
BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NASH) and cryptogenic cirrhosis (CC) is constantly increasing in adolescents and young adults (AYAs). METHODS: In a retrospective UNOS database evaluation, we analyzed postoperative outcomes of AYAs with nonalcoholic NASH/CC undergoing LT between January 1st , 2003 and March 5th , 2021. After exclusions, 85,970 LT recipients, 393 (47.1%) AYAs with NASH/CC and 441 (52.9%) AYAs with other metabolic conditions, were analyzed...
September 24, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37752015/protective-effect-of-subcutaneous-drains-on-wound-infections-in-kidney-transplantation
#2
JOURNAL ARTICLE
Hifsa Noor, Carlos Verdiales, Michael Moser
BACKGROUND: Wound infections following kidney transplantation are common, with a reported incidence of 5%-19%. In the first few days after surgery, these patients receive extremely high doses of immunosuppression and high volumes of intravenous fluids, and they represent a specific subgroup of surgical patients that may benefit from using prophylactic subcutaneous drains. METHODS: We analyzed a nonrandomized series of 112 consecutive kidney transplants between January 2017 and December 2019: those who received a subcutaneous drain in addition to the standard retroperitoneal drain (SQ drain group) vs those with a retroperitoneal drain alone (standard group)...
September 24, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37752014/feasibility-of-organ-transportation-by-a-drone-an-experimental-study-using-a-rat-model
#3
JOURNAL ARTICLE
Takahiro Enjoji, Akihiko Soyama, Masayuki Fukumoto, Li Peilin, Kunihito Matsuguma, Hajime Imamura, Yasuhiro Maruya, Takanobu Hara, Hajime Matsushima, Tota Kugiyama, Tomohiko Adachi, Masaaki Hidaka, Sho Hamamoto, Shiro Takashima, Takahiro Maeda, Kengo Kanetaka, Susumu Eguchi
BACKGROUND: Recently, the successful delivery of organs for transplantation using drones was reported. We investigated the influence of transportation by drones on the quality of liver grafts using a rat model. METHODS: Livers of 12 rats (8 and 32 weeks old) were divided into 2 groups of six. Livers were split into 2 parts and allocated to the drone or control groups (both n = 12). The drone experiment was conducted between islands in Nagasaki Prefecture, Japan...
September 24, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37748966/the-long-term-outcome-of-kidney-transplant-recipients-in-the-eighth-decade-compared-with-recipients-in-the-seventh-decade-of-life
#4
JOURNAL ARTICLE
Shirley Rahel Visan, Roni Baruch, Doron Schwartz, Idit F Schwartz, Yaacov Goykhman, Michal Ariela Raz, Moshe Shashar, Keren Cohen-Hagai, Naomi Nacasch, Orit Kliuk-Ben-Bassat, Ayelet Grupper
BACKGROUND: With the aging of the population, more older patients are being considered for kidney transplantation; therefore, it is crucial to evaluate the risks and benefits of transplantation in this population. This study aimed to assess long-term outcomes of kidney transplantation in a cohort of patients who underwent kidney transplantation at age >70 years, compared with patients aged 60 to 69 years at transplantation. METHODS: Included in the study were 261 consecutive kidney transplant recipients: 52 were aged >70 years, and 209 were aged 60 to 69 years at transplantation...
September 23, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37748965/draining-lymph-nodes-in-human-kidney-pancreas-transplant-potential-implications-in-alloimmunity-and-tolerance
#5
JOURNAL ARTICLE
Justin H Nguyen
BACKGROUND: Draining lymph nodes (DLNs) are implicated in alloimmunity and tolerance regulation. The role of DLNs in human organ transplant is unknown due to the lack of relevant clinical tissues. METHODS: During a combined kidney and pancreas transplant, the distal vena cava and both right and left common and external iliac vessels were mobilized and exposed. Draining lymph nodes along these vessels were removed sequentially and archived before the pancreas transplant...
September 23, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37748964/donor-safety-first-postoperative-hepatectomy-outcomes-in-living-liver-donors
#6
JOURNAL ARTICLE
Abdullah Khalid, Bilal Ahmed Khan, Imran Ali Syed, Zohaa Faiz, Ihsan Haq, Yasir Khan, Sohail Rashid, Faisal Saud Dar
BACKGROUND: Living donor liver transplantation (LDLT) has become a popular treatment option because some countries lack a deceased organ program and the growing demand for liver transplants. Although postoperative outcomes are similar to deceased donor liver transplants, there is still an element of risk to the donor. The Clavien-Dindo classification system has been used to standardize reporting across different institutions and surgeons to categorize surgical outcomes. METHODS: Between January 1, 2022, and December 31, 2022, 207 living donors underwent hepatectomies at our center...
September 23, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37743190/no-difference-between-tacrolimus-and-cyclosporine-a-on-depression-among-kidney-transplantation-recipients
#7
JOURNAL ARTICLE
Hongyang Chen, Kepu Liu, Di Wei, Pinxiao Wang, Geng Zhang, Changsheng Chen, Jianlin Yuan
BACKGROUND: The 2 main types of calcineurin inhibitors (CNI) are tacrolimus (TAC) and cyclosporine A (CsA); both are needed by patients who receive kidney transplants. A common adverse reaction of TAC is depression, which is listed in its instructions. However, depression occurred rarely, according to the instructions manual for CsA. METHODS: Scales measuring depression were sent to recipients who had taken TAC or CsA to observe whether there was a difference in depression between patients who consumed the 2 drugs...
September 22, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37743189/metabolic-syndrome-and-dietary-intake-are-associated-with-quality-of-life-in-kidney-transplant-recipients
#8
JOURNAL ARTICLE
Thu-Ha Nguyen, Zulfitri Azuan Mat Daud, Ruzita Abd Talib, Rozita Mohd, Bee-Koon Poh
BACKGROUND: Although metabolic syndrome (MetS) is a significant risk factor, and dietary intake may affect the quality of life (QoL) of kidney transplant recipients (KTRs), the association between them are unclear. This study identified MetS and nutritional factors associated with the QoL of KTRs. METHODS: This study reports baseline data from a longitudinal study that was conducted at a hospital in Vietnam. KTRs aged ≥18 years and >3 months post-transplantation were recruited...
September 22, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37739830/utilization-of-paragonix-sherpapak-cardiac-transport-system-for-the-preservation-of-donor-hearts-after-circulatory-death
#9
JOURNAL ARTICLE
Marian Urban, Anthony W Castleberry, Aleem Siddique, Brian D Lowes, Douglas A Stoller, Scott W Lundgren, John Y Um
BACKGROUND: Donation after circulatory death (DCD) heart transplantation is being increasingly adopted by transplant centers. The optimal method of DCD heart preservation during transport after in situ thoracoabdominal normothermic regional perfusion (TA-NRP) is not known. METHODS: We evaluated our experience with the Paragonix SherpaPak Cardiac Transport System (SCTS) for the transport of DCD cardiac allografts after TA-NRP recovery between January 2021 and December 2022...
September 20, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37730451/machine-learning-model-to-predict-graft-rejection-after-kidney-transplantation
#10
JOURNAL ARTICLE
Arthur Cesar Dos Santos Minato, Pedro Guilherme Coelho Hannun, Abner Macola Pacheco Barbosa, Naila Camila da Rocha, Juliana Machado-Rugolo, Marilia Mastrocolla de Almeida Cardoso, Luis Gustavo Modelli de Andrade
BACKGROUND: There are few predictive studies about early posttransplant outcomes taking into account baseline and posttransplant variables. The objective of this study was to create a predictive model for 30-day graft rejection using machine learning techniques. METHODS: Retrospective study with 1255 patients undergoing transplant from living and deceased donors at a tertiary health service in Brazil. Recipient, donor, transplantation, and postoperative period data were collected from physical and electronic records...
September 18, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37730450/mortality-and-cardiovascular-outcomes-in-adult-non-liver-solid-organ-transplant-patients-with-nonalcoholic-steatohepatitis
#11
JOURNAL ARTICLE
Nirjhar Dutta, Nicholas Marka, John Lake, Nicholas Lim
BACKGROUND: The effect of nonalcoholic steatohepatitis (NASH) on mortality or major adverse cardiovascular events (MACE) in non-liver solid organ transplant recipients (NL-SOT) is unknown. METHODS: Using a retrospective design, adult NL-SOT recipients who had biopsy-proven NASH were compared NL-SOT recipients with normal liver function tests and imaging; propensity matched at a 1:10 ratio on the following: age, sex, race, transplant year, transplant organ, smoking status, and diabetes status...
September 18, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37722929/an-atypical-course-of-visceral-leishmaniasis-after-kidney-transplantation-a-case-report-from-iran
#12
JOURNAL ARTICLE
Sina Kardeh, Fatemeh Masjedi, Shima Faezi-Marian, Alireza Shamsaeefar, Mahsa Torabi Jahromi, Maryam Pakfetrat, Jamshid Roozbeh
BACKGROUND: Organ transplantation can lead to human visceral leishmaniasis (VL) transmission in humans. This report aims to describe the possible complications related to an atypical course of VL after kidney transplantation. CASE PRESENTATION: A 61-year-old man who suffered end-stage renal failure received a deceased donor kidney transplant after 2 years of hemodialysis. Tacrolimus, mycophenolate mofetil, and prednisolone were used for immunosuppressive therapy, and renal function remained stable for 2...
September 16, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37714809/transmission-of-lung-adenocarcinoma-from-a-single-donor-in-2-transplant-recipients-a-case-report-with-literature-review
#13
JOURNAL ARTICLE
Andre Arsenault, Parth Sharma, Jennifer Buckley, Alex Braun, Eric Ewing, Sunpreet Rhakra, Lee Cummings, Dhruv Bansal
Malignancies transmitted to recipients during solid organ transplants carry significant morbidity and mortality. We present 2 cases of adenocarcinoma of donor lung origin transmitted via liver and kidney transplant from a single donor. Both recipients developed metastatic adenocarcinoma of lung origin with p.L858R mutation in the epidermal growth factor receptor gene and a microsatellite signature of donor origin. Osimertinib was trialed in the liver recipient; however, it was discontinued because of hepatotoxicity and disease progression...
September 13, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37661468/tixagevimab-cilgavimab-decreases%C3%A2-the-rate-of-sars-cov-2-infection-among-solid-organ-transplant-recipients
#14
JOURNAL ARTICLE
Ava M Sanayei, Adriana Montalvan, Isabella Faria, Julia Ochalla, Martha Pavlakis, Barbra M Blair, Carolyn D Alonso, Michael Curry, Behnam Saberi
BACKGROUND: SARS-CoV-2 infection in solid organ transplant (SOT) recipients is associated with high morbidity and mortality. Tixagevimab/cilgavimab monoclonal antibodies were previously authorized for pre-exposure prophylaxis for immunocompromised individuals. We aimed to determine if tixagevimab/cilgavimab could prevent breakthrough SARS-CoV-2 infection in SOT recipients. MATERIAL AND METHODS: We conducted a prospective single-center study of SOT recipients who received tixagevimab/cilgavimab compared with those who did not...
September 1, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37661467/domino-liver-transplantation-for-unresectable-colon-cancer-liver-metastasis-from-a-donor-with-heterozygous-familial-hyperlipidemia-a-case-report
#15
JOURNAL ARTICLE
Yuzuru Sambommatsu, David A Bruno, Daisuke Imai, Seung Duk Lee, Aamir A Khan, Amit Sharma, Muhammad Saeed, Adrian H Cotterell, Marlon F Levy, Chandra Bhati, Vinay Kumaran
Liver transplantation (LT) is a potential curative treatment for unresectable colorectal cancer liver metastasis (CRLM). Familial hypercholesterolemia (FH) is an inherited condition characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels. Liver transplantation is offered for selected cases, and an explanted liver can be used as a domino graft. We report the first report of domino LT for unresectable CRLM using a liver from a patient with heterozygous FH. The domino donor was a 30-year-old female with a history of heterozygous FH...
September 1, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37658010/case-report-of-needle-disruption-of-the-retroperitoneal-lymph-nodes-for-refractory-chylothorax-after-double-lung-transplantation
#16
JOURNAL ARTICLE
Hiroshi Kagawa, John Stringham, Craig Selzman, Matthew Goodwin, Laura Frye, Sanjeev Raman, Barbara Cahill, Matthew Morrell
Chylothorax is a rare complication after double lung transplantation. We report a case of a 55-year-old man with idiopathic pulmonary fibrosis. He underwent a double lung transplantation with venoarterial extracorporeal membrane support. The surgery was uncomplicated; however, his postoperative course was complicated with a refractory chylothorax that started postoperative day 4. Medical management could not control the chylothorax, including nil per os, total parenteral nutrition, and octreotide administration...
August 30, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37652784/iatrogenic-acute-ascending-aortic-dissection-during-combined-heart-liver-transplant-for-amyloidosis
#17
JOURNAL ARTICLE
Ishaq J Wadiwala, Pankaj Garg, Vivienne Pham, C Burcin Taner, Houssam Farres, Murli Krishna, Si M Pham
We report a case of iatrogenic acute type A aortic dissection (ATAAD) during a combined heart-liver transplant in a patient with amyloid-associated cardiac and hepatic failure. The patient developed ATAAD of the recipient's aorta during the heart transplantation. Because there was no sign of malperfusion or proximal extension into the donor aorta, we proceeded with the liver transplantation and continued medical management for ATAAD. The patient was discharged uneventfully 30 days after the transplant, and computed tomography coronary angiogram after 4 months showed stable dissection...
August 30, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37652783/suspected-malignant-hyperthermia-in-a-brain-dead-donor-during-anesthesia-for-organ-procurement-surgery-a-case-report
#18
JOURNAL ARTICLE
Hoon Jung, Hyunjee Kim, Taeyoung Yu, Jinsong Yeo, Won-Jung Shin, Hyun-Su Ri, Kyung Hwa Kwak, Dong Gun Lim, Sioh Kim
We report an unusual case of highly suspected malignant hyperthermia after inducing anesthesia in a brain-dead 18-year-old male patient undergoing organ procurement surgery. The patient was administered desflurane (3 vol%) and rocuronium bromide (50 mg) to induce and maintain general anesthesia. He experienced hypercapnia and tachycardia within 5 minutes of anesthesia induction; however, his body temperature rapidly rose only after 15 minutes. The volatile anesthetic was discontinued, and dantrolene was administered at a low dose (1 mg/kg) to avert possible hepatotoxic effects on the donor liver...
August 29, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37648577/living-donor-initiated-domino-split-liver-transplantation-in-pediatric-setup-a-case-report-with-literature-review
#19
JOURNAL ARTICLE
Altan Alim, Cihan Karataş, Akın Akbulut, Bahadır Hakan Oğuz, Ömer Özden, Şenol Emre, Gültekin Hoş, Barış Demir, Nuray Uslu Kızılkan, Aydın Alper, Turan Kanmaz
BACKGROUND: In patients undergoing liver transplantation for metabolic diseases, removing the patient's liver for transplantation to another recipient is called "domino liver transplantation." The extracted liver can be divided and transplanted into 2 recipients, which is called domino split-liver transplantation in the literature. However, in our study, the domino liver was obtained from a pediatric patient. METHODS: A patient with maple syrup urine disease (MSUD) underwent a living donor liver transplant, and the explanted liver was divided in situ into right and left lobes and transplanted to 2 separate patients...
August 28, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37633757/liver-transplantation-for-acute-liver-failure-during-pregnancy-case-report-and-literature-review
#20
JOURNAL ARTICLE
Yousu Shen, Xiling Shi, Mingsheng Zhang, Zhidan Xu, Junxiang Yin
Liver failure during pregnancy is a rare and highly fatal condition frequently resulting from the patient's pre-existing chronic liver disease. There is no established protocol for managing this condition, and physicians tend to adopt a conservative approach due to concerns about the impact of liver transplantation on fetal development. However, conservative treatment may exacerbate the condition, increasing the risk of fetal and miscarriage deaths. In this study, we present a case of acute-on-chronic liver failure resulting from chronic hepatitis during the 19th week of gestation...
August 24, 2023: Transplantation Proceedings
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