Tie-Yan Fan, Yan Yan, Qian Lu, Jun Li, Hong Chen
The use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab, to treat drug-resistant hypercholesterolemia is increasing; however, to date there have been no studies on the use of alirocumab to treat the hyperlipidemia that follows liver transplantation. Here we report a case of successful management of hyperlipidemia, albeit without total reversal of elevated serum triglycerides, with alirocumab monotherapy in a liver transplantation patient who was resistant to rosuvastatin and fenofibrate...
June 14, 2024: Transplantation Proceedings
Jhosimar Alvarez, Daniel Reis Waisberg, Liliana Ducatti, Vinicius Rocha-Santos, Rodrigo Bronze Martino, Rafael Soares Pinheiro, Rubens Macedo Arantes, Luciana Bertocco Haddad, Joao Paulo Santos, Paola Espinoza Alvarez, Pedro Marin-Castro, Igor Ferreira Vieira, Maciana Santos Silva, Juliani Dourado Almeida, Flávio Henrique Galvão, Luiz Augusto Carneiro-D'Albuquerque, Wellington Andraus
BACKGROUND: Liver adenomatosis is characterized by multiple adenomas diffusely distributed throughout the liver parenchyma. Studies addressing liver transplantation for those cases are scarce, and the criteria used to indicate transplantation are still debatable. OBJECTIVE: To report a single-center experience of liver transplantation for diffuse adenomatosis. METHODS: Single-center retrospective study involving all adult patients who underwent liver transplantation due to adenomatosis from January/2010 to June/2023...
June 10, 2024: Transplantation Proceedings
Juliani Dourado Almeida, Daniel Reis Waisberg, Rodrigo Bronze Martino, Vinicius Rocha-Santos, Rafael Soares Pinheiro, Rubens Macedo Arantes, Liliana Ducatti, Lucas Souto Nacif, Andre Dong Lee, Luciana Bertocco Haddad, Alice Tung Song, Maciana Santos Silva, Jhosimar Alvarez, Pedro Marin-Castro, Igor Ferreira Vieira, Flávio Henrique Galvão, Luiz Augusto Carneiro-D'Albuquerque, Wellington Andraus
BACKGROUND: Hepatic artery thrombosis is the most common vascular complication of liver transplantation. When occurring late in the postoperative course, it may have no clinical repercussions, and conservative treatment may be implemented. Some patients, however, will develop severe biliary complications due to ischemic cholangiopathy and require retransplantation. The aim of this study is to report the outcomes of retransplantation in this population. METHODS: This is a single-center retrospective study involving all adult patients who underwent liver retransplantation due to late hepatic artery thrombosis from January/2010 to December/2022...
June 10, 2024: Transplantation Proceedings
Igor Ferreira Vieira, Daniel Reis Waisberg, Vinicius Rocha-Santos, Rafael Soares Pinheiro, Rodrigo Bronze Martino, Liliana Ducatti, Rubens Macedo Arantes, Lucas Souto Nacif, Andre Dong Lee, Luciana Bertocco Haddad, Alice Tung Song, Pedro Marin-Castro, Jhosimar Alvarez, Maciana Santos Silva, Juliani Dourado Almeida, Flavio Henrique Galvão, Luiz Augusto Carneiro-D Albuquerque, Wellington Andraus
INTRODUCTION: Polycystic liver disease and giant hepatic hemangioma may present with severe symptom burden and indicate orthotopic liver transplantation. The left-to-right piggyback approach is a useful technique for performing total hepatectomy of enlarged livers. OBJECTIVE: The purpose of this study is to analyze the results of liver transplantation in patients with benign massive hepatomegaly. METHODS: This is a single-center retrospective study involving all adult patients who underwent liver transplantation due to benign massive hepatomegaly from January 2002 to June 2023...
June 10, 2024: Transplantation Proceedings
Letícia Nogueira Datrino, Matheus Lopes Boccuzzi, Rafael Matosinho Silva, Pedro Henrique Baptistella Teno Castilho, Wagner José Riva, Jéssica Silva Rocha, Francisco Tustumi
INTRODUCTION: This study evaluated the efficacy and safety of mycophenolate mofetil (MMF) associated with tacrolimus (TAC) in patients undergoing kidney-pancreas and kidney transplants, in comparison with cyclosporine (CyA), azathioprine (AZA), everolimus (EVL), sirolimus (SRL), manitimus (MAN), mizoribine (MZR), and enteric-coated mycophenolate sodium (ECMPS) in combination or monotherapy. METHODS: A systematic review and meta-analysis of randomized clinical trials was performed...
June 9, 2024: Transplantation Proceedings
Rose Mary Attieh, Dawn Roach, Hani M Wadei, Namrata Parikh, Hay Me Me, Ravindra V Durvasula, Justin Oring
We report a case of adenovirus nephritis (ADVN) in a kidney transplant recipient (KTR) occurring within 8 days post-transplantation. The patient, a 35-year-old male, displayed systemic symptoms, high-grade fever, and acute kidney injury (AKI) without signs of hemorrhagic cystitis (HC). Extensive diagnostic workup revealed widespread necrotizing granulomatous inflammation in the allograft, leading to the identification of adenovirus (ADV) via histopathology and polymerase chain reaction (PCR) testing. The source of ADV transmission remained uncertain, raising questions about the potential donor-derived infection...
June 7, 2024: Transplantation Proceedings
Taehwa Kim, Hye Ju Yeo, Bong Soo Son, Dohyung Kim, Woo Hyun Cho, Hee Yun Seol
No abstract text is available yet for this article.
June 7, 2024: Transplantation Proceedings
Eun Ah Choi, Ja Eun Lee, Gaab-Soo Kim
BACKGROUND: ABO-incompatible living donor liver transplantation (ABOi LDLT) is a complex procedure involving the reduction of anti-A and anti-B antibodies by therapeutic plasma exchange (TPE) to prevent acute antibody-mediated rejection. Fresh frozen plasma (FFP) is often used as replacement fluid during TPE. CASE DESCRIPTION: We report an ABOi LDLT case in which the patient experienced an anaphylactic reaction to FFP during TPE. Additional TPE was performed using 5% albumin as replacement fluid...
June 7, 2024: Transplantation Proceedings
Flávia Misawa Hama, Marcelo Biscegli Jatene, Adailson Siqueira, José Eduardo Krieger, Estela Azeka
Congenital heart disease is the most common birth defect, and heart transplantation is the main treatment of choice. As genetic causes can be identified in a considerable proportion of cases, investigation of possible family cardiac history is essential. We analyzed the profiles of pediatric heart transplant recipients in terms of family history of heart disease. This single-center retrospective study included pediatric patients who underwent heart transplantation at a tertiary hospital between 2013 and 2023...
June 5, 2024: Transplantation Proceedings
Kazunori Ueda, Tatsuaki Watanabe, Yui Watanabe, Takashi Hirama, Hisashi Oishi, Hiromichi Niikawa, Yasushi Matsuda, Masafumi Noda, Yasushi Hoshikawa, Yoshinori Okada
A 41-year-old woman with lymphangioleiomyomatosis developed a bronchial anastomotic stenosis after left single lung transplantation (LTx). A part of the hyperinflated right native lung was excised in an attempt to remedy the left lung compression, which appeared to affect the bronchial anastomotic stenosis and ventilation/perfusion mismatch. However, a persistent air leak after the surgery caused empyema and an open window thoracotomy (OWT) was performed. She remained oxygen-dependent and was relisted for lung transplantation...
June 3, 2024: Transplantation Proceedings
Conrad Rauber, Jan Pfeiffenberger, Arianeb Mehrabi, Markus Mieth, Eugen Zizer, Uta Merle
BACKGROUND: Glycogen storage disorder (GSD) type IIIa is a rare inherited genetic disorder affecting liver and muscle tissue. Liver transplantation (LT) improves metabolic control, but muscle involvement persists. CASE: We report the case of a 31-year-old man who underwent orthotopic LT for end-stage liver disease caused by GSD type IIIa. After LT, he developed worsening clinical signs of myopathy, along with exponentially increasing levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and creatine kinase...
June 3, 2024: Transplantation Proceedings
Takahiko Omameuda, Taiichi Wakiya, Yasunaru Sakuma, Yasuharu Onishi, Toshiyuki Yamada, Katsutoshi Takanami, Yukihiro Sanada, Yuta Hirata, Toshio Horiuchi, Naohiro Sata
Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of amino groups from alanine to ketoglutaric acid. ALT is an established marker of liver diseases. Occasionally, ALT levels may be abnormally low due to various factors, making accurate assessment difficult. To date, no studies have documented ALT alterations following Living donor liver transplantation (LDLT) in patients with low ALT levels. Here, we present a case of abnormally low ALT levels that were ameliorated by LDLT. A 27-year-old woman underwent LDLT for refractory cholangitis with biliary atresia...
June 1, 2024: Transplantation Proceedings
Joanna Śliwka, Szymon Pawlak, Agnieszka Kuczaj, Mirosława Herdyńska-Wąs, Piotr Przybyłowski, Tomasz Hrapkowicz
OBJECTIVE: To assess the principles of qualification and the range of organ transplantation in a patient with diagnosis of system sclerosis with pulmonary manifestation and severe myocardial insufficiency. METHODS: We present the case of a 43-year-old patient with confirmed systemic sclerosis with pulmonary manifestations and biventricular heart insufficiency after disease exacerbation and sudden cardiac arrest in the pulseless electrical activity (PEA) mechanism with effective resuscitation, with increasing shortness of breath and the need for inotropes and levosimendan infusion without a significant improvement in his general status...
May 31, 2024: Transplantation Proceedings
Yafei Guo, Shilan Li, Zebin Zhu, Wei Cai, Hao Zheng, Dalong Yin, Shugeng Zhang
Caroli disease (CD) is a congenital disease of the intrahepatic biliary system, which manifests as cystic dilatation of the intrahepatic bile ducts. The disease has a low incidence and atypical clinical manifestations; therefore, it can be easily misdiagnosed. Hepatitis B infection is a viral infection that affects liver cells, leading to degeneration, necrosis, and regeneration of the cells and formation of false lobules, and ultimately nodular cirrhosis, which can lead to liver dysfunction and liver failure...
May 29, 2024: Transplantation Proceedings
Daiki Hokkoku, Kazuki Sasaki, Shogo Kobayashi, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi
Nocardia is a gram-positive bacillus with the microscopic appearance of branching hyphae and is mainly distributed in the soil. Nocardiosis more frequently occurs in immunosuppressed patients. Since nocardiosis has a high mortality rate, immediate diagnosis and treatment are needed. We report the first case of pulmonary nocardiosis caused by Nocardia pseudobrasiliensis after liver transplantation. A 58-year-old woman underwent living-donor transplantation for primary biliary cholangitis. Seven months after transplantation, she came to our hospital complaining of fever and anorexia...
May 29, 2024: Transplantation Proceedings
Daisuke Akiyama, Junya Kanda, Yuta Hanyu, Hiroki Amagase, Tadakazu Kondo, Takayuki Miyamoto, Takahiro Yasumi, Noriyoshi Yoshinaga, Akifumi Takaori-Kondo
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare inherited autosomal recessive immune deficiency that usually manifests during infancy or early childhood, rarely occurring in adults. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for FHL. However, optimal conditioning regimens for adult-onset FHL have not yet been established. Herein, we report a case of adult-onset FHL. A 37-year-old man presented with fever, liver dysfunction, and pancytopenia, which improved temporarily with corticosteroid therapy...
May 29, 2024: Transplantation Proceedings
Marcin Bartoszewicz, Patrycja Prokop, Maciej Kosieradzki, Piotr Fiedor
For many rare disease (RD) patients, allogenic transplantation represents an effective therapy, improving overall survival rates and quality of life (QoL). Globally, ∼1% of liver transplants are performed for RDs and rare indications. However, patients and carers report unmet needs on their pathway toward treatment-in education and therapeutic measures, oftentimes shouldering expertise-building responsibility themselves. These issues are exacerbated in child patients. Estimates indicate that 6% to 8% of Poland's population (2...
May 28, 2024: Transplantation Proceedings
Shin Tanaka, Kentaroh Miyoshi, Seiichiro Sugimoto, Shinichi Toyooka
Double-lung transplantation (DLT) is favored for enhanced long-term survival despite the risk of major complications, particularly in elderly patients or those with comorbidities. Two-stage contralateral single-lung transplantation (SLT) leading to DLT is considered a valuable option to combine the advantages of less invasive SLT with DLT survival benefits. This study detailed the intraoperative challenges encountered during the procedure. A 54-year-old patient with chronic lung allograft dysfunction after right SLT underwent contralateral (left) SLT because of left lung dysfunction...
May 27, 2024: Transplantation Proceedings
Marianna Juhász, Bence Antal, Gabriella Herczeg, Balázs Nemes, Béla Fülesdi, Tamás Végh
Pneumonia is a common nosocomial complication in transplant patients. Stenotrophomonas maltophilia is recognized as a common cause and is typically seen in immunocompromised and critically ill patients. S. maltophilia, a nonfermenting gram-negative rod, ranks as the third most common nosocomial pathogen, following Pseudomonas aeruginosa and Acinetobacter. The bacteria are frequently found in environmental sources and are prevalent in healthcare facilities, including in tap water faucets, shower outlets, air-cooling systems, intravenous fluids, catheters, dialysis machines, and oxygen humidifiers...
May 27, 2024: Transplantation Proceedings
Shuangwen Qin, Xiuhong Lu, Ling Li, Debin Huang
An uncommon and dangerous disease with a fatality rate of more than 95% is caused by the amoeba known as Balamuthia mandrillaris. Here, we discuss the treatment of a patient who underwent a renal transplant and contracted the amoeba B. mandrillaris. The patient had a sudden onset of high fever on the 13th day after renal transplantation; on the morning of the 16th postoperative day, the patient's condition worsened and he was transferred to the ICU for treatment; on the 17th postoperative day, the patient was given mechanical ventilation; and on the 20th postoperative day, he underwent a lumbar large-pool puncture, combined with intrathecal injection of the administered medication...
May 27, 2024: Transplantation Proceedings
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