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Transplantation Proceedings

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February 22, 2019: Transplantation Proceedings
J Gameiro, S Jorge, M Neves, A Santana, J Guerra
In the face of access failure for renal replacement therapy or severe complications despite or due to dialysis, high-urgency renal transplant (HU-RT) allocation is possible. Vascular access failure patients have multiple comorbidities and a higher risk of cardiovascular and thrombotic events. Thus, it is presumed that graft and patient survivals might be worse for these patients. The aim of this paper was to analyze the characteristics and outcomes of HU-RT patients due to access failure for renal replacement therapy when comparing them to a population of deceased-donor renal transplant (DDRT) patients...
January 21, 2019: Transplantation Proceedings
P Lozano, M I Orue-Echabarria, J M Asencio, H Sharma, C J Lisbona, L Olmedilla, J M Pérez Peña, M M Salcedo, A Skaro, E Velasco, A Colon, B D Zorita, L Rodríguez, J Ferreiroa, J Á L Baena
BACKGROUND: The increase in indications for liver transplantation has led to acceptance of donors with expanded criteria. The donor risk index (DRI) was validated with the aim of being a predictive model of graft survival based on donor characteristics. Intraoperative arterial hepatic flow and indocyanine green clearance (PDR-ICG) are easily measurable variables in the intraoperative period that may be influenced by graft quality. Our aim was to analyze the influence of DRI on intraoperative liver hemodynamic alterations and on intraoperative dynamic liver function testing (PDR-ICG)...
January 14, 2019: Transplantation Proceedings
P G Muñoz, A M Santiago, C B Bellido, C C Franco, J M Á Martínez, L M M Gómez, G S Artacho, J M C Tuñón, L N Morales, F J P Ruíz, M Á G Bravo
Herein we report a case of liver dysfunction caused by consumption of vitamin A supplements leading to liver transplantation. The patient was a 48-year-old male with a medical history of congenital ichthyosiform erythroderma in treatment with vitamin A until 12 years of age, at which point he discontinued the supplements because he had developed ascites. Liver cirrhosis was diagnosed as secondary to hypervitaminosis A on the basis of histologic examination of liver biopsy and the absence of other potential causes of chronic liver disease...
January 14, 2019: Transplantation Proceedings
R Ciria, M D Ayllon-Teran, S González-Rubio, I Gome-Luque, G Ferrín, A Moreno, M Sánchez-Frías, F Alconchel, C Herrera, V Martín, J M Sánchez-Hidalgo, Á Arjona-Sánchez, Y Okuda, I Cabrera, B Benavente, M J Rodriguez, I Jurado-Martínez, J M Dueñas-Jurado, J C Robles-Arista, M Rodriguez-Perálvarez, M de La Mata García, P López-Cillero, J Briceño
BACKGROUND: Ex vivo machine perfusion (MP) has been reported as a possibly method to rescue discarded organs. The main aim of this study was to report an initial experience in Spain using MP for the rescue of severely marginal discarded liver grafts, and to, secondarily, define markers of viability to test the potential applicability of these devices for the real increase in the organ donor pool. METHODS: The study began in January 2016. Discarded grafts were included in a research protocol that consisted of standard retrieval followed by 10 hours of cold ischemia...
January 14, 2019: Transplantation Proceedings
R Hamura, K Furukawa, T Sakamoto, T Gocho, H Shiba, K Yanaga
A 54-year-old woman underwent living donor liver transplantation (LDLT) for primary biliary cholangitis (PBC) three years earlier. She took cyclosporine A (CyA) 150 mg/day as immunosuppression for prevention of rejection and PBC recurrence. Routine upper gastrointestinal endoscopy showed chronic atrophic gastritis and hyperplastic polyp, and rapid urease test was positive. Anti-Helicobacter pylori (H. pylori) serum IgG was elevated to 51 U/ml. We performed H. pylori eradication therapy with amoxicillin, clarithromycin and lansoprazole measuring the blood CyA concentration every day...
January 9, 2019: Transplantation Proceedings
S S Kulkarni, H Chen, D A Josbeno, A Schmotzer, C Hughes, A Humar, P Sood, V Rachakonda, M A Dunn, A D Tevar
INTRODUCTION: Frailty measures can predict perioperative surgical risk in liver transplant patients. The 5-meter walk test (5MWT) and hand grip strength (HGS) are easy and reproducible frailty measures. We hypothesized that they could capture frailty in liver transplant listed patients and would be associated with dropping out of the waiting list. METHODS: We conducted a retrospective analysis of patients undergoing outpatient liver transplant listing at the University of Pittsburgh Medical Center from 2013 to 2016...
January 9, 2019: Transplantation Proceedings
M Mohamed, L Kang, C Zhang, B Edenfield, J Sykes, T Brown, J L Johnson, F Rehman, J H Nguyen
Small-for-size-liver grafts (SFSG) in adult transplant recipients have elevated risk of graft failure, limiting its application in clinical liver transplantation. Relevant preclinical model of SFSG is lacking. Relevant to deceased-donor split liver transplant and living-donor liver transplant in adult recipients, in this study, we present our initial characterization of SFSG model using monosegments of a discarded human donor liver.
January 9, 2019: Transplantation Proceedings
Yanue Shi, Huang Lin, Jiankun Cao, Chao Cui
BACKGROUND: Botulinum toxin type A (BTXA) has been reported to increase survival of critically ischemic skin flaps; however, the effect of BTXA in human dermal microvascular endothelial cells (HDMECs) remains to be investigated. This study aimed to investigate the protective effect of BTXA in HDMECs exposed to an in vitro model of ischemia/reperfusion injury. METHODS: HDMECs were isolated from human upper eyelid tissue and were randomly divided into 3 groups: 1...
January 7, 2019: Transplantation Proceedings
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Transplantation Proceedings
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Transplantation Proceedings
(no author information available yet)
No abstract text is available yet for this article.
March 2019: Transplantation Proceedings
D Singh, M Hassan, N Lim
Hepatitis B virus (HBV) reactivation in patients with prior exposure to HBV and protective levels of hepatitis B surface antibody (HBsAb) is a rare phenomenon and is termed reverse seroconversion. We describe a case of reactivation of HBV infection following reverse seroconversion in a patient who underwent umbilical cord allogeneic hematopoietic cell transplantation (UHCT). The patient developed acute hepatitis with positive hepatitis B surface antigen (HBsAg) and HBV DNA in the context of prior strongly positive HBsAb...
March 2019: Transplantation Proceedings
L A C Sardinha, M V O Athayde, S L L Rodrigues, M R P D Cunha, V P Dantas Filho, H J L Zambelli, M L Lima, S Araujo, I F S F Boin
The recovery or collection of postmortem semen raises relevant ethical and social concerns. In this study we report 2 cases witnessed by the authors in an organ procurement organization in Brazil. The patients had a diagnosis of brain death, were organ donors, and had no consent for the use of postmortem sperm. In Brazil, the diagnosis of brain death has been clearly established since 1997, with the most recent update in 2017, but has not considered the possibility of the collection of sperm or eggs from the donor...
March 2019: Transplantation Proceedings
M E Currie, Y Shudo, J Mooney, Y J Woo
In this case report, we present a successful case of en bloc heart-lung transplant in a patient with advanced cardiopulmonary respiratory failure from amiodarone-associated pulmonary fibrosis that occurred post-left ventricular assist device implantation.
March 2019: Transplantation Proceedings
D Pisaniello, G Monti, A Ceriello, W Santaniello, F Calise, O Cuomo
Ventral hernias often occur in transplanted patients because of weakness of the abdominal wall, poor muscle mass, and ascitis. In this report we describe the case of a re-recurrent ventral hernia seen emergently in a liver transplant recipient, who was treated using a singular 3-layer approach by placement of an intraperitoneal mesh, stressing technical aspects of the plasty as well as the importance of a sublay technique in the reinforcement of a previous prosthetic plasty.
March 2019: Transplantation Proceedings
S Reimondez, Á Alcaraz, E Giordano Segade, N Agüero Ramaccioni, G Casarez Díaz, M A Maraschio
Situs inversus totalis is an infrequent genetic malformation affecting 0.01% of the population and consists of the total rotation of the organs 180 degrees, generating the so-called mirror-image reversal. For many years donors with this pathology were discouraged from organ donation. We present a case of hepatic and renal transplantation using the 2 techniques described, orthotopic and retroversus. The recipient was a 69-year-old man with end-stage liver and kidney disease due to alcoholism and diabetes, respectively, and a Model for End-Stage Liver Disease score of 32...
March 2019: Transplantation Proceedings
K Kimura, K Kudo, T Kurihara, S Yoshiya, Y Mano, K Takeishi, S Itoh, N Harada, T Ikegami, T Yoshizumi, T Ikeda
Cholangitis is a major complication following transplantation. We report a living donor liver transplant (LDLT) patient with cholangitis due to multiple stones in the intrahepatic bile duct during hepaticojejunostomy anastomosis, who was successfully treated with the rendezvous technique using double balloon endoscope. A 64-year-old woman underwent LDLT with right lobe graft and hepaticojejunostomy for Wilson disease. There was bile leakage with biliary peritonitis, which was treated conservatively after transplant...
March 2019: Transplantation Proceedings
M Spaggiari, H Mashbari, C Di Bella, E Benedetti, I Tzvetanov
Cadaveric split liver transplantation (SLT) is a valid option to increase the pool of cadaveric organs, obtaining 2 functioning grafts from a single donor. Typically, SLT is performed for 1 adult and 1 pediatric recipient. However, on the heels of great results achieved in living donor liver transplantation, splitting cadaveric liver into full right graft and full left graft for 2 adults has become a feasible idea. The rate of biliary complications remains the "Achilles heel" in partial graft liver transplantation, either from cadaveric or living donors...
March 2019: Transplantation Proceedings
J Park, M Lee, J Kim, H J Choi, A Kwon, H S Chung, S H Hong, C S Park, J H Choi, M S Chae
BACKGROUND: Pericardial effusion is a common feature of end-stage liver disease. In this case report we describe the intraoperative management of recurrent pericardial effusion, without re-pericardiocentesis, to prevent circulatory collapse during a critical surgical time-point; that is, during manipulation of the major vessels and graft reperfusion. METHODS: A 47-year-old woman with hepatitis B was scheduled to undergo deceased donor liver transplantation (LT)...
March 2019: Transplantation Proceedings
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