journal
https://read.qxmd.com/read/38634498/longitudinal-changes-in-resting-state-functional-connectivity-as-markers-of-vulnerability-or-resilience-in-first-degree-relatives-of-patients-with-bipolar-disorder
#41
JOURNAL ARTICLE
Julian Macoveanu, Lydia Fortea, Hanne Lie Kjærstad, Klara Coello, Maria Faurholt-Jepsen, Patrick M Fisher, Gitte Moos Knudsen, Joaquim Radua, Eduard Vieta, Sophia Frangou, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
BACKGROUND: There is a significant contribution of genetic factors to the etiology of bipolar disorder (BD). Unaffected first-degree relatives of patients (UR) with BD are at increased risk of developing mental disorders and may manifest cognitive impairments and alterations in brain functional and connective dynamics, akin to their affected relatives. METHODS: In this prospective longitudinal study, resting-state functional connectivity was used to explore stable and progressive markers of vulnerability i...
April 18, 2024: Psychological Medicine
https://read.qxmd.com/read/38634486/seasonality-in-regional-brain-glucose-metabolism
#42
JOURNAL ARTICLE
Rui Zhang, Dardo Tomasi, Ehsan Shokri-Kojori, Peter Manza, Sukru Baris Demiral, Gene-Jack Wang, Nora D Volkow
BACKGROUND: Daylength and the rates of changes in daylength have been associated with seasonal fluctuations in psychiatric symptoms and in cognition and mood in healthy adults. However, variations in human brain glucose metabolism in concordance with seasonal changes remain under explored. METHODS: In this cross-sectional study, we examined seasonal effects on brain glucose metabolism, which we measured using 18F-fluorodeoxyglucose-PET in 97 healthy participants...
April 18, 2024: Psychological Medicine
https://read.qxmd.com/read/38629200/the-selective-serotonin-reuptake-inhibitor-sertraline-alters-learning-from-aversive-reinforcements-in-patients-with-depression-evidence-from-a-randomized-controlled-trial
#43
JOURNAL ARTICLE
Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huys
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for depression and anxiety. However, little is known about how pharmacological action is related to cognitive and affective processes. Here, we examine whether specific reinforcement learning processes mediate the treatment effects of SSRIs. METHODS: The PANDA trial was a multicentre, double-blind, randomized clinical trial in UK primary care comparing the SSRI sertraline with placebo for depression and anxiety...
April 17, 2024: Psychological Medicine
https://read.qxmd.com/read/38623694/risk-factors-for-suicide-reattempt-a-systematic-review-and-meta-analysis
#44
REVIEW
Andres Pemau, Carolina Marin-Martin, Marina Diaz-Marsa, Alejandro de la Torre-Luque, Wala Ayad-Ahmed, Ana Gonzalez-Pinto, Nathalia Garrido-Torres, Lucia Garrido-Sanchez, Natalia Roberto, Purificación Lopez-Peña, Lorea Mar-Barrutia, Iria Grande, Marti Guinovart, Daniel Hernandez-Calle, Luis Jimenez-Treviño, Clara Lopez-Sola, Roberto Mediavilla, Adrian Perez-Aranda, Miguel Ruiz-Veguilla, Elisa Seijo-Zazo, Alba Toll, Matilde Elices, Victor Perez-Sola, Jose Luis Ayuso-Mateos
BACKGROUND: Suicide is one of the main external causes of death worldwide. People who have already attempted suicide are at high risk of new suicidal behavior. However, there is a lack of information on the risk factors that facilitate the appearance of reattempts. The aim of this study was to calculate the risk of suicide reattempt in the presence of suicidal history and psychosocial risk factors and to estimate the effect of each individual risk factor. METHODS: This systematic review and meta-analysis were conducted following the PRISMA-2020 guidelines...
April 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38623689/youth-adversity-and-trajectories-of-depression-anxiety-symptoms-in-adolescence-in-the-context-of-intersectionality-in-the-united-kingdom
#45
JOURNAL ARTICLE
Laura Havers, Ruichong Shuai, Peter Fonagy, Mina Fazel, Craig Morgan, Daisy Fancourt, Paul McCrone, Melanie Smuk, Kamaldeep Bhui, Sania Shakoor, Georgina M Hosang
BACKGROUND: Youth adversity is associated with persistence of depression and anxiety symptoms. This association may be greater for disadvantaged societal groups (such as females) compared with advantaged groups (e.g. males). Given that persistent symptoms are observed across a range of disadvantaged, minoritized, and neurodivergent groups (e.g. low compared with high socio-economic status [SES]), the intersection of individual characteristics may be an important moderator of inequality...
April 16, 2024: Psychological Medicine
https://read.qxmd.com/read/38205522/the-causal-association-between-maternal-depression-anxiety-and-infection-in-pregnancy-and-neurodevelopmental-disorders-among-410-461-children-a-population-study-using-quasi-negative-control-cohorts-and-sibling-analysis
#46
JOURNAL ARTICLE
Holly Hope, Matthias Pierce, Hend Gabr, Maja R Radojčić, Eleanor Swift, Vicky P Taxiarchi, Kathryn M Abel
BACKGROUND: To address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies. METHODS: Four primary care cohorts of UK children (pregnancy, 1 and 2 years prior to pregnancy, and siblings) born between 1 January 1990 and 31 December 2017 were constructed. NDD included autism/autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disability, cerebral palsy, and epilepsy...
June 2024: Psychological Medicine
https://read.qxmd.com/read/38179660/the-mental-health-of-australians-bereaved-during-the-first-two-years-of-the-covid-19-pandemic-a-latent-class-analysis
#47
JOURNAL ARTICLE
F Maccallum, L J Breen, J L Phillips, M R Agar, A Hosie, J Tieman, M DiGiacomo, T Luckett, J Philip, S Ivynian, S Chang, A Dadich, C H Grossman, I Gilmore, J Harlum, I Kinchin, N Glasgow, E A Lobb
BACKGROUND: The COVID-19 pandemic disrupted many areas of life, including culturally accepted practices at end-of-life care, funeral rites, and access to social, community, and professional support. This survey investigated the mental health outcomes of Australians bereaved during this time to determine how these factors might have impacted bereavement outcomes. METHODS: An online survey indexing pandemic and bereavement experiences, levels of grief, depression, anxiety, and health, work, and social impairment...
May 2024: Psychological Medicine
https://read.qxmd.com/read/37987188/long-term-diagnostic-stability-predictors-of-diagnostic-change-and-time-until-diagnostic-change-of-first-episode-psychosis-a-21-year-follow-up-study
#48
JOURNAL ARTICLE
David Peralta, Lucía Janda, Elena García de Jalón, Lucía Moreno-Izco, Ana M Sánchez-Torres, Manuel J Cuesta, Victor Peralta
BACKGROUND: Although diagnostic instability in first-episode psychosis (FEP) is of major concern, little is known about its determinants. This very long-term follow-up study aimed to examine the diagnostic stability of FEP diagnoses, the baseline predictors of diagnostic change and the timing of diagnostic change. METHODS: This was a longitudinal and naturalistic study of 243 subjects with FEP who were assessed at baseline and reassessed after a mean follow-up of 21 years...
May 2024: Psychological Medicine
https://read.qxmd.com/read/38619307/letter-to-the-editor-gut-feelings-associations-of-emotions-and-emotion-regulation-with-the-gut-microbiome-in-women
#49
JOURNAL ARTICLE
Hisao Toyoshima, Norio Yamamoto, Shinnosuke Komiya
No abstract text is available yet for this article.
April 15, 2024: Psychological Medicine
https://read.qxmd.com/read/38618989/midlife-diseases-of-despair-and-cardiometabolic-risk-testing-shared-origins-in-adolescent-psychopathology
#50
JOURNAL ARTICLE
Kallisse R Dent, Grace M Brennan, Lara Khalifeh, Leah S Richmond-Rakerd
BACKGROUND: Rising midlife mortality in the United States is largely attributable to 'deaths of despair' (deaths from suicide, drug poisonings, and alcohol-related diseases) and deaths from cardiometabolic conditions. Although despair- and cardiometabolic-related mortality are increasing concurrently, it is unclear whether they share common developmental origins. We tested adolescent psychopathology as a potential common origin of midlife diseases of despair and cardiometabolic risk. METHODS: Participants ( N = 4578) were from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative cohort followed from adolescence to early midlife...
April 15, 2024: Psychological Medicine
https://read.qxmd.com/read/38606591/the-relationship-between-childhood-trauma-psychotic-symptoms-and-cognitive-schemas-in-patients-with-schizophrenia-their-siblings-and-healthy-controls-results-from-the-eu-gei-study
#51
JOURNAL ARTICLE
Alp Üçok, Handan Noyan, Sinan Gülöksüz, Meram Can Saka, Köksal Alptekin, Cem Atbaşoğlu, Elçin Akturan, Gülşah Karadayı, Zeynep Baran Tatar, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Halis Ulaş, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan, Haldun Soygür, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Bart P F Rutten, Jim van Os
BACKGROUND: The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms. METHODS: Seven hundred and forty-two patients with SCZ, 718 of their unaffected siblings and 1039 controls from three EU-GEI sites were assessed for CT, symptom severity, and cognitive schemas about self/others...
April 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38606582/the-effectiveness-and-safety-of-dialectical-behavior-therapy-for-suicidal-ideation-and-behavior-in-autistic-adults-a-pragmatic-randomized-controlled-trial
#52
JOURNAL ARTICLE
Anne Huntjens, L M C Wies van den Bosch, Bram Sizoo, Ad Kerkhof, Filip Smit, Mark van der Gaag
BACKGROUNDS: Many autistic people in mental health are suicidal. This study evaluated the effectiveness of dialectical behavior therapy (DBT) v. treatment as usual (TAU) in reducing suicidal ideation and suicide attempts. METHODS: At six Dutch mental health centers, 123 outpatients (18-65 years) with DSM-5 diagnosed autism spectrum disorder (ASD) and suicidal behavior were randomly assigned to the DBT intervention group ( n = 63) or TAU control group ( n = 60). Assessments were conducted at baseline, post-treatment at 6 months and 12-month follow-up...
April 12, 2024: Psychological Medicine
https://read.qxmd.com/read/38587021/early-auditory-processing-abnormalities-alter-individual-learning-trajectories-and-sensitivity-to-computerized-cognitive-training-in-schizophrenia
#53
JOURNAL ARTICLE
Juan L Molina, Yash B Joshi, John A Nungaray, Joyce Sprock, Mouna Attarha, Bruno Biagianti, Michael L Thomas, Neal R Swerdlow, Gregory A Light
BACKGROUND: Auditory system plasticity is a promising target for neuromodulation, cognitive rehabilitation and therapeutic development in schizophrenia (SZ). Auditory-based targeted cognitive training (TCT) is a 'bottom up' intervention designed to enhance the speed and accuracy of auditory information processing, which has been shown to improve neurocognition in certain SZ patients. However, the dynamics of TCT learning as a function of training exercises and their impact on neurocognitive functioning and therapeutic outcomes are unknown...
April 8, 2024: Psychological Medicine
https://read.qxmd.com/read/38587016/investigating-change-in-network-structure-of-eating-disorder-symptoms-after-delivery-of-a-smartphone-app-based-intervention
#54
JOURNAL ARTICLE
Jake Linardon, Christopher J Greenwood, Stephanie Aarsman, Matthew Fuller-Tyszkiewicz
BACKGROUND: Eating disorder (ED) research has embraced a network perspective of psychopathology, which proposes that psychiatric disorders can be conceptualized as a complex system of interacting symptoms. However, existing intervention studies using the network perspective have failed to find that symptom reductions coincide with reductions in strength of associations among these symptoms. We propose that this may reflect failure of alignment between network theory and study design and analysis...
April 8, 2024: Psychological Medicine
https://read.qxmd.com/read/38571303/use-of-antipsychotic-medication-benzodiazepines-and-psychiatric-hospitalization-in-cannabis-related-versus-cannabis-unrelated-schizophrenia-a-nationwide-register-based-cohort-study
#55
JOURNAL ARTICLE
Carsten Hjorthøj, Anne Stürup, Mette Karlsen, Helene Speyer, Merete Osler, Dost Ongur, Merete Nordentoft
BACKGROUND: Evidence suggests that cannabis may be a causal factor for development of schizophrenia. We aimed to investigate whether use of antipsychotic medication, benzodiazepines, and psychiatric service use differs among patients with schizophrenia depending on whether psychosis was precipitated by a diagnosis of cannabis use disorder (CUD). METHODS: We utilized the nationwide Danish registries to identify all individuals with an incident diagnosis of schizophrenia from 1995 to 2016...
April 4, 2024: Psychological Medicine
https://read.qxmd.com/read/38571298/structure-function-coupling-and-hierarchy-specific-antidepressant-response-in-major-depressive-disorder
#56
JOURNAL ARTICLE
Xinyi Wang, Li Xue, Lingling Hua, Junneng Shao, Rui Yan, Zhijian Yao, Qing Lu
BACKGROUND: Extensive research has explored altered structural and functional networks in major depressive disorder (MDD). However, studies examining the relationships between structure and function yielded heterogeneous and inconclusive results. Recent work has suggested that the structure-function relationship is not uniform throughout the brain but varies across different levels of functional hierarchy. This study aims to investigate changes in structure-function couplings (SFC) and their relevance to antidepressant response in MDD from a functional hierarchical perspective...
April 4, 2024: Psychological Medicine
https://read.qxmd.com/read/38563302/assessing-regional-intracortical-myelination-in-schizophrenia-spectrum-and-bipolar-disorders-using-the-optimized-t1w-t2w-ratio
#57
JOURNAL ARTICLE
Kjetil Nordbø Jørgensen, Stener Nerland, Nora Berz Slapø, Linn B Norbom, Lynn Mørch-Johnsen, Laura Anne Wortinger, Claudia Barth, Dimitrios Andreou, Ivan I Maximov, Oliver M Geier, Ole A Andreassen, Erik G Jönsson, Ingrid Agartz
BACKGROUND: Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated the T1w/T2w-ratio and its age trajectories in patients and healthy controls (CTR) and explored associations with antipsychotic medication use and psychotic symptoms. METHODS: Patients with SCZ ( n = 64; mean age = 30...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563297/age-atypical-brain-functional-networks-in-autism-spectrum-disorder-a-normative-modeling-approach
#58
JOURNAL ARTICLE
Anhang Jiang, Xuefeng Ma, Shuang Li, Lingxiao Wang, Bo Yang, Shizhen Wang, Mei Li, Guangheng Dong
BACKGROUND: Despite extensive research into the neural basis of autism spectrum disorder (ASD), the presence of substantial biological and clinical heterogeneity among diagnosed individuals remains a major barrier. Commonly used case‒control designs assume homogeneity among subjects, which limits their ability to identify biological heterogeneity, while normative modeling pinpoints deviations from typical functional network development at individual level. METHODS: Using a world-wide multi-site database known as Autism Brain Imaging Data Exchange, we analyzed individuals with ASD and typically developed (TD) controls (total n = 1218) aged 5-40 years, generating individualized whole-brain network functional connectivity (FC) maps of age-related atypicality in ASD...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563288/the-mediating-role-of-reflective-functioning-and-general-psychopathology-in-the-relationship-between-childhood-conduct-disorder-and-adult-aggression-among-offenders
#59
JOURNAL ARTICLE
Karen Yirmiya, Matthew Constantinou, Elizabeth Simes, Anthony Bateman, James Wason, Jessica Yakeley, Mary McMurran, Mike Crawford, Alison Frater, Paul Moran, Barbara Barrett, Angus Cameron, Zoe Hoare, Elizabeth Allison, Stephen Pilling, Stephen Butler, Peter Fonagy
BACKGROUND: The nature of the pathway from conduct disorder (CD) in adolescence to antisocial behavior in adulthood has been debated and the role of certain mediators remains unclear. One perspective is that CD forms part of a general psychopathology dimension, playing a central role in the developmental trajectory. Impairment in reflective functioning (RF), i.e., the capacity to understand one's own and others' mental states, may relate to CD, psychopathology, and aggression. Here, we characterized the structure of psychopathology in adult male-offenders and its role, along with RF, in mediating the relationship between CD in their adolescence and current aggression...
April 2, 2024: Psychological Medicine
https://read.qxmd.com/read/38563286/clinical-illness-course-and-family-related-outcomes-among-parents-with-a-first-episode-of-schizophrenia-spectrum-disorder-a-20-year-follow-up-of-the-opus-trial
#60
JOURNAL ARTICLE
Helene Gjervig Hansen, Ida Christine Tholstrup Gjøde, Marie Starzer, Anne Ranning, Carsten Hjorthøj, Nikolai Albert, Merete Nordentoft, Anne Amalie Elgaard Thorup
BACKGROUND: Studies investigating parenthood and how it affects long-term outcomes are lacking among individuals with schizophrenia spectrum disorders. This study aimed to examine the life of participants 20 years after their first diagnosis with a special focus on parenthood, clinical illness course, and family-related outcomes. METHODS: Among 578 individuals diagnosed with first-episode schizophrenia spectrum disorder between 1998 and 2000, a sample of 174 participants was reassessed at the 20-year follow-up...
April 2, 2024: Psychological Medicine
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