Patawut Bovonratwet, Scott Kulm, David A Kolin, Junho Song, Kyle W Morse, Matthew E Cunningham, Todd J Albert, Harvinder S Sandhu, Han Jo Kim, Sravisht Iyer, Olivier Elemento, Sheeraz A Qureshi
BACKGROUND: Identifying genetic risk factors for spinal disorders may lead to knowledge regarding underlying molecular mechanisms and the development of new treatments. METHODS: Cases of lumbar spondylolisthesis, spinal stenosis, degenerative disc disease, and pseudarthrosis after spinal fusion were identified from the UK Biobank. Controls were patients without the diagnosis. Whole-genome regressions were used to test for genetic variants potentially implicated in the occurrence of each phenotype...
March 16, 2023: Journal of Bone and Joint Surgery. American Volume