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International Journal of Colorectal Disease
Kenta Iguchi, Jun Watanabe, Yusuke Suwa, Keigo Chida, Yosuke Atsumi, Masakatsu Numata, Tsutomu Sato, Kazuhisa Takeda, Chikara Kunisaki
PURPOSE: The purpose of this study is to evaluate the effect of preoperative endoscopic tattooing using India ink (ETI) on the number of retrieved lymph nodes (LNs) dissected during laparoscopic surgery for stage I right-sided colon cancer (RCC). METHODS: This single-center, retrospective study included stage I RCC patients who underwent laparoscopic surgery between January 2010 and December 2021. The clinicopathological background and number of LNs retrieved were compared between patients managed with and without ETI...
March 23, 2023: International Journal of Colorectal Disease
Ufuk Uylas, Ramazan Gundogdu, Fatih Sumer, Emine Samdanci, Cuneyt Kayaalp
BACKGROUND: Since cancer development is inevitable in patients with familial adenomatous polyposis (FAP), we aimed to determine the incidence of incidental malignancy in prophylactic colectomy specimens. METHODS: The files of patients who underwent prophylactic surgery for FAP between 2010 and 2020 were retrospectively reviewed. The incidence of incidental malignancy in histopathological specimens was examined and a comprehensive literature review was made. RESULTS: Fifty-five patients were included in the study, of whom 30 patients had a diagnosis of primary malignancy...
March 23, 2023: International Journal of Colorectal Disease
Mitsuru Yokota, Akitaka Morikawa, Hiroya Matsuoka, Jun Muto, Kazuki Hashida, Yoshio Nagahisa, Toshihiko Masui, Michio Okabe, Hirohisa Kitagawa, Kazuyuki Kawamoto
PURPOSE: To determine whether frequent measurement of tumor markers triggers early detection of colorectal cancer recurrence. METHODS: Of 1,651 consecutive patients undergoing colorectal cancer surgery between 2010 and 2016, 1,050 were included. CEA and CA 19-9 were considered to be postoperative tumor markers and were measured every 3 months for 3 years, and then every 6 months for 2 years. Sensitivity analysis of elevated CEA and CA19-9 levels and multivariate analysis of factors associated with elevated CEA and CA19-9 levels were performed...
March 22, 2023: International Journal of Colorectal Disease
Evi Zhuleku, Beatriz Antolin-Fontes, Andras Borsi, Riikka Nissinen, Ivana Bravatà, Jennifer Norma Barthelmes, Jennifer Lee, Alun Passey, Daniel Wirth, Ulf Maywald, Bernd Bokemeyer, Thomas Wilke, Marco Ghiani
PURPOSE: The aim of this study was to investigate the burden of disease among a real-world cohort of patients with prevalent Crohn's disease (CD) in Germany. METHODS: We conducted a retrospective cohort analysis using administrative claims data from the German AOK PLUS health insurance fund. Continuously insured patients with a CD diagnosis between 01 October 2014 and 31 December 2018 were selected and followed for at least 12 months or longer until death or end of data availability on 31 December 2019...
March 20, 2023: International Journal of Colorectal Disease
Cheng-Wei Fan, Po-Huang Chen, Hong-Jie Jhou, Yi-Chiao Cheng
PURPOSE: Recent evidence-based publications disclosed that negative pressure wound therapy (NPWT) may reduce the incidence rate of surgical site infection (SSI) and length of stay (LOS) compared with conventional drainage in patient status post abdominoperineal resection (APR) and extralevator abdominoperineal excision (ELAPE). METHODS: Data sources: Eligible randomized controlled trials and retrospective and prospective studies published before January 2023 were retrieved from databases (Cochrane Library, PubMed, and Embase)...
March 18, 2023: International Journal of Colorectal Disease
Zhenfei Wu, Lingling Zhao, Shaoguang Feng, Jinjian Luo
PURPOSE: The aim of this study was to investigate the predictive value of hyperfibrinogenemia and hyponatremia for perforated appendicitis in children. METHODS: A retrospective review of 521 pediatric patients (≤ 15 years) with acute appendicitis confirmed by histopathology from January 2017 to December 2020 was performed. Patients were divided in two groups, those with non-perforated (n = 379; 73%) and perforated appendicitis (n = 142; 27%)...
March 17, 2023: International Journal of Colorectal Disease
Matthew G Davey, Maeve O'Neill, Mark Regan, Babak Meshkat, Emmeline Nugent, Myles Joyce, Aisling M Hogan
INTRODUCTION: The 12-gene recurrence score (RS) is a clinically validated assay which predicts recurrence risk in patients with stage II/III colon cancer. Decisions regarding adjuvant chemotherapy may be guided using this assay or based on the judgement of tumour board. AIMS: To assess the concordance between the RS and MDT decisions regarding adjuvant chemotherapy in colon cancer. METHODS: A systematic review was performed in accordance with PRISMA guidelines...
March 13, 2023: International Journal of Colorectal Disease
Yajie Wang, Quan Rao, Yiming Ma, Xiaofei Li
OBJECTIVE: To analyse the safety and effectiveness of platelet-rich plasma (PRP) in anal fistula patients. METHODS: Online databases including PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to December 5, 2022, for eligible studies about evaluating the efficacy of platelet-rich plasma (PRP) in treating anal fistula. Literature search, screening, data extraction, and quality assessment were carried out by two independent investigators...
March 11, 2023: International Journal of Colorectal Disease
Ming Sun, Guangzhao Yang, Yu Wang
PURPOSE: Colonoscopy is the gold standard for the diagnosis of colorectal cancer (CRC). Before a colonoscopy, an adequate bowel preparation (BP) is required. Currently, more novel regimens with different effects have been proposed and used successively. This network meta-analysis aims to compare the cleaning effects and patients' tolerability of several BP regimens. METHODS: We performed a network meta-analysis of randomized controlled trials including sixteen kinds of BP regimens...
March 11, 2023: International Journal of Colorectal Disease
Mengyao Yi, Yong Wu, Meng Li, Tianyu Zhang, Ying Chen
PURPOSE: Patients undergoing laparoscopic colorectal cancer resection have a high incidence of postoperative gastrointestinal dysfunction (POGD). Remote ischemic preconditioning (RIPC) is an organ protection measure. The study investigated the effect of RIPC on postoperative gastrointestinal function. METHODS: In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 100 patients undergoing elective laparoscopic colorectal cancer resection were randomly assigned in a 1:1 ratio to receive RIPC or sham RIPC (control)...
March 11, 2023: International Journal of Colorectal Disease
Erene Flores-Rodríguez, Lucia Garrido-López, Raquel Sánchez-Santos, Oscar Cano-Valderrama, Laura Rodríguez-Fernández, Manuel Nogueira-Sixto, Marta Paniagua-García Señorans, Vincenzo Vigorita, Enrique Moncada-Iribarren
INTRODUCTION AND OBJECTIVES: Indocyanine green (ICG) was introduced as a promising diagnostic tool to provide real-time assessment of intestinal vascularization. Nevertheless, it remains unclear whether ICG could reduce the rate of postoperative AL. The objective of this study is to assess its usefulness and to determine in which patients is most useful and would benefit the most from the use of ICG for intraoperative assessment of colon perfusion. METHODS: A retrospective cohort study was conducted in a single center, including all patients who underwent colorectal surgery with intestinal anastomosis between January 2017 and December 2020...
March 10, 2023: International Journal of Colorectal Disease
Simon Lundström, Erik Agger, Marie-Louise Lydrup, Fredrik Jörgren, Pamela Buchwald
PURPOSE: This study aimed to investigate the prognostic effect of tumor deposits (TDs) in lymph node negative rectal cancer. METHODS: Patients who had undergone surgery for rectal cancer with curative intention between 2011 and 2014 were extracted from the Swedish Colorectal Cancer Registry. Patients with positive lymph nodes, undisclosed TD status, stage IV disease, non-radical resections, or any outcome (local recurrence (LR), distant metastasis (DM) or mortality) within 90 days after surgery were excluded...
March 10, 2023: International Journal of Colorectal Disease
Liyanran Yan, Xueli Zhang, Yan Li, Chengjiang Liu, Hua Yang, Chunchun Yang
PURPOSE: To systematically reevaluate the role of psychological factors in functional gastrointestinal disorders (FGIDs) and thus provide a scientific basis for the psychological treatment of FGIDs. METHODS: A literature search was conducted using the PubMed, Embase, Web of Science, and Cochrane Library databases from January 2018 to August 2022 for researches on psychological factors affecting patients with functional gastrointestinal disorders. Meta-analysis was carried out with Stata17...
March 9, 2023: International Journal of Colorectal Disease
Miren Orive, Irantzu Barrio, Santiago Lázaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Sarai Cortajarena, Amaia Bilbao, Urko Aguirre, Cristina Sarasqueta, José M Quintana
PURPOSE: To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient's health-related quality of life (HRQoL) status. METHODS: Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires...
March 9, 2023: International Journal of Colorectal Disease
Yan Wang, Longsong Li, Xiaotong Niu, Fei Gao, Ningli Chai, Enqiang Linghu
BACKGROUND: Melanosis coli is characterized by brown mucosa with pigmentation. Studies have showed an increased adenoma detection rate in melanosis patients, whether it is caused by a contrast effect or an oncogenic effect is still controversial. The detection of serrated polys in melanosis patients remains unknown. AIMS: The study aimed to clarify the correlation of adenoma detection rate with melanosis coli and discuss outcomes in less-experienced endoscopists...
March 8, 2023: International Journal of Colorectal Disease
Siyu Zhou, Ying Cui, Yun Zhang, Tianyu Zhao, Jing Cong
PURPOSE: Fecal microbiota transplantation (FMT) has been found to be a potential treatment for Crohn's disease (CD). We sought to perform a systematic review and meta-analysis to evaluate the efficacy and safety of FMT in CD. METHODS: Electronic databases were searched for studies until January 2023. Clinical remission was established as the primary outcome. The secondary outcome was clinical response, endoscopic remission, minor adverse events, serious adverse events, and changes in disease activity indices, biochemical indicators, and microbial diversities...
March 8, 2023: International Journal of Colorectal Disease
Jingjuan Huang, Sihua Ye, Shaolan Feng, Minqi Zheng, Meihua Zhong
OBJECTIVE: To systematically evaluate the prevalence of hand-foot syndrome (HFS) in patients with colorectal cancer undergoing chemotherapy. METHODS: The PubMed, Embase, and Cochrane Library databases were searched, from their inception to September 20, 2022, to identify studies on the prevalence of HFS in patients with colorectal cancer receiving chemotherapy. Comprehensive retrieval of literature was performed using the literature tracing method. We calculated the prevalence of HFS in patients with colorectal cancer undergoing chemotherapy based on meta-analyses...
March 6, 2023: International Journal of Colorectal Disease
Katharina Esswein, Marco Volpi, Marijana Ninkovic, Veronika Kröpfl, Elisabeth Gasser, Andreas Lorenz, Lea Stecher, Reinhold Kafka-Ritsch, Stefan Schneeberger, Dietmar Öfner, Alexander Perathoner
PURPOSE: Patients with colon cancer are usually included in an intensive 5-year surveillance protocol after curative resection, independent of the tumor stage, though early stages have a considerably lower risk of recurrence. The aim of this study was to analyze the adherence to an intensive follow-up and the risk of recurrence in patients with colon cancer in UICC stages I and II. METHODS: In this retrospective study, we assessed patients who underwent resection for colon cancer in UICC stages I and II between 2007 and 2016...
March 4, 2023: International Journal of Colorectal Disease
Alicia Brenig, Ilse Broekaert, Patrick Gerner, Carsten Posovszky, Christoph Hünseler, Alexander Joachim
PURPOSE: To assess the current attitude and the status quo towards the use of microbiome analysis and fecal microbiota transfer (FMT) in pediatric patients in German-speaking pediatric gastroenterology centers. METHODS: A structured online survey among all certified facilities of the German-speaking society of pediatric gastroenterology and nutrition (GPGE) was conducted from November 01, 2020, until March 30, 2021. RESULTS: A total of 71 centers were included in the analysis...
March 3, 2023: International Journal of Colorectal Disease
Shintaro Kanaka, Akihisa Matsuda, Takeshi Yamada, Yuji Miyamoto, Yasuyuki Yokoyama, Satoshi Matsumoto, Hiromichi Sonoda, Ryo Ohta, Seiichi Shinji, Kumiko Sekiguchi, Hideo Baba, Hiroshi Yoshida
PURPOSE: Extended colectomy is sometimes chosen for treatment of transverse colon cancer (TCC) because of concerns about short- and long-term outcomes. However, there is still a lack of evidence regarding the optimal surgical procedure. METHODS: We retrospectively collected and analyzed data of patients who underwent surgical treatment of pathological stage II/III TCC at four hospitals from January 2011 to June 2019. We excluded the patients with TCC located at distal transverse colon, and just evaluated and analyzed proximal and middle third TCC...
March 3, 2023: International Journal of Colorectal Disease
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