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International Journal of Colorectal Disease

A Picciariello, V Papagni, G Martines, M De Fazio, R Digennaro, D F Altomare
AIM: To evaluate the reason for failure of STARR (stapled transanal rectal resection) operation for obstructed defecation. METHODS: A retrospective study (June 2012-December 2017) was performed using a prospectively maintained database of patients who underwent STARR operation for ODS (obstructed defecation syndrome), complaining of persisting or de novo occurrence of pelvic floor dysfunctions. Postoperative St Mark's and ODS scores were evaluated. A VAS was used to score pelvic pain...
February 19, 2019: International Journal of Colorectal Disease
Andrew Emmanuel, Anil Ghosh, Christo Lapa, Shraddha Gulati, Margaret Burt, Bu'Hussain Hayee, Amyn Haji
PURPOSE: Almost any colorectal superficial neoplastic lesion can be treated by endoscopic resection (ER) but very little is known about outcomes of ER leaving circumferential or near-circumferential mucosal defects. We report the outcomes of ER leaving ≥ 75% circumferential mucosal defects performed in a western expert centre. METHODS: Five hundred eighty-seven ERs of large colorectal lesions ≥ 20 mm were grouped according to the extent of the mucosal defect and comparisons made between those with < 75% and ≥ 75% defects...
February 19, 2019: International Journal of Colorectal Disease
Teresa Draeger, Vinzenz Völkel, Valentin Schnitzbauer, Michael Gerken, Stefan Benz, Monika Klinkhammer-Schalke, Alois Fürst
INTRODUCTION: Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach. MATERIALS AND METHODS: This study compared outcomes of laparoscopic and open surgery in rectal cancer patients. Perioperative mortality and 5-year overall, relative, and recurrence-free survival rates were analyzed separately for three age groups...
February 18, 2019: International Journal of Colorectal Disease
S J Rottier, J de Jonge, L C Dreuning, J van Pelt, A A W van Geloven, X D Y Beele, P M Huisman, W Y Deurholt, C A Rottier, M A Boermeester, W H Schreurs
PURPOSE: The underling pathophysiological mechanisms that cause the formation of colonic diverticula (diverticulosis) remain unclear. Connective tissue changes due to ageing that cause changes in collagen structure of the colonic wall is one theory. Alpha-1-antitrypsin (A1AT) is a protease inhibitor known to protect connective tissue in other organs. Associations between (carriers of) A1AT deficiency and the development of colonic diverticula will be the main focus of this study. METHODS: A multicentre prospective case-controlled study...
February 15, 2019: International Journal of Colorectal Disease
Imran Mohamed, Sigmund Chan, Aneel Bhangu, Sharad Karandikar
The above article originally published with an error present in Table 1 and is now presented correctly in this article.
February 15, 2019: International Journal of Colorectal Disease
Hytham K S Hamid, Ahmed O Hamedelneel
No abstract text is available yet for this article.
February 14, 2019: International Journal of Colorectal Disease
Simon Näverlo, Karin Strigård, Ulf Gunnarsson
PURPOSE: To see if road distance to hospital influences stoma reversal rate, time from index operation to stoma reversal, and occurrence of permanent stoma. METHODS: Data from all diagnosed cases of rectal cancer from three counties in northern Sweden were extracted from the Swedish Rectal Cancer Registry. The three counties are sparsely populated, with a population density roughly one fifth the average density in Sweden. Distances to nearest, operating, and largest hospital were obtained using Google Maps™...
February 12, 2019: International Journal of Colorectal Disease
Sohyun Kim, Sang Hun Jung, Jae Hwang Kim
PURPOSE: Patients with rectal anastomosis commonly experience various ileostomy-related complications. This study aimed to elucidate the usefulness of a fecal diversion device (FDD) as an alternative to ileostomy for protecting rectal anastomosis. METHODS: Patients with rectal anastomosis were randomly assigned to the ileostomy and FDD groups except in cases of emergency surgery. The primary endpoint was the clinical safety and effectiveness of FDD. The mean operation time, delay of diet advancement, length of hospital stay, FDD and stoma durations, and anastomotic leakage (AL) management methods were compared...
February 11, 2019: International Journal of Colorectal Disease
R L Goetgebuer, C J van der Woude, L de Ridder, M Doukas, A C de Vries
BACKGROUND AND AIM: Epstein-Barr virus (EBV) is a proposed trigger in the etiopathogenesis of inflammatory bowel disease (IBD) and is associated with lymphoproliferative diseases. Nevertheless, testing for EBV DNA in the intestinal mucosa and screening for EBV infection before initiation of a drug therapy are not routinely performed. The aim of this article is to increase awareness of the relevance of EBV infection in specific clinical situations. METHODS: In this short communication, we describe the disease course of three IBD patients with EBV infection, varying from EBV reactivation during disease flare up to a trigger of EBV-related mucocutaneous ulcer (EBV-MCU) and haemophagocytic lymphohistiocytosis (HLH)...
February 9, 2019: International Journal of Colorectal Disease
Hiroaki Miyake, Koji Murono, Hiroshi Nagata, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Yasutaka Shuno, Kazuhito Sasaki, Soichiro Ishihara
PURPOSE: The doubling times of tumor volume and tumor markers are associated with the prognosis of liver or lung metastases from colorectal cancer (CRC). However, no studies have assessed peritoneal metastases. Therefore, we aimed to elucidate the association between doubling time and the prognosis of patients who underwent radical surgery for metachronous peritoneal metastases of CRC. METHODS: We calculated the tumor doubling times (TDT) of peritoneal metastases and serum carcinoembryonic antigen-doubling times (CEA-DT) in 33 consecutive patients who underwent radical surgery for metachronous peritoneal metastases between January 2006 and April 2017...
February 9, 2019: International Journal of Colorectal Disease
Rao K Mehmood, Jody Parker, L Bhuvimanian, Eyas Qasem, Ahmed A Mohammed, Muhammad Zeeshan, Kirsten Grugel, Paul Carter, Shakil Ahmed
The authors wish to clarify a number of points that were incorrectly stated in the original article. These changes do not invalidate the article.
February 9, 2019: International Journal of Colorectal Disease
Roberto Peltrini, Paola Antonella Greco, Luigi Bucci
No abstract text is available yet for this article.
February 9, 2019: International Journal of Colorectal Disease
Juliane Kupsch, Matthias Kuhn, Klaus E Matzel, Joerg Zimmer, Olga Radulova-Mauersberger, Anja Sims, Helmut Witzigmann, Sigmar Stelzner
PURPOSE: Treatment of rectal cancer often results in disturbed anorectal function, which can be quantified by the Low Anterior Resection Syndrome (LARS) score. This study investigates the association of impaired anorectal function as measured with the LARS score with quality of life (QoL) as measured with the EORTC-QLQ-C30 and CR38 questionnaires. METHODS: All stoma-free patients who had undergone sphincter-preserving surgery for rectal cancer from 2000 to 2014 in our institution were retrieved from a prospective database...
February 5, 2019: International Journal of Colorectal Disease
Piercarlo Meinero, Marco La Torre, Giorgio Lisi, Alessandro Stazi, Antonella Carbone, Luca Regusci, Fabrizio Fasolini
BACKGROUND: Pilonidal disease (PD) is a common disease of the natal cleft, which can lead to complications including infection and abscess formation. Various operative management options are available, but the ideal technique is still debatable. Recurrent PD after surgical treatment is frequent event for the 25-30% of cases. The present study evaluated endoscopic pilonidal sinus treatment (EPSiT) in recurrent and multi-recurrent PD. METHODS: Of the consecutive prospective patients with recurrent PD, 122 were enrolled in a prospective international multicenter study conducted at a secondary and tertiary colorectal surgery centers...
February 4, 2019: International Journal of Colorectal Disease
Boris Jansen-Winkeln, N Holfert, H Köhler, Y Moulla, J P Takoh, S M Rabe, M Mehdorn, M Barberio, C Chalopin, T Neumuth, I Gockel
PURPOSE: This study evaluated the use of hyperspectral imaging for the determination of the resection margin during colorectal resections instead of clinical macroscopic assessment. METHODS: The used hyperspectral camera is able to record light spectra from 500 to 1000 nm and provides information about physiologic parameters of the recorded tissue area intraoperatively (e.g., tissue oxygenation and perfusion). We performed an open-label, single-arm, and non-randomized intervention clinical trial to compare clinical assessment and hyperspectral measurement to define the resection margin in 24 patients before and after separation of the marginal artery over 15 min; HSI was performed each minute to assess the parameters mentioned above...
February 2, 2019: International Journal of Colorectal Disease
Charlotte Andrianjafy, Laure Luciano, Camille Bazin, Karine Baumstarck, Michel Bouvier, Véronique Vitton
BACKGROUND: The aim of the study was to describe the results of 3D high-resolution anorectal manometry (3DHRAM) in a large cohort of patients with functional anorectal disorders. METHODS: In this single-center retrospective study, all consecutive patients referred for investigation of fecal incontinence (FI) or dyssynergic defecation (DD) underwent 3DHRAM. The parameters analyzed were usual manometric data, repartition of dyssynergic patterns, and the prevalence of a new "muscular subtype classification" underlying dyssynergia, anal sphincter defects, and pelvic floor disorders...
January 31, 2019: International Journal of Colorectal Disease
Tarek H Hassab, James M Church
PURPOSE: Data on the management of appendix orifice lesions are limited. We present our experience on the management of appendix orifice lesions focusing on the range of size, histology, treatment, and outcomes for polyps at the appendix orifice. METHODS: Retrospective descriptive study at a tertiary referral center. PATIENTS: Those having appendix orifice lesion removed and sent for histology between 2000 and 2017. INTERVENTIONS(S): Polypectomy, surgery...
January 30, 2019: International Journal of Colorectal Disease
Motoi Uchino, Hiroki Ikeuchi, Toshihiro Bando, Teruhiro Chohno, Hirofumi Sasaki, Yuki Horio, Ryuichi Kuwahara, Tomohiro Minagawa, Yoshiko Goto, Kaoru Ichiki, Kazuhiko Nakajima, Yoshiko Takahashi, Takashi Ueda, Yoshio Takesue
PURPOSE: It is unclear whether immunomodulators or biologics, with the exception of corticosteroids, can be risk factors for postoperative infectious complications of ulcerative colitis (UC). Moreover, many immunosuppressive therapies including some biologics are used mainly to treat UC, and many patients are on multi-agent immunosuppressive therapy at the time of surgery. Therefore, we evaluated the influence of pre-operative multiple immunosuppressive agents on the occurrence of surgical site infection (SSI) in UC during the era of biologics...
January 26, 2019: International Journal of Colorectal Disease
Maria Widmar, Jordan A Munger, Alex Mui, Stephen R Gorfine, David B Chessin, Daniel A Popowich, Joel J Bauer
BACKGROUND: The safety of undiverted restorative proctocolectomy (RPC) is debated. This study compares long-term outcomes after pouch leak in diverted and undiverted RPC patients. METHODS: Data were obtained from a prospectively maintained registry from a single surgical practice. One-stage and staged procedures with an undiverted pouch were considered undiverted pouches; all others were considered diverted pouches. The outcomes measured were pouch excision and long-term diversion defined as the need for loop ileostomy at 200 weeks after pouch creation...
January 25, 2019: International Journal of Colorectal Disease
Guangwei Sun, Yalun Li, Yangjie Peng, Dapeng Lu, Fuqiang Zhang, Xueyang Cui, Qingyue Zhang, Zhuang Li
PURPOSE: We aimed to explore whether the preoperative prognostic nutritional index (PNI) could be an indicator of prognostic outcomes in colorectal cancer (CRC) patients. METHODS: A systematic review and meta-analysis was conducted using the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to a high PNI versus a low PNI in CRC patients were included. RESULTS: A total of 10 studies involving 6372 patients were included in our meta-analysis...
January 24, 2019: International Journal of Colorectal Disease
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