Journals American Journal of Gastroente...

American Journal of Gastroenterology
Branden Tarlow, John Gubatan, Muhammad Ali Khan, George Cholankeril
No abstract text is available yet for this article.
September 11, 2020: American Journal of Gastroenterology
Millie D Long
Risks of nonmelanoma skin cancer in patients with inflammatory bowel disease (IBD) have been well described. Newer data have classified risks of subsequent squamous cell carcinoma or basal cell carcinoma in patients with IBD after an initial skin cancer excision. In this editorial, risks of continuing medical therapy for IBD after a skin cancer diagnosis are discussed in the context of a holistic preventive care approach for patients with IBD.
September 11, 2020: American Journal of Gastroenterology
Qing He, Guo Zhang, Ye Gu, Jitao Wang, Qiyuan Tang, Zicheng Jiang, Chuxiao Shao, Hongguang Zhang, Zhenhuai Chen, Baoyi Ma, Dengxiang Liu, Guanghang Xie, Dan Xu, Yifei Huang, Haijun Zhang, Mingkai Liang, Huihong Huang, Yan Wang, Hongyan Liu, Jie Yang, Hongqiu Pan, Shengqiang Zou, Fujian Li, Fang Wang, Chuan Liu, Wenjuan Wang, Bin Xiong, Xun Li, Lei Liu, Jianrong Yang, Xiaolong Qi
No abstract text is available yet for this article.
September 11, 2020: American Journal of Gastroenterology
James K Ruffle, Linda Tinkler, Christopher Emmett, Alexander C Ford, Parashkev Nachev, Qasim Aziz, Adam D Farmer, Yan Yiannakou
INTRODUCTION: Chronic constipation is classified into 2 main syndromes, irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC), on the assumption that they differ along multiple clinical characteristics and are plausibly of distinct pathophysiology. Our aim was to test this assumption by applying machine learning to a large prospective cohort of comprehensively phenotyped patients with constipation. METHODS: Demographics, validated symptom and quality of life questionnaires, clinical examination findings, stool transit, and diagnosis were collected in 768 patients with chronic constipation from a tertiary center...
August 31, 2020: American Journal of Gastroenterology
John B Whitfield, Steven Masson, Suthat Liangpunsakul, Sebastian Mueller, Guruprasad P Aithal, Florian Eyer, Dermot Gleeson, Andrew Thompson, Felix Stickel, Michael Soyka, Ann K Daly, Heather J Cordell, Tatiana Foroud, Lawrence Lumeng, Munir Pirmohamed, Bertrand Nalpas, Jean-Marc Jacquet, Romain Moirand, Pierre Nahon, Sylvie Naveau, Pascal Perney, Paul S Haber, Helmut K Seitz, Christopher P Day, Philippe Mathurin, Timothy R Morgan, Devanshi Seth
INTRODUCTION: Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk. METHODS: We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73...
August 31, 2020: American Journal of Gastroenterology
Junjie Xu, Xiao Liang, Xiujun Cai
No abstract text is available yet for this article.
August 28, 2020: American Journal of Gastroenterology
Jason R Baker, Baha Moshiree, Satish Rao, Leila Neshatian, Linda Nguyen, William D Chey, Richard Saad, Jose M Garza, Shamaila Waseem, Abraham R Khan, John E Pandolfino, C Prakash Gyawali
The American Neurogastroenterology and Motility Society Task Force recommends that gastrointestinal motility procedures should be performed in motility laboratories adhering to the strict recommendations and personal protective equipment (PPE) measures to protect patients, ancillary staff, and motility allied health professionals. When available and within constraints of institutional guidelines, it is preferable for patients scheduled for motility procedures to complete a coronavirus disease 2019 (COVID-19) test within 48 hours before their procedure, similar to the recommendations before endoscopy made by gastroenterology societies...
August 28, 2020: American Journal of Gastroenterology
Clementine Levy, Guillaume Lassailly, Erika Parmentier, Thibault Duburcq, Philippe Mathurin, Julien Poissy
INTRODUCTION: We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. METHODS: This is a retrospective cohort of critical patients in a teaching hospital: 12 treated with lopinavir/ritonavir and 30 in the standard-of-care group. RESULTS: Elevation occurred more frequently in patients treated with lopinavir/ritonavir (33% vs 6.7%). DISCUSSION: Caution is advised regarding the use of lopinavir/ritonavir in the most severe cases of Severe Acute Respiratory Syndrome Coronavirus...
August 27, 2020: American Journal of Gastroenterology
Zhujun Cao, Yuhan Liu, Minghao Cai, Yumin Xu, Xiaogang Xiang, Gangde Zhao, Wei Cai, Hui Wang, Weijing Wang, Qing Xie
INTRODUCTION: Acute-on-chronic liver failure (ACLF) is defined by the European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) consortium and the North American Consortium for the Study of End-Stage Liver Disease (NACSELD) as an acute deterioration of cirrhosis with multiple organ failures and high short-term mortality. However, their diagnostic criteria differ. We aimed to compare these 2 criteria in the prediction of prognosis in hospitalized cirrhosis. METHODS: This was a prospective study of nonelectively hospitalized patients with cirrhosis (N = 468) from a single tertiary hospital between 2016 and 2018...
August 27, 2020: American Journal of Gastroenterology
Michael Hoffmeister, Hendrik Bläker, Lina Jansen, Elizabeth Alwers, Efrat L Amitay, Prudence R Carr, Matthias Kloor, Esther Herpel, Wilfried Roth, Jenny Chang-Claude, Hermann Brenner
INTRODUCTION: In previous studies, the protective effect of colonoscopy was generally stronger for distal colorectal cancer than for proximal colorectal cancer (CRC). This study aimed to investigate whether reduction of CRC risk through colonoscopy varies according to major tumor markers and pathways of CRC. METHODS: This is a population-based case-control study from Germany, including 2,132 patients with a first diagnosis of CRC and information on major molecular tumor markers and 2,486 control participants without CRC...
August 27, 2020: American Journal of Gastroenterology
Yang Liu, Ling Sun, Jianhong Zhang, Chuanfei Li, Xin Yang
No abstract text is available yet for this article.
August 26, 2020: American Journal of Gastroenterology
Jeffrey F Mather, Richard L Seip, Raymond G McKay
INTRODUCTION: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. METHODS: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020. RESULTS: Of 878 patients in the analysis, 83 (9.5%) received famotidine. In comparison to patients not treated with famotidine, patients treated with famotidine were younger (63...
August 26, 2020: American Journal of Gastroenterology
Alexandre Nuzzo, Francisca Joly, Maxime Ronot, Yves Castier, Audrey Huguet, Catherine Paugam-Burtz, Dominique Cazals-Hatem, Alexy Tran-Dinh, Aymeric Becq, Yves Panis, Yoram Bouhnik, Leon Maggiori, Olivier Corcos
INTRODUCTION: To investigate the factors associated with a delayed diagnosis (DD) of acute mesenteric ischemia (AMI). METHODS: An observational cohort study from an intestinal failure center. The primary outcome was DD >24 hours. RESULTS: Between 2006 and 2015, 74 patients with AMI were included and 39 (53%) had a DD. Plasma lactate <2 mmol/L (odd ratio: 3.2; 95% confidence interval: 1.1-9.1; P = 0.03) and unenhanced computed tomography scan (odds ratio: 5...
August 26, 2020: American Journal of Gastroenterology
Isabel Garrido, Maria João Cardoso, João Tiago Guimarães, Guilherme Macedo
No abstract text is available yet for this article.
August 26, 2020: American Journal of Gastroenterology
Liangtao Ye, Changhua Zhang, Max Seidensticker, Julia Mayerle, Florian P Reiter, Enrico N De Toni
No abstract text is available yet for this article.
August 26, 2020: American Journal of Gastroenterology
Gionata Fiorino, Daniela Gilardi, Simona Radice, Federica Furfaro, Mariangela Allocca, Silvio Danese
INTRODUCTION: The risk of coronavirus disease-19 infection for healthcare professionals and patients in hospitals remains unclear. METHODS: We investigated whether precautions adopted in our inflammatory bowel disease (IBD) unit have minimized the risks of infection for all patients accessing our facilities in a 1-month period by assessing the rate of coronavirus disease-19 infection in the follow-up period. RESULTS: Three hundred-twenty patients with IBD were included...
August 26, 2020: American Journal of Gastroenterology
Sara Santos, Guilherme Simões, Joana Lemos, Joana Saiote, Rafaela Loureiro, Isabel Seves
INTRODUCTION: We aim to discuss the utility of self-expandable esophageal metal stent (SEMS) in variceal bleeding in challenging cases. METHODS: Case description, discussion on patient management and decision-making process in an uncommon situation, from a multidisciplinary point of view. RESULTS: We report a case of a cirrhotic patient with refractory variceal bleeding who underwent a SEMS placement, which remained in situ for 9 months. This decision was based on the initial poor status and short life expectancy, limiting the consideration of other options for lowering portal hypertension, along with an underlying prothrombotic predisposition...
August 25, 2020: American Journal of Gastroenterology
Christopher V Almario, William D Chey, Brennan M R Spiegel
INTRODUCTION: Proton pump inhibitors (PPIs) increase the risk for enteric infections that is likely related to PPI-induced hypochlorhydria. Although the impact of acid suppression on severe acute respiratory syndrome coronavirus 2 is unknown thus far, previous data revealed that pH ≤3 impairs the infectivity of the similar severe acute respiratory syndrome coronavirus 1. Thus, we aimed to determine whether use of PPIs increases the odds for acquiring coronavirus disease 2019 (COVID-19) among community-dwelling Americans...
August 25, 2020: American Journal of Gastroenterology
Gary R Lichtenstein, David T Rubin
No abstract text is available yet for this article.
August 24, 2020: American Journal of Gastroenterology
Borko Nojkov, Shi-Yi Zhou, Russell D Dolan, Elisabeth M Davis, Henry D Appelman, Xueyan Guo, Kenya Jackson, Matthew B Sturm, Thomas D Wang, Chung Owyang, Julia J Liu, William D Chey
INTRODUCTION: Duodenal epithelial barrier impairment and immune activation may play a role in the pathogenesis of functional dyspepsia (FD). This study was aimed to evaluate the duodenal epithelium of patients with FD and healthy individuals for detectable microscopic structural abnormalities. METHODS: This is a prospective study using esophagogastroduodenoscopy enhanced with duodenal confocal laser endomicroscopy (CLE) and mucosal biopsies in patients with FD (n = 16) and healthy controls (n = 18)...
August 24, 2020: American Journal of Gastroenterology
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