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American Journal of Gastroenterology

Ningli Chai, Jiale Zou, Enqiang Linghu, Mi Chai, Longsong Li, Xiangyao Wang, Wengang Zhang, Jingyuan Xiang, Zhenjuan Li
OBJECTIVES: To assess the safety and effectiveness of autologous skin-grafting surgery (ASGS) for preventing esophageal stenosis after complete circular endoscopic submucosal tunnel dissection (ccESTD) for superficial esophageal neoplasms. METHODS: Between October 2017 and March 2018, 8 patients who underwent ccESTD and ASGS were included. We assessed the occurrence of esophageal stenosis and adverse events. RESULTS: No adverse events occurred, including perforation, bleeding, wound infection, or stent migration...
March 15, 2019: American Journal of Gastroenterology
Animesh Jain, Nghia H Nguyen, James A Proudfoot, Christopher F Martin, William J Sandborn, Michael D Kappelman, Millie D Long, Siddharth Singh
INTRODUCTION: We conducted a cohort study on the impact of obesity on disease activity and Patient-Reported Outcomes Measurement Information System (PROMIS) measures in the inflammatory bowel disease (IBD) Partners cohort. METHODS: We performed a cross-sectional and longitudinal study within IBD Partners, an internet-based cohort of >15,000 patients living with Crohn's disease (CD) and ulcerative colitis (UC). We included adult patients with IBD, with recorded body mass index (BMI), with at least 6 months of follow-up, excluding patients with BMI < 18...
March 11, 2019: American Journal of Gastroenterology
Kathleen Zawaly, Colin Rumbolt, Ahmed M Abou-Setta, Christine Neilson, Rasheda Rabbani, Ryan Zarychanski, Harminder Singh
INTRODUCTION: Split-dose bowel preparation leads to superior colon cleansing for colonoscopy. However, the magnitude of benefit in detecting colonic polyps is uncertain. We performed a systematic review to synthesize the data on whether using a split-dose bowel preparation regimen improves the detection of polyps when compared with other dosing methods or regimen products. METHODS: We searched MEDLINE, EMBASE, and CENTRAL databases (from the inception to June 2017) for randomized controlled trials that assessed the following: split-dose vs day-before, split-dose vs same-day (as colonoscopy), or different types of split-dose regimens for patients undergoing colonoscopy...
March 11, 2019: American Journal of Gastroenterology
Asad Jehangir, Henry P Parkman
OBJECTIVES: Gastroparesis (Gp) can be a challenging disorder to manage due to the paucity of treatment options. We do not know how frequently patients with Gp symptoms resort to cannabinoids to address their symptoms. This study (i) determines the prevalence of cannabinoid use in patients with Gp symptoms, (ii) describes the patients with Gp symptoms using cannabinoids, and (iii) assesses the patients' perceived benefit of cannabinoids for Gp symptoms. METHODS: Consecutive outpatients with symptoms suggestive of Gp seen on follow-up at our academic center from June 2018 to September 2018 filled out questionnaires on their symptoms and the current treatments...
March 8, 2019: American Journal of Gastroenterology
Pilar Brito-Zerón, Khurram Bari, Robert P Baughman, Manuel Ramos-Casals
Involvement of the gastrointestinal (GI) tract is an infrequent extrathoracic presentation of sarcoidosis. We reviewed 305 cases of GI involvement reported in 238 patients, in whom GI sarcoidosis was the first sign of the disease in half the cases. The disease does not affect the GI tract uniformly, with a clear oral-anal gradient (80% of reported cases involved the esophagus, stomach, and duodenum). Clinicopathological mechanisms of damage may include diffuse mucosal infiltration, endoluminal exophytic lesions, involvement of the myenteric plexus, and extrinsic compressions...
March 8, 2019: American Journal of Gastroenterology
Oyuntugs Byambasukh, Dorien Zelle, Eva Corpeleijn
OBJECTIVES: We examined the dose-dependent association of habitual moderate-to-vigorous physical activity (MVPA) with the biochemical markers for nonalcoholic fatty liver disease (NAFLD) and whether this association changes with age and degree of impaired glucose metabolism. We also investigated whether the associations depend on the domain of MVPA. METHODS: In this study, using data from the population-based Lifelines cohort (N = 42,661), MVPA was self-reported on the short questionnaire to assess health-enhancing physical activity...
March 8, 2019: American Journal of Gastroenterology
Sachin Wani, J Lucas Williams, Srinadh Komanduri, V Raman Muthusamy, Nicholas J Shaheen
INTRODUCTION: Guidelines recommend that patients with non-dysplastic Barrett's esophagus (NDBE) undergo surveillance endoscopy every 3-5 years. Using a national registry, we assessed compliance to recommended surveillance intervals in patients with NDBE and identified factors associated with compliance. METHODS: We analyzed data from the GI Quality Improvement Consortium registry. Data abstracted include procedure indication, demographics, endoscopy/pathology results, and recommendations for future endoscopy...
March 7, 2019: American Journal of Gastroenterology
Feryal Ilkova, Tan Attila
No abstract text is available yet for this article.
March 7, 2019: American Journal of Gastroenterology
Kyosuke Kaji, Atsushi Hashiba, Chika Uotani, Yasushi Yamaguchi, Toshio Ueno, Kenji Ohno, Ichiro Takabatake, Tokio Wakabayashi, Hisashi Doyama, Itasu Ninomiya, Masato Kiriyama, Shigekazu Ohyama, Manabu Yoneshima, Nobu Koyama, Yasuo Takeda, Kenji Yasuda
No abstract text is available yet for this article.
March 6, 2019: American Journal of Gastroenterology
Edward L Barnes, Michael D Kappelman, Millie D Long, Donna M Evon, Christopher F Martin, Robert S Sandler
OBJECTIVES: There is increased interest in measuring patient-reported outcomes (PROs) such as quality of life (QoL) among patients with inflammatory bowel disease (IBD). We aimed to create and validate a new measure of QoL to assess the psychosocial burden of IBD using publicly available assessment tools. METHODS: Using the Crohn's & Colitis Foundation's IBD Partners cohort, we performed several cross-sectional and longitudinal analyses to create a new PRO-based evaluation (PROBE) of QoL among patients with Crohn's disease (CD) and ulcerative colitis (UC)...
March 1, 2019: American Journal of Gastroenterology
Emily B Hollister
Although causal relationships between specific microbes and cancer are well recognized, a growing body of evidence suggests that the broader community of gut microbes may influence cancer risk, provide diagnostic insight, shape clinical course, and impact treatment success in the gastrointestinal tract and beyond. In this issue, Murphy et al. reviewed evidence for the role of the microbiome in clinical oncology. Given that the gut microbiome may be modified by treatments ranging from diet and live biotherapeutics to microbial transplantation, microbiome-directed therapies hold tremendous promise for personalized therapies and improved treatment outcomes...
February 28, 2019: American Journal of Gastroenterology
William D Cheng, Karl J Wold, Lucy B Bollinger, M Isabel Ordiz, Robert J Shulman, Kenneth M Maleta, Mark J Manary, Indi Trehan
INTRODUCTION: Environmental enteric dysfunction (EED) predisposes children throughout the developing world to high rates of systemic exposure to enteric pathogens and stunting. Effective interventions that treat or prevent EED may help children achieve their full physical and cognitive potential. The objective of this study is to test whether 2 components of breast milk would improve a biomarker of EED and linear growth during the second year of life. METHODS: A prospective, randomized, double-blind, placebo-controlled clinical trial among children aged 12-23 months was conducted in rural Malawi...
February 28, 2019: American Journal of Gastroenterology
Shingo Ogiwara, Makoto Furihata, Kumiko Fukami, Atsushi Yamashita, Takashi Yao, Taro Osada
No abstract text is available yet for this article.
February 26, 2019: American Journal of Gastroenterology
Sam E Mason, Liam Poynter, Zoltan Takats, Ara Darzi, James M Kinross
OBJECTIVES: Accurate, real-time, endoscopic risk stratification of colorectal polyps would improve decision-making and optimize clinical efficiency. Technologies to manipulate endoscopic optical outputs can be used to predict polyp histology in vivo; however, it remains unclear how accuracy has progressed and whether it is sufficient for routine clinical implementation. METHODS: A meta-analysis was conducted by searching MEDLINE, Embase, and the Cochrane Library...
February 26, 2019: American Journal of Gastroenterology
Kenya Kamimura, Yoko Shinagawa-Kobayashi, Kenichi Mizuno, Shuji Terai
No abstract text is available yet for this article.
February 26, 2019: American Journal of Gastroenterology
Christopher J Danford, Steven C Lin, Jacqueline L Wolf
Sclerosing mesenteritis is a rare non-neoplastic disorder characterized by fat necrosis, chronic inflammation, and fibrosis typically of the small bowel mesentery. Our understanding of this disorder is limited by its rarity as well as inconsistent terminology used across the literature. While prior abdominal surgery or trauma, autoimmunity, infection, ischemia, and malignancy have been suggested to be involved in the pathogenesis of the disorder, it remains poorly understood. The clinical course of sclerosing mesenteritis is generally benign with a large proportion of patients diagnosed incidentally on imaging obtained for other indications...
February 26, 2019: American Journal of Gastroenterology
Piet C de Groen
No abstract text is available yet for this article.
February 26, 2019: American Journal of Gastroenterology
Jing Yang, Yi Zhang, Ling Fan, Yang-Jie Zhu, Ting-Yi Wang, Xing-Wei Wang, Dong-Feng Chen, Chun-Hui Lan
OBJECTIVES: This study assessed the effectiveness, adverse events, patient adherence, and costs of modified dual therapy compared with bismuth-containing quadruple therapy for treating Helicobacter pylori infection in Chinese patients. We also sought to determine whether modified dual therapy could be used as an alternative first-line treatment for H. pylori infection. METHODS: A total of 232 H. pylori-infected, treatment-naive patients were enrolled in this open-label, randomized controlled clinical trial...
February 25, 2019: American Journal of Gastroenterology
David T Rubin, Ashwin N Ananthakrishnan, Corey A Siegel, Bryan G Sauer, Millie D Long
Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the preferred approach to the management of adults with UC and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. In instances where the evidence was not appropriate for GRADE, but there was consensus of significant clinical merit, "key concept" statements were developed using expert consensus...
February 21, 2019: American Journal of Gastroenterology
Qi-Shan Zeng, Chun-Cheng Wu, Wei Liu, Lian-Song Ye, Shan Jiang, Yu-Hang Zhang, Bing Hu
No abstract text is available yet for this article.
February 21, 2019: American Journal of Gastroenterology
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