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American Journal of Gastroenterology

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https://read.qxmd.com/read/31313712/response-to-tursi
#1
M Ellionore Jarbrink-Sehgal, Loui Rassam, Aws Jasim, Marjorie Walker, Nicholas J Talley, Lars Agreus, Anna Andreasson, Peter Thelin Schmidt
No abstract text is available yet for this article.
July 16, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31313711/the-va-mission-act-and-community-care-for-veterans-what-every-community-gi-doc-needs-to-know
#2
Megan A Adams, George G Sayre, Sameer D Saini
No abstract text is available yet for this article.
July 16, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31313710/outbreak-in-new-york-measles-hepatitis
#3
Oliver A Stewart, Joseph Kingsbery, Shannon Chang
No abstract text is available yet for this article.
July 16, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31313709/response-to-zidar-et-al
#4
M Ellionore Jarbrink-Sehgal, Loui Rassam, Aws Jasim, Marjorie Walker, Nicholas J Talley, Lars Agréus, Anna Andreasson, Peter T Schmidt
No abstract text is available yet for this article.
July 16, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31306149/novel-methylated-dna-markers-discriminate-advanced-neoplasia-in-pancreatic-cysts-marker-discovery-tissue-validation-and-cyst-fluid-testing
#5
Shounak Majumder, William R Taylor, Tracy C Yab, Calise K Berger, Brian A Dukek, Xiaoming Cao, Patrick H Foote, Chung Wah Wu, Douglas W Mahoney, Harry R Aslanian, Carlos Fernández-Del Castillo, Leona A Doyle, James J Farrell, William E Fisher, Linda S Lee, Yvonne N Lee, Walter Park, Clifton Rodrigues, Bonnie Elyssa Gould Rothberg, Ronald R Salem, Diane M Simeone, Sumithra Urs, George Van Buren, Thomas C Smyrk, Hatim T Allawi, Graham P Lidgard, Massimo Raimondo, Suresh T Chari, Michael L Kendrick, John B Kisiel, Mark D Topazian, David A Ahlquist
OBJECTIVES: Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms to predict advanced neoplasia (HGD/PC) in PCLs lack diagnostic accuracy. In pancreatic tissue and cyst fluid (CF) from PCLs, we sought to identify and validate novel methylated DNA markers (MDMs) that discriminate HGD/PC from low-grade dysplasia (LGD) or no dysplasia (ND). METHODS: From an unbiased whole-methylome discovery approach using predefined selection criteria followed by multistep validation on case (HGD or PC) and control (ND or LGD) tissues, we identified discriminant MDMs...
July 15, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31306150/what-quality-metrics-should-we-apply-in-barrett-s-esophagus
#6
Madhav Desai, Prateek Sharma
A GI Quality improvement consortium registry study published in this issue of The American Journal of Gastroenterology confirms the lack of adherence to surveillance intervals and guidelines in patients with Barrett's esophagus (BE). Given the widespread use of upper endoscopy for evaluation of patients with gastroesophageal reflux disease and surveillance of BE, the lack of well-defined standard criteria for performing a high quality upper endoscopy calls for the establishment of valid quality indicators in BE endoscopy...
July 11, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31306151/fecal-microbiota-transplantation-in-patients-with-primary-sclerosing-cholangitis-the-next-steps-in-this-promising-story
#7
Jessica R Allegretti, Zain Kassam
No abstract text is available yet for this article.
July 10, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31295162/response-to-al-sulais-et-al
#8
Thomas Greuter, Stephan R Vavricka, Michael Scharl
No abstract text is available yet for this article.
July 5, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31295161/prucalopride-in-gastroparesis-a-randomized-placebo-controlled-crossover-study
#9
Florencia Carbone, Karen Van den Houte, Egbert Clevers, Christopher N Andrews, Athanassos Papathanasopoulos, Lieselot Holvoet, Lukas Van Oudenhove, Philip Caenepeel, Joris Arts, Tim Vanuytsel, Jan Tack
OBJECTIVES: Prokinetics are considered the preferred treatment option for gastroparesis, but evidence of their efficacy is scarce. Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist used in the treatment of constipation, is able to enhance the gastric emptying rate. In a double-blind, randomized, placebo-controlled crossover study, we evaluated the efficacy of prucalopride to improve the gastric emptying rate and symptoms in patients with gastroparesis. METHODS: Thirty-four patients with gastroparesis (28 idiopathic, 7 men, mean age 42 ± 13 years) were evaluated in a double-blind crossover trial of 4-week treatment periods with placebo or prucalopride 2 mg q...
July 5, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31274511/a-clinician-s-guide-to-celiac-disease-hla-genetics
#10
Nicholas K Brown, Stefano Guandalini, Carol Semrad, Sonia S Kupfer
Celiac disease is a common inflammatory disease triggered by dietary gluten in genetically susceptible individuals. The strongest and best-characterized genetic susceptibilities in celiac disease are class II human leukocyte antigen (HLA) genes known as HLA-DQ2 and DQ8. HLA genetic testing is available through a number of commercial and academic laboratories and is used in the evaluation of celiac disease and to identify at-risk family members. Importantly, HLA genetic testing has a high negative predictive value for celiac disease, but a low positive predictive value...
July 4, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31261253/mesalazine-and-nephrolithiasis-leave-no-stone-unturned
#11
Melek Simsek, Nanne K H de Boer
No abstract text is available yet for this article.
July 1, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31261252/correction-endoscopic-retrieval-of-a-single-edge-blade
#12
Xianhui Zeng, Dan Yang, Yuyan Zhang, Yan Li, Bing Hu
No abstract text is available yet for this article.
July 1, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31246695/iberogast-induced-acute-liver-failure-reexposure-and-in-vitro-assay-support-causality
#13
Florian Gerhardt, Andreas Benesic, Hans L Tillmann, Sebastian Rademacher, Christian Wittekind, Alexander L Gerbes, Robert Henker, Thomas Berg, Hans-Peter Maidhof, Heiner Trauer, Johannes Wiegand
No abstract text is available yet for this article.
June 26, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31246694/persistent-postprandial-regurgitation-vs-rumination-in-patients-with-refractory-gastroesophageal-reflux-disease-symptoms-identification-of-a-distinct-rumination-pattern-using-ambulatory-impedance-ph-monitoring
#14
Kenichiro Nakagawa, Akinari Sawada, Yoshimasa Hoshikawa, Kornilia Nikaki, Shirley Sonmez, Philip Woodland, Etsuro Yazaki, Daniel Sifrim
OBJECTIVES: Up to 20% of patients with refractory gastroesophageal reflux disease (GERD) might have postprandial rumination. The aim of this study was to distinguish persistent GERD-related postprandial regurgitation from rumination in patients with refractory GERD undergoing ambulatory multichannel intraluminal impedance-pH (MII-pH) monitoring. METHODS: We first characterized 24-hour and postprandial MII-pH patterns in 28 consecutive patients with confirmed rumination syndrome (positive clinical and high-resolution manometry/impedance)...
June 26, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31241546/managing-the-measurement-of-colonoscopy-quality
#15
Jason A Dominitz, Cynthia W Ko
The adenoma detection rate (ADR) is our current best colonoscopy quality indicator, but it is not without limitations. In this issue of the Journal, novel ADR benchmarks are proposed based on historical local colonoscopy results. These minimally acceptable, standard of care, and aspirational benchmarks may encourage continuous quality improvement through the explicit determination of notably higher but proven achievable ADR targets, although validation in clinical practice is needed. Ultimately, we must transition from ADR measurement to the implementation of robust quality improvement processes that assure the best outcomes for our patients...
June 25, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31232833/response-to-forbes
#16
Benjamin A Lerner, Benjamin Lebwohl
No abstract text is available yet for this article.
June 20, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31232832/the-gut-microbiome-in-inflammatory-bowel-disease-lessons-learned-from-other-immune-mediated-inflammatory-diseases
#17
Natalie C Knox, Jessica D Forbes, Christy-Lynn Peterson, Gary Van Domselaar, Charles N Bernstein
There is a growing appreciation for the role of the gut microbiome in human health and disease. Aided by advances in sequencing technologies and analytical methods, recent research has shown the healthy gut microbiome to possess considerable diversity and functional capacity. Dysbiosis of the gut microbiota is believed to be involved in the pathogenesis of not only diseases that primarily affect the gastrointestinal tract but also other less obvious diseases, including neurologic, rheumatologic, metabolic, hepatic, and other illnesses...
June 20, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31241548/response-to-mahla-et-al
#18
Enoka S Gonsalkorala, Mussarat N Rahim, Michael A Heneghan
No abstract text is available yet for this article.
June 19, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31241547/validation-of-risk-scoring-systems-in-ursodeoxycholic-acid-treated-patients-with-primary-biliary-cholangitis
#19
Cumali Efe, Koray Taşçılar, Ida Henriksson, Ellina Lytvyak, Fatema Alalkim, Hirsh Trivedi, Fatih Eren, Johanna Eliasson, Benedetta Terziroli Beretta-Piccoli, Janett Fischer, Ali Rıza Calışkan, Maneerat Chayanupatkul, Claudia Coppo, Henriette Ytting, Tugrul Purnak, Luigi Muratori, Mårten Werner, Paolo Muratori, Fredrik Rorsman, Kristina Önnerhag, Fulya Günşar, Emma Nilsson, Alexandra Heurgué-Berlot, Fatih Güzelbulut, Nurhan Demir, Can Gönen, David Semela, Murat Aladağ, Murat Kıyıcı, Thomas D Schiano, Aldo J Montano-Loza, Thomas Berg, Ersan Ozaslan, Eric M Yoshida, Alan Bonder, Hanns-Ulrich Marschall, Staffan Wahlin
INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts. METHODS: We performed a study on data of 1746 UDCA-treated patients with PBC from 25 centers in Europe, United States, and Canada...
June 19, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31211708/risk-of-developing-metachronous-advanced-colorectal-neoplasia-after-polypectomy-in-patients-with-multiple-diminutive-or-small-adenomas
#20
Nam Hee Kim, Yoon Suk Jung, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn
INTRODUCTION: Current post-polypectomy guidelines recommend a 3-year surveillance interval for ≥3 nonadvanced adenomas (NAAs) without discrimination between diminutive (1-5 mm) and small (6-9 mm) adenomas. We compared the risk of metachronous advanced colorectal neoplasia (ACRN) among these groups. METHODS: We studied 9,733 patients who underwent ≥1 adenoma removal and follow-up colonoscopic surveillance. Patients were classified based on baseline adenoma characteristics: group 1, 1-2 NAAs (n = 8,051); group 2, ≥3 diminutive NAAs (n = 293); group 3, ≥3 small NAAs (n = 258); and group 4, advanced adenomas (AAs) (n = 1,131)...
June 18, 2019: American Journal of Gastroenterology
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