Moon Haeng Hur, Min Kyung Park, Terry Cheuk-Fung Yip, Chien-Hung Chen, Hyung-Chul Lee, Won-Mook Choi, Seung Up Kim, Young-Suk Lim, Soo Young Park, Grace Lai-Hung Wong, Dong Hyun Sinn, Young-Joo Jin, Sung Eun Kim, Cheng-Yuan Peng, Hyun Phil Shin, Chi-Yi Chen, Hwi Young Kim, Han Ah Lee, Yeon Seok Seo, Dae Won Jun, Eileen L Yoon, Joo Hyun Sohn, Sang Bong Ahn, Jae-Jun Shim, Soung Won Jeong, Yong Kyun Cho, Hyoung Su Kim, Myoung-Jin Jang, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
INTRODUCTION: Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) for the prevention of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients; however, it has distinct long-term renal and bone toxicities. This study aimed to develop and validate a machine learning model (designated as PLAN-S) to predict an individualized risk of HCC during ETV or TDF therapy. METHODS: This multinational study included 13,970 CHB patients...
March 7, 2023: American Journal of Gastroenterology