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Journals American Journal of Gastroente...

American Journal of Gastroenterology

https://read.qxmd.com/read/36927957/a-review-of-the-cardiovascular-safety-of-prucalopride-in-patients-with-chronic-idiopathic-constipation
#1
JOURNAL ARTICLE
Jan Tack, Katayoun Derakhchan, André Gabriel, William Spalding, Brian Terreri, Ashraf Youssef, Bahij Kreidieh, Peter R Kowey, Mena Boules
Prokinetic agents, specifically 5-hydroxytryptamine type 4 (5-HT4) receptor agonists, have been shown to provide relief in chronic idiopathic constipation (CIC). The first 5-HT4 agonists were initially withdrawn from use owing to associations with serious cardiovascular (CV) events. This review summarizes CV safety data for prucalopride, a high-affinity 5-HT4 agonist approved in the USA in 2018 for adults with CIC. No significant effects of prucalopride on CV safety were observed in animal models or early-phase clinical studies, including a thorough QT study at therapeutic (2 mg) or supratherapeutic (10 mg) doses...
March 16, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36892545/evaluation-of-computer-aided-detection-during-colonoscopy-in-the-community-ai-see-a-multicenter-randomized-clinical-trial
#2
JOURNAL ARTICLE
Mike T Wei, Uday Shankar, Russell Parvin, Syed Hasan Abbas, Sushant Chaudhary, Yishai Friedlander, Shai Friedland
BACKGROUND: There has been increasing interest in artificial intelligence in gastroenterology. To reduce miss rate during colonoscopy, there has been significant exploration in computer aided detection (CADe) devices. In this study, we evaluate the use of CADe in colonoscopy in community-based, non-academic practices. METHODS: Between September 28, 2020 and September 24, 2021, a randomized controlled trial (AI-SEE) was performed evaluating the impact of CADe on polyp detection in 4 community-based endoscopy centers in the USA...
March 9, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36892528/from-hepaticogastrostomy-to-choledochoduodenostomy-a-rare-stent-migration-after-eus-guided-hepaticogastrostomy
#3
JOURNAL ARTICLE
Xiangyu Kong, Fanyang Kong, Weihui Liu, Ke Qi, Ting Yang, Zhendong Jin, Kaixuan Wang
No abstract text is available yet for this article.
March 9, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36892512/increased-risk-of-hospitalization-surgery-and-venous-thromboembolism-among-patients-with-inflammatory-bowel-disease-and-malnutrition-in-a-large-community-based-healthcare-system
#4
JOURNAL ARTICLE
Liat S Fine, Shiyun Zhu, Aida Shirazi, Jeffrey K Lee, Fernando S Velayos
INTRODUCTION: Patients with inflammatory bowel disease (IBD) constitute a high-risk population for malnutrition. Routine screening with standardized tools is recommended but can be challenging. Outcome data specific to IBD are sparse. METHODS: We performed a retrospective cohort study (2009-2019) and electronically screened a large community-based population with IBD for malnutrition risk by extracting height and longitudinal weight, data elements used in the Malnutrition Universal Screening Tool (MUST)...
March 9, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36892506/effectiveness-of-fenofibrate-in-treatment-na%C3%A3-ve-patients-with-primary-biliary-cholangitis-a-randomized-clinical-trial
#5
JOURNAL ARTICLE
Yansheng Liu, Guanya Guo, Linhua Zheng, Ruiqing Sun, Xiufang Wang, Juan Deng, Gui Jia, Chunmei Yang, Lina Cui, Changcun Guo, Yulong Shang, Ying Han
OBJECTIVES: Primary biliary cholangitis (PBC) is a progressive autoimmune liver disease, and patients with inadequate response to ursodeoxycholic acid (UDCA) treatment show reduced long-term survival. Recent studies have shown that fenofibrate is an effective off-label therapy for PBC. However, prospective studies on biochemical response including timing of fenofibrate administration are lacking. This study is aimed to evaluate the efficacy and safety of fenofibrate in UDCA treatment- naïve patients with PBC...
March 9, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36881437/personalized-antiviral-drug-selection-in-chronic-hepatitis-b-patients-using-a-machine-learning-model-a-multinational-study
#6
JOURNAL ARTICLE
Moon Haeng Hur, Min Kyung Park, Terry Cheuk-Fung Yip, Chien-Hung Chen, Hyung-Chul Lee, Won-Mook Choi, Seung Up Kim, Young-Suk Lim, Soo Young Park, Grace Lai-Hung Wong, Dong Hyun Sinn, Young-Joo Jin, Sung Eun Kim, Cheng-Yuan Peng, Hyun Phil Shin, Chi-Yi Chen, Hwi Young Kim, Han Ah Lee, Yeon Seok Seo, Dae Won Jun, Eileen L Yoon, Joo Hyun Sohn, Sang Bong Ahn, Jae-Jun Shim, Soung Won Jeong, Yong Kyun Cho, Hyoung Su Kim, Myoung-Jin Jang, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
INTRODUCTION: Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) for the prevention of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients; however, it has distinct long-term renal and bone toxicities. This study aimed to develop and validate a machine learning model (designated as PLAN-S) to predict an individualized risk of HCC during ETV or TDF therapy. METHODS: This multinational study included 13,970 CHB patients...
March 7, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36881434/large-recurrent-lateral-spreading-tumor-resected-en-bloc-with-soft-bipolar-snare
#7
JOURNAL ARTICLE
Shunsuke Yamamoto Fjges, Kensuke Matsushima, Yuko Sakakibara, Ryotaro Sakamori, Eiji Mita
No abstract text is available yet for this article.
March 7, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36881433/sudden-undulating-movements-of-the-abdominal-wall-an-exuberant-case-of-belly-dancer-s-syndrome
#8
JOURNAL ARTICLE
Joana Aguieiras Cabrera, Leonor P Silva, Margarida Mota
No abstract text is available yet for this article.
March 7, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36791387/spontaneous-fistulization-of-walled-off-pancreatic-necrosis-into-the-stomach
#9
JOURNAL ARTICLE
Khaled Elfert, Sammy Ho
No abstract text is available yet for this article.
March 7, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36757156/patients-with-crohn-s-disease-and-permanent-ileostomy-are-universally-excluded-from-clinical-trials-a-systematic-review
#10
JOURNAL ARTICLE
Sudheer K Vuyyuru, Florian Rieder, Virginia Solitano, Tran M Nguyen, Eileen Crowley, Neeraj Narula, Siddharth Singh, Christopher Ma, Vipul Jairath
INTRODUCTION: We performed a systematic review to investigate whether patients with Crohn's disease (CD) and permanent ileostomy (PI) have been included in clinical trials evaluating biologics and small molecules. METHODS: MEDLINE, Embase and Cochrane library (CENTRAL) data bases were searched from inception to May 16, 2022 for placebo controlled induction and/or maintenance randomized controlled trials assessing biologics and oral small molecules in adult patients with active CD...
March 7, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36862380/correction-to-american-college-of-gastroenterology-guidelines-update-diagnosis-and-management-of-celiac-disease
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 3, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36716447/strategies-for-the-use-of-dupilumab-in-eosinophilic-esophagitis
#12
JOURNAL ARTICLE
Bryan G Sauer, Barrett H Barnes, Emily C McGowan
No abstract text is available yet for this article.
March 2, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36848311/the-impact-of-patient-age-and-corticosteroids-in-patients-with-sulfonamide-hepatotoxicity
#13
JOURNAL ARTICLE
Robert J Fontana, David E Kleiner, Naga Chalasani, Herbert Bonkovsky, Jiezhun Gu, Huiman Barnhart, Yi-Ju Li, Jay H Hoofnagle
UNLABELLED: OBJECTIVESSulfonamides are widely used to treat and prevent various bacterial and opportunistic infections. The aim of this study was to describe the clinical presentation and outcomes of a large cohort of patients with sulfonamide hepatotoxicity. METHODS: Between 2004 to 2020, 105 patients with hepatotoxicity attributed to trimethoprim/ sulfamethoxazole (TMP-SMZ) (n=93) or other sulfonamides (n=12) were enrolled. Available liver biopsies were reviewed by a single hepatopathologist...
February 27, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36827590/use-of-the-stethoscope-to-diagnose-gastrointestinal-and-hepatic-disorders
#14
JOURNAL ARTICLE
Lawrence J Brandt
No abstract text is available yet for this article.
February 24, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36827588/long-term-major-papilla-metastasis-from-lobular-breast-cancer-mimicking-ampullary-neoplasm-an-endoscopic-ultrasound-diagnosis
#15
JOURNAL ARTICLE
Stefano Mazza, Andrea Drago, Giulia Tanzi, Sara Soro, Maria Chiara Verga, Biagio Elvo, Carmen Laurenza, Imma di Luna, Roberto Grassia
No abstract text is available yet for this article.
February 24, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36746415/liver-cirrhosis-increases-the-risk-of-herpes-zoster-a-nationwide-population-based-cohort-study
#16
JOURNAL ARTICLE
Dongsub Jeon, Ye-Jee Kim, Seonok Kim, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
INTRODUCTION: Limited data are available regarding the association between liver cirrhosis (LC) and the risk of herpes zoster (HZ). This study aimed to determine the risk of HZ in patients with LC. METHODS: HZ was defined as the presence of the International Classification of Diseases-10th revision code for HZ and concomitant prescription of antiviral medication. The incidence rates and standardized incidence ratios (SIRs) of HZ in patients with LC were analyzed using data from the Health Insurance Review and Assessment Service in Korea claims database from 2009 to 2019...
February 24, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36746413/evaluating-a-novel-portable-self-administrable-device-beacon-that-measures-critical-flicker-frequency-as-a-test-for-hepatic-encephalopathy
#17
JOURNAL ARTICLE
Philip Vutien, Richard Li, Ravi Karkar, Sean A Munson, James Fogarty, Kara Walter, Michael Yacoub, George N Ioannou
INTRODUCTION: We compared critical flicker frequency (CFF) thresholds obtained using a novel portable device "Beacon" with thresholds from the commercially available Lafayette Flicker Fusion System (Lafayette-FFS) in patients with cirrhosis. METHODS: One hundred fifty-three participants with chronic liver disease underwent CFF testing using Beacon and Lafayette-FFS with a method-of-limits and/or forced-choice protocol. RESULTS: Beacon demonstrated excellent test-retest reliability (intraclass correlation 0...
February 24, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36580497/remit-uc-real-world-effectiveness-and-safety-of-tofacitinib-for-moderate-to-severely-active-ulcerative-colitis-a-canadian-ibd-research-consortium-multicenter-national-cohort-study
#18
JOURNAL ARTICLE
Christopher Ma, Remo Panaccione, Yasi Xiao, Yuvan Khandelwal, Sanjay K Murthy, Emily C L Wong, Neeraj Narula, Catherine Tsai, Farhad Peerani, Marica Reise-Filteau, Brian Bressler, Samantha Y Starkey, Dustin Loomes, Rocio Sedano, Vipul Jairath, Talat Bessissow
INTRODUCTION: We aimed to evaluate the real-world effectiveness and safety of tofacitinib for the treatment of ulcerative colitis (UC). METHODS: REMIT-UC is a Canadian multicenter cohort study. Standardized data collection was performed on 334 consecutive adult outpatients with UC treated with tofacitinib. The primary outcomes were achievement of clinical and endoscopic remission. Safety outcomes were reported using incidence rates (events/100 patient-years of exposure)...
February 24, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36826512/is-vaccination-against-covid-19-associated-with-inflammatory-bowel-disease-flare-self-controlled-case-series-analysis-using-the-uk-cprd
#19
JOURNAL ARTICLE
Timothy R Card, Georgina Nakafero, Matthew J Grainge, Christian D Mallen, Jonathan S Nguyen Van-Tam, Hywel C Williams, Abhishek Abhishek
INTRODUCTION: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) flare. METHODS: Patients with IBD vaccinated against COVID-19 who consulted for disease flare between December 1, 2020, and December 31, 2021, were ascertained from the Clinical Practice Research Datalink. IBD flares were identified using consultation and corticosteroid prescription records. Vaccinations were identified using product codes and vaccination dates...
February 22, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/36799905/conventional-antibiotics-for-spontaneous-bacterial-peritonitis-are-they-still-effective
#20
JOURNAL ARTICLE
Mahathi Avadhanam, Anand V Kulkarni
No abstract text is available yet for this article.
February 20, 2023: American Journal of Gastroenterology
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