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American Journal of Gastroenterology

Sampsa Pikkarainen, Timi Martelius, Ari Ristimäki, Sanna Siitonen, Mikko R J Seppänen, Martti Färkkilä
OBJECTIVES: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID. METHODS: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Data on endoscopies, histology, and laboratory studies were retrieved from patient files...
February 8, 2019: American Journal of Gastroenterology
Keisuke Hata, Hiroyuki Anzai, Hiroki Ikeuchi, Kitaro Futami, Kouhei Fukushima, Akira Sugita, Motoi Uchino, Daijiro Higashi, Michio Itabashi, Kazuhiro Watanabe, Kazutaka Koganei, Toshimitsu Araki, Hideaki Kimura, Tsunekazu Mizushima, Takeshi Ueda, Soichiro Ishihara, Yasuo Suzuki
OBJECTIVES: To determine the effectiveness of surveillance colonoscopy (SC) and optimize its use by assessing real-world surgically resected cases of ulcerative colitis (UC)-associated colorectal cancer (CRC) and dysplasia. METHODS: Clinicopathological data of 406 (238 CRC and 168 dysplasia) patients who underwent surgical resection in 10 UC specialized institutions were retrospectively reviewed. The overall survival (OS) rates were compared between the SC and non-SC groups...
February 8, 2019: American Journal of Gastroenterology
Jeff Y Yang, Anne F Peery, Jennifer L Lund, Virginia Pate, Robert S Sandler
INTRODUCTION: Although hemorrhoids are a common indication for seeking health care, there are no contemporary estimates of burden and cost. We examined data from an administrative claims database to estimate health care use and aggregate costs. METHODS: We conducted a cross-sectional study using the MarketScan Commercial Claims and Encounters Database for 2014. The analysis included 18.9 million individuals who were aged 18-64 and continuously enrolled with prescription coverage...
February 7, 2019: American Journal of Gastroenterology
Yao He, Zhenhua Zhu, Yujun Chen, Fang Chen, Yufang Wang, Chunhui Ouyang, Hong Yang, Meifang Huang, Xiaodong Zhuang, Ren Mao, Shomron Ben-Horin, Xiaoping Wu, Qin Ouyang, Jiaming Qian, Nonghua Lu, Pinjing Hu, Minhu Chen
OBJECTIVES: Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. METHODS: In total, 310 eligible patients were recruited from 6 tertiary inflammatory bowel disease centers. Among them, 212 consecutive patients (143 CD and 69 ITB) were used in the derivation cohort for the establishment of diagnostic equation and nomogram; 7 investigative modalities including clinical manifestations, laboratory results, endoscopic findings, computed tomography enterography features, and histology results were used to derive the diagnostic model and nomogram...
February 7, 2019: American Journal of Gastroenterology
Søren S Olesen, Camilla Nøjgaard, Jakob L Poulsen, Stephan L Haas, Miroslav Vujasinovic, Matthias Löhr, Björn Lindkvist, Louise Bexander, Antanas Gulbinas, Evangelos Kalaitzakis, Mohamed Ebrahim, Friedemann Erchinger, Trond Engjom, Stine Roug, Srdan Novovic, Truls Hauge, Anne Waage, Johanna Laukkarinen, Mikael Parhiala, Aldis Pukitis, Imanta Ozola-Zālīte, Asbjørn M Drewes
OBJECTIVES: Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between complications and risk factors have mostly been limited to single complications or highly focused on single etiologies. Using an objective data-driven approach (cluster analysis), we characterized complication clusters and their associations with etiological risk factors in a large cohort of patients with CP. METHODS: This was a multicenter, cross-sectional study including 1,071 patients with CP from the Scandinavian and Baltic countries...
February 5, 2019: American Journal of Gastroenterology
Anand S Jain, Dustin A Carlson, Joseph Triggs, Michael Tye, Wenjun Kou, Ryan Campagna, Eric Hungness, Donald Kim, Peter J Kahrilas, John E Pandolfino
INTRODUCTION: To compare the utility of the distensibility index (DI) on functional lumen imaging probe (FLIP) topography to other esophagogastric junction (EGJ) metrics in assessing treatment response in achalasia in the context of esophageal anatomy. METHODS: We prospectively evaluated 79 patients (at ages 17-81 years; 47% female patients) with achalasia during follow-up after pneumatic dilation, Heller myotomy, or per-oral endoscopic myotomy with timed barium esophagram, high-resolution impedance manometry, and FLIP...
February 5, 2019: American Journal of Gastroenterology
Tzipi Braun, Ayelet Di Segni, Marina BenShoshan, Sandra Neuman, Nina Levhar, Michael Bubis, Orit Picard, Katya Sosnovski, Gilat Efroni, Sarit Farage Barhom, Efrat Glick Saar, Avishay Lahad, Batia Weiss, Doron Yablecovitch, Adi Lahat, Rami Eliakim, Uri Kopylov, Shomron Ben-Horin, Yael Haberman
OBJECTIVES: Crohn's disease (CD) is a chronic relapsing-remitting gut inflammatory disorder with a heterogeneous unpredictable course. Dysbiosis occurs in CD; however, whether microbial dynamics in quiescent CD are instrumental in increasing the risk of a subsequent flare remains undefined. METHODS: We analyzed the long-term dynamics of microbial composition in a prospective observational cohort of patients with quiescent CD (45 cases, 217 samples) over 2 years or until clinical flare occurred, aiming to identify whether changes in the microbiome precede and predict clinical relapse...
February 5, 2019: American Journal of Gastroenterology
Min-Hyung Kim, Jooyoung Chang, Warrick Junsuk Kim, Samprit Banerjee, Sang Min Park
No abstract text is available yet for this article.
February 5, 2019: American Journal of Gastroenterology
Monika Sarkar, Lisa B VanWagner, James G Terry, J Jeffrey Carr, Mary Rinella, Pamela J Schreiner, Cora E Lewis, Norah Terrault
INTRODUCTION: Cross-sectional data note lower levels of testosterone and sex hormone-binding globulin (SHBG) levels in men with nonalcoholic fatty liver disease (NAFLD). Whether sex hormone levels in young men are predictive of later risk of NAFLD is not known. METHODS: Among men in the prospective population-based multicenter Coronary Artery Risk Development in Young Adults study (mean age 50; n = 837), we assessed whether testosterone and SHBG levels measured at study year 10 (median age 35 years) were associated with prevalent NAFLD at study year 25...
February 4, 2019: American Journal of Gastroenterology
Vincent Zimmer, Christoph Heinrich
No abstract text is available yet for this article.
February 1, 2019: American Journal of Gastroenterology
David J Cangemi, Ryan Flanagan, Kenneth Barshop, Braden Kuo, Kyle Staller
OBJECTIVES: Plain film abdominal x-ray (AXR) is frequently used in the evaluation of constipation, but studies assessing the association between stool burden on AXR and colonic transit have been limited. We sought to investigate the relationship between colonic stool burden and slow transit constipation, as determined by a radiopaque marker (ROM) transit study. METHODS: A retrospective cohort population was assembled, consisting of adult patients with chronic constipation who underwent testing with both a ROM study and anorectal manometry at 2 tertiary care centers over 5 years...
February 1, 2019: American Journal of Gastroenterology
Jessica R Allegretti, Zain Kassam, Madeline Carrellas, Benjamin H Mullish, Julian R Marchesi, Alexandros Pechlivanis, Mark Smith, Ylaine Gerardin, Sonia Timberlake, Daniel S Pratt, Joshua R Korzenik
BACKGROUND: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with no effective medical therapies. A perturbation of the gut microbiota has been described in association with PSC, and fecal microbiota transplantation (FMT) has been reported to restore the microbiome in other disease states. Accordingly, we aimed at evaluating the safety, change in liver enzymes, microbiota, and metabolomic profiles in patients with PSC after FMT. METHODS: An open-label pilot study of patients with PSC with concurrent inflammatory bowel disease and alkaline phosphatase (ALP) > 1...
January 31, 2019: American Journal of Gastroenterology
Corey A Siegel
Telemedicine can take a number of forms. A popular approach is the use of telemonitoring, which takes advantage of available technology to follow patients remotely. Cross and colleagues present the results of a well-done randomized controlled trial to assess the impact of a telemonitoring program for patients with inflammatory bowel disease. They did not show a difference in disease activity, but this study leads us to question whether we know the appropriate outcomes to follow for telemedicine interventions...
January 30, 2019: American Journal of Gastroenterology
Robert Battat, Marjolijn Duijvestein, Leonardo Guizzetti, Daksh Choudhary, Brigid S Boland, Parambir S Dulai, Claire E Parker, Tran M Nguyen, Siddharth Singh, Niels Vande Casteele, Rish K Pai, Brian G Feagan, William J Sandborn, Vipul Jairath
OBJECTIVES: Histologic remission is a potentially valuable means of assessing disease activity and treatment response in ulcerative colitis (UC). However, the efficacy of existing therapies to achieve this outcome is unclear. We performed a systematic review and meta-analysis of histologic outcomes in UC randomized controlled trials and examined the relationship between histologic and endoscopic outcomes. METHODS: MEDLINE, EMBASE, CENTRAL, and the Cochrane IBD Register were searched for randomized controlled trials of aminosalicylates, corticosteroids, immunosuppressives, biologics, and small molecules...
January 25, 2019: American Journal of Gastroenterology
Ziding Feng, Jorge A Marrero, Saira Khaderi, Amit G Singal, Fasiha Kanwal, Nicole Loo, Laura Beretta, Jing Ning, Hashem B El-Serag
OBJECTIVES: The Texas Hepatocellular Carcinoma Consortium cohort study investigates risk factors of hepatocellular carcinoma (HCC) and biomarkers for early HCC detection in patients with liver cirrhosis. METHODS: Adult patients with liver cirrhosis are enrolled at 5 clinical centers from 3 cities in Texas, with a target of 5,000 patients. Clinical history, risk factor questionnaires, liver imaging, laboratory data, and blood samples were collected at enrollment and at each 6-month follow-up visit...
January 23, 2019: American Journal of Gastroenterology
Sonia Friedman, Bente M Nørgård
No abstract text is available yet for this article.
January 23, 2019: American Journal of Gastroenterology
Nancy Gupta, Stephen B Hanauer
No abstract text is available yet for this article.
January 23, 2019: American Journal of Gastroenterology
Raj Vuppalanchi, Regina Weber, Sarah Russell, Samer Gawrieh, Niharika Samala, James E Slaven, Lauren Harden, Naga Chalasani
OBJECTIVES: To investigate the effect of meal intake on liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) in patients with biopsy-proven nonalcoholic fatty liver disease undergoing vibration-controlled transient elastography. METHODS: LSM and CAP were assessed at baseline and serially for 6 hours after meal intake in 24 patients. RESULTS: A significant increase in LSM was seen up to the 2-hour time point (26 ± 25%, P = 0...
January 23, 2019: American Journal of Gastroenterology
Jasmohan S Bajaj, Puneeta Tandon, Jacqueline G OʼLeary, Florence Wong, Scott W Biggins, Guadalupe Garcia-Tsao, Patrick S Kamath, Benedict Maliakkal, Michael B Fallon, Jennifer C Lai, Paul J Thuluvath, Hugo E Vargas, Ram M Subramanian, Leroy R Thacker, K Rajender Reddy
OBJECTIVES: Antibiotic prophylaxis is recommended for prevention of the first episode of spontaneous bacterial peritonitis (SBP; primary prophylaxis 1°) and subsequent episodes (secondary prophylaxis 2°). We aimed to compare outcomes in cirrhotic inpatients on 1° vs 2° SBP prophylaxis. METHODS: Data from North American Consortium for the Study of End-Stage Liver Disease were evaluated for cirrhosis details, reasons for admission/medications, inpatient course recorded, and outcomes over 90 days...
January 23, 2019: American Journal of Gastroenterology
Jacob E Kurlander, Jennifer K Kennedy, Joel H Rubenstein, Caroline R Richardson, Sarah L Krein, Raymond De Vries, Sameer D Saini
OBJECTIVE: Little is known about how reports on the adverse effects of proton pump inhibitors (PPIs) impact patients' perceptions of these drugs and medication use. We sought to determine patients' level of concern about PPI adverse effects and its association with attempts to discontinue these drugs. METHODS: This study is an online survey of US adults who use PPIs for gastroesophageal reflux disease. Topics included awareness of and concern about PPI adverse effects, prior discussion with providers, and attempts to stop PPI because of concern about adverse effects...
January 23, 2019: American Journal of Gastroenterology
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