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American Journal of Gastroenterology

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https://read.qxmd.com/read/31517639/alcoholic-liver-disease-epidemiology-in-the-united-states-a-retrospective-analysis-of-3-us-databases
#1
Katherine Dang, Grishma Hirode, Ashwani Singal, Vinay Sundaram, Robert J Wong
OBJECTIVES: Alcoholic liver disease (ALD) prevalence, particularly the subset with advanced liver disease, is not well defined. Herein, we aim to provide a comprehensive assessment of ALD epidemiology across the spectrum of disease severity and across different settings using 3 unique US databases. METHODS: We performed a retrospective, observational study of US adults with ALD using 2001-2016 National Health and Nutrition Examination Survey (NHANES), 2007-2014 Nationwide Inpatient Sample (NIS), and 2007-2017 United Network for Organ Sharing (UNOS) registry...
September 11, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31517638/histologic-findings-of-advanced-fibrosis-and-cirrhosis-in-patients-with-nonalcoholic-fatty-liver-disease-who-have-normal-aminotransferase-levels
#2
Samer Gawrieh, Laura A Wilson, Oscar W Cummings, Jeanne M Clark, Rohit Loomba, Bilal Hameed, Manal F Abdelmalek, Srinivasan Dasarathy, Brent A Neuschwander-Tetri, Kris Kowdley, David Kleiner, Edward Doo, James Tonascia, Arun Sanyal, Naga Chalasani
OBJECTIVES: Patients with nonalcoholic fatty liver disease (NAFLD) and normal aminotransferase levels may have advanced liver histology. We conducted a study to characterize the prevalence of and factors associated with advanced liver histology in patients with histologically characterized NAFLD and normal aminotransferase levels. METHODS: We evaluated 534 adults with biopsy-proven NAFLD and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <40U/L within 3 months of their liver biopsy...
September 11, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31503018/application-of-risk-scores-in-the-daily-management-of-primary-biliary-cholangitis-response-to-corpechot-and-chazouill%C3%A3-res
#3
Cumali Efe, Koray Taşçılar, Aldo J Montano-Loza, Eric M Yoshida, Staffan Wahlin
No abstract text is available yet for this article.
September 10, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31498154/back-to-back-comparison-of-colonoscopy-with-virtual-chromoendoscopy-using-a-third-generation-narrow-band-imaging-system-to-chromoendoscopy-with-indigo-carmine-in-patients-with-lynch-syndrome
#4
Christophe Cellier, Guillaume Perrod, Chrystelle Colas, Marion Dhooge, Jean-Christophe Saurin, Thierry Lecomte, Emmanuel Coron, Gabriel Rahmi, Camille Savale, Stanislas Chaussade, Jérôme Bellanger, Xavier Dray, Nicolas Benech, Marc Le Rhun, Jean-Pierre Barbieux, Héléna Pereira, Gilles Chatellier, Elia Samaha
INTRODUCTION: Colonoscopic screening with indigo carmine chromoendoscopy (ICC) in patients with Lynch syndrome (LS) improves the adenoma detection rate but is time consuming and poorly used in clinical practice. Narrow-band imaging (NBI), a virtual chromoendoscopy technique, highlights superficial mucosal vessels and improves adenoma characterization. We conducted a prospective multicenter trial in a back-to-back fashion to compare the third-generation NBI with ICC for detecting colonic adenomas in patients with LS...
September 9, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31498153/mucous-membrane-pemphigoid-presenting-with-esophageal-manifestations-a-case-series
#5
Taryn DeGrazia, Rachel Eisenstadt, Field F Willingham, Ron Feldman
No abstract text is available yet for this article.
September 9, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31498155/managing-immunosuppressed-patients-with-inflammatory-bowel-disease-during-a-measles-outbreak
#6
Erica R Cohen, Mark Salem, Christina Ha
No abstract text is available yet for this article.
September 6, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31490197/gastric-necrosis-associated-with-necrotizing-pancreatitis
#7
Ramzi Mulki, Rushikesh Shah, Emad Qayed
No abstract text is available yet for this article.
September 3, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31478919/using-patients-social-network-to-improve-compliance-to-outpatient-screening-colonoscopy-appointments-among-blacks-a-randomized-clinical-trial
#8
Adeyinka O Laiyemo, John Kwagyan, Carla D Williams, Jessica Rogers, Angesom Kibreab, Momodu A Jack, Edward E Lee, Hassan Brim, Hassan Ashktorab, Charles D Howell, Duane T Smoot, Elizabeth A Platz
OBJECTIVES: Patient navigation improves colorectal cancer screening among underserved populations, but limited resources preclude widespread adoption in minority-serving institutions. We evaluated whether a patient's self-selected social contact person can effectively facilitate outpatient screening colonoscopy. METHODS: From September 2014 to March 2017 in an urban tertiary center, 399 black participants scheduled for outpatient screening colonoscopy self-selected a social contact person to be a facilitator and provided the person's phone number...
September 2, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31478920/ulc%C3%A3-re-perfor%C3%A3-bouch%C3%A3
#9
Fateh Bazerbachi, Vinay Chandrasekhara
No abstract text is available yet for this article.
August 30, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464738/accessing-food-and-drug-administration-resources-in-clinical-practice-a-primer-for-the-practicing-gastroenterologist
#10
Eric D Shah, Dawn B Beaulieu, Bruce Yacyshyn
No abstract text is available yet for this article.
August 28, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464737/response-to-lai-proton-pump-inhibitors-and-fracture-risk
#11
Toshihiro Sugiyama
No abstract text is available yet for this article.
August 28, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31453812/obesity-is-the-most-common-risk-factor-for-chronic-liver-disease-results-from-a-risk-stratification-pathway-using-transient-elastography
#12
Rebecca Harris, Timothy R Card, Toby Delahooke, Guruprasad P Aithal, Indra N Guha
INTRODUCTION: Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease. We aimed to elucidate the effect of a raised body mass index on the risk of liver disease using data from a community risk stratification pathway. METHODS: We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity...
August 27, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31449155/readmissions-for-cirrhosis-within-the-healthcare-readmissions-reduction-program-a-hidden-challenge
#13
Zachary Henry
With the passage of the Affordable Care Act, the Healthcare Readmissions Reduction Program (HRRP) was implemented, leading to significant reductions in readmissions for congestive heart failure, pneumonia, and myocardial infarction. Patients with cirrhosis have a complex and difficult to manage underlying disease process and are often left out of large policy decisions such as the HRRP although they represent a population at high risk for readmission and other negative outcomes. In this editorial, hospital readmissions in patients with cirrhosis are discussed in the context of the HRRP and evolving models of care...
August 23, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31449158/-trivial-cysts-redefine-the-risk-of-cancer-in-presumed-branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-a-potential-target-for-follow-up-discontinuation
#14
Giovanni Marchegiani, Stefano Andrianello, Tommaso Pollini, Andrea Caravati, Marco Biancotto, Erica Secchettin, Deborah Bonamini, Giuseppe Malleo, Claudio Bassi, Roberto Salvia
OBJECTIVES: The management of small and incidental branch duct intraductal papillary mucinous neoplasms (BD-IPMNs) still is of concern. The aim is assessing the safety of a surveillance protocol through the evaluation of their progression to malignancy. METHODS: All presumed BD-IPMNs observed from 2000 to 2016 were included. Only patients presenting without worrisome features (WFs) and high-risk stigmata (HRS) at diagnosis were included. Development of WF, HRS, pancreatic cancer (PC), and survival were analyzed...
August 22, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31449157/role-of-reflux-in-the-pathogenesis-of-eosinophilic-esophagitis-comprehensive-appraisal-with-off-and-on-ppi-impedance-ph-monitoring
#15
Marzio Frazzoni, Roberto Penagini, Leonardo Frazzoni, Nicola de Bortoli, Aurelio Mauro, Salvatore Tolone, Helga Bertani, Maria Marsico, Margherita Marocchi, Santino Marchi, Rita Conigliaro, Edoardo Savarino
OBJECTIVES: Role of reflux and mechanisms of response to proton pump inhibitor (PPI) therapy in eosinophilic esophagitis (EoE) have not yet been fully elucidated. Comprehensive assessment by impedance-pH monitoring could clarify these issues. METHODS: Prospective multicenter study comparing EoE patients with healthy controls and gastroesophageal reflux disease cases. Patients with EoE were evaluated off- and on PPI; responsiveness was assessed by histology. Impedance-pH appraisal included chemical clearance, assessed with the postreflux swallow-induced peristaltic wave (PSPW) index, and mucosal integrity measured with mean nocturnal baseline impedance (MNBI)...
August 21, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31449156/variability-and-lability-of-ammonia-levels-in-healthy-volunteers-and-patients-with-cirrhosis-implications-for-trial-design-and-clinical-practice
#16
Jasmohan S Bajaj, Patricia Pringle Bloom, Raymond T Chung, Tarek I Hassanein, Marielys Padilla-Martinez, Zeid Kayali, Don C Rockey, Roula Sasso, Alagar R Muthukumar, William M Lee, William S Denney, Edith A Gavis, Cami Anderson, Larry Blankstein, Aoife M Brennan, Marja K Puurunen, Eric Lawitz
BACKGROUND: Ammonia levels are used to assess hepatic encephalopathy, but their levels are highly variable in clinical practice. METHODS: We studied factors associated with variation in ammonia values in cirrhotic patients without previous hepatic encephalopathy and healthy volunteers (HVs). RESULTS: Ammonia increased by 12% and 18% at 1 and 2 hour, respectively, after a protein meal in 64 cirrhotic patients (P < 0.001). In 237 HVs, ammonia levels varied significantly between sites (P < 0...
August 21, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464746/head-to-head-comparison-of-the-performance-of-17-risk-models-for-predicting-presence-of-advanced-neoplasms-in-colorectal-cancer-screening
#17
Le Peng, Yesilda Balavarca, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner
OBJECTIVES: Many risk scores have been proposed to predict presence of advanced colorectal neoplasms, but a comprehensive comparison conducted in the same population is sparse. The aim of this study was to evaluate and directly compare the diagnostic performance of published risk prediction models for advanced colorectal neoplasms. METHODS: Data were drawn from 2 cohorts of subjects undergoing screening colonoscopy in Germany, i.e., KolosSal (n = 16,195) and BliTz (n = 7,444)...
August 20, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464745/reporting-adverse-drug-events
#18
Linda A Feagins, George G Abdelsayed, Jason Schairer
No abstract text is available yet for this article.
August 20, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464744/peripheral-t-cell-lymphoma-presenting-as-pseudoachalasia
#19
Pradeep Reddy Kathi, Nikhila Thammineni, Lakshmi Pathai, Baraa Alosh, Murray N Ehrinpreis
No abstract text is available yet for this article.
August 20, 2019: American Journal of Gastroenterology
https://read.qxmd.com/read/31464743/patients-with-nonalcoholic-steatohepatitis-experience-severe-impairment-of-health-related-quality-of-life
#20
Zobair M Younossi, Maria Stepanova, Eric J Lawitz, K Rajender Reddy, Vincent Wai-Sun Wong, Alessandra Mangia, Andrew J Muir, Ira Jacobson, C Stephen Djedjos, Anuj Gaggar, Robert P Myers, Issah Younossi, Fatema Nader, Andrei Racila
INTRODUCTION: Although there is substantial evidence suggesting poor health-related quality of life (HRQL) in patients with chronic hepatitis C (CHC), similar data in nonalcoholic steatohepatitis (NASH) have not been fully assessed. The aim is to compare HRQL scores in patients with CHC to those with NASH. METHODS: Matched patients with advanced fibrosis (bridging fibrosis and compensated cirrhosis) due to CHC and NASH completed Short Form-36 (SF-36) questionnaire, Chronic Liver Disease Questionnaire (CLDQ), and Work Productivity and Activity Instrument questionnaire...
August 20, 2019: American Journal of Gastroenterology
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