Journals American Journal of Gastroente...

American Journal of Gastroenterology
Jie Li, Michael H Le, Monique T Barakat, Ramsey C Cheung, Mindie H Nguyen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) and infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) are major causes of liver disease in adults. However, data for children and adolescents are limited. Our study aimed to characterize the prevalence, trend, and risk factors of infection of HBV and HCV and possible NAFLD for this population. METHODS: We analyzed 6,647 children and adolescents (aged 6-21 years) from the 1999-2016 National Health and Nutrition Examination Survey...
July 30, 2021: American Journal of Gastroenterology
Judy Nee, Sarah Ballou, John M Kelley, Ted J Kaptchuk, William Hirsch, Jesse Katon, Vivian Cheng, Vikram Rangan, Anthony Lembo, Johanna Iturrino
INTRODUCTION: Peppermint oil is often used to treat irritable bowel syndrome (IBS); however, the overall quality of previous studies is low, and findings have been heterogeneous. This study aimed to compare the effects of peppermint oil vs placebo in relieving IBS symptoms. METHODS: In a 6-week, randomized, double-blind, placebo-controlled trial at a single academic center in the United States, individuals diagnosed with IBS (Rome IV criteria), with moderate to severe symptoms based on the IBS Severity Scoring System (IBS-SSS score ≥175), were randomized to enteric-coated peppermint oil 180 mg 3 times daily vs placebo in a 1:2 ratio...
July 28, 2021: American Journal of Gastroenterology
Emanuele Dilaghi, Francesca Baldaro, Emanuela Pilozzi, Laura Conti, Antonio Palumbo, Gianluca Esposito, Bruno Annibale, Edith Lahner
INTRODUCTION: Corpus atrophic gastritis (CAG) is associated with intestinal metaplasia (IM) and pseudopyloric metaplasia (PPM). Prospective data on corpus mucosa PPM and its link to the development of gastric cancer (GC) are lacking. This study aimed to investigate the relationship between the presence of corpus mucosa PPM at baseline and the development of GC at follow-up in patients with CAG. METHODS: A longitudinal cohort study was conducted on patients with consecutive CAG adhering to endoscopic-histological surveillance...
July 27, 2021: American Journal of Gastroenterology
Fei-Pi Lin, Jacqueline M Visina, Pamela M Bloomer, Michael A Dunn, Deborah A Josbeno, Xingyu Zhang, Ana Clemente-Sanchez, Amit D Tevar, Christopher B Hughes, John M Jakicic, Andrés Duarte-Rojo
INTRODUCTION: Frailty is a predictor of morbidity and mortality in cirrhosis. Although evidence for prehabilitation is promising, the data for liver transplant (LT) candidates are limited. The primary aim of this study was to evaluate the effect of a novel prehabilitation strategy on changes in frailty metrics and survival in LT candidates. The secondary aim was to determine liver-related and extrahepatic conditions associated with frailty. METHODS: In this ambispective cohort study, all patients underwent frailty assessment using the liver frailty index (LFI), 6-minute walk test, and gait speed test performed by a dedicated physical therapist...
July 27, 2021: American Journal of Gastroenterology
Qiangsheng He, Bin Xia, Wenbo Meng, Die Fan, Zi-Chong Kuo, Junjie Huang, Xiwen Qin, Huachun Zou, Yulong He, Changhua Zhang, Shuo Fang, Yihang Pan, Man Yang, Jinqiu Yuan
INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes...
July 27, 2021: American Journal of Gastroenterology
Hengjing Li, Daniel Boakye, Xuechen Chen, Michael Hoffmeister, Hermann Brenner
INTRODUCTION: Incidence of colorectal cancer (CRC) in young adults has been increasing in recent decades in many countries for still widely unclear reasons. Suspected candidates include increasing prevalence of overweight and obesity, but specific evidence on their role for early-onset CRC (EOCRC) is sparse. We conducted a systematic review and meta-analysis to summarize available evidence on the association of body mass index (BMI) with EOCRC. METHODS: We systematically searched PubMed, EMBASE, and Web of Science up to February 2021 for studies that evaluated the association of BMI (before diagnosis but not near diagnosis) with CRC risk and reported specific results for EOCRC...
July 23, 2021: American Journal of Gastroenterology
Mentore Ribolsi, Michele Pier Luca Guarino, Paola Balestrieri, Annamaria Altomare, Alessandro Tullio, Tommasangelo Petitti, Michele Cicala
INTRODUCTION: The clinical management of chronic cough patients is challenging, and their response to proton pump inhibitors (PPIs) is considered as unsatisfactory. Few data concerning the association between impedance-pH variables and PPI response in these patients are available. Mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave (PSPW) index increase the diagnostic yield of impedance-pH in gastroesophageal reflux disease. METHODS: Demographic, clinical, and endoscopy findings; impedance-pH; and high-resolution manometry tracings from consecutive patients assessed for cough were evaluated...
July 21, 2021: American Journal of Gastroenterology
Yanfei Wang, Yiqian Jiang, Zhongxin Zhu
No abstract text is available yet for this article.
July 20, 2021: American Journal of Gastroenterology
Nicole Harrison, Ross Humes, Manish Singla
No abstract text is available yet for this article.
July 19, 2021: American Journal of Gastroenterology
Carlos Moctezuma-Velazquez, Juan G Abraldes
Several observational studies have shown an association between statin use and lower incidence of liver cancer. However, several potential biases limit a causal interpretation that could lead to a recommendation of statin prescription to patients with cirrhosis in the absence of a cardiovascular indication. Ongoing randomized trials will soon provide a clearer picture on the efficacy and safety of statins for preventing liver cancer and other complications of cirrhosis.
July 19, 2021: American Journal of Gastroenterology
Lauren D Feld
No abstract text is available yet for this article.
July 19, 2021: American Journal of Gastroenterology
Christian Labenz, Joachim Labenz
No abstract text is available yet for this article.
July 19, 2021: American Journal of Gastroenterology
Yu Liu, Liang-Hao Hu
No abstract text is available yet for this article.
July 19, 2021: American Journal of Gastroenterology
Cecilia Benz, John Smith, Ravi Mani, Tejo Musunuru, Jing He, Ikenna Okereke
No abstract text is available yet for this article.
July 15, 2021: American Journal of Gastroenterology
Yuanjie Sun, Zhishun Liu
No abstract text is available yet for this article.
July 15, 2021: American Journal of Gastroenterology
Andrew J Kruger, Hisham Hussan, Peter P Stanich, Darrell M Gray, Kyle M Porter, Alice Hinton, Gottumukkala S Raju, Somashekar G Krishna
INTRODUCTION: Despite the increasing availability of advanced endoscopic resections and its favorable safety profile, surgery for nonmalignant colorectal polyps has continually increased. We sought to evaluate readmission rates and outcomes of elective surgery for nonmalignant colorectal polyps on a national level in the United States. METHODS: The Nationwide Readmissions Database (2010-2014 [International Classification of Diseases, Ninth Revision] and 2016-2018 [International Classification of Diseases, 10th Revision]) was used to identify all adult subjects (age ≥18 years) who underwent elective surgical resection of nonmalignant colorectal polyps...
July 13, 2021: American Journal of Gastroenterology
Kenta Ushida, Miho Shimizu, Yoshinori Yamamoto, Ryo Momosaki
No abstract text is available yet for this article.
July 13, 2021: American Journal of Gastroenterology
Caroline L Seiler, Michel Kiflen, Juan Pablo Stefanolo, Julio César Bai, Premysl Bercik, Ciaran P Kelly, Elena F Verdu, Paul Moayyedi, Maria Ines Pinto-Sanchez
No abstract text is available yet for this article.
July 9, 2021: American Journal of Gastroenterology
Ellyn K Dunbar, Phil J Greer, Stephen T Amann, Samer Alkaade, Peter Banks, Randall Brand, Darwin L Conwell, Christopher E Forsmark, Timothy B Gardner, Nalini M Guda, Michele D Lewis, Jorge D Machicado, Thiruvengadam Muniraj, Georgios I Papachristou, Joseph Romagnuolo, Bimaljit S Sandhu, Stuart Sherman, Adam Slivka, C Mel Wilcox, Dhiraj Yadav, David C Whitcomb
INTRODUCTION: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are progressive inflammatory syndromes with variable features. Pain is the primary feature that contributes to low physical and mental quality of life with a third of patients reporting severe pain. Pain experience is worsened by depression. Here, we tested the hypothesis that genetic risk of the psychiatric conditions of anxiety and post-traumatic stress disorder (PTSD) is associated with pain in CP and RAP + CP subjects...
July 8, 2021: American Journal of Gastroenterology
Alessandro Repici, Annalisa Cappello, Marco Spadaccini, Rosangela Nicoletti, Silvia Carrara, Alessandro Fugazza, Piera Alessia Galtieri, Laura Lamonaca, Chiara Romana, Matteo Badalamenti, Milena Di Leo, Gaia Pellegatta, Elisa Chiara Ferrara, Andrea Anderloni, Roberta Maselli
INTRODUCTION: Multiple therapeutic modalities including surgery and rigid and flexible endoscopy have been adopted to manage Zenker's diverticulum (ZD). Minimally invasive flexible endoscopic septotomy (FES) techniques have been increasingly favored over the past 20 years; however, long-term data are still scanty. The aim of this study is to evaluate early and long-term outcomes of FES for naive ZD in a single-center setting. METHODS: From 2010 to 2017, ZD patients treated with FES were included in a prospectively maintained database (NCT03948438)...
July 7, 2021: American Journal of Gastroenterology
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