Journals American Journal of Gastroente...

American Journal of Gastroenterology
Niels Teich, Andreas Stallmach, Tony Bruns
No abstract text is available yet for this article.
May 7, 2021: American Journal of Gastroenterology
Rui-Ping Lai
No abstract text is available yet for this article.
May 4, 2021: American Journal of Gastroenterology
Emidio Scarpellini, Karen Van den Houte, Jolien Schol, I-Hsuan Huang, Ester Colomier, Florencia Carbone, Jan Tack
INTRODUCTION: Functional dyspepsia (FD) is a prevalent condition with multifactorial pathophysiology, including impaired gastric accommodation (GA), hypersensitivity to gastric distention, and delayed gastric emptying. Drink tests (DT) have been proposed as a potential biomarker for the presence and severity of gastric sensorimotor dysfunction. Thus, we aimed to summarize the state of knowledge on different DT and their potential as a biomarker for FD. METHODS: A PubMed and MEDLINE search was conducted for English language articles, reviews, meta-analyses, case series, and randomized controlled trials, including also published meeting abstracts...
May 4, 2021: American Journal of Gastroenterology
Jorn C Goet, Carla F Murillo Perez, Maren H Harms, Annarosa Floreani, Nora Cazzagon, Tony Bruns, Florian Prechter, George N Dalekos, Xavier Verhelst, Nikolaos K Gatselis, Keith D Lindor, Willem J Lammers, Aliya Gulamhusein, Anna Reig, Marco Carbone, Frederik Nevens, Gideon M Hirschfield, Adriaan J van der Meer, Henk R van Buuren, Bettina E Hansen, Albert Parés
INTRODUCTION: Comparative data on scores that predict outcome in primary biliary cholangitis (PBC) are scarce. We aimed to assess and compare the prognostic value of the Mayo Risk Score (MRS, 1989 and 1994), UK-PBC score, and GLOBE score in a large international cohort of patients with PBC. METHODS: Ursodeoxycholic acid-treated patients from 7 centers participating in the GLOBAL PBC Study Group were included. The discriminatory performance of the scores was assessed with concordance statistics at yearly intervals up to 5 years...
May 4, 2021: American Journal of Gastroenterology
Giulia Tosetti, Massimo Primignani
No abstract text is available yet for this article.
April 29, 2021: American Journal of Gastroenterology
Kornilia Nikaki, Chung Lee, Ahsen Ustaoglu, Annalisa Alessandrella, Annamaria Staiano, Philip Woodland, Daniel Sifrim
INTRODUCTION: Esophageal mucosa innervation in adults with nonerosive reflux disease (NERD) is more superficial compared with healthy volunteers. We delineated the esophageal mucosal innervation in pediatric NERD and controls. METHODS: Distal and proximal pediatric esophageal biopsies were immunohistochemically stained with calcitonin gene-related peptide and transient receptor potential cation channel subfamily V member 1. RESULTS: Mucosal innervation was assessed in 18 controls (9M:9F, median age: 9 years) and 11 NERD patients (6M:5F, median age: 5 years)...
April 29, 2021: American Journal of Gastroenterology
Indu Grover, Deepak Gunjan, Namrata Singh, Jaya Benjamin, Lakshmy Ramakrishnan, Ravindra M Pandey, Hem C Sati, Anoop Saraya
INTRODUCTION: In patients with cirrhosis, highly prevalent vitamin D deficiency and low bone mineral density (BMD) increase the burden of disease, and role of vitamin D supplementation is not clear. So, our aim was to determine the effect of vitamin D supplementation on vitamin D level and BMD in patients with cirrhosis. METHODS: Patients with cirrhosis (18-60 years) of any etiology were enrolled. We measured serum 25(OH)D, parathyroid hormone, thyroid-stimulating hormone, free T4, bone-specific alkaline phosphatase, insulin-like growth factor (IGF)-1, and health-related quality of life at entry and at 1 year; however, serum calcium was measured at 3-month interval...
April 29, 2021: American Journal of Gastroenterology
Sally Tran, Donghak Jeong, Linda Henry, Ramsey C Cheung, Mindie H Nguyen
INTRODUCTION: Previous studies, mostly small and single center, have shown gaps in the evaluation and monitoring of patients with chronic hepatitis B (CHB) virus infection. We aimed to examine the rates and predictors of adherence to guidelines for CHB care in a large nationwide cohort. METHODS: We identified adult patients with CHB infection from the Truven MarketScan databases of commercially insured and Medicare patients with private insurance supplement (2007-2014) using International Classification of Diseases, Ninth Revision, Clinical Modification codes...
April 29, 2021: American Journal of Gastroenterology
Christina Thornton, Ranjani Somayaji, Michael Parkins, Mark G Swain, Kathleen J Ramos, Christopher H Goss, Abdel A Shaheen
INTRODUCTION: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States. METHODS: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database. RESULTS: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis...
April 29, 2021: American Journal of Gastroenterology
Ying Y Gibbens, Ramona Lansing, Michele L Johnson, Christopher H Blevins, David A Katzka, Prasad G Iyer
INTRODUCTION: We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). METHODS: Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured. RESULTS: The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects...
April 22, 2021: American Journal of Gastroenterology
Paul J Thuluvath, Joseph J Alukal, Talan Zhang
INTRODUCTION: A model that can predict short-term mortality in patients with the Budd-Chiari syndrome (BCS) with a high degree of accuracy is currently lacking. The primary objective of our study was to develop an easy-to-use in-hospital mortality prediction model in patients with BCS using easily available clinical variables. METHODS: Data were extracted from the National Inpatient Sample to identify all adult patients with a listed diagnosis of BCS from 2008 to 2017 using ICD-9 or ICD-10 codes...
April 21, 2021: American Journal of Gastroenterology
Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Yasuhiro Hagiwara, Mario De Bellis, Simone Famularo, Elena Panettieri, Yutaka Matsuyama, Ryosuke Tateishi, Tomoaki Ichikawa, Takashi Kokudo, Namiki Izumi, Shoji Kubo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Osamu Nakashima, Takamichi Murakami, Jean-Nicolas Vauthey, Felice Giuliante, Luciano De Carlis, Fabrizio Romano, Andrea Ruzzenente, Alfredo Guglielmi, Masatoshi Kudo, Norihiro Kokudo
INTRODUCTION: Most studies predicting survival after resection, transarterial chemoembolization (TACE), and ablation analyzed diameter and number of hepatocellular carcinomas (HCCs) as dichotomous variables, resulting in an underestimation of risk variation. We aimed to develop and validate a new prognostic model for patients with HCC using largest diameter and number of HCCs as continuous variables. METHODS: The prognostic model was developed using data from patients undergoing resection, TACE, and ablation in 645 Japanese institutions...
April 21, 2021: American Journal of Gastroenterology
Wen Zhang, Kamal Mahawar, Chetan Parmar, Weiju Chen, Cunchuan Wang, Wah Yang
No abstract text is available yet for this article.
April 19, 2021: American Journal of Gastroenterology
Marina Serper, K Rajender Reddy, Meenakshi Bewtra, Nuzhat Ahmad, Shivan J Mehta
INTRODUCTION: To assess beliefs about safety, effectiveness, and delivery of the coronavirus disease 2019 (COVID-19) vaccine among chronic Gastroenterology and Hepatology patients at an academic health system. METHODS: We asked about vaccine beliefs, vaccine concerns, and preferred location to receive the COVID-19 vaccine. RESULTS: A total of 1,215 patients responded (response rate: 37%). Most patients believed that vaccines are safe, effective, and that they would take the COVID-19 vaccine at a medical office or pharmacy...
April 19, 2021: American Journal of Gastroenterology
Matteo Ghisa, Brigida Barberio, Andrea Buda, Edoardo Savarino
No abstract text is available yet for this article.
April 13, 2021: American Journal of Gastroenterology
Joel H Rubenstein, Trivellore Raghunathan, Cecilia Doan, Jennifer Schneider, Wei Zhao, Valbona Metko, Kimberly Nofz, Maryam Khodadost, Douglas A Corley
INTRODUCTION: Guidelines suggest screening of individuals who are at increased risk of esophageal adenocarcinoma (EAC). Tools for identifying patients at risk of Barrett's esophagus have been validated. Here, we aimed to compare and validate the tools for the primary outcomes of interest: EAC and esophagogastric junction adenocarcinoma (EGJAC). METHODS: Retrospective longitudinal analysis of the Kaiser Permanente Northern California Multiphasic Health Checkup Cohort, a community-based cohort including 206,974 patients enrolled between 1964 and 1973 followed through 2016...
April 13, 2021: American Journal of Gastroenterology
Giorgia Gualtieri, Edoardo Savarino, Brigida Barberio, Salvatore Tolone
No abstract text is available yet for this article.
April 9, 2021: American Journal of Gastroenterology
Sanchit Sharma, Anoop Saraya
No abstract text is available yet for this article.
April 9, 2021: American Journal of Gastroenterology
Maisa I Abdalla, Barrett G Levesque
With the early success of their trials for the treatment of ulcerative colitis, corticosteroids gained popularity as a treatment for inflammatory bowel disease (IBD). However, when used chronically, corticosteroids are not effective in maintaining remission and associated with toxic effects. Steroid-free remission has become a major treatment goal. Prolonged corticosteroid use is currently a sign of suboptimal quality of care. Trends over the past 2 decades, spanning the emergence of biologic therapies for IBD, are explored here in the University of Manitoba IBD Epidemiologic Database...
April 8, 2021: American Journal of Gastroenterology
Dong Ji, Yan Chen, Qinghua Shang, Huabao Liu, Lin Tan, Jing Wang, Yongping Chen, Qin Li, Qinghua Long, Laicheng Song, Li Jiang, Guangming Xiao, Zujiang Yu, Liang Chen, Xiaoyu Hu, Xiaodong Wang, Da Chen, Zhiqin Li, Zheng Dong, Guofeng Chen, Yongping Yang
INTRODUCTION: Little reliable evidence has been reported regarding usefulness of liver stiffness measurement (LSM) for monitoring the hepatic fibrosis changes during treatment. We aimed to assess the association between changes in LSM and histological outcomes in patients with chronic hepatitis B. METHODS: In this prospective multicenter study, 727 treatment-naive patients receiving entecavir-based therapy, who underwent paired biopsies at treatment baseline and week 72, were analyzed...
April 8, 2021: American Journal of Gastroenterology
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