Yang Qu, Changfeng Xiao, Xueyao Wu, Jingwei Zhu, Chenjiarui Qin, Lin He, Huijie Cui, Li Zhang, Wenqiang Zhang, Chunxia Yang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Ben Zhang, Wenzhi Wang, Xia Jiang
Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary modulator, sex hormone-binding globulin (SHBG), remains inconclusive. This study aims to elucidate the genetic overlap between SHBG and heel estimated bone mineral density (eBMD), a widely-accepted tool for osteoporosis management and fracture risk assessment. Using summary statistics from large-scale genome-wide association studies conducted for SHBG (N = 370,125), SHBG adjusted for body mass index (SHBGa, N = 368,929), and eBMD (N = 426,824), a comprehensive genome-wide cross-trait approach was performed to quantify global and local genetic correlations, identify pleiotropic loci, and infer causal associations...
August 24, 2023: Journal of Bone and Mineral Research