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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://read.qxmd.com/read/30786075/maternal-transient-receptor-potential-vanilloid-6-trpv6-is-involved-in-offspring-bone-development
#1
Claudia Fecher-Trost, Femke Lux, Kai-Markus Busch, Ahsan Raza, Manuel Winter, Franziska Hielscher, Thabet Belkacemi, Bram van der Eerden, Ulrich Boehm, Marc Freichel, Petra Weissgerber
Embryonic growth and bone development depend on placental Ca2+ transport across the feto-maternal barrier to supply minerals to the fetus. The individual factors and cellular mechanisms that regulate placental Ca2+ transfer, however, are only beginning to emerge. We find that the Ca2+ -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of the fetal labyrinth, in the yolk sac, and in the maternal part of the placenta. Lack of functional TRPV6 channels in the mother leads to a reduced Ca2+ content in both placenta and embryo...
February 20, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779862/osteogenic-dkk1-mediates-glucocorticoid-induced-but-not-arthritis-induced-bone-loss
#2
Juliane Colditz, Sylvia Thiele, Ulrike Baschant, Annette I Garbe, Christof Niehrs, Lorenz C Hofbauer, Martina Rauner
Dickkopf-1 (Dkk1) is a negative regulator of bone formation and bone mass and is deregulated in bone loss induced by arthritis and glucocorticoid (GC) exposure. However, the role of Dkk1 in these pathological processes is still unknown. Here, we used conditional Dkk1 knock-out mice to determine the role of Dkk1 produced by osteolineage cells in the development of arthritis and GC-induced bone loss. Osteoprogenitor (Osx-Cre)- and osteocyte (Dmp1-Cre)-specific knock-out mice and their Cre-negative controls were subjected to two arthritis models, K/BxN and antigen-induced arthritis...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779861/cost-effectiveness-of-osteoporosis-interventions-to-improve-quality-of-care-after-upper-extremity-fracture-results-from-a-randomized-trial-c-stop-trial
#3
Sumit R Majumdar, Douglas A Lier, Finlay A McAlister, Jeffrey A Johnson, Brian H Rowe, Lauren A Beaupre
We assessed the cost-effectiveness of two models of osteoporosis care after upper extremity fragility fracture using a high-intensity Fracture Liaison Service (FLS) Case-Manager intervention versus a low-intensity FLS (i.e., Active Control), and both relative to usual care. This analysis used data from a pragmatic patient-level parallel-arm comparative effectiveness trial of 361 community-dwelling participants 50 years or older with upper extremity fractures undertaken at a Canadian academic hospital. We used a decision-analytic Markov model to evaluate the cost-effectiveness of the three treatment alternatives...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779860/cost-effectiveness-of-osteoporosis-screening-using-biomechanical-computed-tomography-for-patients-with-a-previous-abdominal-ct
#4
Maria Pisu, David L Kopperdahl, Cora E Lewis, Kenneth G Saag, Tony M Keaveny
Osteoporosis screening rates by DXA are low (9.5% women, 1.7% men) in the U.S. Medicare population aged 65 and older. Addressing this care gap, we estimated the benefits of a validated osteoporosis diagnostic test suitable for patients age 65 and older with an abdominal computed tomography (CT) scan taken for any indication but without a recent DXA. Our analysis assessed a hypothetical cohort of 1,000 such patients in a given year, and followed them for five years. Separately for each sex, we used Markov modeling to compare two mutually exclusive scenarios: 1) utilizing the CT scans, perform one-time "biomechanical computed tomography" (BCT) analysis to identify high-risk patients on the basis of both femoral strength and hip BMD T-scores; 2) ignore the CT scan, and rely instead on usual care, consisting of future annual DXA screening at typical Medicare rates...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779859/treated-osteoporosis-is-still-osteoporosis
#5
E Michael Lewiecki, Neil Binkley, John P Bilezikian
No abstract text is available yet for this article.
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779858/fra1-controls-rheumatoid-factor-autoantibody-production-by-bone-marrow-plasma-cells-and-the-development-of-autoimmune-bone-loss
#6
Bettina Grötsch, Anja Lux, Yoann Rombouts, Anna-Carin Hoffmann, Darja Andreev, Falk Nimmerjahn, Wei Xiang, Hans Ulrich Scherer, Georg Schett, Aline Bozec
Next to pro-inflammatory cytokines, autoimmunity has been identified as key trigger for osteoclast activation and bone loss. IgG rheumatoid factor immune complexes (IgG-RF), which are present in rheumatoid arthritis (RA) patients were shown to boost osteoclast differentiation. To date, the regulation of IgG-RF production in absence of inflammatory triggers however is unknown. Herein, we describe Fra1 as a key checkpoint that controls IgG-RF production by plasma cells and regulates autoimmune-mediated bone loss...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779856/a-meta-analysis-of-genome-wide-association-studies-identifies-three-loci-associated-with-stiffness-index-of-the-calcaneus
#7
Hsing-Fang Lu, Kuo-Sheng Hung, Hou-Wei Chu, Henry Sung-Ching Wong, Jihye Kim, Bo Youl Choi, Mi Kyung Kim, Yu-Ting Tai, Shiro Ikegawa, Er-Chieh Cho, Wei-Chiao Chang
The stiffness index (SI) from quantitative ultrasound measurements is a good indicator of bone-mineral density and may be used to predict risk of osteoporotic fracture. We conducted a genome-wide association study (GWAS) for SI using 7,742 individuals from the Taiwan Biobank, followed by a replication study in a Korean population (n = 2,955). Approximately 6.1 million SNPs were subjected to association analysis, and SI-associated variants were identified. We further conducted meta-analysis of Taiwan Biobank significant SNPs with a Korean population-based cohort...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779854/cyclic-dinucleotides-inhibit-osteoclast-differentiation-through-sting-mediated-interferon-%C3%AE-signaling
#8
Yeongkag Kwon, Ok-Jin Park, Jiseon Kim, Jae Ho Cho, Cheol-Heui Yun, Seung Hyun Han
Cyclic dinucleotides (CDNs) such as cyclic diadenylate monophosphate and cyclic diguanylate monophosphate are commensal bacteria-derived second messengers in the gut that modulate bacterial survival, colonization, and biofilm formation. Recently, CDNs have been discovered to have an immunomodulatory activity by inducing the expression of type I interferon (IFN) through STING signaling pathway in macrophages. Since CDNs are possibly absorbed and delivered into the bone marrow, where bone-resorbing osteoclasts are derived from monocyte/macrophage lineages, CDNs could affect bone metabolism by regulating osteoclast differentiation...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30779853/sinusoidal-electromagnetic-fields-increase-peak-bone-mass-in-rats-by-activating-wnt10b-%C3%AE-catenin-in-primary-cilia-of-osteoblasts
#9
Jian Zhou, Yu-Hai Gao, Bao-Ying Zhu, Jia-Le Shao, Hui-Ping Ma, Cory J Xian, Ke-Ming Chen
Extremely-low frequency electromagnetic fields have been considered as a potential candidate for the prevention and treatment of osteoporosis; however, their action mechanism and optimal magnetic flux density (intensity) parameter are still elusive. The present study found that 50 Hz sinusoidal electromagnetic fields (SEMFs) at 1.8 mT increased the peak bone mass of young rats by increasing bone formation. Gene array expression studies with femoral bone samples showed that SEMFs increased the expression levels of collagen-1α1 and Wnt10b, a critical ligand of the osteogenic Wnt/β-catenin pathway...
February 19, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30742350/chronic-kidney-disease-worsens-health-outcomes-in-diabetic-patients-after-hip-fracture-surgery-an-asian-nationwide-population-based-cohort-study
#10
Po-Hua Huang, Tien-Hsing Chen, Yu-Sheng Lin, Su-Ju Lin, Liang-Tseng Kuo, Chi-Lung Chen, Pei-An Yu, Wei-Hsiu Hsu
There is an increased tendency for hip fractures in patients with chronic kidney disease (CKD). Although surgery is the mainstay of treatment for hip fractures, there is scant information on outcomes after hip fracture surgery in diabetic patients at different stages of CKD. In this population-based cohort study, we compared the surgical outcome, readmission, and mortality rates after osteosynthesis of hip fractures in diabetic patients with different stages of renal function. Diabetic patients who received primary osteosynthesis for hip fracture between January 1997 and December 2013 were enrolled...
February 11, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30730595/adults-with-cerebral-palsy-have-higher-prevalence-of-fracture-compared-to-adults-without-cerebral-palsy-independent-of-osteoporosis-and-cardiometabolic-diseases
#11
Daniel G Whitney, Andrea I Alford, Maureen J Devlin, Michelle S Caird, Edward A Hurvitz, Mark D Peterson
Individuals with cerebral palsy (CP) have increased risk of fracture throughout their lifespan due to an underdeveloped musculoskeletal system, excess body fat, diminished mechanical loading, and early development of noncommunicable diseases. However, the epidemiology of fracture among adults with CP is unknown. The purpose of this cross-sectional study was to determine the prevalence of fracture among a large sample of privately-insured adults with CP, as compared to adults without CP. Data were from the Optum Clinformatics® Data Mart, a de-identified nationwide claims database of beneficiaries from a single private payer...
February 7, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30730590/reliability-of-annual-changes-and-monitoring-time-intervals-for-bone-strength-size-density-and-micro-architectural-development-at-the-distal-radius-and-tibia-in-children-a-1-year-hr-pqct-follow-up
#12
Amy Bunyamin, Kelsey Björkman, Chantal Kawalilak, Seyedmahdi Hosseinitabatabaei, Adrian Teare, James Johnston, Saija Kontulainen
High-resolution peripheral quantitative computed tomography (HR-pQCT) imaging, together with computational finite element analysis (FEA), offers an attractive, non-invasive tool to quantify bone strength development in pediatric studies. Evidence of annual changes and errors in repeated HR-pQCT measures is limited, and time intervals required to reliably capture changes in children's bone strength or micro-architecture have not yet been defined. Our objectives were to: 1) quantify annual changes in bone strength and micro-architectural properties, 2) define precision errors for pediatric bone strength outcomes; 3) characterize annual changes in contrast to pediatric precision errors; and 4) estimate monitoring time intervals (MTIs) required to reliably characterize bone development at the distal radius and tibia...
February 7, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30730587/towards-a-consensus-on-vitamin-d-supplementation-and-bone-health
#13
LETTER
Toshihiro Sugiyama
No abstract text is available yet for this article.
February 7, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30723960/incident-fragility-fractures-have-a-long-term-negative-impact-on-health-related-quality-of-life-of-older-people-the-canadian-multicentre-osteoporosis-study
#14
Sayem Borhan, Alexandra Papaioannou, Olga Gajic-Veljanoski, Courtney Kennedy, George Ioannidis, Claudie Berger, David Goltzman, Robert Josse, Christopher S Kovacs, David A Hanley, Jerilynn C Prior, Suzanne N Morin, Stephanie M Kaiser, Angela M Cheung, Lehana Thabane, Jonathan Adachi
Although the short-term impact of incident fragility fractures on health-related quality of life (HRQL) of older people has been confirmed, we lack long-term evidence. We explored the impact of incident fragility fractures on HRQL, among people aged 50 years and older, using 10-year prospective data from the Canadian Multicentre Osteoporosis Study (CaMos). This study was based on data from 7753 (2187 men and 5566 women) participants of CaMos. The HRQL, measured through the Health Utility Index (HUI), was captured at baseline and year 10...
February 5, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30721543/cooperation-of-pu-1-with-irf8-and-nfatc1-defines-chromatin-landscapes-during-rankl-induced-osteoclastogenesis
#15
Naohiro Izawa, Daisuke Kurotaki, Seitaro Nomura, Takanori Fujita, Yasunori Omata, Tetsuro Yasui, Jun Hirose, Takumi Matsumoto, Taku Saito, Yuho Kadono, Hiroyuki Okada, Takeshi Miyamoto, Tomohiko Tamura, Hiroyuki Aburatani, Sakae Tanaka
Receptor activator of nuclear factor κB ligand (RANKL) induces osteoclast (OC) differentiation from bone marrow-derived macrophages (BMMs). The transcription factors nuclear factor of activated T cells 1 (NFATc1) and interferon regulatory factor (IRF) 8 play positive and negative roles, respectively, in this process. However, genome-wide mapping of the active cis-regulatory elements regulating OC differentiation has not been performed, and little is known about the global landscape of OC-specific gene regulation...
February 5, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30721533/simplod-a-structure-integrated-database-of-collagen-lysyl-hydroxylase-lh-plod-enzyme-variants
#16
Luigi Scietti, Matteo Campioni, Federico Forneris
PLOD genes encode for procollagen lysyl hydroxylase enzymes (LH/PLOD), a family of proteins essential for collagen biosynthesis. Several mutations affect these genes causing severe disorders, such as Ehlers-Danlos and Bruck syndrome, as well a connective tissue disease with phenotype resembling osteogenesis imperfecta caused by lack of LH3 functions. The recently determined three-dimensional structures of the full-length human LH3/PLOD3 isoform, together with the structure of a fragment of a viral LH/PLOD homolog, are now allowing molecular mapping of the numerous disease-causing mutations, providing insights often suitable for the interpretation of the resulting disease phenotypes...
February 5, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30721528/slc20a2-encoding-the-phosphate-transporter-pit2-is-an-important-genetic-determinant-of-bone-quality-and-strength
#17
Sarah Beck-Cormier, Christopher J Lelliott, John G Logan, David T Lafont, Laure Merametdjian, Victoria D Leitch, Natalie C Butterfield, Hayley J Protheroe, Peter I Croucher, Paul A Baldock, Alina Gaultier-Lintia, Yves Maugars, Gael Nicolas, Christopher Banse, Sébastien Normant, Nicolas Magne, Emmanuel Gérardin, Nina Bon, Sophie Sourice, Jérôme Guicheux, Laurent Beck, Graham R Williams, J H Duncan Bassett
Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of bone mineral density, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2-/- mice lacking the phosphate transporter SLC20A2...
February 5, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30715766/role-of-epigenomics-in-bone-and-cartilage-disease
#18
REVIEW
Joyce Bj van Meurs, Cindy G Boer, Laura Lopez-Delgado, Jose A Riancho
Phenotypic variation in skeletal traits and diseases is the product of genetic and environmental factors. Epigenetic mechanisms include information-containing factors, other than DNA sequence, that cause stable changes in gene expression and are maintained during cell divisions. They represent a link between environmental influences, genome features, and the resulting phenotype. The main epigenetic factors are DNA methylation, posttranslational changes of histones, and higher-order chromatin structure. Sometimes non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are also included in the broad term of epigenetic factors...
February 4, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30715760/amino-bisphosphonates-and-cardiovascular-risk-a-new-hypothesis-involving-the-effects-on-gamma-delta-t-cells
#19
LETTER
Alessandro Giollo, Maurizio Rossini, Davide Gatti, Giovanni Adami, Giovanni Orsolini, Angelo Fassio, Cristian Caimmi, Luca Idolazzi, Ombretta Viapiana
No abstract text is available yet for this article.
February 4, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://read.qxmd.com/read/30715752/external-bone-size-is-a-key-determinant-of-strength-decline-trajectories-of-aging-male-radii
#20
Erin Mr Bigelow, Daniella M Patton, Ferrous S Ward, Antonio Ciarelli, Michael Casden, Andrea Clark, Robert W Goulet, Michael D Morris, Stephen H Schlecht, Gurjit S Mandair, Todd L Bredbenner, David H Kohn, Karl J Jepsen
Given prior work showing associations between remodeling and external bone size, we tested the hypothesis that wide bones would show a greater negative correlation between whole-bone strength and age compared with narrow bones. Cadaveric male radii (n = 37 pairs, 18 to 89 years old) were evaluated biomechanically, and samples were sorted into narrow and wide subgroups using height-adjusted robustness (total area/bone length). Strength was 54% greater (p < 0.0001) in wide compared with narrow radii for young adults (<40 years old)...
February 4, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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