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Journals Journal of Bone and Mineral Re...

Journal of Bone and Mineral Research

https://read.qxmd.com/read/38624186/assessment-of-causal-association-between-the-socio-economic-status-and-osteoporosis-and-fractures-a-bidirectional-mendelian-randomization-study-in-european-population
#1
JOURNAL ARTICLE
Jia-Yue Duan, Rui-Xuan You, Yong Zhou, Feng Xu, Xiao Lin, Su-Kang Shan, Ming-Hui Zheng, Li-Min Lei, Fu-Xing-Zi Li, Bei Guo, Yun-Yun Wu, Xi Chen, Ke-Xin Tang, Ye-Chi Cao, Yan-Lin Wu, Si-Yang He, Rong Xiao, Ling-Qing Yuan
BACKGROUND: The relationship between socio-economic status and bone-related diseases is attracting increasing attention. Therefore, a bidirectional Mendelian randomization (MR) analysis was performed in this study. METHODS: Genetic data on factors associated with socio-economic status (average total household income before tax, years of schooling completed and Townsend Deprivation Index at recruitment), femoral neck bone mineral density (FN-BMD), heel bone mineral density (eBMD), osteoporosis, and five different sites of fracture (spine, femur, lower leg-ankle, foot, and wrist-hand fractures) were derived from genome-wide association summary statistics of European ancestry...
April 16, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38619297/evaluating-the-comparability-of-osteoporosis-treatments-using-propensity-score-and-negative-control-outcome-methods-in-uk-and-denmark-electronic-health-record-databases
#2
JOURNAL ARTICLE
Eng Hooi Tan, Trishna Rathod-Mistry, Victoria Y Strauss, James O'Kelly, Francesco Giorgianni, Richard Baxter, Vanessa C Brunetti, Alma Becic Pedersen, Vera Ehrenstein, Daniel Prieto-Alhambra
Evidence on the comparative effectiveness of osteoporosis treatments is heterogeneous. This may be attributed to different populations and clinical practice, but also to differing methodologies ensuring comparability of treatment groups before treatment effect estimation and the amount of residual confounding by indication. This study assessed the comparability of denosumab vs oral bisphosphonate (OBP) groups using propensity score (PS) methods and negative control outcome (NCO) analysis. A total of 280 288 women aged ≥50 years initiating denosumab or OBP in 2011-2018 were included from the UK Clinical Practice Research Datalink (CPRD) and the Danish National Registries (DNR)...
April 15, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38619281/rankl-signaling-drives-skeletal-muscle-into-the-oxidative-profile
#3
JOURNAL ARTICLE
Paulo Henrique Cavalcanti de Araújo, Maria Eduarda Ramos Cezine, Anderson Vulczak, Luiz Carlos Vieira, Flávia Sayuri Matsuo, Júlia Maranghetti Remoto, Audrei Dos Reis Santos, Elen Haruka Miyabara, Luciane Carla Alberici, Mariana Kiomy Osako
The bone-muscle unit refers to the reciprocal regulation between bone and muscle by mechanical interaction and tissue communication via soluble factors. The receptor activator of NF-κB ligand (RANKL) stimulation induces mitochondrial biogenesis and increases the oxidative capacity in osteoclasts and adipocytes. RANKL may bind to the membrane bound receptor activator of NF-κB (RANK) or to osteoprotegerin (OPG), a decoy receptor that inhibits RANK-RANKL activation. RANK is highly expressed in skeletal muscle, but the contribution of RANKL to healthy skeletal muscle fiber remains elusive...
April 15, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38613689/bone-biopsy-for-the-diagnosis-of-osteomalacia-can-we-avoid-it
#4
JOURNAL ARTICLE
Maria Belen Zanchetta, Alessandro Corsi
No abstract text is available yet for this article.
April 13, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38613445/effects-of-vitamin-d3-omega-3%C3%A2-s-and-a-simple-strength-training-exercise-program-on-bone-health-the-do-health-randomized-controlled-trial
#5
JOURNAL ARTICLE
Kistler-Fischbacher Melanie, Armbrecht Gabriele, Gängler Stephanie, Theiler Robert, Rizzoli Renè, Dawson-Hughes Bess, A Kanis John, C Hofbauer Lorenz, C Schimmer Ralph, Vellas Bruno, A P Da Silva José, Orav E John, W Kressig Reto, Egli Andreas, Lang Wei, A Wanner Guido, A Bischoff-Ferrari Heike
INTRODUCTION: Evidence on the effects of Vitamin D, omega-3 s and exercise on aBMD in healthy older adults is limited. We examined whether vitamin D3, omega-3 s, or a simple home-based exercise program (SHEP), alone or in combination, over three years, improve lumbar spine (LS), femoral neck (FN) or total hip (TH) aBMD assessed by DXA. METHODS: aBMD was a secondary outcome in DO-HEALTH, a 3-year, multicenter, double-blind, randomized 2 × 2 × 2 factorial design trial in generally healthy older adults age ≥ 70 years...
April 13, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38591788/ultrashort-echo-time-mri-detects-significantly-lower-collagen-but-higher-pore-water-in-the-tibial-cortex-of-female-patients-with-osteopenia-and-osteoporosis
#6
JOURNAL ARTICLE
Saeed Jerban, Yajun Ma, Zhao Wei, Meghan Shen, Zubaid Ibrahim, Hyungseok Jang, Pengzhe Lu, Douglas G Chang, Gina Woods, Christine B Chung, Eric Y Chang, Jiang Du
Ultrashort echo time (UTE) MRI can quantify the major proton pool densities in cortical bone, including total (TWPD), bound (BWPD), and pore water (PWPD) proton densities, as well as the macromolecular proton density (MMPD), associated with the collagen content, which is calculated using macromolecular fraction (MMF) from UTE magnetization transfer (UTE-MT) modeling. This study aimed to investigate the differences in water and collagen contents in tibial cortical bone, between female osteopenia (OPe) patients, osteoporosis (OPo) patients, and young participants (Young)...
April 9, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38590263/low-dose-infigratinib-increases-bone-growth-and-corrects-growth-plate-abnormalities-in-an-achondroplasia-mouse-model
#7
JOURNAL ARTICLE
Benoit Demuynck, Justine Flipo, Nabil Kaci, Carl Dambkowski, Morgan Paull, Elena Muslimova, Bhavik P Shah, Laurence Legeai-Mallet
Achondroplasia, the most common form of disproportionate short stature, is caused by gain-of-function point mutations in fibroblast growth factor receptor 3 (FGFR3). Abnormally elevated activation of FGFR3 modulates chondrocyte proliferation and differentiation via multiple signaling pathways, such as the MAPK pathway. Using a mouse model mimicking achondroplasia (Fgfr3Y367C/+), we have previously shown that daily treatment with infigratinib (BGJ398), a selective and orally bioavailable FGFR1-3 inhibitor, at a dose of 2 mg/kg, significantly increased bone growth...
April 9, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38590141/the-american-society-for-bone-and-mineral-research-task-force-on-clinical-algorithms-for-fracture-risk-report
#8
JOURNAL ARTICLE
Sherri-Ann M Burnett-Bowie, Nicole C Wright, Elaine W Yu, Lisa Langsetmo, Gabby M H Yearwood, Carolyn J Crandall, William D Leslie, Jane A Cauley
Using race and ethnicity in clinical algorithms potentially contributes to health inequities. The American Society for Bone and Mineral Research (ASBMR) Professional Practice Committee convened the ASBMR Task Force on Clinical Algorithms for Fracture Risk to determine the impact of race and ethnicity adjustment in the US Fracture Risk Assessment Tool (US-FRAX). The Task Force engaged the University of Minnesota Evidence-based Practice Core to conduct a systematic review investigating the performance of US-FRAX for predicting incident fractures over 10 years in Asian, Black, Hispanic, and White individuals...
April 9, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38578978/oral-daily-pth-1-34-tablets-eb613-in-postmenopausal-women-with-low-bmd-or-osteoporosis-a-randomized-placebo-controlled-six-month-phase-2-study
#9
JOURNAL ARTICLE
Liana Tripto-Shkolnik, Auryan Szalat, Gloria Tsvetov, Vanessa Rouach, Chana Sternberg, Anke Hoppe, Gregory Burshtein, Hillel Galitzer, Miranda Toledano, Gil Harari, Arthur C Santora, Felicia Cosman
Anabolic treatment is indicated for high and very-high risk patients with osteoporosis, but acceptance is limited because current anabolic medications require subcutaneous injections. The purpose of this study was to assess the effects of a novel orally administered parathyroid hormone (PTH) tablet on serum markers of bone formation [N-terminal propeptide of Type I procollagen (PINP) and osteocalcin (OC)] and bone resorption [crosslinked C-telopeptide (CTX)], bone mineral density (BMD) and safety in postmenopausal women with low BMD or osteoporosis...
April 5, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38560996/racial-differences-as-an-explanation-of-observed-differences-in-bone-tissue-stiffness-hardness-and-bone-turnover-markers
#10
JOURNAL ARTICLE
Jakob Starup-Linde, Helena Bardenfleth, Torben Harsløf, Bente Langdahl
No abstract text is available yet for this article.
April 1, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38547399/maternal-diabetes-and-fracture-risk-in-offspring-a-population-based-analysis
#11
JOURNAL ARTICLE
Viral N Shah, William D Leslie, Maria-Elena Lautatzis, Kun Liu, Heather J Prior, Brandy Wicklow
Factors affecting intrauterine environment exerts influence on skeletal health and fracture risk in later life. Diabetes during pregnancy is known to influence birth weight and is associated with fetal overgrowth. However, the effects of maternal diabetes on fracture risk in offspring is unknown. This study was aimed to evaluate the association between maternal diabetes and fracture risk in offspring. Using population-based administrative health data for Manitoba, Canada, we identified deliveries complicated by gestational diabetes and type 2 diabetes between April 1, 1980 and March 31, 2020...
March 28, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38528315/the-hypoxia-signature-across-skeletal-progenitor-cells
#12
JOURNAL ARTICLE
Elena Sabini, Ernestina Schipani
No abstract text is available yet for this article.
March 25, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38526976/affinity-targeting-of-therapeutic-proteins-to-the-bone-surface-local-delivery-of-sclerostin-neutralizing-antibody-enhances-efficacy
#13
JOURNAL ARTICLE
Boya Zhang, W Benton Swanson, Margaret Durdan, Heather N Livingston, Michaela Dodd, Sachith M Vidanapathirana, Alec Desai, Lindsey Douglas, Yuji Mishina, Megan Weivoda, Colin F Greineder
Currently available biotherapeutics for the treatment of osteoporosis lack explicit mechanisms for bone localization, potentially limiting efficacy and inducing unintended off-target toxicities. While various strategies have been explored for targeting the bone surface, critical aspects remain poorly understood, including the optimal affinity ligand, the role of binding avidity and circulation time, and, perhaps most importantly, whether or not this strategy can enhance the functional activity of clinically relevant protein therapeutics...
March 25, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38502868/a-delicate-balance-the-challenges-of-hypoparathyroidism
#14
JOURNAL ARTICLE
Garyfallia Papaioannou, Michael Mannstadt
A 38-year-old woman with chronic non-surgical hypoparathyroidism, managed elsewhere, presented to our practice with symptomatic hypocalcemia. At the age of 17, she began to suffer from muscle cramps, paresthesia, and ongoing diffuse pain. It took years before she was correctly diagnosed with hypoparathyroidism. Her symptoms were severe enough that she required emergency room (ER) visits several times a year. After she was properly diagnosed and started on calcium and calcitriol therapy, she continued to experience frequent episodes of severe hypocalcemia...
March 19, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38501786/anti-fracture-treatment-efficacy-by-age
#15
JOURNAL ARTICLE
Marian Schini, Tatiane Vilaca, Eric Vittinghoff, Li-Yung Lui, Susan K Ewing, Austin Thompson, Douglas C Bauer, Mary L Bouxsein, Dennis M Black, Richard Eastell
There is a common belief that antiosteoporosis medications are less effective in older adults. This study used data from randomized controlled trials (RCTs) to determine whether the anti-fracture efficacy of treatments and their effects on bone mineral density (BMD) differ in people ≥70 compared to those <70 years. We used individual patient data from 23 RCTs of osteoporosis medications collected as part of the FNIH-ASBMR SABRE project. We assessed the following fractures: radiographic vertebral, non-vertebral, hip, all clinical and all fractures...
March 19, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38630872/diagnosis-and-therapeutic-decisions-of-osteoporosis-in-chronic-kidney-disease
#16
JOURNAL ARTICLE
Hanne Skou Jørgensen, Sharon Moe, Thomas L Nickolas
No abstract text is available yet for this article.
March 17, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38493502/the-potential-of-the-proteome-to-predict-fracture
#17
EDITORIAL
Ryan C Chai, Robert D Blank
No abstract text is available yet for this article.
March 16, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38484114/genome-wide-association-study-of-osteoporosis-identifies-genetic-risk-and-interactions-with-dash-diet-and-sugar-sweetened-beverages-in-a-hispanic-cohort-of-older-adults
#18
JOURNAL ARTICLE
Liam E Fouhy, Chao-Qiang Lai, Laurence D Parnell, Katherine L Tucker, José M Ordovás, Sabrina E Noel
BACKGROUND: Osteoporosis (OP) and low bone mass can be debilitating and costly conditions if not acted on quickly. This disease is also difficult to diagnose as symptoms develop unnoticed until fracture occurs. Therefore, gaining understanding of the genetic risk associated with these conditions could be beneficial for healthcare professionals in early detection and prevention. METHODS: The Boston Puerto Rican Osteoporosis (BPROS) study, an ancillary study to the Boston Puerto Rican Health Study (BPRHS), collected information regarding bone and bone health...
March 14, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38484138/calcium-balance-considerations-for-the-bone-response-to-exercise
#19
JOURNAL ARTICLE
Sarah J Wherry
No abstract text is available yet for this article.
March 13, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477792/lepr-stromal-cells-respond-to-periodontitis-and-attenuate-alveolar-bone-repair-via-ccrl2-mediated-wnt-inhibition
#20
JOURNAL ARTICLE
Yongliang Chen, Yuteng Weng, Jie Huang, Qin Li, Bin Sun, Haicheng Wang, Zuolin Wang
The impaired bone healing in tooth extraction sockets due to periodontitis presents a major obstacle to restoring oral health. The mechanisms regulating osteogenic capacity of jawbone derived stromal cells in periodontitis microenvironment remain elusive. Leptin receptor (LepR) expressing stromal cells, which largely overlap with Cxcl12-abundant reticular (CAR) cells in bone tissue, rapidly proliferate and differentiate into bone-forming cells during extraction socket healing to support alveolar bone repair...
March 12, 2024: Journal of Bone and Mineral Research
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