journal
https://read.qxmd.com/read/38423280/the-clinical-frailty-scale-for-risk-stratification-in-patients-with-fibrotic-interstitial-lung-disease
#21
JOURNAL ARTICLE
Sabina A Guler, Daniel-Costin Marinescu, Gerard Cox, Celine Durand, Jolene H Fisher, Amanda Grant-Orser, Gillian C Goobie, Nathan Hambly, Kerri A Johannson, Nasreen Khalil, Martin Kolb, Stacey Lok, Sarah MacIsaac, Helene Manganas, Veronica Marcoux, Julie Morisset, Ciaran Scallan, Shane Shapera, Kelly Sun, Boyang Zheng, Christopher J Ryerson, Alyson W Wong
BACKGROUND: Previous studies have shown the importance of frailty in patients with fibrotic interstitial lung disease (ILD). RESEARCH QUESTION: Is the Clinical Frailty Scale (CFS) a valid tool to improve risk stratification in patients with fibrotic ILD? STUDY DESIGN AND METHODS: Patients with fibrotic ILD were included from the prospective multicenter Canadian Registry for Pulmonary Fibrosis. The CFS was assessed using available information from initial ILD clinic visits...
February 27, 2024: Chest
https://read.qxmd.com/read/38423279/abnormal-exertional-breathlessness-on-cardiopulmonary-cycle-exercise-testing-in-relation-to-self-reported-and-physiological-responses-in-chronic-airflow-limitation
#22
JOURNAL ARTICLE
Magnus Ekström, Pei Zhi Li, Hayley Lewthwaite, Jean Bourbeau, Wan C Tan, Dennis Jensen
BACKGROUND: Exertional breathlessness is a cardinal symptom of cardiorespiratory disease. RESEARCH QUESTION: How does breathlessness abnormality graded using normative reference equations during cardiopulmonary exercise testing (CPET) relate to self-reported and physiological responses in people with chronic airflow limitation (CAL). STUDY DESIGN AND METHODS: Analysis of people aged ≥40 years with CAL undergoing CPET in the Canadian Cohort Obstructive Lung Disease study...
February 27, 2024: Chest
https://read.qxmd.com/read/38423278/veno-venous-extracorporeal-membrane-oxygenation-vv-ecmo-candidacy-decision-making-lessons-and-hypotheses-from-a-single-center-observational-analysis
#23
JOURNAL ARTICLE
Jonah Rubin, Alison S Witkin, Jerome C Crowley, Eriberto Michel, David M Furfaro, Ricardo Teijeiro-Paradis, Annette Ilg, Raghu Seethala, Sophia Zhao, Eddy Fan
BACKGROUND: Utilization of veno-venous extracorporeal membrane oxygenation (V-V ECMO) is increasing, but candidacy selection processes are variable and subject to bias. RESEARCH QUESTION: What are the reasons behind V-V ECMO candidacy decisions, and are decisions made consistently across patients? STUDY DESIGN AND METHODS: Prospective observational study of all patients, admitted or outside hospital referrals, considered for V-V ECMO at a tertiary referral center...
February 27, 2024: Chest
https://read.qxmd.com/read/38417700/how-i-do-it-applying-non-invasive-ventilation-in-treatment-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-using-evidence-based-interprofessional-clinical-practice
#24
REVIEW
Mary Jo S Farmer, Christine Callahan, Ashley M Hughes, Karen Riska, Nicholas Hill
When administered as first-line intervention to patients admitted with acute hypercapnic respiratory failure secondary to chronic obstructive pulmonary disease exacerbation in conjunction with guideline recommended therapies, noninvasive ventilation (NIV) has been shown to reduce mortality and endotracheal intubation. Opportunities to increase uptake of NIV continue to exist despite inclusion of this therapy in clinical guidelines. Identifying patients appropriate for NIV, and subsequently providing close monitoring to determine an improvement in clinical condition involves a team consisting of physician, nurse and respiratory therapist in institutions that successfully implement NIV...
February 26, 2024: Chest
https://read.qxmd.com/read/38403186/non-invasive-electromagnetic-phrenic-nerve-stimulation-in-critically-ill-patients-a-feasibility-study
#25
JOURNAL ARTICLE
Alessandro Panelli, Aline M Grimm, Sven Krause, Michael A Verfuß, Bernhard Ulm, Julius J Grunow, Hermann G Bartels, Niklas M Carbon, Thomas Niederhauser, Steffen Weber-Carstens, Laurent Brochard, Stefan J Schaller
BACKGROUND: Electromagnetic stimulation of the phrenic nerve induces diaphragm contractions, but no coils for clinical use have been available. We recently demonstrated the feasibility of ventilation using bilateral transcutaneous non-invasive electromagnetic phrenic nerve stimulation (NEPNS) preoperatively in lung-healthy, normal-weight patients in a dose-dependent manner. RESEARCH QUESTION: Is NEPNS feasible in critically ill patients in an ICU setting? STUDY DESIGN AND METHODS: This feasibility non-randomized controlled study aimed to enroll patients within 36h of intubation, who were expected to remain ventilated for ≥72h...
February 23, 2024: Chest
https://read.qxmd.com/read/38395297/international-variation-in-severe-exacerbation-rates-in-patients-with-severe-asthma
#26
JOURNAL ARTICLE
Tae Yoon Lee, David Price, Chandra Prakash Yadav, Rupsa Roy, Laura Lim Huey Mien, Eileen Wang, Michael E Wechsler, David J Jackson, John Busby, Liam G Heaney, Paul E Pfeffer, Bassam Mahboub, Diahn-Warng Perng Steve, Borja G Cosio, Luis Perez-de-Llano, Riyad Al-Lehebi, Désirée Larenas-Linnemann, Mona Al-Ahmad, Chin Kook Rhee, Takashi Iwanaga, Enrico Heffler, Giorgio Walter Canonica, Richard Costello, Nikolaos G Papadopoulos, Andriana I Papaioannou, Celeste M Porsbjerg, Carlos A Torres-Duque, George C Christoff, Todor A Popov, Mark Hew, Matthew Peters, Peter G Gibson, Jorge Maspero, Celine Bergeron, Saraid Cerda, Elvia Angelica Contreras Contreras, Wenjia Chen, Mohsen Sadatsafavi
BACKGROUND: Exacerbation frequency strongly influences treatment choices in patients with severe asthma. RESEARCH QUESTION: What is the extent of the variability of exacerbations rate across countries and its implications in disease management? STUDY DESIGN AND METHODS: We retrieved data from the International Severe Asthma Registry, an international observational cohort of patients with a clinical diagnosis of severe asthma. We identified patients aged ≥18 years who did not initiate any biologics prior to baseline visit...
February 21, 2024: Chest
https://read.qxmd.com/read/38387649/disproportionate-use-of-the-emergency-department-by-patients-3-years-after-evali
#27
JOURNAL ARTICLE
Michael S Zhang, Taylor Nee, Michael Lynch, Jason Rose, Alison Morris, Divay Chandra
No abstract text is available yet for this article.
February 20, 2024: Chest
https://read.qxmd.com/read/38387648/anaerobic-antibiotic-coverage-in-aspiration-pneumonia-and-the-associated-benefits-and-harms-a-retrospective-cohort-study
#28
JOURNAL ARTICLE
Anthony D Bai, Siddhartha Srivastava, Geneviève C Digby, Vincent Girard, Fahad Razak, Amol A Verma
BACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines. RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis? METHODS: We conducted a multicenter retrospective cohort study across 18 hospitals in Ontario, Canada from January 1, 2015 to January 1, 2022...
February 20, 2024: Chest
https://read.qxmd.com/read/38387647/barriers-and-facilitators-of-surrogates-providing-consent-for-critically-ill-patients-in-clinical-trials-a-qualitative-study
#29
JOURNAL ARTICLE
Dustin C Krutsinger, Shannon I Maloney, Katherine R Courtright, Karsten Bartels
BACKGROUND: Enrollment into critical care clinical trials is often hampered by the need to rely on surrogate decision-makers. To identify potential interventions facilitating enrollment into critical care clinical trials, a better understanding of surrogate decision-making for critical care clinical trial enrollment is needed. RESEARCH QUESTION: What are the barriers and facilitators of critical care trial enrollment? What are surrogate decision-makers' perspectives on proposed interventions to facilitate trial enrollment? STUDY DESIGN AND METHODS: We conducted semistructured interviews with 20 surrogate decision-makers of critically ill patients receiving mechanical ventilation...
February 20, 2024: Chest
https://read.qxmd.com/read/38387646/ct-imaging-assessment-of-response-to-treatment-in-allergic-bronchopulmonary-aspergillosis-in-adults-with-bronchial-asthma
#30
JOURNAL ARTICLE
Cendrine Godet, Anne-Laure Brun, Francis Couturaud, François Laurent, Jean-Pierre Frat, Sylvain Marchand-Adam, Frédéric Gagnadoux, Elodie Blanchard, Camille Taillé, Bruno Philippe, Sandrine Hirschi, Claire Andréjak, Arnaud Bourdin, Cécile Chenivesse, Stéphane Dominique, Gilles Mangiapan, Marlène Murris-Espin, Frédéric Rivière, Gilles Garcia, François-Xavier Blanc, François Goupil, Anne Bergeron, Thomas Flament, Pascaline Priou, Hervé Mal, Joe de Keizer, Stéphanie Ragot, Jacques Cadranel
BACKGROUND: One of the major challenges in managing allergic bronchopulmonary aspergillosis (ABPA) remains consistent and reproducible assessment of response to treatment. RESEARCH QUESTION: What are the most relevant changes in computed tomography (CT-scan) parameters over time for assessing response to treatment? STUDY DESIGN AND METHODS: In this ancillary study of a randomized clinical trial (NEBULAMB), asthmatic patients with available CT-scan and without exacerbation during a 4-month ABPA exacerbation treatment period (corticosteroids and itraconazole) were included...
February 20, 2024: Chest
https://read.qxmd.com/read/38382876/clinician-and-patient-identified-solutions-to-reduce-the-fragmentation-of-post-icu-care-in-australia
#31
JOURNAL ARTICLE
Nina Leggett, Kate Emery, Thomas C Rollinson, Adam M Deane, Craig French, Jo-Anne Manski-Nankervis, Glenn Eastwood, Briannah Miles, Sophie Witherspoon, Jonathan Stewart, Mark Merolli, Yasmine Ali Abdelhamid, Kimberley J Haines
BACKGROUND: Critical care survivors experience multiple care transitions, with no formal follow-up care pathway. RESEARCH QUESTION: What are the potential solutions to improve the communication between treating teams and integration of care following an Intensive Care Unit (ICU) admission - from the perspective of patients, their caregivers, intensivists, and General Practitioners (GPs) from diverse socioeconomic areas? STUDY DESIGN: & Methods: Qualitative design using semi-structured interviews with intensivists, GPs, and patients and caregivers...
February 19, 2024: Chest
https://read.qxmd.com/read/38373673/automatic-mechanical-ventilation-versus-manual-bag-ventilation-during-cardiopulmonary-resuscitation-a-pilot-randomized-controlled-trial
#32
JOURNAL ARTICLE
Jonghwan Shin, Hui Jai Lee, Kwang Nam Jin, Jung Ho Shin, Kyoung Min You, Stephen Gyung Won Lee, Jin Hee Jung, Kyoung Jun Song, Jieun Pak, Tae Yun Park, Chang Je Park, Gi Tak Bae
BACKGROUND: There is insufficient evidence supporting that mechanical ventilation can replace the manual ventilation method during cardiopulmonary resuscitation (CPR). RESEARCH QUESTION: Is using automatic mechanical ventilation feasible and comparable to the manual ventilation method during CPR? STUDY DESIGN AND METHODS: This is a pilot randomized controlled trial comparing automatic mechanical ventilator (MV) and manual bag ventilation (BV) during CPR of out-of-hospital cardiac arrest (OHCA)...
February 17, 2024: Chest
https://read.qxmd.com/read/38369254/partnering-with-sarcoidosis-patients-to-implement-a-community-advisory-board
#33
JOURNAL ARTICLE
Leila Bushweller, Sandra Hodges, Linda Meyer, Johnie Reed, Karen Saunders, Rhonda Jenkins, Kristen A Berg, J Daryl Thornton, Manuel L Ribeiro Neto, Daniel A Culver, Logan Harper
BACKGROUND: Community advisory boards (CABs) are increasingly recognized as a means of incorporating patient experience into clinical practice and research. The power of community advisory boards is derived from engaging with community members as equals throughout the research process. Despite this, little is known of community member experience and views on best practices for running a CAB in a rare pulmonary disease. RESEARCH QUESTION: What are CAB members' views on the best practices for CAB formation and maintenance in a rare pulmonary disease? STUDY DESIGN AND METHODS: In August 2021 we formed the Cleveland Clinic Sarcoidosis Health Partners (CC-HP) as a community advisory board (CAB) to direct research and clinic improvement initiatives at a quaternary sarcoidosis center...
February 16, 2024: Chest
https://read.qxmd.com/read/38367957/lung-consolidations-depth-and-gas-exchange-in-different-types-of-neonatal-respiratory-failure-the-union-multicenter-study
#34
JOURNAL ARTICLE
Daniele De Luca, Anna Foti, Almudena Alonso-Ojembarrena, Valentina Condò, Letizia Capasso, Roberto Raschetti, Luca Bonadies, Eugenio Baraldi, Fabio Mosca, Francesco Raimondi
No abstract text is available yet for this article.
February 16, 2024: Chest
https://read.qxmd.com/read/38365177/achieving-goals-of-care-decisions-in-chronic-critical-illness-a-multi-institutional-qualitative-study
#35
JOURNAL ARTICLE
Sarah K Andersen, Yanran Yang, Erin K Kross, Barbara Haas, Anna Geagea, Teresa L May, Joanna Hart, Sean M Bagshaw, Elizabeth Dzeng, Baruch Fischhoff, Douglas B White
BACKGROUND: Clinicians, patients, and families alike perceive a need to improve how goals of care (GOC) decisions occur in chronic critical illness (CCI) but little is currently known about this decision making process. RESEARCH QUESTION: How do intensivists from various health systems facilitate decision-making about GOC for patients with CCI? What are barriers to, and facilitators of, this decision-making process? STUDY DESIGN: AND METHODS: We conducted semi-structured interviews with a purposeful sample of intensivists from the United States and Canada using a 'mental models' approach adapted from decision science...
February 14, 2024: Chest
https://read.qxmd.com/read/38365176/rheumatoid-arthritis-increases-the-risk-of-chronic-obstructive-pulmonary-disease-a-nationwide-retrospective-cohort-study
#36
JOURNAL ARTICLE
Chiwook Chung, Hyungjin Kim, Kyungdo Han, Jinhyoung Jung, Yeonghee Eun, Hyun Lee, Junhee Park, Dong Wook Shin, Sei Won Lee
BACKGROUND: Most reports of pulmonary manifestations in rheumatoid arthritis (RA) have been related to interstitial lung diseases. RA and chronic obstructive pulmonary disease (COPD) are both chronic inflammatory systemic diseases. RESEARCH QUESTION: Does RA increase the risk of developing COPD? Is there a difference between seropositive and seronegative RA in the risk of COPD? STUDY DESIGN AND METHODS: Using the Korean National Health Insurance Database, we screened individuals diagnosed with RA between 2010 and 2017...
February 14, 2024: Chest
https://read.qxmd.com/read/38365175/an-update-on-patient-reported-outcomes-in-asthma
#37
REVIEW
Tianshi David Wu, Zuzana Diamant, Nicola A Hanania
TOPIC IMPORTANCE: Patient-reported outcomes (PROs) are information provided by patients on their condition, function, well-being, or experience. Instruments to quantify PROs, called patient-reported outcome measures (PROMs), allow standardized assessment of a unique dimension of health which cannot be physically measured. Here, we discuss how to critically appraise PROMs and provide an update on their use in asthma clinical practice and research. REVIEW FINDINGS: Asthma-specific PROMs have been developed to measure a wide array of disease characteristics, including symptoms, medication use, exacerbations, and impairments to emotional and physical function...
February 14, 2024: Chest
https://read.qxmd.com/read/38365174/automated-real-time-detection-of-lung-sliding-using-artificial-intelligence-a-prospective-diagnostic-accuracy-study
#38
JOURNAL ARTICLE
Hans Clausdorff Fiedler, Ross Prager, Delaney Smith, Derek Wu, Chintan Dave, Jared Tschichart, Ben Wu, Blake Van Berlo, Richard Malthaner, Robert Arntfield
BACKGROUND: Rapid evaluation for pneumothorax (PTX) is a common clinical priority. Although lung ultrasound (LUS) is often used to assess for PTX, its diagnostic accuracy varies based on patient and provider factors. To enhance the performance of LUS for pulmonary pathology, artificial intelligence (AI) assisted imaging has been adopted, however, the diagnostic accuracy of AI-Assisted LUS (AI-LUS) deployed in real-time to diagnose PTX remains unknown. RESEARCH QUESTION: In patients with suspected PTX, what is the real-time diagnostic accuracy of AI-LUS to recognize the absence of lung sliding? STUDY DESIGN AND METHODS: We performed a prospective AI-assisted diagnostic accuracy study of AI-LUS to recognize the absence of lung sliding in a convenience sample of patients with suspected pneumothorax...
February 14, 2024: Chest
https://read.qxmd.com/read/38360172/pulmonary-cellular-toxicity-in-alpha-1-antitrypsin-deficiency
#39
JOURNAL ARTICLE
Kristine M Abo, Carly Merritt, Maria C Basil, Susan M Lin, Edward Cantu, Michael P Morley, Pushpinder Bawa, Marissa Gallagher, Derek E Byers, Edward E Morrisey, Andrew A Wilson
No abstract text is available yet for this article.
February 13, 2024: Chest
https://read.qxmd.com/read/38354905/an-approach-to-caring-for-patients-and-family-of-patients-dying-in-the-icu
#40
REVIEW
Ann L Jennerich
TOPIC IMPORTANCE: Death is common in the intensive care unit (ICU), and often occurs after a decision to withhold or withdraw life-sustaining therapies. Care of the dying is a core skill for ICU clinicians, requiring expert communication, primarily with family of critically ill patients. REVIEW FINDINGS: There is limited high-quality evidence to support specific practices related to the care of dying patients in the ICU, thus many of the recommendations that exist are based on expert opinion...
February 12, 2024: Chest
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