journal
https://read.qxmd.com/read/38453002/atrial-arrhythmias-in-patients-with-pulmonary-hypertension
#21
REVIEW
Kyle O'Meara, Gregory Stone, Eric Buch, Adam Brownstein, Rajan Saggar, Richard Channick, Alexander E Sherman, Aron Bender
TOPIC IMPORTANCE: Atrial arrhythmia (AA) are common in patients with pulmonary hypertension (PH) and contribute to morbidity and mortality. Given the growing PH population, understanding the pathophysiology, clinical impact, and management of AA in PH is important. REVIEW FINDINGS: AA occurs in PH with a 5-year incidence of 10% to 25%. AA confers a higher morbidity and mortality, and restoration of normal sinus rhythm improves survival and functionality. AA is thought to develop because of structural alterations of the right atrium caused by changes to the right ventricle (RV) due to elevated pulmonary artery pressures...
March 5, 2024: Chest
https://read.qxmd.com/read/38447641/interdisciplinary-diagnosis-and-management-of-patients-with-interstitial-lung-disease-and-connective-tissue-disease
#22
REVIEW
Sabina A Guler, Tobias Scheschkowski, Anja Renner, Lea Kämpf, Matthias Gasser, Britta Maurer
Diagnosis of interstitial lung diseases (ILD) can be challenging, and the identification of an associated connective tissue disease (CTD) is crucial to estimate prognosis and establish the optimal treatment approach. Diagnostic delay, limited expertise and fragmented care are barriers that impede the delivery of comprehensive healthcare for patients with rare, complex and multiorgan diseases such as CTD and ILD. In this article we present our perspective on the interdisciplinary diagnosis and interprofessional treatment of patients with ILD and suspected CTD or CTD at risk for ILD...
March 4, 2024: Chest
https://read.qxmd.com/read/38447640/comparison-between-reveal-lite-2-and-compera-2-0-for-risk-stratification-in-pulmonary-arterial-hypertension
#23
JOURNAL ARTICLE
Sandeep Sahay, Nelson Villasmil Hernandez, Fredrick Wang, Matthew Wooten, Duc T Nguyen, Charles Fauvel, Raymond Benza, Edward A Graviss
BACKGROUND: Risk stratification is the cornerstone of the management of pulmonary arterial hypertension (PAH). Current ESC/ERS guidelines recommend using the COMPERA 3-strata risk model at baseline, and the COMPERA 2.0 4-strata model at follow-up. However, the guidelines did not take into consideration other available risk scores such as REVEAL Lite 2. RESEARCH QUESTION: Is REVEAL Lite 2 better at discriminating risk than the COMPERA risk assessment models at baseline or follow up evaluations? STUDY DESIGN AND METHODS: We analyzed data from the consecutively enrolled PAH patients between the period of June 2011 to February 2022 in the PAH registry at our expert Pulmonary Hypertension Center...
March 4, 2024: Chest
https://read.qxmd.com/read/38447639/use-of-intravenous-albumin-a-guideline-from-the-international-collaboration-for-transfusion-medicine-guidelines
#24
Jeannie Callum, Nikolaos J Skubas, Aarti Bathla, Homa Keshavarz, Edward G Clark, Bram Rochwerg, Dean Fergusson, Sesmu Arbous, Seth R Bauer, Louise China, Mark Fung, Rachel Jug, Michael Neill, Cary Paine, Katerina Pavenski, Prakesh S Shah, Susan Robinson, Hua Shan, Zbigniew M Szczepiorkowski, Thierry Thevenot, Bovey Wu, Simon Stanworth, Nadine Shehata
BACKGROUND: Albumin is commonly employed across a wide range of clinical settings to improve hemodynamics, facilitate fluid removal, and manage complications of cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines for the use of albumin in patients requiring critical care, undergoing cardiovascular surgery, kidney replacement therapy, or experiencing complications of cirrhosis. METHODS: Co-chairs oversaw the guideline development process and the panel included researchers, clinicians, methodologists, and a patient representative...
March 4, 2024: Chest
https://read.qxmd.com/read/38432552/clinical-correlates-of-a-non-plexiform-vasculopathy-in-patients-diagnosed-with-idiopathic-pulmonary-arterial-hypertension
#25
JOURNAL ARTICLE
Esther J Nossent, Josien Smits, Celine Seegers, Lilian J Meijboom, Anco Boonstra, J Aman, F S De Man, Harm Jan Bogaard, Teodora Radonic, Peter Dorfmüller, Anton Vonk Noordegraaf
BACKGROUND: The clinical phenotype of idiopathic pulmonary arterial hypertension (IPAH) patients has changed. . Whether or not subgroups of IPAH patients have different vascular phenotypes is a subject of debate. RESEARCH QUESTION: What are the histological patterns and their clinical correlates in patients diagnosed with IPAH or hereditary PAH? STUDY DESIGN AND METHODS: In this this cross-sectional registry study lung histology of 50 IPAH patients was qualitatively assessed by two experienced pathologists...
March 1, 2024: Chest
https://read.qxmd.com/read/38431050/effect-of-corticosteroids-on-long-term-humoral-and-memory-t-cell-responses-in-follow-up-visit-of-hospitalized-patients-with-covid-19
#26
JOURNAL ARTICLE
Yeming Wang, Li Guo, Guohui Fan, Yang Han, Qiao Zhang, Weiyang Wang, Lili Ren, Hui Zhang, Geng Wang, Xueyang Zhang, Tingxuan Huang, Lan Chen, Lixue Huang, Xiaoying Gu, Dan Cui, Xinming Wang, Jingchuan Zhong, Ying Wang, Hui Li, Chaolin Huang, Jianwei Wang, Bin Cao
BACKGROUND: Corticosteroids have beneficial effects in improving outcomes in hospitalized patients with severe COVID-19 by suppressing excessive immune responses. However, the effect of corticosteroids on the humoral and T-cell responses of survivors of COVID-19 1 year after infection remains uncertain because it relates to the extent of immediate, antigen-specific defense provided by protective memory. RESEARCH QUESTION: What is the effect of corticosteroids on long-term humoral and T-cell immune responses? STUDY DESIGN AND METHODS: In this retrospective cohort study conducted at a single center, we analyzed data from a cohort who had survived COVID-19 to compare the 1-year seropositivity and titer changes in neutralizing antibodies (NAbs) and SARS-CoV-2-specific antibodies...
March 1, 2024: Chest
https://read.qxmd.com/read/38431051/azithromycin-induced-asthma-remission-in-adults-with-persistent-uncontrolled-asthma-a-secondary-analysis-of-a-randomised-double-blind-placebo-controlled-trial
#27
JOURNAL ARTICLE
Dennis Thomas, Vanessa M McDonald, Sean Stevens, Melissa Baraket, Sandra Hodge, Alan James, Christine Jenkins, Guy B Marks, Matthew Peters, Paul Reynolds, John W Upham, Ian A Yang, Peter G Gibson
BACKGROUND: Asthma remission is a potential treatment goal. RESEARCH QUESTION: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared to placebo? STUDY DESIGN AND METHODS: This secondary analysis used data from the AMAZES clinical trial - a double-blind placebo-controlled trial that evaluated the safety and efficacy of azithromycin on asthma exacerbations. The primary remission definition (referred to as clinical remission) was zero exacerbations and zero oral corticosteroids (OCS) during the previous six months evaluated at 12 months and Asthma Control Questionnaire (ACQ-5) ≤1 at 12 months...
February 29, 2024: Chest
https://read.qxmd.com/read/38417700/applying-noninvasive-ventilation-in-treatment-of-acute-exacerbation-of-copd-using-evidence-based-interprofessional-clinical-practice
#28
REVIEW
Mary Jo S Farmer, Christine Callahan, Ashley M Hughes, Karen Riska, Nicholas Hill
When administered as first-line intervention to patients admitted with acute hypercapnic respiratory failure secondary to COPD exacerbation in conjunction with guideline-recommended therapies, noninvasive ventilation (NIV) has been shown to reduce mortality and endotracheal intubation. Opportunities to increase uptake of NIV continue to exist despite inclusion of this therapy in clinical guidelines. Identifying patients appropriate for NIV, and subsequently providing close monitoring to determine an improvement in clinical condition involves a team consisting of physician, nurse, and respiratory therapist in institutions that successfully implement NIV...
February 28, 2024: Chest
https://read.qxmd.com/read/38423280/the-clinical-frailty-scale-for-risk-stratification-in-patients-with-fibrotic-interstitial-lung-disease
#29
JOURNAL ARTICLE
Sabina A Guler, Daniel-Costin Marinescu, Gerard Cox, Celine Durand, Jolene H Fisher, Amanda Grant-Orser, Gillian C Goobie, Nathan Hambly, Kerri A Johannson, Nasreen Khalil, Martin Kolb, Stacey Lok, Sarah MacIsaac, Helene Manganas, Veronica Marcoux, Julie Morisset, Ciaran Scallan, Shane Shapera, Kelly Sun, Boyang Zheng, Christopher J Ryerson, Alyson W Wong
BACKGROUND: Previous studies have shown the importance of frailty in patients with fibrotic interstitial lung disease (ILD). RESEARCH QUESTION: Is the Clinical Frailty Scale (CFS) a valid tool to improve risk stratification in patients with fibrotic ILD? STUDY DESIGN AND METHODS: Patients with fibrotic ILD were included from the prospective multicenter Canadian Registry for Pulmonary Fibrosis. The CFS was assessed using available information from initial ILD clinic visits...
February 27, 2024: Chest
https://read.qxmd.com/read/38423279/abnormal-exertional-breathlessness-on-cardiopulmonary-cycle-exercise-testing-in-relation-to-self-reported-and-physiological-responses-in-chronic-airflow-limitation
#30
JOURNAL ARTICLE
Magnus Ekström, Pei Zhi Li, Hayley Lewthwaite, Jean Bourbeau, Wan C Tan, Dennis Jensen
BACKGROUND: Exertional breathlessness is a cardinal symptom of cardiorespiratory disease. RESEARCH QUESTION: How does breathlessness abnormality graded using normative reference equations during cardiopulmonary exercise testing (CPET) relate to self-reported and physiological responses in people with chronic airflow limitation (CAL). STUDY DESIGN AND METHODS: Analysis of people aged ≥40 years with CAL undergoing CPET in the Canadian Cohort Obstructive Lung Disease study...
February 27, 2024: Chest
https://read.qxmd.com/read/38423278/venovenous-extracorporeal-membrane-oxygenation-candidacy-decision-making-lessons-and-hypotheses-from-a-single-center-observational-analysis
#31
JOURNAL ARTICLE
Jonah Rubin, Alison S Witkin, Jerome C Crowley, Eriberto Michel, David M Furfaro, Ricardo Teijeiro-Paradis, Annette Ilg, Raghu Seethala, Sophia Zhao, Eddy Fan
BACKGROUND: Use of venovenous extracorporeal membrane oxygenation (ECMO) is increasing, but candidacy selection processes are variable and subject to bias. RESEARCH QUESTION: What are the reasons behind venovenous ECMO candidacy decisions, and are decisions made consistently across patients? STUDY DESIGN AND METHODS: Prospective observational study of all patients, admitted or outside hospital referrals, considered for venovenous ECMO at a tertiary referral center...
February 27, 2024: Chest
https://read.qxmd.com/read/38403186/non-invasive-electromagnetic-phrenic-nerve-stimulation-in-critically-ill-patients-a-feasibility-study
#32
JOURNAL ARTICLE
Alessandro Panelli, Aline M Grimm, Sven Krause, Michael A Verfuß, Bernhard Ulm, Julius J Grunow, Hermann G Bartels, Niklas M Carbon, Thomas Niederhauser, Steffen Weber-Carstens, Laurent Brochard, Stefan J Schaller
BACKGROUND: Electromagnetic stimulation of the phrenic nerve induces diaphragm contractions, but no coils for clinical use have been available. We recently demonstrated the feasibility of ventilation using bilateral transcutaneous non-invasive electromagnetic phrenic nerve stimulation (NEPNS) preoperatively in lung-healthy, normal-weight patients in a dose-dependent manner. RESEARCH QUESTION: Is NEPNS feasible in critically ill patients in an ICU setting? STUDY DESIGN AND METHODS: This feasibility non-randomized controlled study aimed to enroll patients within 36h of intubation, who were expected to remain ventilated for ≥72h...
February 23, 2024: Chest
https://read.qxmd.com/read/38724161/response
#33
LETTER
Steven D Nathan, Eric Shen, Chunqin Deng
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724160/is-higher-dose-of-inhaled-treprostinil-truly-superior-to-lower-dose-of-inhaled-treprostinil-in-patients-with-pulmonary-hypertension-associated-with-interstitial-lung-diseases
#34
LETTER
Léon Genecand, Frédéric Lador, David Montani, Thomas Perneger
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724159/response
#35
LETTER
Jean Bourbeau, Mohit Bhutan, Paul Hernandez, Darcy D Marciniuk
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724158/impact-of-triple-therapy-vs-dual-bronchodilator-therapy-on-mortality-rates-in-copd
#36
LETTER
Daniel J Tan, Wouter H van Geffen, E Haydn Walters
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724157/response
#37
LETTER
Susanne Hansen, Marianne Baastrup Soendergaard, Celeste Porsbjerg
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724156/how-much-do-we-know-about-clinical-response-and-remission-to-add-on-biologics-in-severe-asthma-in-a-real-world-setting
#38
LETTER
Wen Wen Wu, Gang Wang
No abstract text is available yet for this article.
May 2024: Chest
https://read.qxmd.com/read/38724155/pleural-effusion-caused-by-an-unusual-mass-in-the-right-hemithorax
#39
JOURNAL ARTICLE
Magnus Bluhm, Bassam Atmeh, Stephan Boehm, Jan Hendrik Rüschoff, Peter Bode, Corina Dommann-Scherrer
An 80-year-old woman presented with complaints of weakness and dizziness. She had a medical history of subacute cerebral ischemia, vertigo, hypertension, and thalassemia minor. The patient was born and raised in Turkey and has lived in Switzerland for 50 years. Her sister died of a mesothelioma caused by asbestos exposure at the age of 60 years but had lived in Turkey until her death. The patient had neither a history of TB nor B symptoms. She has never smoked.
May 2024: Chest
https://read.qxmd.com/read/38724154/postoperative-hemodynamic-collapse-a-case-for-intraarrest-transesophageal-echocardiogram
#40
JOURNAL ARTICLE
Eugene Yuriditsky, James M Horowitz
No abstract text is available yet for this article.
May 2024: Chest
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