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PloS One

Marika Vitali, Rubina Sirri, Martina Zappaterra, Paolo Zambonelli, Giulia Giannini, Domenico Pietro Lo Fiego, Roberta Davoli
Supplementing pig diets with n-3 polyunsaturated fatty acids (n-3 PUFA) may produce meat products with an increased n-3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE)...
2019: PloS One
Behrouz Taheri, Mohsen Mohammadi, Iraj Nabipour, Niloofar Momenzadeh, Mona Roozbehani
[This corrects the article DOI: 10.1371/journal.pone.0206578.].
2019: PloS One
Yvonne J Rosenberg, George K Lewis, David C Montefiori, Celia C LaBranche, Mark G Lewis, Lori A Urban, Jonathan P Lees, Lingjun Mao, Xiaoming Jiang
Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective...
2019: PloS One
Eri Saeki, Shinji Yasuhira, Masahiko Shibazaki, Hiroshi Tada, Minoru Doita, Tomoyuki Masuda, Chihaya Maesawa
[This corrects the article DOI: 10.1371/journal.pone.0209296.].
2019: PloS One
(no author information available yet)
No abstract text is available yet for this article.
2019: PloS One
Martial Caillaud, Jérôme Guillard, Damien Richard, Serge Milin, Damien Chassaing, Marc Paccalin, Guylène Page, Agnès Rioux Bilan
As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age...
2019: PloS One
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0111079.].
2019: PloS One
Johannes Ehler, Axel Petzold, Matthias Wittstock, Stephan Kolbaske, Martin Gloger, Jörg Henschel, Amanda Heslegrave, Henrik Zetterberg, Michael P Lunn, Paulus S Rommer, Annette Grossmann, Tarek Sharshar, Georg Richter, Gabriele Nöldge-Schomburg, Martin Sauer
[This corrects the article DOI: 10.1371/journal.pone.0211184.].
2019: PloS One
(no author information available yet)
No abstract text is available yet for this article.
2019: PloS One
Patricia Rarau, Justin Pulford, Hebe Gouda, Suparat Phuanukoonnon, Chris Bullen, Robert Scragg, Bang Nguyen Pham, Barbara McPake, Brian Oldenburg
[This corrects the article DOI: 10.1371/journal.pone.0211068.].
2019: PloS One
Fernanda S Tonin, Helena H Borba, Antonio M Mendes, Astrid Wiens, Fernando Fernandez-Llimos, Roberto Pontarolo
BACKGROUND: The conduction and report of network meta-analysis (NMA), including the presentation of the network-plot, should be transparent. We aimed to propose metrics adapted from graph theory and social network-analysis literature to numerically describe NMA geometry. METHODS: A previous systematic review of NMAs of pharmacological interventions was performed. Data on the graph's presentation were collected. Network-plots were reproduced using Gephi 0.9.1. Eleven geometric metrics were tested...
2019: PloS One
Donald E Frederick, Tyler J VanderWeele
Supported employment is a treatment whereby those with severe mental illness (or other disabilities) receive aid searching for competitive employment and mental health (or other) treatments concurrently. The most popular implementation of supported employment is individual placement and support (IPS). We conducted meta-analytic analyses of the randomized controlled trials of IPS. We found that subjects in IPS, compared to usual treatment conditions, had better vocational outcomes (obtained any competitive employment: RR = 1...
2019: PloS One
Bo Wang, Biting Bian, Chunlei Wang, Changxia Li, Hua Fang, Jing Zhang, Dengjing Huang, Jianqiang Huo, Weibiao Liao
Hydrogen gas (H2) plays an important role in plant development and stress responses. Here, cucumber (Cucumis sativus L.) explants were used to investigate the roles of H2 in adventitious root development under cadmium (Cd) stress and its physiological mechanism. The results showed that hydrogen-rich water (HRW) promoted adventitious rooting under Cd stress and 50% HRW obtained the maximal biological response. Compared with Cd treatment, HRW + Cd treatment significantly reduced the content of malondialdehyde (MDA), hydrogen peroxide (H2O2), superoxide radical (O2-), thiobarbituric acid reactive substances (TBARS), ascorbic acid (AsA) and reduced glutathione (GSH), as well as relative electrical conductivity (REC), lipoxygenase (LOX) activity, AsA/docosahexaenoic acid (DHA) ratio, and GSH/oxidized glutathione (GSSG) ratio, while increasing DHA and GSSG content...
2019: PloS One
Yulin Li, Anita Appius, Thirupathi Pattipaka, Andrea Feyereislova, Adrian Cassidy, Apar Kishor Ganti
[This corrects the article DOI: 10.1371/journal.pone.0209709.].
2019: PloS One
Andreea Rădoi, Maria A Poca, Darío Gándara, Lidia Castro, Mauricio Cevallos, Maria E Pacios, Juan Sahuquillo
Self-report measures, particularly symptom inventories, are critical tools for identifying patients with persistent post-concussion symptoms and their follow-up. Unlike in military or sports-related assessment, in general civilian settings pre-injury levels of concussion-like symptoms are lacking. Normative data are available in adolescent and college populations, but no reference data exist to guide clinical adult explorations. The purpose of this study was to use the second edition of the Sport Concussion Assessment Tool (SCAT2) to profile a cohort of 60 healthy community volunteers who had not sustained a head injury...
2019: PloS One
Shinan Shu, Yang Bian, Jian Rong, Dandan Xu
As a sustainable mode of transportation, public bicycles significantly improve daily mobility. The location of stations is a key element for the success of a public bicycle system, as a long walking distance will reduce people's willingness to use this mode of transportation. Building forms in China are different from the open type seen abroad. Many residential, office and school areas are enclosed by walls, and pedestrian flow is concentrated at the entrances/exits of these areas. Therefore, the station must be located close to the building entrance/exit...
2019: PloS One
Victor Simon, Carole Hyacinthe, Sylvie Rétaux
Fish reproductive patterns are very diverse in terms of breeding frequency, mating system, sexual dimorphisms and selection, mate choice, spawning site choice, courtship patterns, spawning behaviors and parental care. Here we have compared the breeding behavior of the surface-dwelling and cave-dwelling morphs of the characiform A. mexicanus, with the goals of documenting the spawning behavior in this emerging model organism, its possible evolution after cave colonization, and the sensory modalities involved...
2019: PloS One
Katja Ried, Thomas Müller, Hans J Briegel
Collective phenomena are studied in a range of contexts-from controlling locust plagues to efficiently evacuating stadiums-but the central question remains: how can a large number of independent individuals form a seemingly perfectly coordinated whole? Previous attempts to answer this question have reduced the individuals to featureless particles, assumed particular interactions between them and studied the resulting collective dynamics. While this approach has provided useful insights, it cannot guarantee that the assumed individual-level behaviour is accurate, and, moreover, does not address its origin-that is, the question of why individuals would respond in one way or another...
2019: PloS One
Dejan Micic, John N Gaetano, Neha Nigam, Matthew Peller, Vijaya L Rao, Carol Semrad, Adam C Stein, Sonia S Kupfer
INTRODUCTION: A small bowel source is suspected when evaluation of overt gastrointestinal (GI) bleeding with upper and lower endoscopy is negative. Video capsule endoscopy (VCE) is the recommended next diagnostic test for small bowel bleeding sources. However, clinical or endoscopic predictive factors for small bowel bleeding in the setting of an overt bleeding presentation are unknown. We aimed to define predictive factors for positive VCE among individuals presenting with overt bleeding and a suspected small bowel source...
2019: PloS One
Stefano Bedini, Guido Flamini, Francesca Cosci, Roberta Ascrizzi, Maria C Echeverria, Evelin V Gomez, Lucia Guidi, Marco Landi, Andrea Lucchi, Barbara Conti
Cutaneous myiasis is a severe worldwide medical and veterinary issue. In this trial the essential oil (EO) of the Andean medicinal plant species Clinopodium nubigenum (Kunth) Kuntze was evaluated for its bioactivity against the myiasis-inducing blowfly Lucilia sericata (Meigen) (Diptera Calliphoridae) and compared with that of the well-known medicinal plant species Lavandula angustifolia Mill. The EOs were analysed and tested in laboratory for their oviposition deterrence and toxicity against L. sericata adults...
2019: PloS One
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