journal
https://read.qxmd.com/read/37726888/intermittent-ex-vivo-lung-perfusion-in-a-porcine-model-for-prolonged-lung-preservation
#1
JOURNAL ARTICLE
Ichiro Sakanoue, Toshihiro Okamoto, Kamal S Ayyat, James J Yun, Carol F Farver, Hisashi Fujioka, Hiroshi Date, Kenneth R McCurry
BACKGROUND: Ex vivo lung perfusion expands the lung transplant donor pool and extends preservation time beyond cold static preservation. We hypothesized that repeated regular ex vivo lung perfusion would better maintain lung grafts. METHODS: Ten pig lungs were randomized into 2 groups. The control underwent 16 h of cold ischemic time and 2 h of cellular ex vivo lung perfusion. The intermittent ex vivo lung perfusion group underwent cold ischemic time for 4 h, ex vivo lung perfusion (first) for 2 h, cold ischemic time for 10 h, and 2 h of ex vivo lung perfusion (second)...
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726887/validation-of-the-integrity-of-the-optn-unos-transplantation-registry-data
#2
JOURNAL ARTICLE
John Stephen Malamon, Bruce Kaplan
No abstract text is available yet for this article.
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726885/thermo-ablation-of-renal-allograft-tumors-every-patient-and-every-nephron-counts
#3
JOURNAL ARTICLE
Peter J Altshuler
No abstract text is available yet for this article.
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726883/using-regression-equations-to-enhance-interpretation-of-histology-lesions-of-kidney-transplant-rejection
#4
JOURNAL ARTICLE
Majid L N Sikosana, Jeff Reeve, Katelynn S Madill-Thomsen, Philip F Halloran
BACKGROUND: The Banff system for histologic diagnosis of rejection in kidney transplant biopsies uses guidelines to assess designated features-lesions, donor-specific antibody (DSA), and C4d staining. We explored whether using regression equations to interpret the features as well as current guidelines could establish the relative importance of each feature and improve histologic interpretation. METHODS: We developed logistic regression equations using the designated features to predict antibody-mediated rejection (AMR/mixed) and T-cell-mediated rejection (TCMR/mixed) in 1679 indication biopsies from the INTERCOMEX study (ClinicalTrials...
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726882/transplant-candidate-outcomes-after-declining-a-dcd-liver-in-the-united-states
#5
JOURNAL ARTICLE
Tanveen Ishaque, Mackenzie A Eagleson, Mary G Bowring, Jennifer D Motter, Sile Yu, Xun Luo, Amber B Kernodle, Sommer Gentry, Jacqueline M Garonzik-Wang, Elizabeth A King, Dorry L Segev, Allan B Massie
BACKGROUND: In the context of the organ shortage, donation after cardiac death (DCD) provides an opportunity to expand the donor pool. Although deceased-donor liver transplantation from DCD donors has expanded, DCD livers continue to be discarded at elevated rates; the use of DCD livers from older donors, or donors with comorbidities, is controversial. METHODS: Using US registry data from 2009 to 2020, we identified 1564 candidates on whose behalf a DCD liver offer was accepted ("acceptors") and 16 981 candidates on whose behalf the same DCD offers were declined ("decliners")...
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726879/unos-decisions-impact-data-integrity-of-the-optn-data-registry
#6
JOURNAL ARTICLE
Demetra S Tsapepas, Kristen King, Syed Ali Husain, Miko E Yu, Benjamin E Hippen, Jesse D Schold, Sumit Mohan
BACKGROUND: The Organ Procurement Transplant Network (OPTN)/United Network for Organ Sharing (UNOS) registry is an important national registry in the field of solid organ transplantation. Data collected are mission critical, given its role in organ allocation prioritization, program performance monitoring by both the OPTN and the Centers for Medicare & Medicaid Services, and countless observational analyses that helped to move the field forward. Despite the multifaceted importance of the OPTN/UNOS database, there are clear indications that investments in the database to ensure the quality and reliability of the data have been lacking...
September 20, 2023: Transplantation
https://read.qxmd.com/read/37726878/thermoablative-treatment-of-de-novo-tumor-in-kidney-allograft
#7
JOURNAL ARTICLE
Sylvain Bodard, Idris Boudhabhay, Charles Dariane, Christophe Delavaud, Sylvain Guinebert, Pierre Guétat, Arnaud Mejean, Marc-Olivier Timsit, Dany Anglicheau, Dominique Joly, Olivier Hélénon, Jean-Michel Correas
BACKGROUND: The overall cancer risk increases in transplant patients, including in kidney allografts. This study aimed to analyze the outcome of patients with kidney allograft malignant tumors who underwent percutaneous thermal ablation. METHODS: We included 26 renal allograft tumors, including 7 clear-cell renal cell carcinoma (RCCs), 16 papillary RCCs, 1 clear-cell papillary RCC, and 2 tubulocystic RCCs, treated in 19 ablation sessions. Outcomes of thermal ablation therapy were assessed, including technical success, adverse events, local tumor progression, development of metastases, survival after thermal ablation, and changes in renal function...
September 20, 2023: Transplantation
https://read.qxmd.com/read/37723639/endoscopic-surveillance-of-the-intestinal-allograft-recommendations-from-the-intestinal-rehabilitation-and-transplant-association-working-group
#8
JOURNAL ARTICLE
Jennifer Garcia, Mihai Oltean, Carolina Rumbo, Lisa Sharkey, Stuart S Kaufman, Esther Ramos Boluda, Girish Gupte, Mercedes Martinez, Jang Moon, Vikram Raghu, Maria Cristina Segovia, Debra Sudan, Cécile Talbotec, Jonas Varkey, Gabriel E Gondolesi, George Mazariegos, Robert Venick
Intestinal transplant (ITx) rejection lacks a reliable noninvasive biomarker and rejection surveillance relies on serial endoscopies and mucosal biopsies followed by histologic assessment. Endoscopic biopsies are also essential for identifying other ITx-related complications such as infectious, allergic, and inflammatory graft enteritis as well as post-transplant lymphoproliferative disease or graft versus host disease. In spite of its central role in ITx, published guidelines on endoscopy and biopsy are lacking and significant variability between centers in terms of timing and technical performance exists...
September 19, 2023: Transplantation
https://read.qxmd.com/read/37723620/expanding-access-to-organ-transplant-for-people-living-with-hiv-can-policy-catch-up-to-outcomes-data
#9
JOURNAL ARTICLE
Sindhu Chandran, Peter G Stock, Garrett R Roll
Advances in antiretroviral and immunosuppressive regimens have improved outcomes following solid organ transplantation in people living with HIV (PLWH). The HIV Organ Policy and Equity Act was conceived to reduce the discard of HIV-positive organs and improve access to transplant for PLWH. Nevertheless, PLWH continue to experience disproportionately low rates of transplant. This overview examines the hurdles to transplantation in PLWH with end-organ disease, the potential and realized impact of the HIV Organ Policy and Equity Act, and changes that could permit expanded access to organ transplant in this population...
September 19, 2023: Transplantation
https://read.qxmd.com/read/37691167/long-term-catch-up-growth-and-risk-factors-for-short-adult-height-after-pediatric-liver-transplantation-a-retrospective-study
#10
JOURNAL ARTICLE
Kentaro Umemura, Atsuyoshi Mita, Yasunari Ohno, Yuichi Masuda, Kazuki Yoshizawa, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Koya Yasukawa, Atsushi Kamachi, Takamune Goto, Hidenori Tomida, Shiori Yamazaki, Akira Shimizu, Yuji Soejima
BACKGROUND: Children requiring liver transplantation generally have severe growth retardation. Recipients experience posttransplantation catch-up growth, although some show short adult heights. We aimed to determine decades-long catch-up growth trends and risk factors for short adult height following liver transplantation. METHODS: We analyzed long-term height Z scores and risk factors for short adult height in a single-center retrospective cohort of 117 pediatric liver transplantation recipients who survived >5 y, with 75 of them reaching adult height...
September 11, 2023: Transplantation
https://read.qxmd.com/read/37691163/transplanting-pediatric-candidates-at-an-optimal-time-for-long-term-growth-insights-from-an-asian-cohort
#11
JOURNAL ARTICLE
Nam-Joon Yi
No abstract text is available yet for this article.
September 11, 2023: Transplantation
https://read.qxmd.com/read/37691154/kidney-donation-after-circulatory-death-using-thoracoabdominal-normothermic-regional-perfusion-the-largest-report-of-the-united-states-experience
#12
JOURNAL ARTICLE
Alice L Zhou, Albert Leng, Jessica M Ruck, Armaan F Akbar, Niraj M Desai, Elizabeth A King
BACKGROUND: Thoracoabdominal normothermic regional perfusion (TA-NRP) has been increasingly used for donation after circulatory death (DCD) procurements in the United States. We present the largest report of outcomes of kidney transplants performed using DCD donor grafts perfused with TA-NRP. METHODS: Adult DCD kidney transplants between 2020 and 2022 in the United Network for Organ Sharing database were included. Donors with ≥50 min between asystole and aortic cross-clamp time in which the heart was also transplanted were considered TA-NRP donors...
September 11, 2023: Transplantation
https://read.qxmd.com/read/37728569/transplant-outcomes-after-exposure-of-deceased-kidney-donors-to-contrast-medium
#13
JOURNAL ARTICLE
Kinita A Chotkan, Luuk B Hilbrands, Hein Putter, Cynthia Konjin, Brigitte Schaefer, Ludo F M Beenen, Robert A Pol, Andries E Braat
BACKGROUND: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied. METHODS: A retrospective analysis of all deceased kidney donors between 2011 and 2021 and their corresponding recipients in the Netherlands was conducted. Multivariable analyses were performed to assess the associations between contrast medium exposure and delayed graft function (DGF)/graft survival...
September 6, 2023: Transplantation
https://read.qxmd.com/read/37728566/the-devil-is-in-the-details-the-effect-of-contrast-medium-administered-before-organ-procurement-on-kidney-transplant-outcomes
#14
JOURNAL ARTICLE
Helio Tedesco Silva
No abstract text is available yet for this article.
September 6, 2023: Transplantation
https://read.qxmd.com/read/37677960/differential-impact-of-the-unos-simultaneous-liver-kidney-transplant-policy-change-among-patients-with-sustained-acute-kidney-injury
#15
JOURNAL ARTICLE
Tomohiro Tanaka, Krista L Lentine, Qianyi Shi, Mark Vander Weg, David A Axelrod
BACKGROUND: Simultaneous liver-kidney transplant (SLK) allocation policy in the United States was revised in August 2017, reducing access for liver transplant candidates with sustained acute kidney injury (sAKI) and potentially adversely impacting vulnerable populations whose true renal function is overestimated by commonly used estimation equations. METHODS: We examined national transplant registry data containing information for all liver transplant recipients from June 2013 to December 2021 to assess the impact of this policy change using instrumental variable estimation based on date of listing...
September 6, 2023: Transplantation
https://read.qxmd.com/read/37677947/context-is-everything
#16
JOURNAL ARTICLE
Brian I Shaw, Lisa M McElroy
No abstract text is available yet for this article.
September 6, 2023: Transplantation
https://read.qxmd.com/read/37677944/survival-after-simultaneous-heart-kidney-transplant-in-recipients-with-a-durable-lvad-and-chronic-kidney-disease-effect-of-the-2018-heart-allocation-policy-change
#17
JOURNAL ARTICLE
Meg Fraser, Arianne C Agdamag, Samy Riad, Bellony N Nzemenoh, Scott Jackson, Joel Money, Ryan Knoper, Cindy M Martin, Tamas Alexy
BACKGROUND: Heart transplantation remains the most definitive therapy for qualified candidates with end-stage heart failure. Concomitant kidney disease is common in this population prompting an increase in simultaneous heart-kidney (SHK) transplantation in recent years. The goal of our study was to explore the effects of the 2018 heart allocation policy (HAP) change on candidate listing characteristics and compare survival rates at 1 y in patients that were supported with a left ventricular assist device (LVAD) pretransplant and underwent SHK or heart alone transplant (HAT)...
September 6, 2023: Transplantation
https://read.qxmd.com/read/37677940/simultaneous-heart-and-kidney-transplantation-for-lvad-supported-patients-with-chronic-kidney-disease
#18
JOURNAL ARTICLE
Sumita Barua, Christopher S Hayward, Peter S Macdonald
No abstract text is available yet for this article.
September 6, 2023: Transplantation
https://read.qxmd.com/read/37677931/multiomics-data-reveal-the-important-role-of-anxa2r-in-t-cell-mediated-rejection-after-renal-transplantation
#19
JOURNAL ARTICLE
Di Zhang, He Zhang, Jun Lu, Xiaopeng Hu
BACKGROUND: T cell-mediated rejection (TCMR) is a severe issue after renal transplantation, but research on its T cell-receptor (TCR) repertoire is lacking. This study intended to elucidate the TCR repertoire landscape in TCMR and hence identify novel potential targets. METHODS: A total of 12 multiomics data sets were collected. The TRUST4 algorithm was used to construct and analyze the TCR repertoire in renal allografts with TCMR and stable renal function. Then, novel TCR-related key genes were identified through various criteria and literature research...
September 6, 2023: Transplantation
https://read.qxmd.com/read/37653586/psychosocial-outcomes-in-nondirected-uterus-donors-1-y-after-donation
#20
JOURNAL ARTICLE
Ann Marie Warren, Briget da Graca, Anji Wall, Mark B Powers, Giovanna Saracino, Giuliano Testa, Liza Johannesson
BACKGROUND: As uterus transplantation transitions to a clinical procedure for women with absolute uterine-factor infertility, transplant centers performing uterus transplantation need information about the experience of living donors. This study examined the psychosocial impact on 17 nondirected uterus donors in the Dallas UtErus Transplant Study 1 y following donation. METHODS: A prospective longitudinal study was conducted to measure psychosocial outcomes of depression, anxiety, posttraumatic stress, quality of life, and resilience [measured using the Hospital Anxiety and Depression Scale or Patient Health Questionnaire 9-Item, Generalized Anxiety Disorder 7-Item, Posttraumatic Stress Disorder Checklist for the DSM-5, health-related quality of life Short Form-36, and Connor-Davidson Resilience Scale 10-Item, respectively) assessed at baseline, at 6-mo and 1-y follow-up...
September 1, 2023: Transplantation
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