journal
https://read.qxmd.com/read/38637929/recognizing-complexity-of-cd8-t-cells-in-transplantation
#1
JOURNAL ARTICLE
Michael Nicosia, Anna Valujskikh
The major role of CD8+ T cells in clinical and experimental transplantation is well documented and acknowledged. Nevertheless, the precise impact of CD8+ T cells on graft tissue injury is not completely understood, thus impeding the development of specific treatment strategies. The goal of this overview is to consider the biology and functions of CD8+ T cells in the context of experimental and clinical allotransplantation, with special emphasis on how this cell subset is affected by currently available and emerging therapies...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38637925/deceased-donor-liver-transplantation-in-india-first-report-of-5-y-outcomes
#2
JOURNAL ARTICLE
Muthukumarassamy Rajakannu, Ashwin Rammohan, Gomathy Narasimhan, Sivakumar Murugesan, Rajesh Rajalingam, Kumar Palaniappan, Sandeep Jasper Rajasekar, Dinesh Jothimani, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela
BACKGROUND: Paucity of deceased donor livers has resulted in a 10-fold rise in living donor liver transplantations (LDLTs) performed in India over the past decade. Nonetheless, number of deceased donor liver transplantation (DDLT) performed has improved with the establishment of simplified legal framework for certification of brain death and organ donation. In this study, we present our outcomes of DDLT performed at various centers, comparing their outcomes and provide a snapshot of the increasing number of DDLT across the state over the years...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38637923/autologous-pancreatic-islet-cell-transplantation-following-pancreatectomy-for-pancreas-diseases-other-than-chronic-pancreatitis-a-15-y-study-of-the-milan-protocol
#3
JOURNAL ARTICLE
Lorenzo Piemonti, Raffella Melzi, Francesca Aleotti, Giovanni Capretti, Rita Nano, Alessia Mercalli, Paola Magistretti, Rossana Caldara, Nicolò Pecorelli, Davide Catarinella, Chiara Gremizzi, Francesca Gavazzi, Francesco De Cobelli, Dario Poretti, Massimo Falconi, Alessandro Zerbi, Gianpaolo Balzano
BACKGROUND: Pancreatogenic diabetes, a consequence of pancreatic tissue loss following pancreatectomy, poses a significant challenge for patients undergoing pancreatic surgery. Islet autotransplantation (IAT) offers a promising approach to prevent or alleviate pancreatogenic diabetes, but its application has been limited to individuals with painful chronic pancreatitis. METHODS: This study presents a 15-y clinical experience with the Milan Protocol, which expands IAT after pancreatectomy to a broader spectrum of patients with malignant and nonmalignant pancreatic diseases...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38637920/changes-in-pancreas-volume-in-living-donor-liver-transplant-recipients
#4
JOURNAL ARTICLE
Cristal Brown, Callaghan Ray, Garrett Kuketz, John Virostko
BACKGROUND: Metabolic factors have a significant role in the morbidity and mortality associated with chronic liver disease. The pancreas has a central role in metabolism and metabolic risk factors but has been largely ignored in liver transplantation. Small pancreas volume has been demonstrated in pathologic conditions such as type 1 and 2 diabetes. METHODS: This study assessed abdominal imaging before and after liver transplantation to determine if liver transplantation induces changes in pancreas volume in living donor liver transplant recipients...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38637919/advancing-the-scientific-basis-for-determining-death-in-controlled-organ-donation-after-circulatory-determination-of-death
#5
JOURNAL ARTICLE
Nicholas B Murphy, Sam D Shemie, Alex Capron, Robert D Truog, Thomas Nakagawa, Andrew Healey, Teneille Gofton, James L Bernat, Kathleen Fenton, Kiran K Khush, Bryanna Schwartz, Stephen P Wall
In controlled organ donation after circulatory determination of death (cDCDD), accurate and timely death determination is critical, yet knowledge gaps persist. Further research to improve the science of defining and determining death by circulatory criteria is therefore warranted. In a workshop sponsored by the National Heart, Lung, and Blood Institute, experts identified research opportunities pertaining to scientific, conceptual, and ethical understandings of DCDD and associated technologies. This article identifies a research strategy to inform the biomedical definition of death, the criteria for its determination, and circulatory death determination in cDCDD...
April 19, 2024: Transplantation
https://read.qxmd.com/read/38632678/identification-of-differentially-expressed-genes-in-cold-storage-associated-kidney-transplantation
#6
JOURNAL ARTICLE
Jiefu Zhu, Xiaohong Xiang, Lang Shi, Zhixia Song, Zheng Dong
BACKGROUND: Although it is acknowledged that ischemia-reperfusion injury is the primary pathology of cold storage-associated kidney transplantation, its underlying mechanism is not well elucidated. METHODS: To extend the understanding of molecular events and mine hub genes posttransplantation, we performed bulk RNA sequencing at different time points (24 h, day 7, and day 14) on a murine kidney transplantation model with prolonged cold storage (10 h)...
April 18, 2024: Transplantation
https://read.qxmd.com/read/38622762/no-improvement-in-intention-to-treat-survival-and-increasing-liver-nonutilization-rate-during-the-meld-era
#7
JOURNAL ARTICLE
Rei Matsumoto, Elizabeth C Verna, Russell Rosenblatt, Jean C Emond, Robert S Brown, Amir A Rahnemai-Azar, Benjamin Samstein, Lorna M Dove, Tomoaki Kato
BACKGROUND: Although post liver transplant survival rates have significantly improved during the past 2-3 decades, the trend in intention-to-treat (ITT) survival (survival from waitlist addition) has not been well studied. METHODS: We conducted a retrospective analysis of Scientific Registry of Transplant Recipients data to determine the trend in ITT survival in liver transplant candidates. Adult (age ≧ 18 y) patients who were on the waitlist between the time period of March 1, 2002, to December 31, 2019 (n = 200 816) and deceased liver donors that were registered between the same time period (n = 152 593) were analyzed...
April 16, 2024: Transplantation
https://read.qxmd.com/read/38616312/certification-training-and-liver-transplant-experience-improves-liver-procurement-outcomes-the-dutch-approach
#8
JOURNAL ARTICLE
Hwai-Ding Lam, Rutger Ploeg, Willemijn N Nijboer, Ian P J Alwayn, Minneke Coenraad, Aline C Hemke, Esther Bastiaannet, Hein Putter, Andrzej Baranski
BACKGROUND: This study investigates the impact of certification training and liver transplant experience on procurement outcomes of deceased donor liver procurement in the Netherlands. METHODS: Three groups (trainee, certified, and master) were formed, with further subdivision based on liver transplant experience. Three key outcomes-surgical injury, graft discard after injury, and donor hepatectomy duration-were analyzed. RESULTS: There were no significant differences in surgical graft injury in the three groups (trainee, 16...
April 15, 2024: Transplantation
https://read.qxmd.com/read/38605438/the-second-international-consensus-guidelines-on-the-management-of-bk-polyomavirus-in-kidney-transplantation
#9
JOURNAL ARTICLE
Camille N Kotton, Nassim Kamar, David Wojciechowski, Michael Eder, Helmut Hopfer, Parmjeet Randhawa, Martina Sester, Patrizia Comoli, Helio Tedesco Silva, Greg Knoll, Daniel C Brennan, Jennifer Trofe-Clark, Lars Pape, David Axelrod, Bryce Kiberd, Germaine Wong, Hans H Hirsch
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation. International experts reviewed current evidence and updated recommendations according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Risk factors for BKPyV-DNAemia and biopsy-proven BKPyV-nephropathy include recipient older age, male sex, donor BKPyV-viruria, BKPyV-seropositive donor/-seronegative recipient, tacrolimus, acute rejection, and higher steroid exposure. To facilitate early intervention with limited allograft damage, all kidney transplant recipients should be screened monthly for plasma BKPyV-DNAemia loads until month 9, then every 3 mo until 2 y posttransplant (3 y for children)...
April 12, 2024: Transplantation
https://read.qxmd.com/read/38597913/nanoparticle-assisted-targeting-delivery-technologies-for-preventing-organ-rejection
#10
JOURNAL ARTICLE
Fanchao Meng, Yang Fu, Haiyang Xie, Hangxiang Wang
Although organ transplantation is a life-saving medical procedure, the challenge of posttransplant rejection necessitates safe and effective immune modulation strategies. Nanodelivery approaches may have the potential to overcome the limitations of small-molecule immunosuppressive drugs, achieving efficacious treatment options for transplant tolerance without compromising overall host immunity. This review highlights recent advances in biomaterial-assisted formulations and technologies for targeted nanodrug delivery with transplant organ- or immune cell-level precision for treating graft rejection after transplantation...
April 8, 2024: Transplantation
https://read.qxmd.com/read/38595232/elevation-of-donor-derived-cell-free-dna-before-biopsy-proven-rejection-in-kidney-transplant
#11
JOURNAL ARTICLE
Jonathan S Bromberg, Suphamai Bunnapradist, Milagros Samaniego-Picota, Sanjiv Anand, Erik Stites, Philippe Gauthier, Zachary Demko, Adam Prewett, Madeleine Armer-Cabral, Kyle Marshall, Navchetan Kaur, Michelle S Bloom, Hossein Tabriziani, Sangeeta Bhorade, Matthew Cooper
BACKGROUND: Standard-of-care biomarkers for renal allograft rejection are lagging indicators, signaling existing organ injury. This precludes early intervention, when immunological cascades leading to rejection are most susceptible. Donor-derived cell-free DNA (dd-cfDNA) shows promise as an early indicator of rejection, allowing earlier and possibly more effective treatment. This analysis was designed to assess this promise using real-world dd-cfDNA testing evidence. METHODS: This retrospective analysis of the prospective, observational ProActive registry study (NCT04091984) assessed dd-cfDNA and serum creatinine levels before biopsy in 424 patients with ≥1 dd-cfDNA test (n = 1013) in the 6 mo before biopsy...
April 8, 2024: Transplantation
https://read.qxmd.com/read/38587920/the-dual-specificity-phosphatase-3-dusp3-a-potential-target-against-renal-ischemia-reperfusion-injury
#12
JOURNAL ARTICLE
Badr Khbouz, Lucia Musumeci, Florian Grahammer, François Jouret
Renal ischemia/reperfusion (I/R) injury is a common clinical challenge faced by clinicians in kidney transplantation. I/R is the leading cause of acute kidney injury, and it occurs when blood flow to the kidney is interrupted and subsequently restored. I/R impairs renal function in both short and long terms. Renal ischemic preconditioning refers to all maneuvers intended to prevent or attenuate ischemic damage. In this context, the present review focuses on the dual-specificity phosphatase 3 (DUSP3), also known as vaccinia H1-related phosphatase, an uncommon regulator of mitogen-activated protein kinase (MAPK) phosphorylation...
April 8, 2024: Transplantation
https://read.qxmd.com/read/38587506/early-immunomodulatory-program-triggered-by-protolerogenic-bifidobacterium-pseudolongum-drives-cardiac-transplant-outcomes
#13
JOURNAL ARTICLE
Samuel J Gavzy, Allison Kensiski, Vikas Saxena, Ram Lakhan, Lauren Hittle, Long Wu, Jegan Iyyathurai, Hima Dhakal, Zachariah L Lee, Lushen Li, Young S Lee, Tianshu Zhang, Hnin Wai Lwin, Marina W Shirkey, Christina M Paluskievicz, Wenji Piao, Emmanuel F Mongodin, Bing Ma, Jonathan S Bromberg
BACKGROUND: Despite ongoing improvements to regimens preventing allograft rejection, most cardiac and other organ grafts eventually succumb to chronic vasculopathy, interstitial fibrosis, or endothelial changes, and eventually graft failure. The events leading to chronic rejection are still poorly understood and the gut microbiota is a known driving force in immune dysfunction. We previously showed that gut microbiota dysbiosis profoundly influences the outcome of vascularized cardiac allografts and subsequently identified biomarker species associated with these differential graft outcomes...
April 8, 2024: Transplantation
https://read.qxmd.com/read/38587504/navigating-the-intersection-fungal-infections-in-transplant-recipients-during-covid-19
#14
JOURNAL ARTICLE
Daniel Wagner Santos, Wanessa Trindade Clemente
No abstract text is available yet for this article.
April 8, 2024: Transplantation
https://read.qxmd.com/read/38578708/liraglutide-protects-pancreatic-islet-from-ischemic-injury-by-reducing-oxidative-stress-and-activating-akt-signaling-during-cold-preservation-to-improve-islet-transplantation-outcomes
#15
JOURNAL ARTICLE
Xiangheng Cai, Jinglin Cao, Le Wang, Jiaqi Zou, Rui Li, Peng Sun, Xuejie Ding, Boya Zhang, Zewen Liu, Xirui Pei, Jiuxia Yang, Yixiang Zhan, Na Liu, Tengli Liu, Rui Liang, Jie Gao, Shusen Wang
BACKGROUND: Islet transplantation is a promising therapy for patients with type 1 diabetes. However, ischemic injury to the donor islets during cold preservation leads to reduced islet quality and compromises transplant outcome. Several studies imply that liraglutide, a glucagon-like peptide-1 receptor agonist, has a positive effect on promoting islet survival, but its impact on islet cold-ischemic injury remains unexplored. Therefore, the aim of this study was to investigate whether liraglutide can improve islet transplantation efficacy by inhibiting cold-ischemic injury and to explore the underlying mechanisms...
April 5, 2024: Transplantation
https://read.qxmd.com/read/38578706/reducing-early-graft-loss-in-xenotransplantation-with-histocompatibility-testing
#16
JOURNAL ARTICLE
Matt Tector, A Joseph Tector
No abstract text is available yet for this article.
April 5, 2024: Transplantation
https://read.qxmd.com/read/38578704/highly-sensitized-candidates-remain-at-risk-for-microvascular-inflammation-even-when-donor-specific-antibody-is-avoided-a-matched-cohort-study
#17
JOURNAL ARTICLE
Amogh Agrawal, Suryanarayanan Balakrishnan, Manish J Gandhi, Mariam P Alexander, Lynn Cornell, Andrew J Bentall, Aleksandra Kukla, Mark Stegall, Carrie A Schinstock
BACKGROUND: Microvascular inflammation (MVI) is a key feature of antibody-mediated rejection (AMR) among patients with HLA donor-specific antibody (DSA), but MVI at AMR thresholds (Banff glomerulitis [g] + peritubular capillaritis [ptc] score ≥ 2) without DSA has been increasingly recognized. We aimed to determine the incidence of MVI among highly sensitized kidney transplant recipients without DSA. METHODS: We performed a single-center, retrospective, matched cohort study comparing outcomes of kidney transplant recipients with cPRA ≥90% with preexisting DSA (n = 49), cPRA ≥90% without preexisting DSA (n = 47), and matched controls with cPRA = 0 without preexisting DSA (n = 49)...
April 5, 2024: Transplantation
https://read.qxmd.com/read/38578699/cell-specific-extracellular-vesicles-and-their-mirna-cargo-released-into-the-organ-preservation-solution-during-cold-ischemia-storage-as-biomarkers-for-liver-transplant-outcomes
#18
JOURNAL ARTICLE
Daniel Vidal-Correoso, Sandra V Mateo, Ana M Muñoz-Morales, Fernando Lucas-Ruiz, Marta Jover-Aguilar, Felipe Alconchel, Laura Martínez-Alarcón, Sara Sánchez-Redondo, Vanesa Santos, Víctor López-López, Antonio Ríos-Zambudio, Pedro Cascales, José Antonio Pons, Pablo Ramírez, Pablo Pelegrín, Héctor Peinado, Alberto Baroja-Mazo
BACKGROUND: Liver transplantation (LT) is crucial for end-stage liver disease patients, but organ shortages persist. Donation after circulatory death (DCD) aims to broaden the donor pool but presents challenges. Complications like acute rejection, hepatic artery thrombosis, and biliary issues still impact posttransplant prognosis. Biomarkers, including extracellular vesicles (EVs) and microRNAs (miRNAs), show promise in understanding and monitoring posttransplant events. This study explores the role of EVs and their miRNA cargo in LT, including their potential as diagnostic tools...
April 5, 2024: Transplantation
https://read.qxmd.com/read/38578698/outcomes-of-heart-transplantation-from-donation-after-circulatory-death-an-up-to-date-systematic-meta-analysis
#19
JOURNAL ARTICLE
Junjie Zong, Weicong Ye, Jizhang Yu, Xi Zhang, Jikai Cui, Zhang Chen, Yuan Li, Song Wang, Shuan Ran, Yuqing Niu, Zilong Luo, Xiaohan Li, Jiulu Zhao, Yanglin Hao, Jiahong Xia, Jie Wu
BACKGROUND: Donation after circulatory death (DCD) heart transplantation (HTx) significantly expands the donor pool and reduces waitlist mortality. However, high-level evidence-based data on its safety and effectiveness are lacking. This meta-analysis aimed to compare the outcomes between DCD and donation after brain death (DBD) HTxs. METHODS: Databases, including MEDLINE, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials, were systematically searched for randomized controlled trials and observational studies reporting the outcomes of DCD and DBD HTxs published from 2014 onward...
April 5, 2024: Transplantation
https://read.qxmd.com/read/38564451/efficacy-and-safety-of-bleselumab-in-preventing-the-recurrence-of-primary-focal-segmental-glomerulosclerosis-in-kidney-transplant-recipients-a-phase-2a-randomized-multicenter-study
#20
JOURNAL ARTICLE
Jun Shoji, William C Goggins, Jason R Wellen, Patrick N Cunningham, Olwyn Johnston, Shirley S Chang, Kim Solez, Vicki Santos, Tami J Larson, Masahiro Takeuchi, Xuegong Wang
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease and frequently recurs after kidney transplantation. Recurrent FSGS (rFSGS) is associated with poor allograft and patient outcomes. Bleselumab, a fully human immunoglobulin G4 anti-CD40 antagonistic monoclonal antibody, disrupts CD40-related processes in FSGS, potentially preventing rFSGS. METHODS: A phase 2a, randomized, multicenter, open-label study of adult recipients (aged ≥18 y) of a living or deceased donor kidney transplant with a history of biopsy-proven primary FSGS...
April 1, 2024: Transplantation
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