journal
Journals Transactions of the Royal Soci...

Transactions of the Royal Society of Tropical Medicine and Hygiene

https://read.qxmd.com/read/36939014/predisposition-to-soil-transmitted-helminth-reinfection-after-four-rounds-of-mass-drug-administration-results-from-a-longitudinal-cohort-in-the-geshiyaro-project-a-transmission-elimination-feasibility-study-in-the-wolaita-zone-of-southern-ethiopia
#1
JOURNAL ARTICLE
Santiago Rayment Gomez, Rosie Maddren, Ewnetu Firdawek Liyew, Melkie Chernet, Ufaysa Anjulo, Adugna Tamiru, Birhan Mengitsu, Kathryn Forbes, Benjamin Collyer, Mihretab Salasibew, Roy Anderson
BACKGROUND: Current WHO strategies for reaching soil-transmitted helminths (STH) elimination as a public health problem excludes treating certain adult populations in endemic areas, creating infection reservoirs that drive 'bounce back' of STH infection to pretreatment levels post-mass drug administration (MDA). Predisposition is a widespread, but poorly understood phenomena among helminth infections where individuals are predisposed to reinfection after repeated treatments. METHODS: This analysis uses Geshiyaro project data, an STH control programme exploring transmission interruption by community-wide MDA and enhanced water, sanitation and hygiene during 2019-2023...
March 20, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36919827/effects-of-selected-blood-derived-factors-on-innate-immunity-in-the-human-body-louse
#2
JOURNAL ARTICLE
Lauren Kress, Benjamin Tegethoff, Jose E Pietri
BACKGROUND: The human body louse (Pediculus humanus humanus) is a host-specific hematophagous ectoparasite that frequently infests populations experiencing a breakdown of hygienic conditions. Body lice are also vectors for several bacterial human pathogens, including Bartonella quintana, the agent of trench fever. However, the factors that influence immunity and infection in body lice are poorly understood. Human infection with B. quintana is associated with alcoholism and homelessness and can coincide with elevated circulating levels of the cytokine IL-10 and the inflammatory marker neopterin...
March 15, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36912044/challenges-and-prospects-of-managing-non-acute-medical-conditions-among-pastoral-populations-in-sub-saharan-africa
#3
JOURNAL ARTICLE
Emmanuel Ekeria, Adefolarin Opawoye, Muhammad S Abubakar, Garba Iliyasu, Abdulrazaq G Habib
In Africa, pastoral populations face several underrecognized health issues. The livelihoods of pastoralists revolve around possession of livestock and they are constantly moving in search of water and pasturage. They are predisposed to chronic zoonotic infections but may also suffer from non-acute non-zoonotic cosmopolitan infectious and non-infectious chronic medical conditions. Given their migratory lifestyle, livelihood, geographic inaccessibility, communication barriers, illiteracy and poverty, it is challenging for pastoralists to access lengthy inpatient clinical care and long-term periodic follow-up that may be required to achieve control or cure of subacute, chronic or lifelong diseases...
March 13, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36864562/zika-virus-knowledge-attitudes-and-prevention-behaviors-among-pregnant-women-in-the-zen-cohort-study-colombia-2017-2018
#4
JOURNAL ARTICLE
Veronica K Burkel, Suzanne M Newton, Jacqueline Acosta, Diana Valencia, Monica Benavides, Van T Tong, Marcela Daza, Christina Sancken, Maritza Gonzalez, Kara Polen, Helena Rodriguez, Milena Borbón, Carol Y Rao, Suzanne M Gilboa, Margaret A Honein, Marta L Ospina, Candice Y Johnson
BACKGROUND: Zika virus (ZIKV) infection during pregnancy can cause severe birth defects in the fetus and is associated with neurodevelopmental abnormalities in childhood. Our objective was to describe ZIKV knowledge and attitudes among pregnant women in Colombia while ZIKV was circulating and whether they predicted the adoption of behaviors to prevent ZIKV mosquito-borne and sexual transmission. METHODS: We used self-reported data from Zika en Embarazadas y Niños (ZEN), a cohort study of women in early pregnancy across three regions of Colombia during 2017-2018...
March 2, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36857513/analysis-of-human-rabies-deaths-reported-at-two-hospitals-in-karachi-pakistan-a-call-to-save-lives-by-reforming-rabies-prevention-facilities
#5
JOURNAL ARTICLE
N Salahuddin, M A Gohar, S Jamali, M A Qureshi, N Baig-Ansari
BACKGROUND: Rabies is endemic in low- and middle-income countries. It is caused mainly by the bite of a rabid dog and is fatal if not treated effectively and in a timely manner with quality post-exposure prophylaxis. Despite a profusion of private and public healthcare centres in Sindh province, most are ill-equipped to treat dog bites. METHODS: We analysed 129 human deaths from rabies who presented at the emergency departments of two tertiary care hospitals in Karachi over 10 y...
March 1, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36846906/lifetime-prevalence-and-knowledge-of-snakebite-among-graduates-in-nigeria
#6
JOURNAL ARTICLE
Godpower C Michael, Bukar A Grema, Auwal A Bala, Abdulgafar L Olawumi, Aisa A Gana, Jeremiah K A Madaki, Abdulrazaq G Habib
BACKGROUND: Given the lack of studies on snakebite envenoming knowledge in the general population, we examined the lifetime prevalence of snakebite and knowledge of snakebite and its prevention and first aid among recent Nigerian graduates in national service. METHODS: This questionnaire-based cross-sectional study involved 351 consenting national youth corps members at a rural orientation camp in Kano, Nigeria. RESULTS: Participants' mean age was 25...
February 27, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36846900/unusual-clinical-presentations-in-leprosy-a-case-series-and-review
#7
JOURNAL ARTICLE
Gitesh Upendra Sawatkar, Apoorva Sharma, Vinay Keshavamurthy, Hitaishi Mehta, Debajyoti Chatterjee, Tarun Narang, Sunil Dogra
Conventionally, leprosy has been divided into various spectra of presentation ranging from the tuberculoid to the lepromatous pole, as well as histoid, pure neuritic leprosy and reactional states. This however is an oversimplification as leprosy can present in unusual clinical forms that may obfuscate the diagnosis. Our objective was to highlight unusual clinical presentations of leprosy occurring across all spectra of the disease. Our case series describes eight uncommon presentations of leprosy seen over a period of 10 y from 2011 to 2021, wherein clinical diagnosis followed by a histopathological confirmation of leprosy was performed...
February 27, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36722432/who-should-accelerate-not-stall-rectal-artesunate-deployment-for-pre-referral-treatment-of-severe-malaria
#8
JOURNAL ARTICLE
Thomas J Peto, James A Watson, Nicholas J White, Arjen M Dondorp
The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects...
February 1, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36715092/forty-years-1980-2019-of-visceral-leishmaniasis-in-nepal-trends-and-elimination-challenges
#9
JOURNAL ARTICLE
Kishor Pandey, Shyam Prakash Dumre, Yogendra Shah, Bipin Kumar Acharya, Laxman Khanal, Uttam Raj Pyakurel, Osamu Kaneko, Basu Dev Pandey
BACKGROUND: Visceral leishmaniasis (VL) is an important re-emerging neglected tropical disease associated with poverty. Despite the elimination initiative started in 2005, VL cases have been expanding into geographic areas in Nepal. The present study aims at exploring the trends of VL from 1980 to 2019. METHODS: This retrospective analysis covers 40 y of VL cases reported by the Epidemiology Diseases Control Division, Nepal. Subgroup analyses for annual incidence were performed by age, sex, seasons, districts and provinces, and VL cases were visualized on in-country maps...
January 28, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36688317/a-literature-review-of-schistosomiasis-in-ghana-a-reference-for-bridging-the-research-and-control-gap
#10
JOURNAL ARTICLE
Enoch Mensah Boateng, Jan Dvorak, Irene Ayi, Marta Chanova
Schistosomiasis is endemic in most sub-Saharan African countries, including Ghana, where the need for effective control involving preventive chemotherapy was indicated by the WHO. Mass drug administration commenced in 2008 and has continued since then in Ghana, but the country remains highly endemic. Here, we review the literature on schistosomiasis to identify research and knowledge gaps potentially affecting disease control. A total of 100 Ghana-related schistosomiasis literature sources were reviewed, showing that most studies were conducted on epidemiology, control of transmission and diagnosis...
January 23, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36637101/comparative-analysis-of-glass-and-hemotek-membrane-feeding-systems-for-malaria-transmission-research
#11
JOURNAL ARTICLE
Wouter Graumans, Michelle Schinkel, Geert-Jan van Gemert, Jeroen Spitzen, Teun Bousema, Pascal Miesen
BACKGROUND: Glass membrane feeders are used in malaria research for artificial blood feeding. This study investigates the use of Hemotek membrane feeders as a standardized alternative feeding system. METHODS: Hemotek feeders were compared with glass feeders by assessing mosquito feeding rate, imbibed blood meal volume and Plasmodium falciparum infection intensity on mosquito guts. RESULTS: While mosquito feeding rate and blood meal volume were comparable between Hemotek and glass feeders, a loss in transmission was observed using the Hemotek feeder with a conventional collagen membrane...
January 13, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36637010/is-there-added-value-from-using-three-serial-samples-when-surveying-the-occurrence-of-intestinal-parasites-in-children
#12
JOURNAL ARTICLE
Luis Enrique Jerez Puebla, Fidel A Núñez-Fernández, Edel La Rosa Osoria, Iraís Atencio Millán, Iredys Cruz Rodríguez, Lázara Rojas Rivero, Yanet Fresco Sampedro, Laura Rodríguez Moreno, Lucy J Robertson
BACKGROUND: Surveys for intestinal parasitic infections (IPIs) often involve samples from three sampling dates analysed by various microscopy techniques. However, analysis of three samples per individual is a huge burden on time and resources. We compared the value from analysing three or fewer samples. METHODS: In this cross-sectional study, three faecal samples were collected every other day from 332 children from two locations in Guantanamo province, Cuba. Samples were analysed by wet mount with Lugol stain, Willis flotation method and Kato-Katz thick smear...
January 13, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36633045/assessment-of-neuropathic-pain-functional-activity-limitation-and-quality-of-life-of-people-affected-by-leprosy-in-an-endemic-area-in-northeast-brazil-a-cross-sectional-study
#13
JOURNAL ARTICLE
Sara Ribeiro Silva, Stéphany Nogueira de Souza, Marya Fernandha Santos Santana, Adriana Maia Domingos, Nathálya da Silva Martins, Hidyanara Luiza de Paula, Heloisa Antunes Araujo, Glicya Monaly Claudino Dos Santos, Paulo Ricardo Martins-Filho, Victor Santana Santos
BACKGROUND: This study investigated the prevalence of neuropathic pain (NP) among people affected by leprosy and its effects on functional limitation and health-related quality of life (HRQoL) in an endemic area in Northeast Brazil. METHODS: This is a cross-sectional study of 122 leprosy patients. Functional limitation and HRQoL were assessed using the Screening of Activity Limitation and Safety Awareness (SALSA) and WHO Quality-of-Life (WHOQoL-BREF) scales, respectively...
January 12, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36625250/geographically-targeted-chronic-infection-screening-lessons-from-a-hepatitis-b-pilot-study-in-the-uk
#14
JOURNAL ARTICLE
Angus M O'Ferrall, Alison MacElhinney-West, Mark S Bell, Michael P Haslam, Gemma Walker, Donna Norton, Sean A Burns, Graham Ferrier, Nicholas J W Easom
Chronic hepatitis B (CHB) most commonly occurs following infection in early childhood. Prevalence varies markedly around the globe. Country of birth is therefore a strong predictor of CHB risk in adults. We used country of birth census data to predict CHB risk and carry out geographically targeted screening in East Yorkshire, UK. Despite engaging individuals born in high-prevalence countries with testing, we observed lower than expected prevalence in targeted highest-risk areas, which may indicate barriers to testing for people with undiagnosed CHB...
January 10, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36622662/covid-19-vaccine-equity-in-africa
#15
JOURNAL ARTICLE
Natasha Turyasingura, Wilmot G James, Sten H Vermund
The coronavirus disease 2019 (COVID-19) pandemic has dominated global health discourse since early 2020. By early 2021, the unprecedented speed of vaccine development against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by government, academia and industry contributed biotechnological tools to reduce severe COVID-19 infections, hospitalizations and deaths. However, vaccine distribution has not been equitable. We address one element of this challenge, namely the low COVID-19 vaccination rates in African countries, which lag behind higher-income nations...
January 9, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36611273/a-prospective-study-of-snakebite-in-a-tertiary-care-hospital-in-south-western-nepal
#16
JOURNAL ARTICLE
Deb Prasad Pandey, Bhola Ram Shrestha, Krishna Prasad Acharya, Khagendra Jang Shah, Chhabilal Thapa-Magar, Ishwari Prasad Dhakal, Fahim Mohamed, Geoffrey K Isbister
BACKGROUND: Snakebite is a neglected public health issue in Nepal. We aimed to characterize patients with snake envenoming admitted to hospital in south-western Nepal. METHODS: This was a prospective cohort study of 476 snakebite patients admitted to Bheri Hospital from May to December 2017. Data were collected on patient demographics, bite circumstances, snake type, treatment-seeking behavior, clinical effects, complications and treatment. RESULTS: There were 139/476 (29%) patients with clinical features of envenomation and 10 deaths (8%), of which six were prehospital deaths; 325/476 (68%) patients used non-recommended prehospital first aid, including 278 (58%) who applied a tourniquet and 43 (9%) consulting traditional healers...
January 6, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36611268/decomplexation-proteomic-analysis-and-purity-assessment-of-a-biologic-for-snakebite-envenoming-philippine-cobra-antivenom
#17
JOURNAL ARTICLE
Praneetha Palasuberniam, Kae Yi Tan, Yi Wei Chan, Francis Bonn Blanco, Choo Hock Tan
BACKGROUND: Philippine Cobra Antivenom (PCAV) is the only snake antivenom manufactured in the Philippines. It is used clinically to treat envenoming caused by the Philippine Spitting Cobra (Naja philippinensis). While PCAV is effective pharmacologically, it is crucial to ensure the safety profile of this biologic that is derived from animal plasma. METHODS: This study examined the composition purity of PCAV through a decomplexation proteomic approach, applying size-exclusion chromatography (SEC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and tandem mass spectrometry liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
January 6, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36610796/outpatient-parenteral-antimicrobial-therapy-for-leishmaniasis-13-years-experience-at-a-large-uk-infectious-diseases-centre
#18
JOURNAL ARTICLE
Vivak Parkash, Nicholas Laundy, Oyewole Christopher Durojaiye
BACKGROUND: Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective and safe. METHODS: We describe cases of leishmaniasis treated through outpatient parenteral antimicrobial therapy (OPAT) over a 13-y period (March 2006-September 2018) at a large teaching hospital. RESULTS: A total of 26 episodes of leishmaniasis were treated successfully, with a mean saving of 14...
January 5, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36594275/molecular-detection-of-schistosoma-species-in-unusual-snail-hosts-a-note-of-caution
#19
JOURNAL ARTICLE
Hudson Alves Pinto
The interaction between snails and species of Schistosoma results from an evolutionary process with an intrinsic host-parasite specificity to the snail genus. Faced with this fact, the recent molecular-based report on the potential infection of the thiarid Melanoides tuberculata with human schistosome should be cautiously interpreted. The high sensibility of molecular tools can result in false positives, perhaps by amplifying DNA from an external (contaminant) or invasive stage of schistosome found in this non-permissive snail host...
January 3, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36579933/depression-anxiety-and-stress-among-hiv-positive-pregnant-women-in-ethiopia-during-the-covid-19-pandemic
#20
JOURNAL ARTICLE
Nebiyu Solomon Tibebu, Belayneh Ayanaw Kassie, Tazeb Alemu Anteneh, Bayew Kelkay Rade
BACKGROUND: Assessing the maternal mental health status during the coronavirus disease 2019 (COVID-19) pandemic is necessary to prevent the occurrence of severe mental disorders. Prenatal depression, anxiety and stress disorders are prominent in pregnant women living with human immunodeficiency virus (HIV) and highly associated with poor maternal and neonatal outcomes. Therefore this study aimed to assess the level of depression, anxiety, and stress among HIV-positive pregnant women in Ethiopia during the COVID-19 pandemic...
December 29, 2022: Transactions of the Royal Society of Tropical Medicine and Hygiene
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