journal
https://read.qxmd.com/read/38604664/pulmonary-artery-pulmonary-artery-collaterals-in-chronic-thromboembolic-pulmonary-hypertension
#21
JOURNAL ARTICLE
Sugang Gong, Huiting Li, Lan Wang
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38604663/heteroresistance-in-tuberculosis-are-we-missing-drug-resistant-bacteria-hiding-in-plain-sight
#22
EDITORIAL
Mirae Park, Giovanni Satta, Pranabashis Haldar
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38575318/unravelling-the-neutrophil-enigma-a-new-insight-into-rsv-induced-bronchiolitis-in-infants
#23
EDITORIAL
Frances Susanna Grudzinska, Aaron Scott
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575317/ablation-for-lung-cancer-hot-or-cold-intervention
#24
EDITORIAL
Pallav L Shah
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575316/mac-attack-mscs-and-macrophages-join-forces-against-chronic-lung-infection
#25
EDITORIAL
Hazel Dunbar, Ian James Hawthorne, Karen English
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575315/extensive-airway-remodelling-in-severe-copd-imparts-resiliency-to-environmental-stressors
#26
EDITORIAL
Moumita Ghosh, Eszter K Vladar
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38548329/to-progress-or-not-to-progress-new-insights-into-the-evolution-of-pleuropulmonary-blastomas-come-from-studying-lung-cysts-in-adolescents-and-adults-with-dicer1-related-tumour-predisposition
#27
EDITORIAL
https://read.qxmd.com/read/38514183/clinical-implications-of-airway-obstruction-with-normal-or-low-fev-1-in-childhood-and-adolescence
#28
JOURNAL ARTICLE
Hans Jacob Lohne Koefoed, Gang Wang, Ulrike Gehring, Sandra Ekstrom, Inger Kull, Roel Vermeulen, Jolanda M A Boer, Anna Bergstrom, Gerard H Koppelman, Erik Melén, Judith M Vonk, Jenny Hallberg
BACKGROUND: Airway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1 ) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1 (classic) or a normal FEV1 in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear. AIMS: To investigate the association between airway obstruction with a low or normal FEV1 in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR)...
March 21, 2024: Thorax
https://read.qxmd.com/read/38508719/prevalence-of-lung-cysts-in-adolescents-and-adults-with-a-germline-dicer1-pathogenic-likely-pathogenic-variant-a-report-from-the-national-institutes-of-health-and-international-pleuropulmonary-blastoma-dicer1-registry
#29
JOURNAL ARTICLE
Alexander T Nelson, Lauren M Vasta, Dave Watson, Jung Kim, Anne K Harris, Ana F Best, Laura A Harney, Ann G Carr, Nicole Frederickson, Louis P Dehner, Christian P Kratz, Kelly N Hagedorn, William A Mize, Alexander Ling, Yoav H Messinger, D Ashley Hill, Kris Ann P Schultz, Douglas R Stewart
BACKGROUND: Pleuropulmonary blastoma (PPB), the hallmark tumour associated with DICER1 -related tumour predisposition, is characterised by an age-related progression from a cystic lesion (type I) to a high-grade sarcoma with mixed cystic and solid features (type II) or purely solid lesion (type III). Not all cystic PPBs progress; type Ir (regressed), hypothesised to represent regressed or non-progressed type I PPB, is an air-filled, cystic lesion lacking a primitive sarcomatous component...
March 20, 2024: Thorax
https://read.qxmd.com/read/38508718/human-mesenchymal-stromal-cells-inhibit-mycobacterium-avium-replication-in-clinically-relevant-models-of-lung-infection
#30
JOURNAL ARTICLE
Timothy D Shaw, Anna D Krasnodembskaya, Gunnar N Schroeder, Declan F Doherty, Johnatas Dutra Silva, Shikha M Tandel, Yue Su, David Butler, Rebecca J Ingram, Cecilia M O'Kane
INTRODUCTION: Novel therapeutic strategies are urgently needed for Mycobacterium avium complex pulmonary disease (MAC-PD). Human mesenchymal stromal cells (MSCs) can directly inhibit MAC growth, but their effect on intracellular bacilli is unknown. We investigated the ability of human MSCs to reduce bacterial replication and inflammation in MAC-infected macrophages and in a murine model of MAC-PD. METHODS: Human monocyte-derived macrophages (MDMs) were infected with M...
March 20, 2024: Thorax
https://read.qxmd.com/read/38499347/distinct-trajectories-of-lung-function-from-childhood-to-mid-adulthood
#31
JOURNAL ARTICLE
Xian Zhang, Andrew R Gray, Robert J Hancox
RATIONALE: Life course trajectories of lung function development and decline influence the risk for lung disease but are poorly documented. OBJECTIVE: To document lung function trajectories from childhood to mid-adult life. METHODS: We modelled forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC at ages 9, 11, 13, 15, 18, 21, 26, 32, 38 and 45 years from a population-based cohort using latent profile analysis to identify distinct subgroups of participants with similar lung function trajectories...
March 18, 2024: Thorax
https://read.qxmd.com/read/38499346/impact-of-post-covid-19-condition-on-health-status-and-activities-of-daily-living-the-prime-post-covid-study
#32
JOURNAL ARTICLE
Maarten Van Herck, Demi M E Pagen, Céline J A van Bilsen, Stephanie Brinkhues, Kevin Konings, Casper D J den Heijer, Suhreta Mujakovic, Henriëtte L G Ter Waarbeek, Chris Burtin, Daisy J A Janssen, Christian J P A Hoebe, Martijn A Spruit, Nicole H T M Dukers-Muijrers
OBJECTIVE: To assess health and activities of daily living (ADL) in SARS-CoV-2-positive adults with and without post-COVID-19 condition (PCC) and compare this with negative tested individuals. Furthermore, different PCC case definitions were compared with SARS-CoV-2-negative individuals. METHODS: All adults tested PCR positive for SARS-CoV-2 at the Public Health Service South Limburg (Netherlands) between June 2020 and November 2021 (n=41 780) and matched PCR negative individuals (2:1, on age, sex, year-quarter test, municipality; n=19 875) were invited by email...
March 18, 2024: Thorax
https://read.qxmd.com/read/38471792/patient-stratification-using-plasma-cytokines-and-their-regulators-in-sepsis-relationship-to-outcomes-treatment-effect-and-leucocyte-transcriptomic-subphenotypes
#33
JOURNAL ARTICLE
David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight
RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar subphenotypes exist in sepsis populations where leucocyte transcriptomic-defined subphenotypes have been reported...
March 12, 2024: Thorax
https://read.qxmd.com/read/38453471/impacts-of-sex-and-gender-on-severe-asthma
#34
EDITORIAL
Kimberley C W Wang, John D Blakey
No abstract text is available yet for this article.
March 7, 2024: Thorax
https://read.qxmd.com/read/38448222/physical-activity-and-body-mass-related-to-catch-up-lung-function-growth-in-childhood-a-population-based-accelerated-cohort-study
#35
JOURNAL ARTICLE
Sarah Koch, Gabriela Prado Peralta, Anne-Elie Carsin, Alicia Abellan, Celine Roda, Maties Torrent, Carmen Iñiguez, Ferran Ballester, Amparo Ferrero, Carlos Zabaleta, Aitana Lertxundi, Mònica Guxens, Martine Vrijheid, Jordi Sunyer, Maribel Casas, Judith Garcia-Aymerich
OBJECTIVE: The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort. METHODS: We applied group-based trajectory modelling to z-scores of forced expiratory volume in 1 second (zFEV1 ) and z-scores of forced vital capacity (zFVC) from 1151 children assessed at around 4, 7, 9, 10, 11, 14 and 18 years. Multinomial logistic regression models were used to test whether potential prenatal and postnatal predictors were associated with lung function trajectories...
March 6, 2024: Thorax
https://read.qxmd.com/read/38448221/adaptive-multi-interventional-trial-platform-to-improve-patient-care-for-fibrotic-interstitial-lung-diseases
#36
REVIEW
Leticia Kawano-Dourado, Tejaswini Kulkarni, Christopher J Ryerson, Pilar Rivera-Ortega, Bruno Guedes Baldi, Nazia Chaudhuri, Manuela Funke-Chambour, Anna-Maria Hoffmann-Vold, Kerri A Johannson, Yet Hong Khor, Sydney B Montesi, Lucilla Piccari, Helmut Prosch, María Molina-Molina, Jacobo Sellares Torres, Iazsmin Bauer-Ventura, Sujeet Rajan, Joseph Jacob, Duncan Richards, Lisa G Spencer, Barbara Wendelberger, Tom Jensen, Melanie Quintana, Michael Kreuter, Anthony C Gordon, Fernando J Martinez, Naftali Kaminski, Victoria Cornelius, Roger Lewis, Wendy Adams, Gisli Jenkins
BACKGROUND: Fibrotic interstitial lung diseases (fILDs) are a heterogeneous group of lung diseases associated with significant morbidity and mortality. Despite a large increase in the number of clinical trials in the last 10 years, current regulatory-approved management approaches are limited to two therapies that prevent the progression of fibrosis. The drug development pipeline is long and there is an urgent need to accelerate this process. This manuscript introduces the concept and design of an innovative research approach to drug development in fILD: a global Randomised Embedded Multifactorial Adaptive Platform in fILD (REMAP-ILD)...
March 6, 2024: Thorax
https://read.qxmd.com/read/38418195/monocyte-nlrp3-inflammasome-and-interleukin-1%C3%AE-activation-modulated-by-alpha-1-antitrypsin-therapy-in-deficient-individuals
#37
JOURNAL ARTICLE
Debananda Gogoi, Howard Yu, Michelle Casey, Rory Baird, Azeez Yusuf, Luke Forde, Michael E O' Brien, Jesse R West, Tammy Flagg, Noel G McElvaney, Edward Eden, Christian Mueller, Mark L Brantly, Patrick Geraghty, Emer P Reeves
INTRODUCTION: Altered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of this study was to investigate whether C3d, a cleavage-product of C3, triggers interleukin (IL)-1β secretion via activation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. The objective was to explore the effect of AAT augmentation therapy in patients with AATD on the C3d/complement receptor 3 (CR3) signalling axis of monocytes and on circulating pro-inflammatory markers...
February 28, 2024: Thorax
https://read.qxmd.com/read/38768987/correction-impact-of-respiratory-muscle-training-on-respiratory-muscle-strength-respiratory-function-and-quality-of-life-in-individuals-with-tetraplegia-a-randomised-clinical-trial
#38
JOURNAL ARTICLE
https://read.qxmd.com/read/38508717/testosterone-and-lung-function-bigger-lungs-slower-decline-or-some-combination-of-both
#39
EDITORIAL
Stephen Milne
No abstract text is available yet for this article.
May 20, 2024: Thorax
https://read.qxmd.com/read/38418196/effects-of-testosterone-and-sex-hormone-binding-globulin-on-lung-function-in-males-and-females-a-multivariable-mendelian-randomisation-study
#40
JOURNAL ARTICLE
Diana A van der Plaat, Alexandra Lenoir, Shyamali Dharmage, James Potts, Francisco Gómez Real, Seif O Shaheen, Debbie Jarvis, Cosetta Minelli, Bénédicte Leynaert
BACKGROUND: Observational studies suggest that total testosterone (TT) and sex hormone-binding globulin (SHBG) may have beneficial effects on lung function, but these findings might be spurious due to confounding and reverse causation. We addressed these limitations by using multivariable Mendelian randomisation (MVMR) to investigate the independent causal effects of TT and SHBG on lung function. METHODS: We first identified genetic instruments by performing genome-wide association analyses of TT and SHBG in the large UK Biobank, separately in males and females...
May 20, 2024: Thorax
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