journal
https://read.qxmd.com/read/37714536/is-antidepressant-use-a-concern-for-patients-with-copd
#1
EDITORIAL
Gianluca Trifirò, Salvatore Crisafulli
No abstract text is available yet for this article.
September 15, 2023: Thorax
https://read.qxmd.com/read/37696622/laryngeal-widening-and-adequate-ventilation-by-expiratory-pressure-load-training-improve-aerobic-capacity-in-copd-a-randomised-controlled-trial
#2
JOURNAL ARTICLE
Keisuke Miki, Kazuyuki Tsujino, Motonari Fukui, Mari Miki, Takamasa Kitajima, Hitoshi Sumitani, Kazuki Hashimoto, Masashi Yokoyama, Hisako Hashimoto, Takuro Nii, Takanori Matsuki, Hiroshi Kida
RATIONALE: Despite strategies acting on peripheral airway obstruction in chronic obstructive pulmonary disease (COPD), exercise intolerance remains inadequately improved. We hypothesised that laryngeal narrowing is a potential treatment target of expiratory pressure load training (EPT) to improve exercise intolerance in COPD. METHODS: The effect of 3-month EPT was assessed in 47 patients with COPD divided into Global Initiative for Chronic Obstructive Lung Disease (GOLD) mild-to-moderate (I-II) and severe-to-very severe (III-IV), randomly allocating 1:1 to EPT or control groups...
September 11, 2023: Thorax
https://read.qxmd.com/read/37696621/atopic-and-non-atopic-effects-of-fish-oil-supplementation-during-pregnancy
#3
JOURNAL ARTICLE
Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann-Marie Malby Schoos, Nicklas Brustad, Anders U Eliasen, Jonathan Thorsen, Bo Chawes, Gözde Gürdeniz, Andreanne Morin, Ken Stark, Jakob Stokholm, Carole Ober, Casper Emil Tingskov Pedersen, Klaus Bønnelykke
BACKGROUND: We recently conducted a double-blinded randomised controlled trial showing that fish-oil supplementation during pregnancy reduced the risk of persistent wheeze or asthma in the child by 30%. Here, we explore the mechanisms of the intervention. METHODS: 736 pregnant women were given either placebo or n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in the third trimester in a randomised controlled trial. Deep clinical follow-up of the 695 children in the trial was done at 12 visits until age 6 years, including assessment of genotype at the fatty acid desaturase (FADS) locus, plasma fatty acids, airway DNA methylation, gene expression, microbiome and metabolomics...
September 11, 2023: Thorax
https://read.qxmd.com/read/37657926/super-responders-to-anti-il-5-anti-il-5r-are-characterised-by-high-sputum-eosinophil-counts-at-baseline
#4
JOURNAL ARTICLE
Sara Gerday, Sophie Graff, Catherine Moermans, Françoise Guissard, Virginie Paulus, Monique Henket, Renaud Louis, Florence Schleich
Several clinical trials have demonstrated that anti-IL-5(R) biologics were able to improve lung function, asthma control and chronic oral corticosteroid exposure and reduce exacerbations among eosinophilic asthmatic patients. However, a certain variability in clinical responses to anti-IL-5(R) biologics was brought to light. Our study aimed at evaluating the role of baseline sputum eosinophils in identifying super-responders to mepolizumab and benralizumab. Our study reinforces the importance to examine sputum eosinophils in patients suffering from severe asthma before starting a biologic as it is associated with the intensity of response to mepolizumab and benralizumab...
September 1, 2023: Thorax
https://read.qxmd.com/read/37657925/covid-19-associated-pulmonary-aspergillosis-in-mechanically-ventilated-patients-a-prospective-multicentre-uk-study
#5
JOURNAL ARTICLE
William Hurt, Jonathan Youngs, Jonathan Ball, Jonathan Edgeworth, Philip Hopkins, David R Jenkins, Susannah Leaver, Andrea Mazzella, Síle F Molloy, Silke Schelenz, Matt P Wise, P Lewis White, Hakeem Yusuff, Duncan Wyncoll, Tihana Bicanic
BACKGROUND: Invasive pulmonary aspergillosis is a complication of severe COVID-19, with regional variation in reported incidence and mortality. We describe the incidence, risk factors and mortality associated with COVID-19-associated pulmonary aspergillosis (CAPA) in a prospective, multicentre UK cohort. METHODS: From March 2020 to March 2021, 266 mechanically ventilated adults with COVID-19 were enrolled across 5 UK hospital intensive care units (ICUs). CAPA was defined using European Confederation for Medical Mycology and the International Society for Human and Animal Mycology criteria and fungal diagnostics performed on respiratory and serum samples...
September 1, 2023: Thorax
https://read.qxmd.com/read/37640549/fibrosing-mediastinitis-haemoptysis-in-the-heartland
#6
JOURNAL ARTICLE
Prince Ntiamoah, Jui Rakesh Shah, Subha Ghosh, Atul Mehta
No abstract text is available yet for this article.
August 28, 2023: Thorax
https://read.qxmd.com/read/37640548/respiratory-management-and-outcomes-in-high-risk-preterm-infants-with-development-of-a-population-outcome-dashboard
#7
JOURNAL ARTICLE
Tng Chang Kwok, Caroline Poulter, Saleh Algarni, Lisa Szatkowski, Don Sharkey
INTRODUCTION: Bronchopulmonary dysplasia (BPD) is associated with adverse long-term respiratory and neurodevelopmental outcomes. No recent studies examined the changing respiratory management and outcomes, particularly severe BPD, across a whole population. PURPOSE: Evaluate the temporal trends in the respiratory management and outcomes of preterm infants born below 32 weeks gestational age and develop an individualised dashboard of the incidence of neonatal outcome...
August 28, 2023: Thorax
https://read.qxmd.com/read/37640547/searching-again-for-answers-in-all-the-wrong-places
#8
EDITORIAL
James Fackler
No abstract text is available yet for this article.
August 28, 2023: Thorax
https://read.qxmd.com/read/37620048/guideline-concordance-for-timely-chest-imaging-after-new-presentations-of-dyspnoea-or-haemoptysis-in-primary-care-a-retrospective-cohort-study
#9
JOURNAL ARTICLE
Minjoung Monica Koo, Luke T A Mounce, Meena Rafiq, Matthew E J Callister, Hardeep Singh, Gary A Abel, Georgios Lyratzopoulos
BACKGROUND: Guidelines recommend urgent chest X-ray for newly presenting dyspnoea or haemoptysis but there is little evidence about their implementation. METHODS: We analysed linked primary care and hospital imaging data for patients aged 30+ years newly presenting with dyspnoea or haemoptysis in primary care during April 2012 to March 2017. We examined guideline-concordant management, defined as General Practitioner-ordered chest X-ray/CT carried out within 2 weeks of symptomatic presentation, and variation by sociodemographic characteristic and relevant medical history using logistic regression...
August 24, 2023: Thorax
https://read.qxmd.com/read/37620047/moving-mountains-in-community-acquired-pneumonia-stone-by-stone-we-progress
#10
EDITORIAL
Frances Susanna Grudzinska
No abstract text is available yet for this article.
August 24, 2023: Thorax
https://read.qxmd.com/read/37620046/fragmentation-of-care-between-intensive-and-primary-care-settings-and-opportunities-for-improvement
#11
JOURNAL ARTICLE
Nina Leggett, Kate Emery, Thomas C Rollinson, Adam Deane, Craig French, Jo-Anne Manski Nankervis, Glenn Eastwood, Briannah Miles, Mark Merolli, Yasmine Ali Abdelhamid, Kimberley Joy Haines
PURPOSE: To explore the gaps in care provided across the transitions from the intensive care unit (ICU) to primary care, in order to improve post-ICU care. METHODS: Semistructured interviews with three participant groups: intensivists, general practitioners (GPs) and patients and carers with framework analysis of textual data were used to investigate experiences of transitions of care post-ICU. Participants were purposively sampled for diversity. Eligible patients were adults, mechanically ventilated for >24 hours, with access to a video-enabled device...
August 24, 2023: Thorax
https://read.qxmd.com/read/37604693/five-year-follow-up-of-phase-ii-trial-of-stromal-cells-for-bronchopulmonary-dysplasia
#12
JOURNAL ARTICLE
So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Sein Sung, Ai-Rhan Kim, Won Soon Park
BACKGROUND: We previously performed a phase II randomised double-blind clinical trial of mesenchymal stromal cell (MSCs) transplantation to prevent bronchopulmonary dysplasia in extremely premature infants. Subsequently, we followed the infants enrolled in this clinical trial to determine the safety and effectiveness of MSCs against bronchopulmonary dysplasia at 5-year follow-up. METHODS: We evaluated infants at 5 years of age receiving placebo or MSCs in a prospective follow-up study...
August 21, 2023: Thorax
https://read.qxmd.com/read/37604692/donor-lung-allocation-scheme-how-can-we-measure-success
#13
EDITORIAL
Hoong Sern Lim, Erika D D Lease
No abstract text is available yet for this article.
August 21, 2023: Thorax
https://read.qxmd.com/read/37591700/reimagining-emphysema-for-a-computational-age
#14
EDITORIAL
Joseph Jacob
No abstract text is available yet for this article.
August 17, 2023: Thorax
https://read.qxmd.com/read/37586744/invitation-strategies-and-participation-in-a-community-based-lung-cancer-screening-programme-located-in-areas-of-high-socioeconomic-deprivation
#15
JOURNAL ARTICLE
Patrick Goodley, Haval Balata, Alberto Alonso, Christopher Brockelsby, Matthew Conroy, Nicola Cooper-Moss, Christopher Craig, Matthew Evison, Kath Hewitt, Coral Higgins, William Johnson, Judith Lyons, Zoe Merchant, Ailsa Rowlands, Anna Sharman, Nicola Sinnott, Matthew Sperrin, Richard Booton, Philip A J Crosbie
INTRODUCTION: Although lung cancer screening is being implemented in the UK, there is uncertainty about the optimal invitation strategy. Here, we report participation in a community screening programme following a population-based invitation approach, examine factors associated with participation, and compare outcomes with hypothetical targeted invitations. METHODS: Letters were sent to all individuals (age 55-80) registered with a general practice (n=35 practices) in North and East Manchester, inviting ever-smokers to attend a Lung Health Check (LHC)...
August 16, 2023: Thorax
https://read.qxmd.com/read/37582630/prospective-study-of-e-cigarette-use-and-respiratory-symptoms-in-adolescents-and-young-adults
#16
JOURNAL ARTICLE
Alayna P Tackett, Robert Urman, Jessica Barrington-Trimis, Feifei Liu, Hanna Hong, Mary Ann Pentz, Talat S Islam, Sandrah P Eckel, Meghan Rebuli, Adam Leventhal, Jonathan M Samet, Kiros Berhane, Rob McConnell
RATIONALE: Electronic cigarette (e-cigarette) aerosol contains volatile aldehydes, including flavourings and oxidant metals with known pulmonary toxicity. OBJECTIVES: To evaluate the associations of e-cigarette use with symptoms of wheeze, bronchitic symptoms and shortness of breath (SOB) across 4 years of prospective data. METHODS: Participants completed questionnaires on respiratory symptoms and past 30-day e-cigarette, cigarette and cannabis use in 2014 (wave 1; N=2094; mean age 17...
August 15, 2023: Thorax
https://read.qxmd.com/read/37553157/british-thoracic-society-guideline-for-pleural-disease
#17
JOURNAL ARTICLE
Mark E Roberts, Najib M Rahman, Nick A Maskell, Anna C Bibby, Kevin G Blyth, John P Corcoran, Anthony Edey, Matthew Evison, Duneesha de Fonseka, Rob Hallifax, Susan Harden, Iain Lawrie, Eric Lim, David McCracken, Rachel Mercer, Eleanor K Mishra, Andrew G Nicholson, Farinaz Noorzad, Kirstie S Opstad, Maria Parsonage, Andrew E Stanton, Steven Walker
No abstract text is available yet for this article.
August 8, 2023: Thorax
https://read.qxmd.com/read/37553156/towards-an-integrated-clinical-network-of-care-for-children-with-sleep-disordered-breathing
#18
EDITORIAL
Heather E Elphick
No abstract text is available yet for this article.
August 8, 2023: Thorax
https://read.qxmd.com/read/37553155/british-thoracic-society-guideline-for-diagnosing-and-monitoring-paediatric-sleep-disordered-breathing
#19
JOURNAL ARTICLE
Hazel J Evans, Neil A Gibson, Joanna Bennett, Samantha Ys Chan, Johanna Gavlak, Katharine Harman, Hasnaa Ismail-Koch, Ruth N Kingshott, Ross Langley, Andrew Morley, Kirstie S Opstad, Kylie Russo, Martin P Samuels, Hui Leng Tan, Daniel Tweedie, Michael Yanney, Andrea Whitney
No abstract text is available yet for this article.
August 8, 2023: Thorax
https://read.qxmd.com/read/37524392/readmission-following-hospital-admission-for-community-acquired-pneumonia-in-england
#20
JOURNAL ARTICLE
Hannah Lawrence, Tricia M McKeever, Wei Shen Lim
INTRODUCTION: Readmission rates following hospital admission with community-acquired pneumonia (CAP) have increased in the UK over the past decade. The aim of this work was to describe the cohort of patients with emergency 30-day readmission following hospitalisation for CAP in England and explore the reasons for this. METHODS: A retrospective analysis of cases from the British Thoracic Society national adult CAP audit admitted to hospitals in England with CAP between 1 December 2018 and 31 January 2019 was performed...
July 31, 2023: Thorax
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