journal
https://read.qxmd.com/read/38631896/environmental-pollutants-exposure-derived-extracellular-vesicles-crucial-players-in-respiratory-disorders
#1
REVIEW
Haoran Shen, Rui Zheng, Mulong Du, David C Christiani
BACKGROUND: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the extracellular vesicle (EV) was an emerging intercellular communication medium, recent studies have highlighted the crucial role of environmental pollutants derived EVs (EPE-EVs) in respiratory disorders. METHODS: PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders and EVs...
April 17, 2024: Thorax
https://read.qxmd.com/read/38604666/new-path-for-understanding-mucociliary-clearance
#2
EDITORIAL
Timothy E Corcoran
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38604665/toxic-metals-and-lung-health-silent-poisons
#3
EDITORIAL
Seif O Shaheen
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38604664/pulmonary-artery-pulmonary-artery-collaterals-in-chronic-thromboembolic-pulmonary-hypertension
#4
JOURNAL ARTICLE
Sugang Gong, Huiting Li, Lan Wang
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38604663/heteroresistance-in-tuberculosis-are-we-missing-drug-resistant-bacteria-hiding-in-plain-sight
#5
EDITORIAL
Mirae Park, Giovanni Satta, Pranabashis Haldar
No abstract text is available yet for this article.
April 10, 2024: Thorax
https://read.qxmd.com/read/38575318/unravelling-the-neutrophil-enigma-a-new-insight-into-rsv-induced-bronchiolitis-in-infants
#6
EDITORIAL
Frances Susanna Grudzinska, Aaron Scott
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575317/ablation-for-lung-cancer-hot-or-cold-intervention
#7
EDITORIAL
Pallav L Shah
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575316/mac-attack-mscs-and-macrophages-join-forces-against-chronic-lung-infection
#8
EDITORIAL
Hazel Dunbar, Ian James Hawthorne, Karen English
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38575315/extensive-airway-remodelling-in-severe-copd-imparts-resiliency-to-environmental-stressors
#9
EDITORIAL
Moumita Ghosh, Eszter K Vladar
No abstract text is available yet for this article.
April 4, 2024: Thorax
https://read.qxmd.com/read/38548329/to-progress-or-not-to-progress-new-insights-into-the-evolution-of-pleuropulmonary-blastomas-come-from-studying-lung-cysts-in-adolescents-and-adults-with-dicer1-related-tumour-predisposition
#10
EDITORIAL
https://read.qxmd.com/read/38514184/improved-pulmonary-function-and-exercise-tolerance-despite-persistent-pulmonary-fibrosis-over-1-year-after-severe-covid-19-infection
#11
JOURNAL ARTICLE
Claire F McGroder, Mary M Salvatore, Belinda M D'Souza, Eric A Hoffman, Matthew R Baldwin, Christine Kim Garcia
We conducted a prospective single-centre cohort study of 104 multi-ethnic severe COVID-19 survivors from the first wave of the pandemic 15 months after hospitalisation. Of those who were assessed at 4 and 15 months, improvement of ground glass opacities correlated with worsened fibrotic reticulations. Despite a high prevalence of fibrotic patterns (64%), pulmonary function, grip strength, 6 min walk distance and frailty normalised. Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies...
March 21, 2024: Thorax
https://read.qxmd.com/read/38514183/clinical-implications-of-airway-obstruction-with-normal-or-low-fev-1-in-childhood-and-adolescence
#12
JOURNAL ARTICLE
Hans Jacob Lohne Koefoed, Gang Wang, Ulrike Gehring, Sandra Ekstrom, Inger Kull, Roel Vermeulen, Jolanda M A Boer, Anna Bergstrom, Gerard H Koppelman, Erik Melén, Judith M Vonk, Jenny Hallberg
BACKGROUND: Airway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1 ) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1 (classic) or a normal FEV1 in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear. AIMS: To investigate the association between airway obstruction with a low or normal FEV1 in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR)...
March 21, 2024: Thorax
https://read.qxmd.com/read/38508719/prevalence-of-lung-cysts-in-adolescents-and-adults-with-a-germline-dicer1-pathogenic-likely-pathogenic-variant-a-report-from-the-national-institutes-of-health-and-international-pleuropulmonary-blastoma-dicer1-registry
#13
JOURNAL ARTICLE
Alexander T Nelson, Lauren M Vasta, Dave Watson, Jung Kim, Anne K Harris, Ana F Best, Laura A Harney, Ann G Carr, Nicole Frederickson, Louis P Dehner, Christian P Kratz, Kelly N Hagedorn, William A Mize, Alexander Ling, Yoav H Messinger, D Ashley Hill, Kris Ann P Schultz, Douglas R Stewart
BACKGROUND: Pleuropulmonary blastoma (PPB), the hallmark tumour associated with DICER1 -related tumour predisposition, is characterised by an age-related progression from a cystic lesion (type I) to a high-grade sarcoma with mixed cystic and solid features (type II) or purely solid lesion (type III). Not all cystic PPBs progress; type Ir (regressed), hypothesised to represent regressed or non-progressed type I PPB, is an air-filled, cystic lesion lacking a primitive sarcomatous component...
March 20, 2024: Thorax
https://read.qxmd.com/read/38508718/human-mesenchymal-stromal-cells-inhibit-mycobacterium-avium-replication-in-clinically-relevant-models-of-lung-infection
#14
JOURNAL ARTICLE
Timothy D Shaw, Anna D Krasnodembskaya, Gunnar N Schroeder, Declan F Doherty, Johnatas Dutra Silva, Shikha M Tandel, Yue Su, David Butler, Rebecca J Ingram, Cecilia M O'Kane
INTRODUCTION: Novel therapeutic strategies are urgently needed for Mycobacterium avium complex pulmonary disease (MAC-PD). Human mesenchymal stromal cells (MSCs) can directly inhibit MAC growth, but their effect on intracellular bacilli is unknown. We investigated the ability of human MSCs to reduce bacterial replication and inflammation in MAC-infected macrophages and in a murine model of MAC-PD. METHODS: Human monocyte-derived macrophages (MDMs) were infected with M...
March 20, 2024: Thorax
https://read.qxmd.com/read/38508717/testosterone-and-lung-function-bigger-lungs-slower-decline-or-some-combination-of-both
#15
EDITORIAL
Stephen Milne
No abstract text is available yet for this article.
March 20, 2024: Thorax
https://read.qxmd.com/read/38499347/distinct-trajectories-of-lung-function-from-childhood-to-mid-adulthood
#16
JOURNAL ARTICLE
Xian Zhang, Andrew R Gray, Robert J Hancox
RATIONALE: Life course trajectories of lung function development and decline influence the risk for lung disease but are poorly documented. OBJECTIVE: To document lung function trajectories from childhood to mid-adult life. METHODS: We modelled forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC at ages 9, 11, 13, 15, 18, 21, 26, 32, 38 and 45 years from a population-based cohort using latent profile analysis to identify distinct subgroups of participants with similar lung function trajectories...
March 18, 2024: Thorax
https://read.qxmd.com/read/38499346/impact-of-post-covid-19-condition-on-health-status-and-activities-of-daily-living-the-prime-post-covid-study
#17
JOURNAL ARTICLE
Maarten Van Herck, Demi M E Pagen, Céline J A van Bilsen, Stephanie Brinkhues, Kevin Konings, Casper D J den Heijer, Suhreta Mujakovic, Henriëtte L G Ter Waarbeek, Chris Burtin, Daisy J A Janssen, Christian J P A Hoebe, Martijn A Spruit, Nicole H T M Dukers-Muijrers
OBJECTIVE: To assess health and activities of daily living (ADL) in SARS-CoV-2-positive adults with and without post-COVID-19 condition (PCC) and compare this with negative tested individuals. Furthermore, different PCC case definitions were compared with SARS-CoV-2-negative individuals. METHODS: All adults tested PCR positive for SARS-CoV-2 at the Public Health Service South Limburg (Netherlands) between June 2020 and November 2021 (n=41 780) and matched PCR negative individuals (2:1, on age, sex, year-quarter test, municipality; n=19 875) were invited by email...
March 18, 2024: Thorax
https://read.qxmd.com/read/38490721/serum-cytokine-biosignatures-for-identification-of-tuberculosis-among-hiv-positive-inpatients
#18
JOURNAL ARTICLE
Huihua Zhang, LingHua Li, YanXia Liu, Wei Xiao, RuiYao Xu, MengRu Lu, WenBiao Hao, YuChi Gao, Xiaoping Tang, Youchao Dai
BACKGROUND: Serum cytokines correlate with tuberculosis (TB) progression and are predictors of TB recurrence in people living with HIV. We investigated whether serum cytokine biosignatures could diagnose TB among HIV-positive inpatients. METHODS: We recruited HIV-positive inpatients with symptoms of TB and measured serum levels of inflammation biomarkers including IL-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ)...
March 15, 2024: Thorax
https://read.qxmd.com/read/38471792/patient-stratification-using-plasma-cytokines-and-their-regulators-in-sepsis-relationship-to-outcomes-treatment-effect-and-leucocyte-transcriptomic-subphenotypes
#19
JOURNAL ARTICLE
David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight
RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar subphenotypes exist in sepsis populations where leucocyte transcriptomic-defined subphenotypes have been reported...
March 12, 2024: Thorax
https://read.qxmd.com/read/38453471/impacts-of-sex-and-gender-on-severe-asthma
#20
EDITORIAL
Kimberley C W Wang, John D Blakey
No abstract text is available yet for this article.
March 7, 2024: Thorax
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