Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann-Marie Malby Schoos, Nicklas Brustad, Anders U Eliasen, Jonathan Thorsen, Bo Chawes, Gözde Gürdeniz, Andreanne Morin, Ken Stark, Jakob Stokholm, Carole Ober, Casper Emil Tingskov Pedersen, Klaus Bønnelykke
BACKGROUND: We recently conducted a double-blinded randomised controlled trial showing that fish-oil supplementation during pregnancy reduced the risk of persistent wheeze or asthma in the child by 30%. Here, we explore the mechanisms of the intervention. METHODS: 736 pregnant women were given either placebo or n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in the third trimester in a randomised controlled trial. Deep clinical follow-up of the 695 children in the trial was done at 12 visits until age 6 years, including assessment of genotype at the fatty acid desaturase (FADS) locus, plasma fatty acids, airway DNA methylation, gene expression, microbiome and metabolomics...
September 11, 2023: Thorax