Mingxing Lei, Taojin Feng, Mingming Zhang, Feifan Chang, Jiang Liu, Baisheng Sun, Ming Chen, Yi Li, Licheng Zhang, Peifu Tang, Pengbin Yin
Background: Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation. This study aims to develop a mouse model of PICS combined with bone trauma to investigate the mechanisms underlying muscle weakness, with a focus on SAA...
March 1, 2024: Shock