Jianzhuo He, Xujie Zhao, Xinfeng Lin, Zhixu Yang, Mingyuan Ma, Li Ma, Qun Liang, Lan Li, Yong Ye, Zehuai Wen, Zhanlin Zhang, Minzhou Zhang, Liheng Guo
Sepsis-induced myocardial dysfunction (SIMD) contributes significantly to cardiovascular dysfunction during septic shock. We aimed to evaluate the potential role of Xinmailong injection (XMLI), a polypeptide medicine extracted from Periplaneta americana, in reversing the progression of myocardial damage to SIMD in sepsis patients. This was a multicenter, randomized, double-blind, parallel-group trial. We recruited all patients consecutively admitted to intensive care units (ICUs) who were aged 18-85 years old and met the sepsis 3...
June 25, 2020: Shock
Xingjiang Mu, Yutian Li, Guo-Chang Fan
Macrophage, as an integral component of the immune system and the first responder to local damage, is on the front line of defense against infection. Over the past century, the prevailing view of macrophage origin states that all macrophage populations resided in tissues are terminally differentiated and replenished by monocytes from bone-marrow (BM) progenitors. Nonetheless, this theory has been reformed by ground-breaking discoveries from the past decades. It is now believed that tissue-resident macrophages (TRMs) are originated from the embryonic precursors and seeded in tissue prenatally...
June 23, 2020: Shock
Satoshi Fukuda, Ernesto Lopez, Koji Ihara, Yosuke Niimi, Clark R Andersen, Sam Jacob, Robert A Cox, Jose D Rojas, Donald S Prough, Perenlei Enkhbaatar
The severity of burn and smoke inhalation-induced acute lung injury (BSI-ALI) is associated with alveolar and interstitial edema, bronchospasm, and airway mucosal hyperemia. Previously we have reported beneficial effects of epinephrine nebulization on BSI-ALI. However, the underlying mechanisms of salutary effects of nebulized epinephrine remain unclear. The present study compared the effects of epinephrine, phenylephrine, and albuterol on a model of BSI-ALI. We tested the hypothesis that both α1- and β2-agonist effects are required for ameliorating more efficiently the BSI-ALI...
June 23, 2020: Shock
Alfio Bertolini, Giorgio Noera
No abstract text is available yet for this article.
June 23, 2020: Shock
Birgit Debrabant, Ulrich Halekoh, Mette Soerensen, Jacob Eifer Møller, Christian Hassager, Martin Frydland, Nicolai Palstrøm, Jacob Hjelmborg, Hans Christian Beck, Lars Melholt Rasmussen
AIM: Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity, and cardiogenic shock (CS) a major cause of hospital mortality after AMI. Especially for ST elevation myocardial infarction (STEMI) patients, fast intervention is essential.Few proteins have proven clinically applicable for AMI. Most proposed biomarkers are based on a priori hypothesis driven studies of single proteins, not enabling identification of novel candidates. For clinical use, the ability to predict AMI is important, however, studies of proteins in prediction models are surprisingly scarce...
June 23, 2020: Shock
Chaofeng Zhang, Shanshan Hu, Graeme R Zosky, Xin Wei, Shuhua Shu, Di Wang, Xiaoqing Chai
OBJECTIVE: Lung-recruited Ly6C monocytes had been shown to be involved in ventilator-induced lung injury (VILI). Our present study aimed to investigate whether the COX-2 inhibition modulates the function of lung-recruited Ly6C monocytes in a mouse model of VILI. METHODS: Mice were exposed to lipopolysaccharide (LPS; 20 ng) intraperitoneally prior to injurious mechanical ventilation (Vt = 30 ml/kg, PEEP = 0 cmH2O). A subgroup of mice was treated with intravenous parecoxib (30 mg/kg), a COX-2 inhibitor, 1 hour prior to ventilation...
June 23, 2020: Shock
Rindi M Uhlich, Robert P Richter, Parker Hu, Alyssa A Kirkman, Amit R Ashtekar, Lei Zheng, Shannon C Walker, Lindy M Reynolds, Russell L Griffin, Jan O Jansen, Jeffrey D Kerby, Jillian R Richter
Traumatic injury and hemorrhagic shock result in endothelial cell activation and vascular dysfunction that, if not corrected, can propagate multiorgan failure. Angiopoietin-1 and angiopoietin-2 are important regulators of endothelial cell function, and the ratio of plasma angiopoietin-2-to-1 is a useful indicator of overall vascular health. We therefore characterized plasma angiopoietin-2/-1 ratios over time after trauma in adults in an effort to gain insight into the pathophysiology that may drive post-traumatic vasculopathy and organ injury...
June 23, 2020: Shock
Biao Xie, XuHui Gao, Yang Huang, Yu Zhang, Shuibo Zhu
BACKGROUND: Studies have shown that remote ischemic postconditioning can improve brain damage caused by ischemia and hypoxia. However, the specific mechanism underlying this phenomenon is still unclear. The purpose of this study was to investigate the effects of remote ischemic postconditioning on neuronal apoptosis and mitophagy after cardiopulmonary resuscitation (CPR) in rats. METHODS: Male Sprague-Dawley rats were used to establish an asphyxia cardiac arrest model by clamping the tracheal duct...
June 23, 2020: Shock
Keliang Xie, Yaoqi Wang, Lijun Yin, Yuzun Wang, Hongguang Chen, Xing Mao, Guolin Wang
Sepsis-associated encephalopathy (SAE) affects approximately one-third of septic patients, and there is a lack of effective therapeutics for SAE. Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation and anti-apoptotic effects and can effectively protect septic mice. Mitochondrial dysfunction, which can be improved by mitochondrial biogenesis, is a type of molecular pathology in sepsis. Peroxisome proliferator-activated receptor gamma co-activator 1α (PGC-1α), which can be inhibited by SR-18292, is the key regulatory factor of mitochondrial biogenesis...
June 23, 2020: Shock
Li Zhong, Ming Wu, Zheying Liu, Yan Liu, Guangli Ren, Lei Su, Zhifeng Liu
BACKGROUND: Severe heat stroke is a clinical syndrome caused by host stress dysfunction due to heat stress and subsequent life-threatening organ dysfunction. We aimed to explore the early risk factors affecting the 90-day prognosis of severe heat stroke patients. METHODS: A case-control study was used to retrospectively analyze the clinical data of 117 severe heat stroke patients admitted to the ICU of the General Hospital of Southern Theater Command from April 2014 to May 2019...
June 23, 2020: Shock
Enrico Calzia, Oscar McCook, Ulrich Wachter, Peter Radermacher, Csaba Szabo
No abstract text is available yet for this article.
June 23, 2020: Shock
Georgios Renieris, Konstantina Katrini, Evangelos Giamarellos-Bourboulis
No abstract text is available yet for this article.
June 23, 2020: Shock
Danielle Tatum, Sharven Taghavi, August Houghton, Jacob Stover, Eman Toraih, Juan Duchesne
BACKGROUND: Due to the rapidly escalating number of cases and the low baseline of overall health in Louisiana, we sought to determine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in hospitalized COVID patients in 2 major metropolitan areas with the highest prevalence of cases and exceedingly high rates of obesity and other comorbid conditions. We hypothesized that elevated NLR would be a prognostic indicator of mortality. METHODS: This was a review of a prospective registry of adult (18+ years) hospitalized SARS-CoV-2 patients from to two large urban safety net hospitals in Louisiana...
June 15, 2020: Shock
Marcin F Osuchowski, Federico Aletti, Jean-Marc Cavaillon, Stefanie B Flohé, Evangelos J Giamarellos-Bourboulis, Markus Huber-Lang, Borna Relja, Tomasz Skirecki, Andrea Szabó, Marc Maegele
Approximately 3 billion people around the world have gone into some form of social separation to mitigate the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The uncontrolled influx of patients in need of emergency care has rapidly brought several national health systems to near-collapse with deadly consequences to those afflicted by Coronavirus Disease 2019 (COVID-19) and other critical diseases associated with COVID-19. Solid scientific evidence regarding SARS-CoV-2/COVID-19 remains scarce; there is an urgent need to expand our understanding of the SARS-CoV-2 pathophysiology to facilitate precise and targeted treatments...
June 10, 2020: Shock
Christoph Thiele, Tim-Philipp Simon, Jeanine Szymanski, Christoph Daniel, Christos Golias, Oliver Hartmann, Joachim Struck, Lukas Martin, Gernot Marx, Tobias Schuerholz
Adrenomedullin is a vasoactive peptide that improves endothelial barrier function in sepsis, but may also cause hypotension and organ failure. Treatment with a non-neutralizing monoclonal anti-adrenomedullin antibody showed improvement in murine sepsis models. We tested the effects of the humanized monoclonal anti-adrenomedullin antibody Adrecizumab in a porcine two hit model of hemorrhagic and septic shock.In this randomized, blinded study 12 German Landrace pigs were bled to half of baseline mean arterial pressure for 45 minutes...
June 9, 2020: Shock
Sharven Taghavi, Danielle Tatum, Tara Reza, Alison Smith, Patrick McGrew, Charles Harris, Chrissy Guidry, Rebecca Schroll, Juan Duchesne
INTRODUCTION: Recent studies have suggested the female hypercoaguable state may have a protective effect in trauma. However, whether this hypercoagulable profile confers a survival benefit in massively transfused trauma patients has yet to be determined. We hypothesized that females would have better outcomes than males after traumatic injury that required massive transfusion protocol (MTP). MATERIALS AND METHODS: All trauma patients that underwent MTP at an urban, level 1, academic trauma center were reviewed from November 2007 to October 2018...
June 9, 2020: Shock
Marcela Hortová-Kohoutková, Federico Tidu, Marco De Zuani, Vladimír Šrámek, Martin Helán, Jan Frič
Phagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by inflammatory pathway activation, which promotes pathogen elimination and inhibits pathogen growth. Delayed pathogen elimination is the first step in sepsis development and a key factor in sepsis resolution. Phagocytosis thus has an important role during sepsis and likely contributes to all of its clinical stages. However, only a few studies have specifically explored and characterized phagocytic activity during sepsis...
June 8, 2020: Shock
Barry Burstein, Saraschandra Vallabhajosyula, Bradley Ternus, Gregory W Barsness, Kianoush Kashani, Jacob C Jentzer
BACKGROUND: Lactate is a prognostic marker in critically ill patients, although currently available illness severity scores do not include lactate as a predictive parameter. We sought to describe the association between lactate and hospital mortality in patients admitted to the cardiac intensive care unit (CICU) with cardiac arrest (CA) and shock. METHODS: Retrospective observational analysis of Mayo Clinic CICU patients admitted from 2007 to 2018 with measured lactate on admission, including patients with and without CA or shock...
June 2, 2020: Shock
Mingli Yuan, Xiaoxiao Xu, Dongping Xia, Zhaowu Tao, Wen Yin, Weijun Tan, Yi Hu, Cheng Song
BACKGROUND AND OBJECTIVE: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia. METHOD: A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. RESULTS: 132 patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching...
June 2, 2020: Shock
Stelios F Assimakopoulos, Iliana Papadopoulou, Dimitra Bantouna, Anne-Lise de Lastic, Maria Rodi, Athanasia Mouzaki, Charalambos A Gogos, Vasiliki Zolota, Ioannis Maroulis
INTRODUCTION: Sepsis is a life-threatening syndrome which can progress to multiple organ dysfunction with high mortality. Intestinal barrier failure exerts a central role in the pathophysiological sequence of events that lead from sepsis to multiple organ dysfunction. The present study investigated the role of hydrocortisone (HC) administration and fecal microbiota transplantation (FMT) in several parameters of the gut barrier integrity, immune activation and survival, in a model of polymicrobial sepsis in rats...
June 2, 2020: Shock
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