journal
https://read.qxmd.com/read/36427100/post-hemorrhagic-shock-mesenteric-lymph-impairs-splenic-dendritic-cell-function-in-mice
#1
JOURNAL ARTICLE
Hua Liu, Jian-Feng Li, Li-Min Zhang, Huai-Huai Wang, Xu-Qing Wang, Gui-Qing Liu, Hui-Bo Du, Yu-Jie Jin, Li-Qiang Xing, Zi-Gang Zhao, Chun-Yu Niu
Dendritic cells (DCs) mediated-immune dysfunction is involved in the process of severe hemorrhagic shock that leads to sepsis. Although post-hemorrhagic shock mesenteric lymph (PHSML) induces immune organs injuries and apoptosis, whether PHSML exerts adverse effects on splenic DCs remains unknown. In this study, we established a hemorrhagic shock model (40 ± 2 mmHg for 60 min) followed by fluid resuscitation with the shed blood and equal Ringer' solution, and drained the PHSML after resuscitation. At 3 h after resuscitation, we harvested the splenic tissue to isolate DCs using anti-CD11c immunomagnetic beads, and then detected the necrotic and apoptotic rates in splenocytes and splenic DCs...
November 28, 2022: Shock
https://read.qxmd.com/read/36427096/baicalein-relieves-brain-injury-via-inhibiting-ferroptosis-and-endoplasmic-reticulum-stress-in-a-rat-model-of-cardiac-arrest
#2
JOURNAL ARTICLE
Zhou Ye, Fan Zhang, Peng Wang, Yingqi Ran, Cong Liu, Jinming Lu, Mingtao Zhang, Lan Yao
BACKGROUND: Cardiac arrest (CA) is one of the leading causes of death worldwide. Endoplasmic reticulum (ER) stress and ferroptosis are proven pathological mechanisms implicated in neuronal damage. Baicalein, a ferroptosis Inhibitor, improved outcomes after traumatic brain injury. We aimed to explore the effects of baicalein on brain injury via ferroptosis and ER stress in a rat model of CA. METHODS: Cardiac arrest models were established in Sprague-Dawley (SD) rats...
November 28, 2022: Shock
https://read.qxmd.com/read/36427079/classic-il-6-signaling-is-associated-with-poor-outcomes-in-burn-patients
#3
JOURNAL ARTICLE
Sarah Rehou, Abdikarim Abdullahi, Marc G Jeschke
BACKGROUND: Interleukin (IL)-6 is a multifunctional cytokine with both a pro- and anti-inflammatory role. In many studies, IL-6 increases rapidly after burn injury and is associated with poor outcomes. However, there are two aspects to IL-6; it can signal via its soluble IL-6 Receptor (sIL-6R), which is referred to as trans-signalling and is regarded as the proinflammatory pathway. The role of sIL-6R post-burn injury has yet to be explored in its entirety. We hypothesized that patients with a lower ratio of IL-6 to sIL-6R would have worse outcomes...
November 28, 2022: Shock
https://read.qxmd.com/read/36427074/telomere-length-of-peripheral-blood-mononuclear-cells-is-associated-with-discharge-disposition-in-older-trauma-patients
#4
JOURNAL ARTICLE
Julie Goswami, Taleen A MacArthur, Dhanya Ramachandran, Cillian Mahony, Annelise S Howick, Tammy Price-Troska, Riley J Thompson, Grant M Spears, Kent R Bailey, Mrinal S Patnaik, Joao F Passos, Myung S Park, Alejandro Ferrer
INTRODUCTION: Little is known regarding peripheral blood mononuclear cell telomere length (PBMC-TL) and response to traumatic injury. The objective of this study was to characterize the role of PBMC-TL in coagulation and clinical outcomes after injury. METHODS: Plasma and buffy coats were prospectively collected from trauma patients and healthy volunteers. DNA was purified and PBMC-TL quantified by qPCR. Thrombin generation kinetics were expressed as lag time (LT, minutes), peak height (PH, nM), time to peak (ttPeak, min), and endogenous thrombin potential (ETP, nM*min)...
November 28, 2022: Shock
https://read.qxmd.com/read/36427072/sciatic-denervation-induced-skeletal-muscle-atrophy-is-associated-with-persistent-inflammation-and-increased-mortality-during-sepsis
#5
JOURNAL ARTICLE
Sumika Osa, Yuki Enoki, Taichi Miyajima, Masahiro Akiyama, Yukio Fujiwara, Kazuaki Taguchi, Yun-Gi Kim, Kazuaki Matsumoto
BACKGROUND: Patients with underlying skeletal muscle atrophy are likely to develop aggravated sepsis. However, no study has experimentally verified the association between the prognosis of sepsis and muscle atrophy, and the mechanism of aggravation of sepsis under muscle atrophy remains unclear. In this study, we investigated the effect of skeletal muscle atrophy induced by sciatic denervation (DN), an experimental muscle atrophy model, on sepsis prognosis. METHODS: Skeletal muscle atrophy was induced by DN of the sciatic nerve in C57BL/6 J male mice...
November 28, 2022: Shock
https://read.qxmd.com/read/36427069/sepsis-needs-diagnostic-start-ups-a-lot-of-them
#6
JOURNAL ARTICLE
John G Younger
No abstract text is available yet for this article.
November 28, 2022: Shock
https://read.qxmd.com/read/36399097/effect-of-irrigation-fluid-composition-on-hemostasis-in-mouse-bleeding-models
#7
JOURNAL ARTICLE
Nijmeh Alsaadi, Adnan Hassoune, Shannon Haldeman, Kelly M Williamson, William Plautz, Lara Hoteit, Jurgis Alvikas, Elizabeth A Andraska, Amudan J Srinivasan, Jillian Bonaroti, Anupamaa Seshadri, Roberto Mota-Alvidrez, Melanie J Scott, Paul A Gardner, Carl H Snyderman, Matthew D Neal
INTRODUCTION: Intraoperative irrigation, usually with normal saline (NS), aids in bleeding identification and management. We investigated the effect of different irrigation fluids, with additives, on hemostasis using two bleeding models. METHODS: C57BL/6 J mice were subjected to a tail bleed model or uncontrolled abdominal hemorrhage via liver laceration followed by abdominal cavity irrigation. We compared NS, Lactated Ringer's (LR), and PlasmaLyte. We examined NS and LR at different temperatures...
November 21, 2022: Shock
https://read.qxmd.com/read/36383390/trained-immunity-a-potential-approach-for-improving-host-immunity-in-neonatal-sepsis
#8
JOURNAL ARTICLE
Valerie E Polcz, Jaimar C Rincon, Russell B Hawkins, Evan L Barrios, Philip A Efron, Lyle L Moldawer, Shawn D Larson
Sepsis, a dysregulated host immune response to infection, is one of the leading causes of neonatal mortality worldwide. Improved understanding of the perinatal immune system is critical to improve therapies to both term and preterm neonates at increased risk of sepsis. Our narrative outlines the known and unknown aspects of the human immune system through both the immune tolerant in utero period and the rapidly changing antigen-rich period after birth. We will highlight the key differences in innate and adaptive immunity noted through these developmental stages, and how the unique immune phenotype in early life contributes to the elevated risk of overwhelming infection and dysregulated immune responses to infection upon exposure to external antigens shortly after birth...
November 17, 2022: Shock
https://read.qxmd.com/read/36383370/clinical-and-prognostic-features-of-cci-pics-patients-a-prospective-observational-clinical-study
#9
JOURNAL ARTICLE
Qingqing Zhou, Hebu Qian, Aixiang Yang, Jian Lu, Jun Liu
OBJECTIVE: To investigate and compare the clinical features and prognosis of chronic critical illness (CCI)/ persistent inflammation immunosuppression and catabolism (PICS). METHODS: This is a prospective observational clinical study. During this study period, we collect ICU patients' data from Suzhou Municipal Hospital and Suzhou Ninth People's Hospital. All patients older than 18 years of age were included and according to the corresponding exclusion and diagnostic criteria, they were divided into four groups: PICS group, CCI group, CCI and PICS group (CCI + PICS), nor CCI and nor PICS group (NCCI+NPICS), collected and recorded age, sex, hospital time, hospital diagnosis, acute physiological and chronic health status score II (APACHEII), sequential organ failure detection score(SOFA), c-reactive protein (CRP), absolute value lymphocyte count (L), serum albumin (Alb), white cells count (WBC), absolute value neutrophils count (N), secondary infection and 28-day case fatality rate separately...
November 17, 2022: Shock
https://read.qxmd.com/read/36378234/genetic-variants-and-serum-profiles-of-cytokines-in-covid-19-severity
#10
JOURNAL ARTICLE
Eman Alefishat, Mira Mousa, Mohammed Albreiki, Herbert F Jelinek, Zainab Al Halwachi, Mariam Khalili, Fathimathuz Waasia, Maimunah Uddin, Nawal Al Kaabi, Bassam Mahboub, Mohammad T Albataineh, Guan K Tay, Habiba S Alsafar
BACKGROUND: Patients with severe COVID-19 are at an increased risk of Acute Respiratory Distress Syndrome (ARDS) and mortality. This is due to the increased levels of pro-inflammatory cytokines that amplify downstream pathways that are controlled by immune regulators. OBJECTIVE: This study aimed to investigate the association between cytokine genetic variants, cytokine serum levels/profiles, and disease severity in critically and non-critically ill COVID-19 patients...
November 16, 2022: Shock
https://read.qxmd.com/read/36378232/trauma-induces-intravascular-hemolysis-exacerbated-by-rbc-transfusion-and-associated-with-disrupted-arginine-nitric-oxide-metabolism
#11
JOURNAL ARTICLE
Terry R Schaid, Mitchell J Cohen, Angelo D'Alessandro, Christopher C Silliman, Ernest E Moore, Angela Sauaia, Monika Dzieciatkowska, William Hallas, Otto Thielen, Margot DeBot, Alexis Cralley, Ian LaCroix, Christopher Erickson, Sanchayita Mitra, Anirban Banerjee, Kenneth Jones, Kirk C Hansen
BACKGROUND: Severe injury can provoke systemic processes that lead to organ dysfunction, and hemolysis of both native and transfused red blood cells (RBC's) may contribute. Hemolysis can release erythrocyte proteins, such as hemoglobin and arginase-1, the latter with the potential to disrupt arginine metabolism and limit physiologic nitric oxide (NO) production. We aimed to quantify hemolysis and arginine metabolism in trauma patients and measure association with injury severity, transfusions, and outcomes...
November 16, 2022: Shock
https://read.qxmd.com/read/36378229/speckle-tracking-quantification-parasternal-intercostal-muscle-longitudinal-strain-to-predict-weaning-outcomes-a-multicentric-observational-study
#12
JOURNAL ARTICLE
Qiancheng Xu, Xiao Yang, Yan Qian, Chang Hu, Weihua Lu, Shuhan Cai, Jianguo Li, Bo Hu
BACKGROUND: The purpose of this study was to determine the feasibility, reliability, and reproducibility of parasternal intercostal muscle longitudinal strain (LSim) quantification by speckle tracking, and the value of maximal LSim to predict weaning outcomes. METHODS: This study was divided into three phases. Phases one and two comprehended prospective observational programs to evaluate the feasibility, reliability, and repeatability of speckle tracking to assess LSim in healthy subjects and mechanically ventilated patients...
November 16, 2022: Shock
https://read.qxmd.com/read/36377404/the-immunopathogenesis-of-polymicrobial-sepsis
#13
JOURNAL ARTICLE
Firas S Zetoune, Peter A Ward
This report deals with the advances made in the areas of complement and its role in sepsis, both in mice and in humans. The study relates to work over the past 25 years (late 1990s to October 2022). During this period of time, there has been very rapid progress in understanding the activation pathways of complement and the activation products of complement, especially the anaphylatoxin C5a and its receptors, C5aR1 and C5aR2. Much has also been learned about these pathways of activation that trigger activation of the innate immune system and the array of strong proinflammatory cytokines that can cause cell and organ dysfunction, as well as complement products that cause immunosuppression...
November 15, 2022: Shock
https://read.qxmd.com/read/36377392/the-effects-of-early-phase-furosemide-use-on-the-progression-of-oliguric-acute-kidney-injury-across-different-central-venous-pressure-a-retrospective-analysis
#14
JOURNAL ARTICLE
Haoquan Huang, Chuwen Hu, Yanni Fu, Zhixiao Han, Minghui Cao, Ganglan Fu
BACKGROUND: Furosemide is a commonly used loop diuretic in critical care. However, its effect on the progression of oliguric acute kidney injury across different central venous pressure (CVP) remains unknown. This study therefore aims to investigate the association between Furosemide6-12h (defined as the use of furosemide within 6 h after the diagnosis of AKI according to the urine output [UO] criteria set by the Kidney Disease: Improving Global Outcomes [KDIGO] guidelines) and the progression of AKI across different CVP6-12h (defined as CVP within 6 h after the diagnosis of AKI by the KDIGO UO criteria) levels...
November 15, 2022: Shock
https://read.qxmd.com/read/36377383/apelin-13-ameliorates-lps-induced-endothelial-to-mesenchymal-transition-and-post-ali-pulmonary-fibrosis-by-suppressing-transforming-growth-factor-%C3%AE-1-signalling
#15
JOURNAL ARTICLE
Huang Liu, Qingqiang Shi, Ling Tang, Hanghang Wang, Daoxin Wang
The pathophysiology of acute respiratory distress syndrome (ARDS) involves cytokine storms, alveolar-capillary barrier destruction, and fibrotic progression. Pulmonary interstitial fibrosis is an important factor affecting the prognosis of ARDS patients. Endothelial to mesenchymal transition (EndMT) plays an important role in the development of fibrotic diseases, and the occurrence of EndMT has been observed in experimental models of LPS-induced ALI. Apelin is an endogenous active polypeptide that plays an important role in maintaining endothelial cell homeostasis and inhibiting fibrotic progression in various diseases...
November 15, 2022: Shock
https://read.qxmd.com/read/36377365/leukocyte-phenotyping-in-sepsis-using-omics-functional-analysis-and-in-silico-modeling
#16
JOURNAL ARTICLE
Jordan C Langston, Qingliang Yang, Mohammad F Kiani, Laurie E Kilpatrick
Sepsis is a major health issue and a leading cause of death in hospitals globally. The treatment of sepsis is largely supportive and there are no therapeutics available that target the underlying pathophysiology of the disease. The development of therapeutics for the treatment of sepsis is hindered by the heterogeneous nature of the disease. The presence of multiple, distinct immune phenotypes ranging from hyperimmune to immunosuppressed can significantly impact the host response to infection. Recently, omics, biomarkers, cell surface protein expression and immune cell profiles have been utilized to classify immune status of sepsis patients...
November 15, 2022: Shock
https://read.qxmd.com/read/36377364/monitoring-of-pulmonary-edema-using-ultrasound-radiofrequency-signal
#17
JOURNAL ARTICLE
Hyuksool Kwon, You Hwan Jo, Jae Hyuk Lee, Ji Eun Hwang, Inwon Park, Seonghye Kim, Dong-Hyun Jang, Doyun Kim, Hyunglan Chang
OBJECTIVE: Excessive accumulation of extravascular lung water impairs respiratory gas exchange and results in respiratory distress. Real-time radiofrequency signals of ultrasound can continuously and quantitatively monitor excessive lung water. This study aims to evaluate the availability of continuous real-time quantitative pulmonary edema monitoring using ultrasound radiofrequency signals and compare it with Pao2/Fio2 (PF) ratio, conventional lung ultrasound, and the Hounsfield unit of chest computed tomography (CT)...
November 15, 2022: Shock
https://read.qxmd.com/read/36374735/dexmedetomidine-prevents-pdia3-decrease-by-activating-%C3%AE-2-adrenergic-receptor-to-alleviate-intestinal-ischemia-reperfusion-in-mice
#18
JOURNAL ARTICLE
Yaqing Zhan, Zhaorong Chen, Yuxin Qiu, Qiwen Deng, Wenqi Huang, Shihong Wen, Jiantong Shen
BACKGROUND: Dexmedetomidine (DEX) attenuates intestinal ischemia/reperfusion (I/R) injury, but its mechanism of action remains to be further elucidated. Protein disulfide isomerase A3 (PDIA3) has been reported as a therapeutic protein for the prevention and treatment for intestinal I/R injury. This study was to investigate whether PDIA3 is involved in intestinal protection of DEX and explore the underlying mechanisms. METHODS: The potential involvement of PDIA3 in DEX attenuation of intestinal I/R injury was tested in PDIA3 Flox/Flox mice and PDIA3 conditional knockout (cKO) in intestinal epithelium mice subjected to 45 min of superior mesenteric artery (SMA) occlusion followed by 4 h of reperfusion...
November 3, 2022: Shock
https://read.qxmd.com/read/36156537/alda-1-treatment-alleviates-lung-injury-after-cardiac-arrest-and-resuscitation-in-swine
#19
JOURNAL ARTICLE
Hongbo Wu, Shanxiang Xu, Mengyuan Diao, Jiangang Wang, Gongping Zhang, Jiefeng Xu
INTRODUCTION: Alda-1, an aldehyde dehydrogenase 2 (ALDH2) activator, has been shown to protect the lung against a variety of diseases including regional ischemia reperfusion injury, severe hemorrhagic shock, hyperoxia and so on. The present study was designed to investigate the effectiveness of Alda-1 treatment in alleviating lung injury after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in swine. METHODS: A total of 24 swine were randomized into three groups: 1) Sham (n = 6), 2) CA/CPR (n = 10), and 3) CA/CPR + Alda-1 (n = 8)...
September 26, 2022: Shock
https://read.qxmd.com/read/36156050/bacterial-pathogen-associated-molecular-patterns-pamps-upregulate-human-glucocorticoid-receptor-expression-in-peripheral-blood-mononuclear-cells
#20
JOURNAL ARTICLE
David G Greenhalgh, Tajia L Green, Debora Lim, Kiho Cho
It is well known that bacterial components (pathogen-associated molecular patterns [PAMPs]) induce a pro-inflammatory response through pattern recognition receptor signaling. What is not known, however, is how the inflammatory response is downregulated. We hypothesize that bacterial products initiate compensatory anti-inflammatory responses by inducing expression of the human glucocorticoid receptor (hGR). Peripheral blood mononuclear cells (PBMCs) were isolated from leukocytes concentrated from single human donors (Leukopaks)...
September 26, 2022: Shock
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