journal
https://read.qxmd.com/read/38546380/muramyl-dipeptide-causes-mitochondrial-dysfunction-and-intestinal-inflammatory-cytokine-responses-in-rats
#1
JOURNAL ARTICLE
Lu-Jia Zhao, Xiao-Yong Dai, You-Wen Ye, Xiu-Feng Pang, Meng Jiang, Wan-Yi Tan, Ying-Hui Xu, Ji-Feng Su, Bin Shi
INTRODUCTION: Intestinal flora and the translocation of its products, such as muramyl dipeptide (MDP), are common causes of sepsis. MDP is a common activator of the intracellular pattern recognition receptor NOD2, and MDP translocation can cause inflammatory damage to the small intestine and systemic inflammatory responses in rats. Therefore, this study investigated the effects of MDP on the intestinal mucosa and distant organs during sepsis and the role of the NOD2/AMPK/LC3 pathway in MDP-induced mitochondrial dysfunction in the intestinal epithelium...
March 28, 2024: Shock
https://read.qxmd.com/read/38526162/mdivi-1-alleviates-sepsis-induced-liver-injury-by-inhibiting-sting-signaling-activation
#2
JOURNAL ARTICLE
Qin Zhang, Zhuanhua Liu, Xiaoxia Huang, Xin Heng, Jie Wu, Zhenfeng Chen, Xiaohua Guo, Jun Fan, Qiaobing Huang
Pro-inflammatory hyperactivation of kupffer cells (KCs) is foremost involved in the pathogenesis of sepsis-induced liver injury. Our previous study found that stimulator of interferon genes (STING) signaling was activated in KCs in response of lipopolysaccharide (LPS) and knocking down dynamin-related protein 1 (DRP1) in KCs effectively inhibited the activation of STING signaling and the subsequent production of pro-inflammatory cytokines. In this study, we demonstrated that in vivo treatment with mitochondrial division inhibitor 1 (Mdivi-1), a selective inhibitor of DRP1, alleviated cecal ligation and puncture (CLP)-induced liver injury with the improvement of liver pathology and function...
March 25, 2024: Shock
https://read.qxmd.com/read/38526151/unveiling-the-causal-association-between-non-infectious-respiratory-disorders-and-sepsis-through-mendelian-randomization-analysis
#3
JOURNAL ARTICLE
Cheng Liu, Li He, Xiangde Zheng
BACKGROUND: The association between sepsis and non-infectious respiratory diseases is well-documented, yet the specific causal link between the two remains unclear. In order to explore this relationship further, we employed a Mendelian randomization (MR) analysis utilizing data from the UK Biobank and FinnGen Biobank. METHODS: We analyzed the summary statistics of a genome-wide association study (GWAS) summary statistics for chronic obstructive pulmonary disease (COPD), asthma, pulmonary embolism (PE), idiopathic pulmonary fibrosis (IPF), obstructive sleep apnea (OSA), lung cancer, sepsis, and sepsis-related mortality...
March 25, 2024: Shock
https://read.qxmd.com/read/38526148/man-vs-machine-provider-directed-vs-precision-automated-critical-care-management-pacc-man-in-a-porcine-model-of-distributive-shock
#4
JOURNAL ARTICLE
Gloria D Sanin, Gabriel E Cambronero, Elizabeth C Wood, James W Patterson, Magan R Lane, Antonio C Renaldo, Bonnie E Laingen, Elaheh Rahbar, Jason Y Adams, Austin Johnson, Lucas P Neff, Timothy K Williams
BACKGROUND: Critical care management of shock is a labor-intensive process. Precision automated critical care management (PACC-MAN) is an automated closed-loop system incorporating physiologic and hemodynamic inputs to deliver interventions while avoiding excessive fluid or vasopressor administration. To understand PACC-MAN efficacy, we compared PACC-MAN to provider-directed management (PDM). We hypothesized that PACC-MAN would achieve equivalent resuscitation outcomes to PDM while maintaining normotension with lower fluid and vasopressor requirements...
March 25, 2024: Shock
https://read.qxmd.com/read/38526139/diammonium-glycyrrhizinate-inhibited-inflammatory-response-and-modulated-serum-metabolism-in-poly-i-c-induced-pneumonia-model-mice
#5
JOURNAL ARTICLE
Yan Meng, Xuanlin Cai, Shan Cong, Jiao Sun, Wenjing Du, Xiumin Ma, Huantian Cui, Li Luo, Li Wang
Currently, the coronavirus disease 2019 (COVID-19) is becoming a serious threat to human health worldwide. Therefore, there is a great need to develop effective drugs against viral pneumonia. Diammonium glycyrrhizinate (DG), derived from Glycyrrhiza glabra L., has been demonstrated with significant anti-inflammatory properties. However, the therapeutic effects and mechanisms of DG on pneumonia require further clarification. In this study, mice received intratracheal injection of polyinosinic-polycytidylic acid (poly(I:C)) to induce pneumonia and were treated with DG...
March 25, 2024: Shock
https://read.qxmd.com/read/38526135/sirt3-mediates-the-cardioprotective-effect-of-therapeutic-hypothermia-after-cardiac-arrest-and-resuscitation-by-restoring-autophagic-flux-via-the-pi3k-akt-mtor-pathway
#6
JOURNAL ARTICLE
Hui Wang, Wenwen Wang, Zhiwei Xue, Huiping Gong
BACKGROUND: Postresuscitation cardiac dysfunction is a significant contributor to early death following cardiopulmonary resuscitation (CPR). Therapeutic hypothermia (TH) mitigates myocardial dysfunction due to cardiac arrest (CA); however, the underlying mechanism remains unclear. Sirtuin 3 (Sirt3) was found to affect autophagic activity in recent research, motivating us to investigate its role in the cardioprotective effects of TH in the treatment of CA. METHODS: Sprague-Dawley rats were used to establish an in vivo CA/CPR model and treated with a selective Sirt3 inhibitor or vehicle...
March 25, 2024: Shock
https://read.qxmd.com/read/38598838/unveiling-the-protective-mechanisms-of-puerarin-against-acute-lung-injury-a-comprehensive-exploration-of-the-roles-and-mechanisms-of-mst1-ers-signaling
#7
JOURNAL ARTICLE
Wen-Xuan Chen, Wen-Long Zhang, Huan-Huan Zhang, Yuan-Zhen Lai, Jun Huang, Yang Lei, Yan-Juan Liu, Xiao-Li Wang, Hua-Fei Deng
OBJECTIVES: Puerarin, the principal active constituent extracted from Pueraria, is believed to confer protection against sepsis-induced lung injury. The study aimed to elucidate the role and mechanism of Mst1/ERS in puerarin-mediated protection against acute lung injury (ALI). METHODS: Monolayer vascular endothelial cell permeability was assessed by gauging the paracellular flow of FITC-dextran 40,000 (FD40). ELISA was employed for the quantification of inflammatory cytokines...
March 21, 2024: Shock
https://read.qxmd.com/read/38517245/causal-roles-of-serum-uric-acid-levels-and-gout-in-sepsis-a-mendelian-randomization-study
#8
JOURNAL ARTICLE
Yujun Qin, Xia Yang, Zong Ning
OBJECTIVE: Several epidemiological studies have identified a potential link between serum uric acid(UA), gout and sepsis. The primary objective of this study is to delve deeper into this connection, investigating the causal effect of UA and gout on sepsis by applying Mendelian Randomization (MR). METHODS: The causal relationship was analyzed using data from genome-wide association study(GWAS). Inverse variance weighting (IVW) was used as the main analysis method...
March 21, 2024: Shock
https://read.qxmd.com/read/38517239/effect-of-stratified-dose-of-norepinephrine-on-cellular-immune-response-in-patients-with-septic-shock-and-the-construction-of-a-prognostic-risk-model
#9
JOURNAL ARTICLE
Qiang Wang, Jiefu Tang, Yao Li, Jiafei Lu, Dexing Yang, Chen He, Ting Li, Kai Fu, Rong Liu
OBJECTIVE: To explore the effect of a stratified dose of norepinephrine (NE) on cellular immune response in patients with septic shock, and to construct a prognostic model of septic shock. METHODS: A total of 160 patients with septic shock (B group) and 58 patients with sepsis (A group) were given standard cluster therapy. Patients with septic shock were divided into four groups (B1-B4 groups: 0.01-0.2, 0.2-0.5, 0.5-1.0, and > 1 μg/kg/min) according to the quartile method of the early (72 h) time-weighted average dose of NE and clinical application...
March 14, 2024: Shock
https://read.qxmd.com/read/38517263/reduced-cx43-expression-induces-autophagy-through-activation-of-the-ampk-mtor-ulk1-signaling-pathway-in-the-common-bile-duct-ligation-rat-heart
#10
JOURNAL ARTICLE
Xiaoyu Wang, Pingping Liao, He Dong, Aijie Liu, Qian Wang, Han Yang, Xiaolin Xu, Dongyue Chai, Lin Zhu, Lin Lyu
BACKGROUNDS: This study aimed to investigate the relationship between Cx43 expression and autophagy mediated by the AMPK-mTOR-Ulk1 signaling pathway in jaundice heart. METHODS: In this study, a jaundice model was established in common bile duct ligation (CBDL) rats. Cardiac injury was assessed using various methods including myocardial injury indicators, echocardiography, TEM, HE staining, Masson staining, IHC, and IF. We investigated the regulatory relationship between Cx43, autophagy, and the AMPK-mTOR-ULK pathway in vivo by administering autophagy agonists (Rapa), autophagy inhibitors (3-MA), and Cx43 inhibitors (Gap 26)...
March 13, 2024: Shock
https://read.qxmd.com/read/38412105/generation-of-tolerogenic-dendritic-cells-under-the-persistent-inflammation-stimulation
#11
JOURNAL ARTICLE
Shumin Miao, Zenan Chang, Bin Gu, Jinlong Jiang, Fei Pei, Yishan Liu, Yu Zhou, Zimeng Liu, Xiang Si, Xiangdong Guan, Jianfeng Wu
Immunosuppression, commonly accompanied by persistent inflammation, is a key feature in the later phase of sepsis. However, the pathophysiological mechanisms underlying this phenomenon remain unclear. Dendritic cells (DCs), specifically tolerogenic DCs (tolDCs), play a crucial role in this process by regulating immune responses through inducing T cell anergy and releasing anti-inflammatory cytokines. Nevertheless, the existing cell models are inadequate for investigating tolDCs during the immunosuppressive phase of sepsis...
February 27, 2024: Shock
https://read.qxmd.com/read/38411611/near-infrared-dye-ir-780-alleviates-hematopoietic-system-damage-by-promoting-hematopoietic-stem-cells-into-quiescence
#12
JOURNAL ARTICLE
Jie Wu, Le Ma, Qiang Gong, Yan Chen, Long Chen, Chunmeng Shi
Worrying about potential radiation exposure is a general concern, but no effective pre-exposure radioprotective countermeasure is generally accepted1. Here, we found a small molecular near-infrared (NIR) dye IR-780, which promoted hematopoietic stem cells (HSCs) into quiescence to resist stress. When mice were treated with IR-780 before stress, increased HSC quiescence and better hematopoietic recovery were observed in IR-780-treated mice in stress conditions. However, when given after radiation, IR-780 did not show obvious benefit...
February 27, 2024: Shock
https://read.qxmd.com/read/38411593/simplified-immune-dysregulation-index-a-novel-marker-predicts-28-day-mortality-of-intensive-care-patients-with-sepsis
#13
JOURNAL ARTICLE
Shengjun Liu, Changjing Zhuge, Jiahui Zhang, Na Cui, Yun Long
BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. There is currently no simple immune-imbalance-driven indicator for patients with sepsis. METHODS: This study was conducted in Peking Union Medical College Hospital. Patients with Sepsis were identified according to Sepsis 3.0 after reviewing patient data from May 2018 through October 2022. LASSO logistic regression was used for features selection. Receiver operating characteristic curves for 28-day mortality were used to compare the predictive performance of level of interleukin-6 (IL-6) and lymphocyte count (LY#) with that of the combined ratio, namely, the IL-6/LY# ratio...
February 27, 2024: Shock
https://read.qxmd.com/read/38407989/interpretable-machine-learning-for-predicting-risk-of-invasive-fungal-infection-in-critically-ill-patients-in-the-intensive-care-unit-a-retrospective-cohort-study-based-on-mimic-iv-database
#14
JOURNAL ARTICLE
Yuan Cao, Yun Li, Min Wang, Lu Wang, Yuan Fang, Yiqi Wu, Yuyan Liu, Yixuan Liu, Ziqian Hao, Hengbo Gao, Hongjun Kang
Invasive fungal infections are characterized by high incidence and high mortality rates characteristics. In this study, we developed a clinical prediction model for invasive fungal infections in critically ill patients based on machine learning algorithms. The results show that the machine learning model based on 20 clinical features has good predictive value.
February 20, 2024: Shock
https://read.qxmd.com/read/38598836/combination-of-hyperoxygenation-and-targeted-temperature-management-improves-functional-outcomes-of-post-cardiac-arrest-syndrome-irrespective-of-causes-of-arrest-in-rats
#15
JOURNAL ARTICLE
Jingru Li, Yiming Shen, Jianjie Wang, Bihua Chen, Yongqin Li
BACKGROUND: The high mortality rates of patients who are resuscitated from cardiac arrest (CA) are attributed to post cardiac arrest syndrome (PCAS). This study evaluated the effect of hyperoxygenation and targeted temperature management (TTM) on PCAS in rats with different causes of CA. METHODS AND RESULTS: One hundred and sixty-eight Sprague-Dawley rats were equally divided into asphyxial and dysrhythmic groups. Animals were further randomized into four subgroups immediately after resuscitation: 1) Normoxia-normothermia (NO-NT): ventilated with 21% oxygen under normothermia; 2) Hyperoxia-normothermia (HO-NT): ventilated with 100% oxygen for 3 h under normothermia; 3) Normoxia-hypothermia (NO-HT): ventilated with 21% oxygen for 3 h under hypothermia; 4) Hyperoxia-hypothermia (HO-HT): ventilated with 100% oxygen for 3 h under hypothermia...
February 14, 2024: Shock
https://read.qxmd.com/read/38517244/the-relationship-between-circulating-immune-cell-phenotypes-and-sepsis-a-mendelian-randomization-study
#16
JOURNAL ARTICLE
Hongmei Liu, Hai Liu, Li Zhou, Shu Wen, Tiankuang Liu, Linqin Ju, Yiwen Liu
OBJECTIVE: The role of immune cells in sepsis remains unclear, and there is some controversy. Here, we aim to systematically assess whether distinct immune cell phenotypes impact the susceptibility to sepsis. METHODS: In this study, we harnessed publicly available summary-level data from genome-wide association studies (GWAS). The selection of genetic variations strongly associated with 731 phenotypes of circulating immune cells served as instrumental variables (IVs)...
February 12, 2024: Shock
https://read.qxmd.com/read/38323918/prmt6-foxo3a-attenuates-apoptosis-by-upregulating-parkin-expression-in-intestinal-ischemia-reperfusion-injury
#17
JOURNAL ARTICLE
Xinwan Wu, Yu Zhou, Hongjiao Xu, Xinyi Zhang, Liangfang Yao, Jinbao Li, Xiang Li
Intestinal ischemia-reperfusion injury (IIRI) is a serious disease with high morbidity and mortality. This study aims to investigate the potential regulatory mechanisms involving protein arginine methyltransferase 6 (PRMT6), Forkhead box O3a (FoxO3a), and Parkin in IIRI and elucidate their roles in mediating cell apoptosis. The IIRI animal model was established and confirmed using Hematoxylin and Eosin (H&E) staining. Oxygen-glucose deprivation and reperfusion (OGD/R) cell model was established to mimic ischemic injury in vitro...
February 7, 2024: Shock
https://read.qxmd.com/read/38321608/comprehensive-therapeutic-efficacy-analysis-of-intravenous-immunoglobulin-in-treating-sepsis-induced-coagulopathy-a-single-center-retrospective-observational-study
#18
JOURNAL ARTICLE
Jingyun Fang, Peng Huang, Wanfu Cui, Ye Lin, Dan Rong, Xu Li
OBJECTIVES: To investigate the efficacy of intravenous immunoglobulin (IVIg) in treating sepsis-induced coagulopathy (SIC). METHODS: A retrospective controlled analysis was conducted on 230 patients with SIC at Ganzhou People's Hospital from January 2016 to December 2022. All patients were screened using propensity score matching and treated according to the SSC2016 guidelines. Compared to the control group (n = 115), patients in the test group (n = 115) received IVIg (200 mg/kg...
February 7, 2024: Shock
https://read.qxmd.com/read/38517275/remimazolam-improves-the-markers-of-post-resuscitation-cerebral-injury-in-a-swine-model-of-cardiac-arrest
#19
JOURNAL ARTICLE
Rongrong Shen, Zhilin Liu, Li Fei, Yixiang Zhang, Linwu Xu, Chaoqi Xuan
INTRODUCTION: Previous studies have manifested that those sedatives acting on γ-aminobutyric acid A (GABAa) receptor could produce effective brain protection against regional and global ischemic stimulation. The present study was designed to investigate the effect of a novel GABAa receptor agonist, remimazolam post-conditioning (RP) on cerebral outcome after global ischemic stimulation induced by cardiac arrest and resuscitation in swine. METHODS: A total of 24 swine were utilized in this study, in which the animals were randomly divided into the following three groups: Sham group (n = 6), CPR group (n = 9), and CPR + RP group (n = 9)...
February 5, 2024: Shock
https://read.qxmd.com/read/38517232/development-and-validation-of-a-nomogram-for-predicting-28-day-in-hospital-mortality-in-sepsis-patients-based-on-an-optimized-apache-ii-score
#20
JOURNAL ARTICLE
Yamin Yuan, Yanfei Meng, Yihui Li, Jinquan Zhou, Jiaqi Wang, Yujing Jiang, Li Ma
PURPOSE: The objective of this study is to establish a nomogram that correlates optimized APACHE II score with sepsis-related indicators, aiming to provide a robust model for early prediction of sepsis prognosis in clinical practice and serve as a valuable reference for improved diagnosis and treatment strategies. METHODS: This retrospective study extracted sepsis patients meeting the inclusion criteria from the MIMIC-IV database to form the training group. An optimized Acute Physiology and Chronic Health Evaluation (APACHE) II score integrated with relevant indicators was developed using a nomogram for predicting the prognosis of sepsis patients...
February 5, 2024: Shock
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