Hilal Üstündağ, Ferdane Danişman Kalindemirtaş, Songül Doğanay, Özlem Demir, Nezahat Kurt, Mehmet Tahir Huyut, Betül Özgeriş, İshak Afşin Kariper
Sepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, the preventive effects of resveratrol (RV) alone and resveratrol-loaded silver nanoparticles (AgNPs+RV) against sepsis-induced damage were investigated and compared in a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Rats were divided into four groups: Sham, CLP, RV, and AgNPs+RV. Pro-inflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin-1 beta [IL-1β], interleukin-6 [IL-6]), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, presepsin, procalcitonin, 8-hydroxy-2'-deoxyguanosine (8-OHDG), vascular endothelial growth factor (VEGF), and Sirtuin-1 (SIRT-1) levels were assessed to determine the treatments' effects...
September 5, 2023: Shock