journal
https://read.qxmd.com/read/38920138/gdf11-overexpression-alleviates-sepsis-induced-lung-microvascular-endothelial-barrier-damage-by-activating-sirt1-nox4-signaling-to-inhibit-ferroptosis
#1
JOURNAL ARTICLE
Zhixiang Wu, Qiong Xi, Qin Zhao, Shan Zhu
Sepsis is a lethal clinical syndrome, and acute lung injury (ALI) is the earliest and most serious complication. We aimed to explore the role of growth differentiation factor 11 (GDF11) in sepsis-induced dysfunction of lung microvascular endothelial barrier in vivo and in vitro to elucidate its potential mechanism related to sirtuin 1 (SIRT1)/NADPH oxidase 4 (NOX4) signaling. Cecal ligation and puncture (CLP)-induced sepsis mice and lipopolysaccharide (LPS)-induced pulmonary microvascular endothelial cells (PMECs) were use in this study...
June 26, 2024: Shock
https://read.qxmd.com/read/38935033/changes-of-histidine-rich-glycoprotein-levels-in-critically-ill-septic-patients
#2
JOURNAL ARTICLE
Ayu Nabila Kusuma Pradana, Tomohiko Akahoshi, Jie Guo, Yukie Mizuta, Shuntaro Matsunaga, Sayoko Narahara, Masaharu Murata, Ken Yamaura
BACKGROUND: Histidine-rich glycoprotein (HRG), a potential prognostic factor in sepsis, lacks clarity regarding its relevance in septic-induced shock, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS) pathogenesis. This study investigated the association between HRG concentrations and these critical conditions. METHODS: Blood samples were collected from 53 critically ill patients on days 1, 3, 5, and 7 after ICU admission at the Kyushu University Hospital...
June 25, 2024: Shock
https://read.qxmd.com/read/38920139/trauma-induced-coagulopathy-prevalence-and-association-with-mortality-persist-twenty-years-later
#3
JOURNAL ARTICLE
William Teeter, Matthew D Neal, Joshua B Brown, Jana B A MacLeod, Roumen Vesselinov, Rosemary A Kozar
INTRODUCTION: A 2003 landmark study identified the prevalence of eTIC at 28% with a strong association with mortality of 8.9%. Over the last 20 years there have been significant advances in both the fundamental understanding of eTIC and therapeutic interventions. METHODS: A retrospective cohort study was performed from 2018-2022 on patients ≥18 using prospectively collected data from two level 1 trauma centers and compared to data from 2003. Demographics, laboratory data and clinical outcomes were obtained...
June 24, 2024: Shock
https://read.qxmd.com/read/38920136/exploring-the-prognostic-necroptosis-related-genes-and-underlying-mechanism-in-sepsis-using-bioinformatics
#4
JOURNAL ARTICLE
Jie Liu, Lin Li, Shuyang He, Xin Zheng, Dan Zhu, Guangyao Kong, Ping Li
Sepsis is a life-threatening disease due to a dysregulated host response to infection, with an unknown regulatory mechanism for prognostic necroptosis-related genes (NRGs). Using GEO datasets GSE65682 and GSE134347, we identified six NRG biomarkers (ATRX, TSC1, CD40, BACH2, BCL2, and LEF1) with survival and diagnostic significance through Kaplan-Meier (KM) and Receiver Operating Characteristic (ROC) analyses. Afterwards, the ingenuity pathway analysis (IPA) highlighted enrichment in hepatic fibrosis pathways and BEX2 protein...
June 24, 2024: Shock
https://read.qxmd.com/read/38904464/activation-of-klotho-sirt1-signaling-pathway-attenuates-myocardial-ischemia-reperfusion-injury-in-diabetic-rats
#5
JOURNAL ARTICLE
Zhen Qiu, Biao Qi, Lu Li, Jiahui Cui, Min Liu, Zhongyuan Xia
Diabetes and myocardial ischemia reperfusion (MIR) injury are characterized by oxidative stress, inflammation, autophagy disorders and cardiac contractile dysfunction. Klotho and SIRT1 regulate the level of oxidative stress to participate in the regulation of many physiological functions such as cell survival, ageing, apoptosis, autophagy, mitochondrial biogenesis and inflammation. We hypothesized that the activation of Klotho/SIRT1 signaling pathway could attenuate MIR in diabetic rats. Type 1 diabetes and MIR injury model were established to examine this hypothesis in vivo...
June 21, 2024: Shock
https://read.qxmd.com/read/38904460/implications-of-ywhah-gene-expression-in-the-early-detection-of-sepsis
#6
JOURNAL ARTICLE
Hua Yao, Yue Zhou, Zhengguang Geng, Fei Gao, De Su, Yan Kang, Bao Fu
Sepsis, a complex and multifaceted condition, is a common occurrence with serious implications for critically ill patients in the Intensive Care Unit (ICU). The YWHAH gene encodes the 14-3-3n protein, a member of the 14-3-3 protein family. While existing research primarily focuses on the role of 14-3-3n in conditions such as schizophrenia and various cancers, our study revealed that the expression of the YWHAH gene remained relatively stable in both infected individuals and healthy controls. Through Venn plot analysis following weighted gene correlation network analysis (WGCNA), we observed a potential association between elevated YWHAH expression and the transition from infection to sepsis...
June 21, 2024: Shock
https://read.qxmd.com/read/38888558/septic-shock-lps-tolerance-protects-mitochondrial-biogenesis-and-respiration
#7
JOURNAL ARTICLE
Andre Augusto Botêga Silva, Denise Frediani Barbeiro, Suely Kunimi Kubo Ariga, Hermes Vieira Barbeiro, Ana Maria Mendonça Coelho, Eleazar Chaib, Marisa Passarelli, Francisco Garcia Soriano
Mitochondrial dysfunction is a recognized feature of sepsis, characterized by ultrastructural damage, diminished oxidative phosphorylation, and depletion of mitochondrial antioxidant capacity observed in deceased septic patients. Lipopolysaccharide (LPS) tolerance induces a controlled response to sepsis. This study aimed to evaluate the function of tolerant mitochondria after cecal ligation and puncture (CLP)-induced sepsis. Mytochondrial oxygen consumption was determined using polarography. Extraction and quantification of RNA for the expression of Tfam, Nrf-1 and Ppargc-1α; and Respiratory complex activity were measured...
June 18, 2024: Shock
https://read.qxmd.com/read/38899838/identification-of-a-novel-sepsis-prognosis-model-based-on-transcriptome-and-proteome-analysis
#8
JOURNAL ARTICLE
Haoran Chen, Haoyue Xue, Xinyi Tang, Chen Wang, Xiaomin Li, Yongpeng Xie
Sepsis is a highly prevalent and deadly disease. Currently, there is a lack of ideal biomarker prognostis models for sepsis. We attempt to construct a model capable of predicting the prognosis of sepsis patients by integrating transcriptomic and proteomic data. Through analysis of proteomic and transcriptomic data, we identified 25 differentially expressed genes (DEGs). Single-factor Cox-Lasso regression analysis identified 16 DEGs (OS-DEGs) associated with patient prognosis. Through multi-factor Cox-Lasso regression analysis, a prognostic model based on these 16 genes was constructed...
June 12, 2024: Shock
https://read.qxmd.com/read/38888542/angiotensin-ii-in-the-treatment-of-distributive-shock-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Eleni Xourgia, Aristomenis K Exadaktylos, Athanasios Chalkias, Mairi Ziaka
BACKGROUND: While non-norepinephrine vasopressors are increasingly used as a rescue therapy in cases of norepinephrine-refractory shock, data on their efficacy are limited. This systematic review and meta-analysis aims to synthesize existing literature on the efficacy of Angiotensin II (ATII) in distributive shock. METHODS: We pre-registered our meta-analysis with PROSPERO (CRD42023456136). We searched PubMed, Scopus, and gray literature for studies presenting outcomes on ATII use in distributive shock...
June 12, 2024: Shock
https://read.qxmd.com/read/38888575/trends-and-outcomes-in-sepsis-hospitalizations-with-and-without-acute-kidney-injury-a-nationwide-inpatient-analysis
#10
JOURNAL ARTICLE
Haibo Li, Ran Yu, Qi Zhou, Jiannan Song, Qi Zhou, Wanli Ma, Jian Wang, Zhanfei Hu, Qinfeng Yang, Keyuan Chen
BACKGROUND: Despite rapid advances in treatment, sepsis currently remains a major public health challenge worldwide. Over the past several years, there has been an increase in the clinical incidence of sepsis, as well as an increase in hospitalization rates, which bear the majority of the economic burden associated with sepsis. Sepsis is a public health burden due to the high fatality rates and accompanying morbidity. However, the sepsis-related mortality rates have fallen steadily over the years...
June 11, 2024: Shock
https://read.qxmd.com/read/38888572/cecal-slurry-as-an-alternative-model-to-cecal-ligation-and-puncture-for-the-study-of-sepsis-induced-cardiovascular-dysfunction
#11
JOURNAL ARTICLE
Gabrielle Delfrate, Lucas Braga Albino, Jamil Assreuy, Daniel Fernandes
Sepsis is a life-threatening condition widely studied by animal models. Cecal ligation and perforation (CLP) is still regarded as the gold standard model for sepsis. However, CLP has limitations due to its invasiveness and variability. Cecal slurry injection (CS) model is a non-surgical and thus less invasive alternative. However, the lack of standardization of the CS model in the literature limits its practical application. Additionally, it is not well studied whether CS model reproduces septic cardiovascular dysfunction in rats, which is a crucial issue in septic patients...
June 11, 2024: Shock
https://read.qxmd.com/read/38888571/investigating-the-relationship-between-bleeding-clotting-and-coagulopathy-during-automated-partial-reboa-strategies-in-a-highly-lethal-porcine-hemorrhage-model
#12
JOURNAL ARTICLE
Antonio C Renaldo, Hebah Soudan, Micaela K Gomez, Aravindh S Ganapathy, Gabriel E Cambronero, James W Patterson, Magan R Lane, Gloria D Sanin, Nathan Patel, Jacob A P Niebler, James E Jordan, Timothy K Williams, Lucas P Neff, Elaheh Rahbar
BACKGROUND: Death due to hemorrhagic shock, particularly, non-compressible truncal hemorrhage (NCTH), remains one of the leading causes of potentially preventable deaths. Automated partial and intermittent resuscitative endovascular balloon occlusion of the aorta (i.e., pREBOA and iREBOA, respectively) are lifesaving endovascular strategies aimed to achieve quick hemostatic control while mitigating distal ischemia. In iREBOA, the balloon is titrated from full occlusion to no occlusion intermittently whereas in pREBOA, a partial occlusion is maintained...
June 11, 2024: Shock
https://read.qxmd.com/read/38888567/genetic-ablation-of-the-c-type-lectin-receptor-clec2d-increases-peritonitis-mortality-inflammation-and-physiology-without-diminishing-organ-injury
#13
JOURNAL ARTICLE
Allan E Stolarski, Jiann-Jyh Lai, Jiyoun Kim, Kenneth L Rock, Daniel Remick
BACKGROUND: Sepsis accounts for substantial morbidity and mortality motivating investigators to continue the search for pathways and molecules driving the pathogenesis of the disease. The current study examined if the novel C-type Lectin Receptor (CLR), Clec2d, plays a significant role in the pathogenesis of sepsis. METHODS: Clec2d knockout (KO) mice were fully backcrossed onto the C57\BL6 background. Acute endotoxemia was induced with an intraperitoneal (i.p.) injection of lipopolysaccharide (LPS)...
June 11, 2024: Shock
https://read.qxmd.com/read/38888490/evaluation-of-vasopressor-inflection-point-for-short-term-prognosis-of-patients-with-septic-shock
#14
JOURNAL ARTICLE
Mei Yang, Shao-Gui Chen
OBJECTIVE: The goal of this study is to investigate the clinical value of vasopressor inflection points in the evaluation of short-term prognosis among individuals afflicted with septic shock. METHODS: A retrospective analysis was conducted on a cohort comprising 56 patients diagnosed with septic shock and receiving treatment at the Department of Critical Care Medicine of the hospital between January 2021 and March 2023. These patients were divided into two groups based on the prognostic outcome: a survival group consisting of 34 patients and a death group consisting of 22 patients...
June 4, 2024: Shock
https://read.qxmd.com/read/38888586/finding-the-sweet-spot-the-association-between-whole-blood-to-red-blood-cells-ratio-and-outcomes-of-hemorrhaging-civilian-trauma-patients
#15
JOURNAL ARTICLE
Hamidreza Hosseinpour, Collin Stewart, Omar Hejazi, Stanley E Okosun, Muhammad Haris Khurshid, Adam Nelson, Sai Krishna Bhogadi, Michael Ditillo, Louis J Magnotti, Bellal Joseph
PURPOSE: To evaluate the dose-dependent effect of Whole Blood (WB) on the outcomes of civilian trauma patients with hemorrhagic shock. METHODS: We performed a 2-year (2020-2021) retrospective analysis of the ACS-TQIP dataset. Adult (≥18) trauma patients with a shock index (SI) >1 who received at least 5 units of PRBC and one unit of WB within the first 4 hours of admission were included. Primary outcomes were 6-hr, 24-hr, and in-hospital mortality. Secondary outcomes were major complications and hospital and ICU length of stay (LOS)...
May 30, 2024: Shock
https://read.qxmd.com/read/38888506/examining-the-impact-of-permissibility-hypercapnia-on-postoperative-delirium-among-elderly-patients-undergoing-thoracoscopic-laparoscopic-esophagectomy-a-single-center-investigative-study
#16
JOURNAL ARTICLE
Jie Song, Yan-Mei Shao, Guang-Hui Zhang, Bing-Qian Fan, Wen-Hui Tao, Xiao-Fen Liu, Xiao-Ci Huang, Xian-Wen Hu
OBJECTIVE: This study explores how permissive hypercapnia, a key aspect of lung protective ventilation, impacts postoperative delirium in elderly patients following thoracic surgery. METHODS: A single-center trial at The Second Hospital of Anhui Medical University involved 136 elderly patients undergoing thoracoscopic esophageal cancer resection. Randomly assigned to maintain PaCO2 35-45 mmHg (group N) or 46-55 mmHg (group H). Primary outcome: postoperative delirium (POD) incidence 1-3 days post-surgery...
May 30, 2024: Shock
https://read.qxmd.com/read/38888503/mechanism-of-microrna-218-5p-in-mitochondrial-biogenesis-of-sepsis-induced-acute-kidney-injury-by-the-regulation-of-pgc-1%C3%AE
#17
JOURNAL ARTICLE
Jing Kuang, Jun Fang, Shuli Hu, Xiuhong Yang, Xuepeng Fan
BACKGROUND: Sepsis-induced acute kidney injury (SI-AKI) is a kind of kidney dysfunction, which brings a lot of suffering. This study aimed to figure out the role of the miR-218-5p/PGC-1α axis in SI-AKI. METHODS: AKI mouse model was established through cecal ligation and puncture. PGC-1α expression was activated using an activator ZLN005 before the serum and tissue samples were collected. Next, pathological structure and apoptosis of kidney tissues were observed...
May 30, 2024: Shock
https://read.qxmd.com/read/38888471/novel-active-proteins-for-sepsis-prognosis-revealed-through-scrna-seq-and-quantitative-proteomics
#18
JOURNAL ARTICLE
Hui Liu, Wei Xiong, Wu Zhong, Yingchun Hu
OBJECTIVE: To uncover critical active proteins influencing sepsis outcomes through multi-omics analysis. METHODS: This study collected peripheral blood from sepsis patients (NS = 26, SV = 27) and controls (Con = 16). Cellular heterogeneity was assessed using scRNA-seq. Cellular populations were identified through clustering and annotation. GSVA was employed to detect pathway alterations in sepsis, while the Viper algorithm estimated protein activity at the single-cell level...
May 30, 2024: Shock
https://read.qxmd.com/read/38888452/-inflammatory-responses-to-polymicrobial-intra-abdominal-sepsis-are-highly-variable-but-strongly-correlated-to-enterobacteriaceae-outgrowth
#19
JOURNAL ARTICLE
Kale S Bongers, Rishi Chanderraj, Huiyin Deng, Yujing Song, Michael W Newstead, Joseph D Metcalf, Nicole R Falkowski, Niyati Puranik, Katsuo Kurabayashi, Robert P Dickson, Benjamin H Singer
Sepsis is a common, heterogeneous, and frequently lethal condition of organ dysfunction and immune dysregulation due to infection. The causes of its heterogeneity, including the contribution of the pathogen, remain unknown. Using cecal slurry, a widely-used murine model of intraperitoneal polymicrobial sepsis, as well as 16S ribosomal RNA sequencing and measurement of immune markers, we performed a series of translational analyses to determine whether microbial variation in cecal slurry composition (representing intra-abdominal pathogens) mediated variation in septic response...
May 30, 2024: Shock
https://read.qxmd.com/read/38888497/hydrogen-rich-saline-upregulates-the-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway-and-reduces-vascular-endothelial-glycocalyx-shedding-in-sepsis-induced-acute-kidney-injury
#20
JOURNAL ARTICLE
Liheng Lin, Deliang Qiu, Fei Yang, Yu Xia, Siyuan Cai, Xiaojun Liao, Wanxin Deng, Changxue Wu
Sepsis causes dysfunction in different organs, but the pathophysiological mechanisms behind it are similar and mainly involve complex haemodynamic and cellular dysfunction. The importance of microcirculatory dysfunction in sepsis is becoming increasingly evident, in which endothelial dysfunction and glycocalyx degradation play a major role. This study aimed to investigate the effects of hydrogen-rich saline (HRS) on renal microcirculation in septic renal failure, and whether Sirt1 was involved in the renoprotective effects of HRS...
May 27, 2024: Shock
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