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Petra Büttner, Danilo Obradovic, Sebastian Wunderlich, Hans-Josef Feistritzer, Erik Holzwirth, Philipp Lauten, Georg Fuernau, Suzanne de Waha-Thiele, Steffen Desch, Holger Thiele
BACKGROUND: Reperfusion strategies in acute myocardial infarction (AMI) may result in ischemia reperfusion injury characterized by increased oxidative stress, inflammation and ultimately death of myocardial tissue which may be of particular importance in infarct-related cardiogenic shock (CS). Many anti-oxidative and immune regulatory processes depend on selenium which in large proportions is bound to circulating selenoprotein P (SelP). Individual SelP patterns may therefore be associated with inflammatory response and possibly mortality in patients with CS post AMI...
March 14, 2019: Shock
Ji Hoon Kim, Yoo Seok Park, Chang-Yun Yoon, Hye Sun Lee, Sinae Kim, Jong Wook Lee, Taeyoung Kong, Je Sung You, Jong Woo Park, Sung Phil Chung
BACKGROUND AND PURPOSE: The early prediction of acute kidney injury (AKI) in sepsis and provision of timely treatment may improve outcomes. We investigated the efficacy of the delta neutrophil index (DNI)-which reflects the fraction of immature granulocytes-in predicting sepsis-induced AKI and 30-day mortality in cases of severe sepsis or septic shock. METHODS: This retrospective, observational cohort study was performed with patients prospectively integrated in a critical pathway of early-goal-directed therapy /SEPSIS...
March 14, 2019: Shock
Hunter B Moore, Ernest E Moore
No abstract text is available yet for this article.
March 5, 2019: Shock
Pratsanee Hiengrach, Wimonrat Panpetch, Navaporn Worasilchai, Ariya Chindamporn, Somying Tumwasorn, Thiranut Jaroonwitchawan, Naraporn Somboonna, Alisa Wilantho, Piraya Chathanathon, Asada Leelahavanichkul
The influence of gut fungi in chronic colitis was investigated by repeated oral administration of Candida albicans in a 3% dextran sulfate solution (DSS) induced-colitis mouse model. Candida administration in the DSS (DSS+Candida) model enhanced the mortality rate and induced bacteremia (without candidemia) resulting from a gut perm-selectivity defect despite similar diarrheal severity in mice treated with DSS alone. The dominant fecal bacteria in DSS+Candida and DSS alone mice were Pseudomonas spp. and Enterobacter spp...
February 28, 2019: Shock
Chuyi Tan, Jia Gu, Huan Chen, Tao Li, Huafei Deng, Ke Liu, Meidong Liu, Sipin Tan, Zihui Xiao, Huali Zhang, Xianzhong Xiao
Recent evidences suggest that metabolic reprogramming plays an important role in the regulation of innate inflammatory response, however, the specific mechanism is unclear. In this study, we found that glycolytic inhibitor 2-deoxyglucose (2-DG) significantly improved the survival rate in cecal ligation and puncture (CLP)-induced septic mice. 2-DG-treated mice developed increased neutrophil migration to the infectious site and more efficient bacterial clearance than untreated mice. 2-DG reversed the down-regulation of chemokine receptor 2 (CXCR2) and the impaired chemotaxis induced by CLP in mice or lipopolysaccharides (LPS) in human neutrophils...
February 27, 2019: Shock
Alexander H Penn, Charnae E Williams, Thomas J Walters, Michael A Dubick, Ivo P Torres Filho
Military pre-hospital care for hemorrhage is often characterized by use of tourniquets (TQ) and permissive hypotensive resuscitation (PHR) with crystalloids or colloids, but these treatments have not been previously combined in an animal model. Although albumin resuscitation solutions have been tested, the potential effects of non-esterified fatty acids (NEFAs) bound to albumin have not been evaluated in vivo, and few studies have investigated concentrated albumin solutions to reduce fluid requirements. We created a militarily relevant rat model of trauma and hemorrhagic shock (T/HS) (27 ml/kg hemorrhage) with TQ and PHR...
February 27, 2019: Shock
Fredrik Kahn, Jonas Tverring, Lisa Mellhammar, Nils Wetterberg, Anna Bläckberg, Erika Studahl, Niklas Hadorn, Robin Kahn, Susanne Nueesch, Philipp Jent, Meret E Ricklin, John Boyd, Bertil Christensson, Parham Sendi, Per Åkesson, Adam Linder
OBJECTIVE: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma-levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medical attention at the emergency department. DESIGN: Prospective, international multicenter, convenience sample study SETTING:: Four general emergency departments at academic centers in Sweden, Switzerland and Canada...
February 19, 2019: Shock
Seung Don Baek, Jae-Young Kang, Seulgi Shin, Hyang-Sook Park, Mi-Soon Kim, So Mi Kim, Eun Kyoung Lee, Jai Won Chang
The factors influencing continuous renal replacement therapy (CRRT) duration for critically ill patients with acute kidney injury (AKI) are unclear. Therefore, we investigated the clinical factors that could influence the duration of CRRT for AKI survivors. In this retrospective observational study, the medical records of all hospital survivors who required CRRT for AKI in intensive care units were analyzed. The CRRT duration (median, 6 days) was categorized as short-duration CRRT (≤ 6 days, n = 65) and long-duration CRRT (> 6 days, n = 59), according to the median CRRT duration...
February 19, 2019: Shock
Jiri Chvojka, Vendula Martinkova, Jan Benes, Lenka Valesova, Vojech Danihel, Lukas Nalos, Martin Matejovic
As controversy persists regarding the benefits of mechanical circulatory support in septic shock with a predominantly vasoplegic phenotype, preclinical studies may provide a useful alternative to fill the actual knowledge gap. Here, we investigated the physiologic responses to venoarterial extracorporeal membrane oxygenation therapy (VA-ECMO) in a clinically relevant porcine peritonitis-induced model of refractory vasodilatory septic shock. In 12 anesthetized, mechanically ventilated and instrumented domestic pigs, septic shock was induced by intraperitoneally inoculating autologous feces...
February 15, 2019: Shock
Natesh Yepuri, Ravi Dhawan, Mitchell Cooney, Napat Pruekprasert, Qinghe Meng, Robert N Cooney
Toll-like receptors are transmembrane proteins which sense and transmit infectious and inflammatory responses to the cells expressing them. Therapeutic strategies for the blockade of excessive Toll-like receptor signaling are being actively pursued for several diseases. Recently, Sparstolonin B, isolated from Chinese herb, which suppresses selectively Toll-like receptors has been studied in various inflammatory models. The objective of this review is to summarize the current literature regarding the use of Sparstolonin B in various in vitro and in vivo studies and to provide an overview regarding the potential use of this agent in different inflammatory diseases...
February 15, 2019: Shock
Suwei Li, Xianyao Wan, Krzysztof Laudanski, Ping He, Lihui Yang
BACKGROUND: Suboptimal ventricular arterial coupling (VAC) is one of the pivotal determinants of inefficient heart performance despite appropriate administration of fluids or vasopressors in shocks. Here, we investigate the performance of VAC in patients who are unresponsive to fluid administration in septic shock. METHODS: This is a retrospective observational study of septic shock patients (n = 35). VAC was evaluated by effective arterial elastance (EaI), left ventricular end-systolic elastance (EesI), and EaI/EesI...
February 15, 2019: Shock
Nawfel Ben-Hamouda, Etienne Challet
No abstract text is available yet for this article.
February 14, 2019: Shock
Benjamin Coiffard, Marc Leone, Jean-Louis Mege
No abstract text is available yet for this article.
February 14, 2019: Shock
Kehong Chen, Jie Yang, Fei Xiao, Jia Chen, Wei Hu, Xiaoyue Wang, Liming Wang, Juan Du, Jianxin Jiang, Yani He
BACKGROUND: Blast lung injury is a high-energy trauma with high mortality for explosion victims. A treatment for blast lung injury is still lacking. The aim of this study was to observe the efficacy and mechanism of peritoneal dialysis combined with glucocorticoids (GC) in the treatment of blast lung injury in rats. METHODS: Rats were randomly divided into five groups: control, sham, GC, peritoneal dialysis (dialysis for short) and dialysis + GC groups. All rats were injured by a biological shock tube-I...
February 6, 2019: Shock
Jan Schulz, Christian Vollmer, Richard Truse, Inge Bauer, Christopher Beck, Olaf Picker, Anna Herminghaus
INTRODUCTION: In septic patients, adequate microvascular oxygenation (μHBO2) of the intestine is vital for their outcome. Recent studies suggest that statins can ameliorate septic microcirculation in a variety of tissues. However, the effect on intestinal microvascular oxygenation and blood flow is largely unknown. Furthermore, there are indications that statin therapy might not be beneficial in the presence of hypercapnia, as observed in septic ARDS patients. Therefore, the present study explores the effect of pravastatin with and without additional moderate acute hypercapnia on intestinal microvascular oxygenation and blood flow in experimental sepsis...
February 1, 2019: Shock
Tao Chen, Tuo Pan, Xuan Luo, Dongjin Wang
PURPOSE: In contrast to arterial lactate, previous studies have proposed central venous-to-arterial CO2 difference (P (v-a)CO2) as a more useful guide for categorizing patients at risk of developing septic shock. It is worthwhile studying P (v-a)CO2 in determining whether it could serve as a useful predictor for poor postoperative outcomes in patients undergoing cardiac surgery. We investigated the ability of P(v-a)CO2 to predict poor outcomes of patients with postoperative cardiogenic shock...
February 1, 2019: Shock
Tajia L Green, Stacey M Leventhal, Debora Lim, Kiho Cho, David G Greenhalgh
Glucocorticoids are widely used in the treatment of numerous inflammatory conditions, including sepsis. Unfortunately, patient response to glucocorticoid therapy can be inconsistent. Variations in the human glucocorticoid receptor (hGR) may contribute to the differential patient response. We screened for hGR variants in the buffy coats of burn patients and peripheral blood mononuclear cells (PBMCs) treated with lipopolysaccharide. Three novel splice variants containing cryptic exons were upregulated in the PBMCs after lipopolysaccharide exposure at 3 and 13 hours with the greatest observed expression at 3 hours...
January 21, 2019: Shock
Elizabeth G Wheatley, Brenda J Curtis, Holly J Hulsebus, Devin M Boe, Kevin Najarro, Diana Ir, Charles E Robertson, Mashkoor A Choudhry, Daniel N Frank, Elizabeth J Kovacs
Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock...
January 18, 2019: Shock
Deya Shang, Fangfang Zhu, Qi Tan, Bo Hu, Dongxing Liu, Mulin Cong, Jiantao Song, Tao Li, Xianfei Ji
OBJECTIVE: To determine whether the inhibition of the G protein-coupled receptor kinase 2 by adenoviral βARKct cardiac gene transfer can ameliorate post-resuscitation myocardial injury in pigs with cardiac arrest (CA) and explore the mechanism of myocardial protection. METHODS: Male landrace domestic pigs were randomized into the sham group (Anesthetized and instrumented, but ventricular fibrillation was not induced) (n = 4), control group (ventricular fibrillation 8 min, n = 8) and βARKct group (ventricular fibrillation 8 min, n = 8)...
January 17, 2019: Shock
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