Kerri Lopez, Andrew Suen, Yang Yang, Sheng Wang, Brittney Williams, Jing Zhu, Jiang Hu, Gary Fiskum, Alan Cross, Rosemary Kozar, Catriona Miller, Lin Zou, Wei Chao
BACKGROUND: Aeromedical evacuation can expose traumatically injured patients to low pressure (hypobaria) and hypoxia. Here we sought to assess the impact of hypobaria on inflammation, organ injury, and mortality in a mouse model of polytrauma. METHODS: Eight to 12 week-old male C57BL/6J mice were subjected to sham or polytrauma consisting of bowel ischemia by superior mesenteric artery (SMA) occlusion, hindlimb muscle crush, and tibia fracture. Two hours after injury, animals were randomized to undergo either 6 hours of hypobaria or sea-level, room air conditions...
December 23, 2020: Shock