Jose Luis Rodriguez-Garcia, Gines Sanchez-Nievas, Juan Arevalo-Serrano, Cristina Garcia-Gomez, Jose Maria Jimenez-Vizuete, Elisa Martinez-Alfaro
OBJECTIVES: The Janus kinase (JAK) inhibitor baricitinib may block viral entry into pneumocytes and prevent cytokine storm in patients with SARS-CoV-2 pneumonia. We aimed to assess whether baricitinib improved pulmonary function in patients treated with high-dose corticosteroids for moderate to severe SARS-CoV-2 pneumonia. METHODS: This observational study enrolled patients with moderate to severe SARS-CoV-2 pneumonia [arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2) <200 mmHg] who received lopinavir/ritonavir and HCQ plus either corticosteroids (CS group, n = 50) or corticosteroids and baricitinib (BCT-CS group, n = 62)...
October 6, 2020: Rheumatology
Alain Lescoat, Alice Ballerie, Valérie Lecureur, Nicolas Belhomme, Claire Cazalets, Stéphane Jouneau, Christophe Paris, Alfredo Menéndez-Navarro, Paul-André Rosental, Patrick Jégo, Catherine Cavalin
No abstract text is available yet for this article.
October 6, 2020: Rheumatology
Ricardo J O Ferreira, Maarten de Wit, Cátia Duarte, José A P da Silva, Mwidimi Ndosi
No abstract text is available yet for this article.
October 6, 2020: Rheumatology
Theodore Pincus, Kathryn A Gibson, Yusuf Yazici, Martin Bergman, Juan Schmukler, Joel A Block
No abstract text is available yet for this article.
October 6, 2020: Rheumatology
Isla Morante, Elena Aurrecoechea, Ignacio Villa, Montserrat Santos, Leyre Riancho, Rubén Queiro
OBJECTIVES: The Assessment of SpondyloArthritis international Society health index (ASAS-HI) was designed to assess the global health of patients with spondyloarthritis, but its performance in psoriatic arthritis (PsA) is hardly known. We addressed the clinimetric properties of this instrument in patients with PsA. METHODS: This was a cross-sectional observational study that included 90 consecutive patients with PsA. The measurement properties of ASAS-HI were analysed against the Disease Activity index for PSoriatic Arthritis (DAPSA) and the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire...
October 4, 2020: Rheumatology
Yusuke Kawamura, Yu Toyoda, Takuma Ohnishi, Ryutaro Hisatomi, Toshihide Higashino, Akiyoshi Nakayama, Seiko Shimizu, Masato Yanagi, Isamu Kamimaki, Rika Fujimaru, Hiroshi Suzuki, Nariyoshi Shinomiya, Tappei Takada, Hirotaka Matsuo
No abstract text is available yet for this article.
October 4, 2020: Rheumatology
Ibrahim Almaghlouth, Jiandong Su, Sindhu R Johnson, Eleanor Pullenayegum, Dafna Gladman, Murray Urowitz
OBJECTIVE: Infection is a leading cause of death in the SLE population. Low immunoglobulin levels might be a potential risk for infection. We aimed to assess whether acquired low levels of any type of immunoglobulin increase the risk of clinically relevant infection in adult patients with SLE. METHODS: We compared adult SLE patients who had acquired any low immunoglobulin levels (IgA, IgM or IgG) for 2 years with patients with normal or high levels with respect to clinically relevant infection (defined as infections requiring intravenous or oral antibiotics) in a prospective cohort study...
October 2, 2020: Rheumatology
Albin Björk, Rui Da Silva Rodrigues, Elina Richardsdotter Andersson, Jorge I Ramírez Sepúlveda, Johannes Mofors, Marika Kvarnström, Vilija Oke, Elisabet Svenungsson, Iva Gunnarsson, Marie Wahren-Herlenius
OBJECTIVES: Infections have been proposed as an environmental risk factor for autoimmune disease. Responses to microbial antigens may be studied in vivo during vaccination. We therefore followed patients with SLE and controls during split-virion influenza vaccination to quantify antibody responses against viral antigens and associated cellular and proteome parameters. METHODS: Blood samples and clinical data were collected from female patients with SLE with no or HCQ and/or low-dose prednisolone treatment (n = 29) and age- and sex-matched healthy controls (n = 17)...
October 2, 2020: Rheumatology
Yoshihiro Nishida, Kazuyuki Kano, Yuji Nobuoka, Takayuki Seo
OBJECTIVE: To evaluate the efficacy and safety of diclofenac etalhyaluronate (DF-HA) (ONO-5704/SI-613), a novel DF-conjugated hyaluronate, in patients with knee OA in Japan. METHODS: In this randomized, double-blind, placebo-controlled phase 2 study, patients were randomly assigned (1:1) to receive either 30 mg of DF-HA or placebo intra-articularly at weeks 0, 4 and 8 and were followed up for 24 weeks. The primary outcomes were changes from baseline in the WOMAC pain subscores, 50-foot walk test pain score and daily pain score...
October 2, 2020: Rheumatology
Inderjit Singh, Rudolf K F Oliveira, Robert Naeije, William M Oldham, Mariana Faria-Urbina, Aaron B Waxman, David M Systrom
OBJECTIVE: Exercise intolerance is a common clinical manifestation of CTD. Frequently, CTD patients have associated cardio-pulmonary disease, including pulmonary hypertension or heart failure that impairs aerobic exercise capacity (pVO2). The contribution of the systemic micro-vasculature to reduced exercise capacity in CTD patients without cardiopulmonary disease has not been fully described. In this study, we sought to examine the role of systemic vascular distensibility, α in reducing exercise capacity (i...
October 1, 2020: Rheumatology
Fulvia Ceccarelli, Alessandra Lo Presti, Giulio Olivieri, Silvia Angeletti, Carlo Perricone, Cristina Garufi, Giancarlo Iaiani, Lucia De Florio, Francesca Antonelli, Marina De Cesaris, Alessandra Giordano, Luigino Amori, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini, Massimo Ciccozzi, Fabrizio Conti
OBJECTIVE: We investigated the genetic diversity, molecular epidemiology and evolutionary dynamics of Staphylococcus aureus (SA) isolated from SLE patients by means of phylogenetic analysis. METHODS: Consecutive SLE patients (ACR 1997 criteria) were enrolled: clinical/laboratory data were collected and nasal swab for SA identification was performed. On the basis of the translation elongation factor (tuf) gene, a phylogenetic analysis was performed to investigate relationships and to assess significant clades...
September 30, 2020: Rheumatology
Ummugulsum Gazel, Gizem Ayan, Dilek Solmaz, Servet Akar, Sibel Zehra Aydin
No abstract text is available yet for this article.
September 30, 2020: Rheumatology
Mrinalini Dey, David M Hughes, Sizheng Steven Zhao
No abstract text is available yet for this article.
September 30, 2020: Rheumatology
Noha A Elsawy, Rim A Mohamed, Rasha A Ghazala, Mennatullah A Abdelshafy, Rehab Elnemr
OBJECTIVES: Anti-carbamylated protein antibodies (anti-CarP Abs) are present in patients with RA, however, their association with bone loss is not confirmed. The purpose of this study was to determine the relation between the serum level of anti-CarP Abs in premenopausal RA women and disease activity and bone loss. METHODS: This case-control study was conducted on 48 premenopausal women with RA and 48 matched healthy premenopausal women. All RA women were subjected to clinical examination, disease activity assessment using the 28-joint DAS (DAS28) and Clinical Disease Activity Index (CDAI), functional assessment using the HAQ, physical activity assessment using the International Physical Activity Questionnaire (IPAQ), fatigue assessment using the Modified Fatigue Impact Scale (MFIS), serological tests as well as anti-CarP Abs using ELISA...
September 30, 2020: Rheumatology
Mohammed Al-Bogami, Jonas Bystrom, Felix Clanchy, Taher E Taher, Pamela Mangat, Richard O Williams, Ali S Jawad, Rizgar A Mageed
OBJECTIVES: About half of RA patients treated with TNFα inhibitors either do not respond or lose their initial therapeutic response over time. The clinical response is measured by reduction in DAS28, which primarily reflects inflammation. However, other effects of TNFα inhibitors, such as impact on bone erosion, are not assessed by DAS28. We aimed to examine the effect of TNFα inhibitors on bone density, bone biomarkers and cytokine production in responder and non-responder patients and assessed mechanisms of action...
September 27, 2020: Rheumatology
Francesca Ingegnoli, Ariane L Herrick, Tommaso Schioppo, Francesca Bartoli, Nicola Ughi, John D Pauling, Alberto Sulli, Maurizio Cutolo, Vanessa Smith
OBJECTIVES: The level of detail included when describing nailfold videocapillaroscopy (NVC) methods varies among research studies, making interpretation and comparison of results challenging. The overarching objective of the present study was to seek consensus on the reporting standards in NVC methodology for clinical research in rheumatic diseases and to propose a pragmatic reporting checklist. METHODS: Based on the items derived from a systematic review focused on this topic, a three-step web-based Delphi consensus on minimum reporting standards in NVC was performed among members of the European League against Rheumatism (EULAR) Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium...
September 27, 2020: Rheumatology
Brian B Løgstrup, Torkell Ellingsen, Alma B Pedersen, Bianka Darvalics, Kevin K W Olesen, Hans Erik Bøtker, Michael Maeng
OBJECTIVES: To compare risk of cardiovascular disease and mortality in patients with incident RA, diabetes mellitus (DM) and the general population (GP). METHODS: Patients diagnosed with incident RA were matched 1:5 by age, sex and year of RA diagnosis with the GP. In the same period, patients with incident DM were included. Outcomes were heart failure (HF), myocardial infarction (MI), coronary revascularization, stroke, major adverse cardiovascular events (MACE) and death up to 10 years after diagnosis...
September 27, 2020: Rheumatology
Roshan Patel, Casril Liebert, Ali Kirresh, Mahmood Ahmad
No abstract text is available yet for this article.
September 26, 2020: Rheumatology
Giorgia Martini, Laura Saggioro, Roberta Culpo, Fabio Vittadello, Alessandra Meneghel, Francesco Zulian
OBJECTIVES: To investigate safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma. METHODS: Consecutive juvenile localized scleroderma patients undergoing systemic treatment were included in a retrospective longitudinal study. Patients treated with MMF because they were refractory or intolerant to MTX (MMF-group) were compared with responders to MTX (MTX-group). Disease activity was assessed by Localized Scleroderma Cutaneous Assessment Tool and thermography...
September 25, 2020: Rheumatology
Dawei Xu, Jan van der Voet, Nils M Hansson, Stefan Klein, Edwin H G Oei, Femke Wagner, Sebastia M A Bierma-Zeinstra, Jos Runhaar
OBJECTIVE: To assess the association between meniscal volume, its change over time and the development of knee OA after 30 months in overweight/obese women. METHODS: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 women with a BMI ≥ 27 kg/m2, free of OA-related symptoms. The primary outcome measure was incident OA after 30 months, defined by one out of the following criteria: medial or lateral joint space narrowing (JSN)  ≥ 1...
September 25, 2020: Rheumatology
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