Rheumatology | Page 3

Julie De Vooght, Jean-Baptiste Vulsteke, Petra De Haes, Xavier Bossuyt, Rik Lories, Ellen De Langhe
Anti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are robustly linked with cancer-associated DM in adults. This review aims to give an overview of the physiological context of TIF1-γ and to determine whether there is a pathophysiological link between anti-TIF1-γ autoantibodies and the occurrence of cancer. Detection of anti-TIF1-γ autoantibodies has a high sensitivity and specificity for cancer-associated DM in adults and is therefore useful for both diagnosis and cancer risk stratification...
December 28, 2019: Rheumatology
Sibylle de Germay, Haleh Bagheri, Fabien Despas, Vanessa Rousseau, François Montastruc
OBJECTIVES: We aimed to investigate whether abatacept used in patients for RA was associated with an increased risk of reporting overall cancer and specific cancers, including breast, lung, lymphoma, melanoma and non-melanoma skin cancer when compared with other biologic DMARDs (bDMARDs). METHODS: We performed an observational study within VigiBase, the World Health Organization's global database of individual case safety reports, from 2007 to 2017 to compare the cases of cancer reported in RA patients exposed to abatacept with those reported in RA patients exposed to other bDMARDs...
December 27, 2019: Rheumatology
Pilar Brito-Zerón, Nihan Acar-Denizli, Wan-Fai Ng, Ildiko Fanny Horváth, Astrid Rasmussen, Raphaele Seror, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Berkan Armagan, Aike A Kruize, Seung-Ki Kwok, Marika Kvarnstrom, Sonja Praprotnik, Damien Sene, Roberto Gerli, Roser Solans, Maureen Rischmueller, Thomas Mandl, Yasunori Suzuki, David Isenberg, Valeria Valim, Piotr Wiland, Gunnel Nordmark, Guadalupe Fraile, Hendrika Bootsma, Hideki Nakamura, Roberto Giacomelli, Valerie Devauchelle-Pensec, Benedikt Hofauer, Michele Bombardieri, Virginia Fernandes Moça Trevisani, Daniel Hammenfors, Sandra G Pasoto, Soledad Retamozo, Tamer A Gheita, Fabiola Atzeni, Jacques Morel, Cristina Vollenweider, Margit Zeher, Kathy Sivils, Bei Xu, Stefano Bombardieri, Pulukool Sandhya, Salvatore De Vita, Antonina Minniti, Jorge Sánchez-Guerrero, Levent Kilic, Eefje van der Heijden, Sung-Hwan Park, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals
OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five continents. RESULTS: The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available...
December 24, 2019: Rheumatology
Himanshi Chaudhary, Roshan Matthew, Rakesh Kumar Pilania, Gummadi Anjani, Madhubala Sharma, Vignesh Pandiarajan, Shano Naseem, Bishan Radotra, Amit Rawat
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
Troels Herlin, Sofie E Jørgensen, Christian Høst, Patrick S Mitchell, Maria Hønholt Christensen, Mira Laustsen, Dorthe A Larsen, Florian I Schmidt, Mette Christiansen, Trine H Mogensen
OBJECTIVES: Here we investigated a patient with inflammatory corneal intraepithelial dyskeratosis, mucosal inflammation, tooth abnormalities and, eczema to uncover the genetic and immunological basis of the disease. METHODS: On suspicion of an autoinflammatory condition, Sanger sequencing of nucleotide-binding oligomerization domain-like, leucine-rich repeat pyrin domain containing 1 (NLRP1) was performed and combined with an in vitro inflammasome reconstitution assay to measure caspase-1-mediated IL-1β cleavage, stimulation of patient peripheral blood mononuclear cells (PBMCs) and whole blood to measure IL-1β, IL-18 production and quantification of apoptosis-associated speck-like protein containing CARD (ASC) speck formation as a measure of inflammasome activation by flow cytometry...
December 24, 2019: Rheumatology
Iris Navarro-Millán, Parag Goyal, Monika M Safford
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
Mark Garton, Iain B McInnes, Naveed Sattar
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
Philip S Helliwell
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
Wenjia Sun, Ting Zhang, Huaxiang Wu, Jing Xue
No abstract text is available yet for this article.
December 24, 2019: Rheumatology
Chengsheng Ju, Rachel Wing Chuen Lai, Ka Hou Christien Li, Joshua Kai Fung Hung, Jenny C L Lai, Jeffery Ho, Yingzhi Liu, Man Fung Tsoi, Tong Liu, Bernard Man Yung Cheung, Ian Chi Kei Wong, Lai Shan Tam, Gary Tse
OBJECTIVES: The aim of this study is to determine major adverse cardiovascular events (MACE) and all-cause mortality comparing between xanthine oxidase inhibitors (XOIs) and non-XOI users, and between allopurinol and febuxostat. METHODS: This is a retrospective cohort study of gout patients prescribed anti-hyperuricemic medications between 2013 and 2017 using a territory-wide administrative database. XOI users were matched 1:1 to XOI non-users using propensity scores...
December 24, 2019: Rheumatology
Bárbara Batista, Susana Escária, Filipe Morais Almeida, Vasco Fernandes, Maria Francisca Moraes-Fontes
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
Sizheng Steven Zhao, Daniel H Solomon, Nicola J Goodson
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
Maria K Kvamme, Elisabeth Lie, Till Uhlig, Tron A Moger, Tore K Kvien, Ivar S Kristiansen
No abstract text is available yet for this article.
December 22, 2019: Rheumatology
Greta Pacini, Sabrina Paolino, Amelia C Trombetta, Federica Goegan, Carmen Pizzorni, Elisa Alessandri, Massimo Patanè, Emanuele Gotelli, Giorgia Ferrari, Francesco Cattelan, Massimo Ghio, Andrea Casabella, Vanessa Smith, Maurizio Cutolo
No abstract text is available yet for this article.
December 20, 2019: Rheumatology
Aksel Thuv Nilsen, Christine Karlsen, Gunnstein Bakland, Richard Watts, Raashid Luqmani, Wenche Koldingsnes
OBJECTIVE: ANCA-associated vasculitides (AAV) have increased in prevalence since the 1980s. We aimed to investigate the incidence and prevalence of AAV during a 15-year period from 1999 to 2013 in Northern Norway, looking for variations during this period. METHODS: Patient records were retrieved from The Northern Norwegian Vasculitis Registry; in addition we searched all regional hospital databases. Patients diagnosed with AAV from 1999 through to 2013 were included...
December 20, 2019: Rheumatology
Maxime M A Verhoeven, Janneke Tekstra, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, George A W Bruyn, Reinhard Bos, Ed N Griep, Ruth Klaasen, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma, Marjolein J H de Hair, Johannes W G Jacobs
OBJECTIVES: U-Act-Early was a 2-year, randomized placebo controlled, double-blind trial, in which DMARD-naïve early RA patients were treated to the target of sustained remission (SR). Two strategies initiating tocilizumab (TCZ), with and without methotrexate (MTX), were more effective than a strategy initiating MTX. The aim of the current study was to determine longer-term effectiveness in daily clinical practice. METHODS: At the end of U-Act-Early, patients were included in a 3-year post-trial follow-up (PTFU), in which treatment was according to standard care and data were collected every 3 months during the first year and every 6 months thereafter...
December 20, 2019: Rheumatology
G Harikrishnan, Neeraj Jain, Vikrant Verma, Vikas Agarwal, Durga Prasanna Misra
No abstract text is available yet for this article.
December 19, 2019: Rheumatology
Lene Terslev, Mikkel Østergaard, Joe Sexton, Hilde Berner Hammer
No abstract text is available yet for this article.
December 17, 2019: Rheumatology
Sara Monti, Cristina Ponte, Claudio Pereira, Federica Manzoni, Catherine Klersy, Federica Rumi, Greta Carrara, Andrew Hutchings, Wolfgang A Schmidt, Bhaskar Dasgupta, Roberto Caporali, Carlomaurizio Montecucco, Raashid Luqmani
OBJECTIVES: To develop a quantitative score based on colour duplex sonography (CDS) to predict the diagnosis and outcome of GCA. METHODS: We selected patients with positive CDS and confirmed diagnosis of GCA recruited into the TA Biopsy (TAB) vs Ultrasound in Diagnosis of GCA (TABUL) study and in a validation, independent cohort. We fitted four CDS models including combinations of the following: number and distribution of halos at the TA branches, average and maximum intima-media thickness of TA and axillary arteries...
December 17, 2019: Rheumatology
Zizhong Liu, Feng Huang, Gui Luo, Yiwen Wang, Ruikai Du, Weijia Sun, Jianwei Li, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Shukuan Ling, Deqing Wang, Yingxian Li
OBJECTIVE: Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS. METHODS: Peripheral blood was obtained from 32 patients with AS and 24 healthy controls. Levels of IL-17A, soluble RANK ligand (RANKL) and osteoprotegerin in serum were evaluated by ELISA, and the relative level of miR-214 in serum was detected by real-time quantitative PCR...
December 17, 2019: Rheumatology
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