journal
https://read.qxmd.com/read/38761433/what-reproductive-follow-up-for-adolescent-and-young-women-after-cancer-a-review
#21
REVIEW
C Decanter, E Elefant, C Poirot, B Courbiere
Fertility capacity has been shown to be one of the main concerns of young cancer survivors. Gonadotoxic treatments may lead to both premature ovarian failure and/or infertility. This review aimed to define which, and when, reproductive indicators should be followed-up to help doctors to counsel patients regarding their fertility and ovarian function, and to determine if a second stage of fertility preservation after the end of cancer treatment is clinically relevant. Longitudinal assessment of anti-Müllerian hormone (AMH) concentrations during cancer treatment indicates the degree of follicular depletion, and allows discrimination between low and high gonadotoxic treatments...
February 16, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38763121/early-versus-late-follicular-phase-ovarian-stimulation-a-randomized-controlled-trial
#22
JOURNAL ARTICLE
Sylvie De Rijdt, Kim Illingworth, Neelke De Munck, Herman Tournaye, Shari Mackens, Michel De Vos, Christophe Blockeel
RESEARCH QUESTION: Is late follicular phase stimulation as efficient as early follicular phase stimulation in a gonadotrophin-releasing hormone (GnRH) antagonist protocol in oocyte donors in terms of the number of oocytes. DESIGN: In this open label, phase 3, non-inferiority, randomized controlled trial using a two-arm design with a 1:1 allocation ratio, 84 oocyte donors were allocated to the early follicular start group (control group, n = 41) or the late follicular start group (study group, n = 43)...
February 12, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38744027/developing-and-validating-a-prediction-model-of-live-birth-following-single-vitrified-warmed-blastocyst-transfer
#23
JOURNAL ARTICLE
Piotr Sokol, Elisabet Clua, María Carme Pons, Sandra García, Annalisa Racca, Thomas Freour, Nikolaos P Polyzos
RESEARCH QUESTION: Can the developed clinical prediction model offer an accurate estimate of the likelihood of live birth, involving blastocyst morphology and vitrification day after single vitrified-warmed blastocyst transfer (SVBT), and therefore assist clinicians and patients? STUDY DESIGN: Retrospective cohort study conducted at a Spanish university-based reproductive medicine unit (2017-2021) including consecutive vitrified-warmed blastocysts from IVF cycles...
February 12, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38701632/artificial-intelligence-powered-assisted-ranking-of-sibling-embryos-to-increase-first-cycle-pregnancy-rate
#24
JOURNAL ARTICLE
Nina Dissler, Daniela Nogueira, Bertrand Keppi, Pierre Sanguinet, Christophe Ozanon, Cendrine Geoffroy-Siraudin, Xavier Pollet-Villard, Alexandra Boussommier-Calleja
RESEARCH QUESTION: Could EMBRYOLY, an artificial intelligence embryo evaluation tool, assist embryologists to increase first cycle pregnancy rate and reduce cycles to pregnancy for patients? DESIGN: Data from 11,988 embryos were collected via EMBRYOLY from 2666 egg retrievals (2019-2022) across 11 centres in France, Spain and Morocco using three time-lapse systems (TLS). Data from two independent clinics were also examined. EMBRYOLY's transformer-based model was applied to transferred embryos to evaluate ranking performances against pregnancy and birth outcomes...
February 12, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38614064/ivf-embryos-in-the-bin-embryo-like-structures-in-the-spotlight
#25
JOURNAL ARTICLE
Guido Pennings
Embryo-like structures (ELS) are intended for the study of embryonic development without the use of human supernumerary embryos. Scientists working in countries that do not allow research on embryos hope that these structures will replace natural embryos. The interest in ELS is largely based on two misconceptions: the belief that there is a shortage of research embryos and the belief that research on ELS will make research on natural embryos redundant. This paper argues that research efforts should be refocused on natural embryos...
February 10, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38688121/anticentromere-antibodies-are-the-most-potent-antinuclear-antibodies-in-reducing-live-birth-outcomes-after-icsi
#26
JOURNAL ARTICLE
Shokichi Teramoto, Tsuyoshi Ueno, Fumihito Aono, Tsuyoshi Okubo, Tomoya Segawa, Hisao Osada, Makio Shozu
RESEARCH QUESTION: How, and to what extent, do anticentromere antibodies (ACA) reduce live birth outcomes after ICSI? STUDY DESIGN: Retrospective cohort study of infertile women aged 30-43 years who underwent ICSI between September 2016 and March 2021. Women with a history or current diagnosis of symptomatic connective tissue disease were excluded. Immunofluorescence staining detected antinuclear antibodies (ANA). Staining pattern and titre (cut-off, 1:160) were used to divide infertile women into three groups: positive for ACA (ACA+) (n = 28); positive for ANA other than ACA (ANA+) (n = 77); and negative for both ACA and ANA (control) (n = 3723)...
February 7, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38735232/screening-women-in-young-adulthood-for-disabling-dysmenorrhoea-a-nationwide-cross-sectional-study-from-the-constances-cohort
#27
JOURNAL ARTICLE
François Margueritte, Xavier Fritel, Annie Serfaty, Mireille Coeuret-Pellicer, Arnaud Fauconnier
RESEARCH QUESTION: How do different warning indicators help to identify disabling dysmenorrhoea among women in young adulthood? DESIGN: A nationwide cross-sectional study of women aged 18-25 years from the CONSTANCES cohort was constructed. Disability was assessed with the Global Activity Limitation Indicator question 'For the past 6 months, have you been limited in routine activities?Yes, severely limited/Yes, limited/ No, not limited'. Dysmenorrhoea pain intensity and other chronic pelvic pain symptoms (dyspareunia and non-menstrual pain) were evaluated according to questions from a specific questionnaire...
February 6, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38735231/progesterone-concentrations-on-blastocyst-transfer-day-in-modified-natural-cycle-frozen-embryo-transfer-cycles
#28
JOURNAL ARTICLE
Marte Saupstad, Sara J Bergenheim, Jeanette W Bogstad, Morten R Petersen, Anna Klajnbard, Lisbeth Prætorius, Nina L C Freiesleben, Anne L Englund, Ellen C L Løkkegaard, Ulla B Knudsen, Merete Husth, Birgit Alsbjerg, Julie E Møller, Tine V Dam, Julie L Forman, Anja Pinborg, Kristine Løssl
RESEARCH QUESTION: Are serum progesterone concentrations on the day of modified natural cycle (mNC) frozen blastocyst transfer (FET) without luteal phase support (LPS) associated with clinical pregnancy rate (CPR)? DESIGN: Data were collected between January 2019 and October 2022 as a sub-study of an ongoing randomized controlled trial assessing pregnancy outcomes in mNC-FET. The sub-study included all women (n = 209) randomized to mNC-FET without LPS at the time of data extraction...
February 6, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38642471/total-duration-of-spontaneous-blastocyst-collapse-during-the-expansion-stage-is-an-independent-predictor-of-euploidy-and-live-birth-rates
#29
JOURNAL ARTICLE
Jiahong Zhu, Jiayi Zou, Lihong Wu, Shun Xiong, Yang Gao, Junxia Liu, Guoning Huang, Wei Han
RESEARCH QUESTION: Is the total duration of spontaneous blastocyst collapse to re-expansion before biopsy related to ploidy and live birth rates after single euploid blastocyst transfer? DESIGN: This was a retrospective cohort study of 600 preimplantation genetic testing cycles for aneuploidy (PGT-A) cycles, involving 2203 biopsied blastocysts, at a large reproductive medicine centre. Features of spontaneous blastocyst collapse from full to expanded stage, before biopsy, were observed using an embryoscope viewer for embryos cultured in a time-lapse incubator...
February 6, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38365564/response-to-cumulative-live-birth-rate-following-progestin-primed-ovarian-stimulation-controversial-results-with-own-and-donated-oocytes
#30
LETTER
Baris Ata, Erkan Kalafat
No abstract text is available yet for this article.
February 5, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38643517/perceptions-of-reproductive-healthcare-providers-regarding-their-involvement-in-offering-expanded-carrier-screening-in-fertility-clinics-a-qualitative-study
#31
JOURNAL ARTICLE
David Klein, Ivy van Dijke, Irene M van Langen, Wybo Dondorp, Phillis Lakeman, Lidewij Henneman, Martina C Cornel
RESEARCH QUESTION: What are the main arguments of reproductive healthcare providers in favour or against their involvement in offering expanded carrier screening (ECS) for recessive disorders at fertility clinics in the Netherlands? DESIGN: Semi-structured interview study with 20 reproductive healthcare providers between May 2020 and January 2021. Participants included 11 gynaecologists, seven fertility doctors, one nurse practitioner and one clinical embryologist, recruited from academic medical centres (n = 13), peripheral facilities associated with academic centres (n = 4), and independent fertility treatment centres (n = 3) in the Netherlands...
February 3, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38378381/cumulative-live-birth-rate-following-progestin-primed-ovarian-stimulation-controversial-results-with-own-and-donated-oocytes
#32
LETTER
Juan Giles, Ernesto Bosch
No abstract text is available yet for this article.
February 3, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38657291/gene-associations-of-lipid-traits-lipid-lowering-drug-target-genes-and-endometriosis
#33
JOURNAL ARTICLE
Ge Zhou, Jin Ren, Qiuyan Huang, Xiaowei Nie, Xingli Tong, Ya Wen Cui, Rongkui Hu, Qi Yao
RESEARCH QUESTION: Does the observed correlation between dyslipidaemia and endometriosis indicate a bidirectional causal association? DESIGN: Bidirectional Mendelian randomization was used to investigate the causal association between lipid traits and endometriosis. Drug-target Mendelian randomization was used to explore potential drug-target genes for managing endometriosis. In cases where lipid-mediated effects via specific drug targets were significant, aggregate analyses, such as summary-data-based Mendelian randomization and colocalization methods, were introduced to validate the outcomes...
February 2, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38648711/impact-of-aneuploidy-on-reproductive-success-in-young-infertile-women-prospective-analysis
#34
JOURNAL ARTICLE
Mandy Katz-Jaffe, Carly Gassen, Rachel Makloski, Laura Reed, William B Schoolcraft
RESEARCH QUESTION: What is the clinical outcome of the first attempt at conception between two embryo selection methods, blastocyst morphology and preimplantation genetic testing for aneuploidies (PGT-A), chosen at the initial physician IVF consultation? DESIGN: In this prospective analysis, a clinical decision regarding embryo selection, blastocyst morphology (group A) or PGT-A (group B) was made during initial physician IVF consultation. Female infertility patients were matched based on maternal age (mean 32...
February 2, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38636349/is-there-a-treatable-cause-of-repeated-implantation-failure-or-is-it-simply-treatment-failure-by-chance
#35
JOURNAL ARTICLE
E R Cutting, K S Abdallah, B W Mol
RESEARCH QUESTION: Does repeated implantation failure (RIF) sometimes have a cause, or is it simply treatment failure by chance? DESIGN: A hypothetical model of a cohort of 1000 women undergoing four repeated IVF attempts was constructed. A proportion of women with RIF carried an underlying risk factor negatively affecting implantation, compared with women without the factor. In strategy A, women had standard IVF without additional treatment; in strategy B, the women received standard IVF plus an additional treatment...
February 1, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38330857/rbmo-25-years-of-making-good-papers-better
#36
EDITORIAL
Nick Macklon, Juan Garcia-Velasco, Kamal Ahuja
No abstract text is available yet for this article.
February 1, 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38185024/moral-justification-for-the-use-of-add-ons-in-assisted-reproductive-technology-experts-views-and-experiences
#37
JOURNAL ARTICLE
Siun Gallagher, Ian Kerridge, Ainsley Newson, Sara Attinger, Robert J Norman, Wendy Lipworth
RESEARCH QUESTION: What factors do assisted reproductive terchnology (ART) providers take into account when they make decisions about offering 'add-ons'? DESIGN: A qualitative analysis of interviews with 31 ART professionals, focusing on their views and experiences in relation to add-ons, including the factors that are considered when doctors make decisions about their use. RESULTS: The participants reported that a range of considerations are taken into account when it comes to justifying the use of a particular add-on in a given circumstance, including the likelihood of benefit and harm, patients' perceived psychological needs and preferences, and organizational expectations...
February 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38177037/is-endometriosis-due-to-evolutionary-maladaptation
#38
REVIEW
Sezcan Mumusoglu, Aaron J W Hsueh
Similar to diabetes and unlike many pathogen-induced diseases, endometriosis is likely a result of maladaptation to the evolutionary heritage of humans. The objective of this article is to review the literature and improve understanding of the evolutionary factors behind endometriosis, leading to more effective prevention and treatment approaches. In primates, spontaneous decidualization of the endometrium evolved to ensure optimal implantation of a limited number of early embryos, unlike many non-primates which depend on early embryos to induce decidualization and subsequent pregnancy...
February 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38160486/should-the-trigger-to-oocyte-retrieval-interval-be-different-in-progestin-primed-ovarian-stimulation-cycles
#39
JOURNAL ARTICLE
Baris Ata, Aysu Cakar, Engin Türkgeldi, Sule Yildiz, İpek Keles, Erkan Kalafat
RESEARCH QUESTION: Does the trigger to oocyte retrieval interval (TORI) affect oocyte maturation rates differently in progestin-primed ovarian stimulation (PPOS) and gonadotrophin-releasing hormone (GnRH) antagonist cycles? DESIGN: This was a retrospective cohort study. The interaction between the stimulation protocol and TORI was assessed in a linear mixed effects multivariable regression analysis with oocyte maturation rate as the dependent variable, and stimulation protocol (GnRH antagonist or PPOS), age (continuous), gonadotrophin type (FSH or human menopausal gonadotrophin), trigger (human chorionic gonadotrophin [HCG] or GnRH agonist), TORI (continuous) and days of stimulation (continuous) as the independent variables...
February 2024: Reproductive Biomedicine Online
https://read.qxmd.com/read/38159467/progestin-primed-ovarian-stimulation-for-whom-when-and-how
#40
REVIEW
Baris Ata, Erkan Kalafat
Progestin-primed ovarian stimulation (PPOS) is being increasingly used for ovarian stimulation in assisted reproductive technology. Different progestins have been used with similar success. The available studies suggest a similar response to ovarian stimulation with gonadotrophin-releasing hormone (GnRH) analogues. Any differences in the duration of stimulation or gonadotrophin consumption are minor and clinically insignificant. PPOS has the advantage of oral administration and lower medication costs than GnRH analogues...
February 2024: Reproductive Biomedicine Online
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