Ernesto Bosch, Elena Labarta, Jose Zuzuarregui, Stamatina Iliodromiti, Scott M Nelson
No abstract text is available yet for this article.
March 19, 2024: Reproductive Biomedicine Online
Sunita Sharma, Shikha Bathwal, Nupur Agarwal, Ratna Chattopadhyay, Indranil Saha, Baidyanath Chakravarty
No abstract text is available yet for this article.
February 27, 2024: Reproductive Biomedicine Online
Guido Pennings
Embryo-like structures (ELS) are intended for the study of embryonic development without the use of human supernumerary embryos. Scientists working in countries that do not allow research on embryos hope that these structures will replace natural embryos. The interest in ELS is largely based on two misconceptions: the belief that there is a shortage of research embryos and the belief that research on ELS will make research on natural embryos redundant. This paper argues that research efforts should be refocused on natural embryos...
February 10, 2024: Reproductive Biomedicine Online
Baris Ata, Erkan Kalafat
No abstract text is available yet for this article.
February 5, 2024: Reproductive Biomedicine Online
Juan Giles, Ernesto Bosch
No abstract text is available yet for this article.
February 3, 2024: Reproductive Biomedicine Online
Nick Macklon, Juan Garcia-Velasco, Kamal Ahuja
No abstract text is available yet for this article.
February 1, 2024: Reproductive Biomedicine Online
Siun Gallagher, Sara Attinger, Angie Sassano, Elizabeth Sutton, Ian Kerridge, Ainsley Newson, Bobbie Farsides, Karin Hammarberg, Roger Hart, Emily Jackson, William Ledger, Christopher Mayes, Catherine Mills, Sarah Norcross, Robert J Norman, Luk Rombauts, Catherine Waldby, Anusch Yazdani, Wendy Lipworth
RESEARCH QUESTION: What are the views and experiences of patient and expert stakeholders on the positive and negative impacts of commercial influences on the provision of assisted reproductive technology (ART) services, and what are their suggestions for governance reforms? DESIGN: Semi-structured interviews were conducted with 31 ART industry experts from across Australia and New Zealand and 25 patients undergoing ART from metropolitan and regional Australia, between September 2020 and September 2021...
January 29, 2024: Reproductive Biomedicine Online
Linyu Zhang, Ying Feng, Xinrui Sun, Shiqi Yi, Xue Xiao, Fang Ma
The effect of obesity on pregnancy outcomes of patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) remains unclear. As such, a meta-analysis of recent studies was conducted to probe the effect of being overweight or obese on ART pregnancy outcomes in patients with PCOS. PubMed, Embase, MEDLINE, Scopus and Web of Science were searched from inception to 22 July 2023 without language restrictions. The main indicators were: live birth rate, clinical pregnancy rate, spontaneous abortion rate and multiple pregnancy rate...
January 26, 2024: Reproductive Biomedicine Online
Sophie H Bolt, A Janneke B M Maas, Astrid Indekeu, Inge van Nistelrooij
RESEARCH QUESTION: What are the lived experiences of donor-conceived people, parents, sperm donors and counsellors related to legal age limits on accessing donor information in the Netherlands? DESIGN: A phenomenological study was carried out that included 20 donor-conceived individuals, 15 parents, 6 sperm donors and 5 counsellors. Data were collected through online qualitative in-depth interviews and focus groups. The data were analysed using Dahlberg's Reflective Lifeworld Approach...
January 24, 2024: Reproductive Biomedicine Online
Alison Maunder, Susan Arentz, Mike Armour, Michael F Costello, Carolyn Ee
RESEARCH QUESTION: Is conducting a randomized control trial (RCT) to assess the effectiveness of whole-system naturopathy in improving pregnancy rates among women with diminished ovarian reserve (DOR) feasible? DESIGN: A two-arm, parallel group, assessor-blinded feasibility RCT was conducted. Women with DOR, trying to conceive naturally or by ART, were randomly assigned to naturopathy plus usual care, or usual care alone for 16 weeks. Primary outcomes were feasibility (recruitment, adherence, retention rates), acceptability and safety...
January 22, 2024: Reproductive Biomedicine Online
Thomas Huang
No abstract text is available yet for this article.
January 19, 2024: Reproductive Biomedicine Online
J Giles, M Cruz, A Cobo, C Vidal, A Requena, J Remohi, E Bosch
No abstract text is available yet for this article.
January 19, 2024: Reproductive Biomedicine Online
Satit Klangsin, Phawat Matemanosak, Krantarat Peeyananjarassri, Saranya Wattanakumtornkul, Teeravut Tubtawee, Sasipong Trongnit, Alan F Geater
RESEARCH QUESTION: Does radiation exposure during hysterosalpingography (HSG) negatively affect serum anti-Müllerian hormone (AMH) levels in infertile women? DESIGN: Prospective cohort study conducted at Songklanagarind Hospital, Thailand, between April 2021 and May 2023. Thirty-two infertile women and 34 control participants were enrolled. Serum AMH levels were assessed in the infertile group at baseline before the HSG procedure and at 1 and 3 months after the procedure...
January 18, 2024: Reproductive Biomedicine Online
Jullin Fjeldstad, Weikai Qi, Natalie Mercuri, Nadia Siddique, Jim Meriano, Alex Krivoi, Dan Nayot
RESEARCH QUESTION: Can a deep learning image analysis model be developed to assess oocyte quality by predicting blastocyst development from images of denuded mature oocytes? DESIGN: A deep learning model was developed utilizing 37,133 static oocyte images with associated laboratory outcomes from eight fertility clinics (six countries). A subset of data (n = 7807) was allocated to test model performance. External model validation was conducted to assess generalizability and robustness on new data (n = 12,357) from two fertility clinics (two countries)...
January 18, 2024: Reproductive Biomedicine Online
Elkin Muñoz, Fernando Bronet, Belen Lledo, Gabriela Palacios-Verdú, Lorena Martinez-Rocca, Signe Altmäe, Josep Pla
A frequent finding after preimplantation genetic diagnostic testing for aneuploidies using next-generation sequencing is an embryo that is putatively mosaic. The prevalence of this outcome remains unclear and varies with technical and external factors. Mosaic embryos can be classified by the percentage of cells affected, type of chromosome involvement (whole or segmental), number of affected chromosomes or affected cell type (inner mass cell, trophectoderm or both). The origin of mosaicism seems to be intrinsic as a post-zygotic mitotic error, but some external factors can play a role...
March 2024: Reproductive Biomedicine Online
Raquel Del Gallego, Barbara Lawrenz, Baris Ata, Erkan Kalafat, Laura Melado, Ibrahim Elkhatib, Human Fatemi
RESEARCH QUESTION: Are basal FSH measurements, when elevated within its normal range, useful for assessing overall ovarian response and predicting unexpected poor or suboptimal ovarian response? DESIGN: Retrospective cohort study of ovarian stimulation cycles. RESULTS: A total of 1058 ovarian stimulation cycles (891 first, 167 repeated) were included. Anti-Müllerian hormone (AMH) values were categorized into four (0 to ≤0.6, >0...
March 2024: Reproductive Biomedicine Online
Faisel Alorf, Sanah Alani, Naama Steiner, Michael H Dahan
RESEARCH QUESTION: What is the success rate of intrauterine insemination (IUI) after failing IVF? DESIGN: This retrospective cohort study evaluated the pregnancy outcomes of 551 patients who underwent a total of 992 IUI cycles at an academic fertility centre between October 2008 and April 2018. RESULTS: The study participants (n = 551) had previously failed one to three fresh IVF cycles and any resultant embryo transfers, and subsequently underwent a total of 992 IUI cycles...
March 2024: Reproductive Biomedicine Online
Valerio Pisaturo, Alessandra Alteri, Kelly Tilleman, David Mortimer
This commentary examines the impact of light conditions in the assisted reproductive technology (ART) laboratory, specifically considering gametes and embryo culture. While these processes traditionally occur in the absence of light within the female reproductive tract, laboratory conditions often involve exposure to varying wavelengths, intensities and light sources. Although literature reports describe potential detrimental effects of certain wavelengths of light on biological material, these findings are often based on experiments that might not reflect actual laboratory conditions...
March 2024: Reproductive Biomedicine Online
Roger J Hart
Many women undergoing IVF take supplements during treatment. The purpose of this review was to systematically review these nutritional supplements. The therapies studied are dehydroepiandrosterone (DHEA), melatonin, co-enzyme Q10 (CoQ1O), carnitine, selenium, vitamin D, myo-inositol, omega-3, Chinese herbs and dietary interventions. A literature search up to May 2023 was undertaken. The data suggest that a simple nutritional approach would be to adopt a Mediterranean diet. With regards to supplements to treat a potential poor ovarian response to ovarian stimulation, starting DHEA and COQ-10 before cycle commencement is better than control therapies...
March 2024: Reproductive Biomedicine Online
Siun Gallagher, Ian Kerridge, Ainsley Newson, Sara Attinger, Robert J Norman, Wendy Lipworth
RESEARCH QUESTION: What factors do assisted reproductive terchnology (ART) providers take into account when they make decisions about offering 'add-ons'? DESIGN: A qualitative analysis of interviews with 31 ART professionals, focusing on their views and experiences in relation to add-ons, including the factors that are considered when doctors make decisions about their use. RESULTS: The participants reported that a range of considerations are taken into account when it comes to justifying the use of a particular add-on in a given circumstance, including the likelihood of benefit and harm, patients' perceived psychological needs and preferences, and organizational expectations...
February 2024: Reproductive Biomedicine Online
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