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Reproductive Biomedicine Online

Narges Mobasseri, Hossein Nikzad, Mohammad Karimian
RESEARCH QUESTION: Is there any genetic association between estrogen receptor alpha [ERα]-PvuII polymorphism and idiopathic male infertility? DESIGN: A total of 226 infertile and 213 fertile men participated in the present case-control study. ERα-PvuII genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP] method. Meta-analysis was also performed by pooling data collected from seven other eligible studies identified by searches of PubMed, Embase, Google Scholar, and Science Direct databases...
January 23, 2019: Reproductive Biomedicine Online
Kay Lankreijer, Thomas M D'Hooghe, Silke Apers, Walter Sermeus, Sjoerd Repping, Eline Af Dancet
Several hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients' assessments regarding seven medication characteristics including 'side effects' and 'ease of use'. Medline, CINAHL and PsycINFO were searched for female fertility patients' written assessments of a hormonal medication. The tools used were appraised and common (i.e. ≥10%) unpleasant consequences were distinguished from rare ones. The 35 eligible studies did not rely on valid and reliable tools and did not provide patient assessments regarding all seven medication characteristics for any of the globally used medications...
January 19, 2019: Reproductive Biomedicine Online
Jana Liebenthron, Markus Montag, Jochen Reinsberg, Maria Köster, Vladimir Isachenko, Katrin van der Ven, Hans van der Ven, Jan-Steffen Krüssel, Michael von Wolff
RESEARCH QUESTION: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible? DESIGN: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity parameters and pregnancy, and delivery rates after transplantation. RESULTS: A total of 92.4% of tissue samples arrived at ideal temperatures of 2-8°C, 0...
January 19, 2019: Reproductive Biomedicine Online
(no author information available yet)
No abstract text is available yet for this article.
January 19, 2019: Reproductive Biomedicine Online
John L Yovich, Robert Casper, Michael Chapman, Jan Tesarik, Richard A Anderson
No abstract text is available yet for this article.
January 19, 2019: Reproductive Biomedicine Online
(no author information available yet)
No abstract text is available yet for this article.
January 19, 2019: Reproductive Biomedicine Online
(no author information available yet)
No abstract text is available yet for this article.
January 19, 2019: Reproductive Biomedicine Online
Tarek El-Toukhy, Omar El Tokhy
No abstract text is available yet for this article.
January 18, 2019: Reproductive Biomedicine Online
S R Catford, M K O'Bryan, R I McLachlan, M B Delatycki, L Rombauts
Ataxia with oculomotor apraxia type 2 (AOA2) is a rare autosomal recessive neurodegenerative disorder characterized by cerebellar atrophy, peripheral neuropathy and oculomotor apraxia. It is caused by mutations in the SETX gene that encodes senataxin, a ubiquitously expressed protein that mediates processes, including transcription, transcription termination, DNA repair, RNA processing, DNA-RNA hybrid (R-loop) elimination and telomere stability. In mice, senataxin is essential for male germ cell development and fertility through its role in meiotic recombination and sex chromosome inactivation...
January 9, 2019: Reproductive Biomedicine Online
Maryam Hezavehei, Homa Mohseni Kouchesfahani, Abdolhossein Shahverdi, Mohsen Sharafi, Ghasem Hosseini Salekdeh, Poopak Eftekhari-Yazdi
RESEARCH QUESTION: Can sublethal stress induced by nitric oxide on fresh human spermatozoa protect the functional properties of post-thaw human spermatozoa? DESIGN: Semen samples were obtained from 46 donors. Twenty semen samples were used to determine toxicity level of nitric oxide by incubation of semen with different concentrations of nitric oxide (0.01 to 400 μM). Then, 26 semen samples were cryopreserved with optimized ranges of nitric oxide: control (NO-0...
January 8, 2019: Reproductive Biomedicine Online
Aila Coello, Eva Sanchez, Begoña Vallejo, Marcos Meseguer, José Remohí, Ana Cobo
RESEARCH QUESTION: Does the presence of dysmorphisms affect post-warming survival and embryo development in vitrified autologous oocytes? DESIGN: A retrospective study comparing post-warming survival, fertilization and embryo development between morphologically normal (n = 269) and dysmorphic oocytes (n = 147). RESULTS: The survival rate was 81.4% in the morphologically normal oocytes and 87.1% in the dysmorphic oocyte group (OR 1...
January 8, 2019: Reproductive Biomedicine Online
Feng Xiong, Guangui Li, Qing Sun, Peilin Chen, Zhuran Wang, Caiyun Wan, Zhihong Yao, Huixian Zhong, Yong Zeng
RESEARCH QUESTION: Do pregnancy, obstetric and perinatal outcomes differ according to initial maternal serum human chorionic gonadotrophin (HCG) level measured on day 11 after single blastocyst transfer? DESIGN: Vitrified-warmed single blastocyst transfer cycles (n = 640) were collected between 1 January 2013 and 30 April 2017 with positive HCG values and retrospectively analysed by receiver operating characteristic curves to predict clinical pregnancy, ongoing pregnancy and delivery...
January 5, 2019: Reproductive Biomedicine Online
Cécile Le Saint, Kimberley Crespo, Amélie Bourdiec, François Bissonnette, Karen Buzaglo, Bernard Couturier, Sandra Bisotto, Simon J Phillips, Melissa Stutz, Jean-Noël Gouze, John S Sampalis, Samir Hamamah, Isaac Jacques Kadoch
RESEARCH QUESTION: Does autologous endometrial cell co-culture (AECC) improve the number of good-quality blastocysts obtained by IVF/intracytoplasmic sperm injection (ICSI), compared with conventional embryo culture medium in a broad group of patients referred to assisted reproductive technology (ART)? DESIGN: This interventional, randomized, double-blind study took place at Clinique Ovo from March 2013 to October 2015 and included 207 healthy patients undergoing an IVF or ICSI protocol, of which 71 were excluded before randomization...
January 5, 2019: Reproductive Biomedicine Online
Kejia Wu, Chunlei Mei, Yao Chen, Lidan Guo, Yuejin Yu, Donghui Huang
RESEARCH QUESTION: What is the effect of C-type natriuretic peptide (CNP) on human sperm capacitation in vitro and what is the mechanism of this effect? DESIGN: CNP/NPR-B expression in the female rat genital tract was examined by immunohistochemistry and western blot assay, and then the role of CNP in human sperm capacitation was determined. The signal transduction pathway of CNP in the process was determined to elucidate the regulation mechanism of CNP by enzyme-linked immunosorbent assay and flow cytometry...
January 5, 2019: Reproductive Biomedicine Online
Isabelle Cédrin-Durnerin, Tiphaine Isnard, Sarah Mahdjoub, Charlotte Sonigo, Alice Seroka, Marjorie Comtet, Charlène Herbemont, Christophe Sifer, Michael Grynberg
RESEARCH QUESTION: Is serum progesterone measurement on the day of embryo transfer associated with outcome of frozen-thawed embryo transfer (FET) in cycles using hormonal replacement therapy (HRT) for endometrium preparation? DESIGN: This single-centre retrospective study assessed the relationship between serum progesterone on embryo transfer day and live birth rates in 227 FET cycles. Endometrial preparation was performed by sequential administration of vaginal oestradiol until endometrial thickness was >7 mm, followed by transdermal oestradiol combined with 600 mg vaginal micronized progesterone...
January 5, 2019: Reproductive Biomedicine Online
Peter Humaidan, Thor Haahr
Clinical researchers in Europe are experiencing an increasing amount of bureaucracy, which in our eyes has now reached surrealistic heights, hampering the future of research, and thus, the development of new treatment regimens and advances in clinical research. In the long term, the current approval and control processes will negatively impact patient care, education, academia and the health economy of our countries. Thus, a debate is necessary including not only healthcare workers, but also politicians and patients...
January 2, 2019: Reproductive Biomedicine Online
Caroline A Smith, Mike Armour, Zewdneh Shewamene, Hsiewe Ying Tan, Robert J Norman, Neil P Johnson
This was a systematic review and meta-analysis to examine the efficacy, effectiveness and safety of acupuncture as an adjunct to embryo transfer compared with controls to improve reproductive outcomes. The primary outcome was clinical pregnancy. Twenty trials and 5130 women were included in the review. The meta-analysis found increased pregnancies (risk ratio [RR] 1.32, 95% confidence interval [CI] 1.07-1.62, 12 trials, 2230 women), live births (RR 1.30, 95% CI 1.00-1.68, 9 trials, 1980 women) and reduced miscarriage (RR 1...
January 2, 2019: Reproductive Biomedicine Online
Liu Jiang, Licheng Ji, Jianyuan Song, Kun Qian
RESEARCH QUESTION: Do serum vitamin D levels in men and women undergoing IVF/intracytoplasmic sperm injection (ICSI) affect embryo development and clinical outcomes? DESIGN: A large retrospective observational cohort study conducted between March 2016 and March 2017; plasma 25-OHD levels were measured before ovarian stimulation in couples undergoing IVF/ICSI (including 1883 women and 1720 men). RESULTS: Women were divided into four groups in terms of serum 25-OHD quartiles: <14...
December 26, 2018: Reproductive Biomedicine Online
HodaMaaly Harb, Firas Al-Rshoud, Bala Karunakaran, Ioannis D Gallos, Arri Coomarasamy
RESEARCH QUESTION: What is the association between hydrosalpinx and pregnancy loss and the effects of treatment for hydrosalpinx? DESIGN: A systematic review and meta-analysis was conducted to investigate the risk of pregnancy loss, and the benefit of treatment in women with hydrosalpinx. Searches were conducted on MEDLINE, Embase, the Cochrane Library and Web of Science. RESULTS: A meta-analysis of 14 observational studies showed a 74% relative increase in the risk of pregnancy loss in women with hydrosalpinx compared with women without hydrosalpinx (relative risk [RR] = 1...
December 25, 2018: Reproductive Biomedicine Online
Zahra Darmishonnejad, Marziyeh Tavalaee, Tayebeh Izadi, Somayeh Tanhaei, Mohammad Hossein Nasr-Esfahani
RESEARCH QUESTION: Telomeres are non-coding, repetitive DNA sequences (TTAGGG repeats) that play an important role in maintaining genome integrity. Unlike in somatic cells, telomere length in spermatozoa increases with male age and is considered as a molecular marker of sperm quality. The aetiology of failed fertilization following intracytoplasmic sperm injection (ICSI) is multifactorial; perhaps one of the reasons for this failure in these individuals is shortened sperm telomere length...
December 23, 2018: Reproductive Biomedicine Online
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