journal
https://read.qxmd.com/read/38823583/transcriptomic-and-epigenetic-landscape-of-nimorazole-enhanced-radiochemotherapy-in-head-and-neck-cancer
#21
JOURNAL ARTICLE
María José Besso, Verena Bitto, Lydia Koi, Wahyu Wijaya Hadiwikarta, Cristina Conde-Lopez, Rosemarie Euler-Lange, Mahnaz Bonrouhi, Karolin Schneider, Annett Linge, Mechthild Krause, Michael Baumann, Ina Kurth
BACKGROUND: Hypoxia remains a challenge for the therapeutic management of head and neck squamous cell carcinoma (HNSCC). The combination of radiotherapy with nimorazole has shown treatment benefit in HNSCC, but the precise underlying molecular mechanisms remain unclear. PURPOSE: To assess and to characterize the transcriptomic/epigenetic landscape of HNSCC tumor models showing differential therapeutic response to fractionated radiochemotherapy (RCTx) combined with nimorazole...
May 30, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38815695/factors-associated-with-acute-esophagitis-during-radiation-therapy-for-lung-cancer
#22
JOURNAL ARTICLE
Daniel J Herr, Huiying Yin, Derek Bergsma, Aleksandar F Dragovic, Martha Matuszak, Margaret Grubb, Michael Dominello, Benjamin Movsas, Larry L Kestin, Thomas Boike, Amit Bhatt, James A Hayman, Shruti Jolly, Matthew Schipper, Peter Paximadis
INTRODUCTION: Limiting acute esophagitis remains a clinical challenge during the treatment of locally advanced non-small cell lung cancer (NSCLC). METHODS: Demographic, dosimetric, and acute toxicity data were prospectively collected for patients undergoing definitive radiation therapy +/- chemotherapy for stage II-III NSCLC from 2012 to 2022 across a statewide consortium. Logistic regression models were used to characterize the risk of grade 2 + and 3 + esophagitis as a function of dosimetric and clinical covariates...
May 28, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38815694/adaptive-mri-guided-stereotactic-body-radiation-therapy-for-locally-advanced-pancreatic-cancer-a-phase-ii-study
#23
JOURNAL ARTICLE
Mathilde Weisz Ejlsmark, Rana Bahij, Tine Schytte, Christian Rønn Hansen, Anders Bertelsen, Faisal Mahmood, Michael Bau Mortensen, Sönke Detlefsen, Britta Weber, Uffe Bernchou, Per Pfeiffer
PURPOSE: Stereotactic body radiotherapy (SBRT) has emerged as a promising new modality for locally advanced pancreatic cancer (LAPC). The current study evaluated the efficacy and toxicity of SBRT in patients with LAPC (NCT03648632). METHODS: This prospective single institution phase II study recruited patients with histologically or cytologically proven adenocarcinoma of the pancreas after more than two months of combination chemotherapy with no sign of progressive disease...
May 28, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38806115/dosimetric-analysis-of-hearing-loss-after-cranial-radiation-therapy-in-children-a-single-institution-study-from-the-french-national-registry-pediart
#24
JOURNAL ARTICLE
William Gehin, Pascal Chastagner, Ludovic Mansuy, Valérie Bernier-Chastagner
PURPOSE: To identify dosimetric predictive factors of sensorineural hearing loss (SNHL) in children after cranial radiation therapy (RT) in a single institution using dosimetric data from the French National Registry PediaRT. METHODS AND MATERIALS: Complete audiological follow-up data were available for 44 children treated with cranial RT between 2014 and 2021 at our institution. The median age at the time of RT initiation was 9 years (range: 2-17 years)...
May 26, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38806114/estimation-of-the-optimal-radiotherapy-utilization-rate-for-childhood-neuroblastoma
#25
JOURNAL ARTICLE
Azumi Fukushima, Varsha Hande, Katherine Wakeham, Michael B Barton, Mohamed S Zaghloul, Daniel C Moreira, Nickhill Bhakta, Kathy Pritchard-Jones, Michael Sullivan, Bilal Mazhar Qureshi, Pauline Njoki Njiraini, Alfredo Polo
BACKGROUND AND PURPOSE: The optimal utilization rate of radiotherapy (oRUR) serves as a benchmark for assessing service demand and improving access to cancer care. While it is estimated that approximately 50 % of adult cancer patients require external beam radiotherapy during their treatment, there is a scarcity of data regarding the optimal use of radiotherapy in pediatric cancer. In this study, we adopted an established method and developed a model to estimate the oRUR in childhood neuroblastoma...
May 26, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38806113/systematic-review-and-meta-analysis-of-deep-learning-applications-in-computed-tomography-lung-cancer-segmentation
#26
REVIEW
Ting-Wei Wang, Jia-Sheng Hong, Jing-Wen Huang, Chien-Yi Liao, Chia-Feng Lu, Yu-Te Wu
BACKGROUND: Accurate segmentation of lung tumors on chest computed tomography (CT) scans is crucial for effective diagnosis and treatment planning. Deep Learning (DL) has emerged as a promising tool in medical imaging, particularly for lung cancer segmentation. However, its efficacy across different clinical settings and tumor stages remains variable. METHODS: We conducted a comprehensive search of PubMed, Embase, and Web of Science until November 7, 2023. We assessed the quality of these studies by using the Checklist for Artificial Intelligence in Medical Imaging and the Quality Assessment of Diagnostic Accuracy Studies-2 tools...
May 26, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38801945/stereotactic-radiotherapy-vs-whole-brain-radiation-therapy-in-egfr-mutated-nsclc-results-reflections-from-the-prematurely-closed-phase-iii-hybrid-trial
#27
JOURNAL ARTICLE
Ming Zeng, Vivek Verma, Xue Chen, Simin Li, Yongliang Sun, Guotao Liu, Xiaoman Tian, Deng Zhang, Jingqiu Li, Yi Liu, Xingyu Liao, Yingyi Liu, Ling Wang, Xiao Wang, Huibing Shi, Bin Li, Binyue Xue, Xing Luo
BACKGROUND: All known randomized trials of stereotactic radiotherapy (SRT) versus whole brain radiotherapy (WBRT) for brain metastases (BMs) comprise mixed histologies. The phase III HYBRID trial (NCT02882984) attempted to evaluate the non-inferiority of SRT vs. WBRT specifically for EGFR-mutated non-small cell lung cancer (EGFRm NSCLC) BMs. METHODS: Inclusion criteria were ≤ 5 BMs (any size) from treatment-naïve EGFRm NSCLC. All patients started a first-generation tyrosine kinase inhibitor on the first day of WBRT (37...
May 25, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38797493/cardiovascular-toxicities-of-radiotherapy-from-practical-issues-to-new-perspectives
#28
EDITORIAL
Marianne C Aznar, Jutta Bergler-Klein, Giuseppe Boriani, David J Cutter, Coen Hurkmans, Mario Levis, Teresa López-Fernández, Alexander R Lyon, Maja V Maraldo
No abstract text is available yet for this article.
May 24, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38797492/the-association-analysis-between-fatigue-and-body-composition-loss-in-patients-with-nasopharyngeal-carcinoma-during-radiotherapy-an-observational-longitudinal-study
#29
JOURNAL ARTICLE
Jihong Song, Xinru Yang, Jieling Wu, Zilan Wu, Sitian Niu, Litao Zhuo, Wenlong Lu, Jinru Ye, Yan Fang, Zhiying Zhan, Hairong Zhang, Xiaomei Li, Jinsheng Hong, Li Su
PURPOSE: This study aimed to reveal the association of fatigue with weekly changes in the body composition in patients with nasopharyngeal carcinoma (NPC) and identified the independent strength. METHODS: Four body composition indexes and fatigue were assessed before treatment (T0, baseline) and once a week throughout radiotherapy (T1-T7). Generalized additive mixed models (GAMMs) were used to explore the trajectories and longitudinal relationships of fatigue and weekly changes in body composition...
May 24, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38795813/estimating-the-long-term-survival-of-unresectable-stage-iii-non-small-cell-lung-cancer-based-on-cure-model-analysis
#30
JOURNAL ARTICLE
Yunpeng Wu, Ying Jiang, Wenqing Wang, Tao Zhang, Yexiong Li Supervisio, Nan Bi
BACKGROUND: The predictors of long-term survival and appropriate surrogate endpoints in unresectable stage III non-small cell lung cancer (NSCLC) treated with radiotherapy, remain unclear, especially in the immune therapy era. METHODS: This study retrospectively analyzed a prospective cohort of 822 patients treated at the Chinese National Cancer Center from 2013 to 2022. Cure fractions, surrogates for long-term survival, and associated factors were assessed using a mixture cure model, with validation against a matched Surveillance, Epidemiology, and End Results (SEER) dataset...
May 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38795812/predict-nutrition-related-adverse-outcomes-in-head-and-neck-cancer-patients-undergoing-radiotherapy-a-systematic-review
#31
REVIEW
Lichuan Zhang, Shuai Jin, Yujie Wang, Zijuan Zhang, Huilin Jia, Decheng Li, Qian Lu
BACKGROUND: Acute nutrition-related adverse outcomes are common in head and neck cancer patients undergoing radiotherapy. Predictive models can assist in identifying high-risk patients to enable targeted intervention. We aimed to systematically evaluate predictive models for predicting severe acute nutritional symptoms, insufficient intake, tube feeding, sarcopenia, and weight loss. METHODS: We searched PubMed, Web of Science, EBSCO, Embase, WanFang, CNKI, and SinoMed...
May 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38782301/development-and-benchmarking-of-a-deep-learning-based-mri-guided-gross-tumor-segmentation-algorithm-for-radiomics-analyses-in-extremity-soft-tissue-sarcomas
#32
JOURNAL ARTICLE
Jan C Peeken, Lucas Etzel, Tim Tomov, Stefan Münch, Lars Schüttrumpf, Julius H Shaktour, Johannes Kiechle, Carolin Knebel, Stephanie K Schaub, Nina A Mayr, Henry C Woodruff, Philippe Lambin, Alexandra S Gersing, Denise Bernhardt, Matthew J Nyflot, Bjoern Menze, Stephanie E Combs, Fernando Navarro
BACKGROUND: Volume of interest (VOI) segmentation is a crucial step for Radiomics analyses and radiotherapy (RT) treatment planning. Because it can be time-consuming and subject to inter-observer variability, we developed and tested a Deep Learning-based automatic segmentation (DLBAS) algorithm to reproducibly predict the primary gross tumor as VOI for Radiomics analyses in extremity soft tissue sarcomas (STS). METHODS: A DLBAS algorithm was trained on a cohort of 157 patients and externally tested on an independent cohort of 87 patients using contrast-enhanced MRI...
May 22, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38782302/assessment-of-gaze-direction-during-head-and-neck-irradiation-and-dosimetric-impact-on-the-retina-macula-and-papilla-in-a-cohort-of-240-patients-with-paraoptic-tumors
#33
JOURNAL ARTICLE
Nathan Azemar, Cathy Fontbonne, Jean Claude Quintyn, Dorothee Lebertz, Jean Marc Fontbonne, Juliette Thariat
In a prospective cohort of 240 paraoptic tumors patients treated with protons, there was 10° inter-individual gaze angle variability (up to 30°). In a random 21-patient subset with initial CTs versus and adaptive CTs, 6 (28.57 %) patients had at least twice a 10°-difference in their gaze angle, with > 5 Gy difference on the retina/macula or papilla in 2/21 (9.52 %) and 1/21 (4.76 %) based on cumulative dose from rescans, respectively.
May 21, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38772479/interobserver-variation-in-organs-at-risk-contouring-in-head-and-neck-cancer-according-to-the-dahanca-guidelines
#34
JOURNAL ARTICLE
Camilla Panduro Nielsen, Ebbe L Lorenzen, Kenneth Jensen, Jesper Grau Eriksen, Jørgen Johansen, Niels Gyldenkerne, Ruta Zukauskaite, Martin Kjellgren, Christian Maare, Camilla Kjær Lønkvist, Kinga Nowicka-Matus, Weronika Maria Szejniuk, Mohammad Farhadi, Zaza Ujmajuridze, Kirsten Marienhagen, Tanja Stagaard Johansen, Jeppe Friborg, Jens Overgaard, Christian Rønn Hansen
No abstract text is available yet for this article.
May 19, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38772478/interpretable-deep-learning-insights-unveiling-the-role-of-1%C3%A2-gy-volume-on-lymphopenia-after-radiotherapy-in-breast-cancer
#35
JOURNAL ARTICLE
Fang Chen, Ping Zhou, Ge Ren, Eric K W Lee, Qin Liu, Yuanyuan Shen, Yang Wang, Aya El Helali, Jian-Yue Jin, Pingfu Fu, Wei Dai, Anne W M Lee, Hao Yu, Feng-Ming Spring Kong
BACKGROUND: Lymphopenia is known for its significance on poor survivals in breast cancer patients. Considering full dosimetric data, this study aimed to develop and validate predictive models for lymphopenia after radiotherapy (RT) in breast cancer. MATERIAL AND METHODS: Patients with breast cancer treated with adjuvant RT were eligible in this multicenter study. The study endpoint was lympopenia, defined as the reduction in absolute lymphocytes and graded lymphopenia after RT...
May 19, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38772477/prospective-phase-ii-trial-on-ablative-stereotactic-body-radiation-therapy-sbrt-for-medically-inoperable-thoracic-nodes-metastases
#36
JOURNAL ARTICLE
D Franceschini, M A Teriaca, P Mancosu, A Bertolini, L Lo Faro, R Spoto, L Dominici, M Badalamenti, L Bellu, D Dei, F La Fauci, C Franzese, M Scorsetti
BACKGROUND: Oligometastases in mediastinal nodes are increasingly prevalent, posing challenges for treatment with stereotactic body radiotherapy (SBRT) due to proximity to organs at risk (OARs). We report the results of a single prospective observational phase II trial on ablative SBRT for medically inoperable thoracic nodes metastases (NCT02970955). MATERIAL AND METHODS: Since 2017, patients with < 3 nodal metastases were evaluated by the tumor board and included if deemed inoperable...
May 19, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38772476/incidence-of-hippocampal-and-perihippocampal-brain-metastases-and-impact-on-hippocampal-avoiding-radiotherapy-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Shari Wiegreffe, Gustavo Renato Sarria, Julian Philipp Layer, Egon Dejonckheere, Younèss Nour, Frederic Carsten Schmeel, Frank Anton Giordano, Leonard Christopher Schmeel, Ilinca Popp, Anca-Ligia Grosu, Eleni Gkika, Cas Stefaan Dejonckheere
BACKGROUND AND PURPOSE: In patients requiring prophylactic cranial irradiation (PCI) or whole-brain radiotherapy (WBRT) for brain metastases (BMs), hippocampal avoidance (HA) has been shown to preserve neurocognitive function and quality of life. Here, we aim to estimate the incidence of hippocampal and perihippocampal BMs and the subsequent risk of local undertreatment in patients undergoing hippocampal sparing radiotherapy. MATERIALS AND METHODS: MEDLINE, Embase, and Scopus were searched with the terms "Hippocampus", "Brain Neoplasms", and related terms...
May 19, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38768715/the-effect-of-time-delayed-contrast-enhanced-scanning-in-determining-the-gross-tumor-target-volume-in-large-volume-brain-metastases
#38
JOURNAL ARTICLE
Shanshan Du, Guanzhong Gong, Mingming Chen, Rui Liu, Kangning Meng, Yong Yin
BACKGROUND AND PURPOSE: To assess the variation in large-volume brain metastases (BMs) boundaries and shapes using enhanced magnetic resonance (MR) scanning with different delay times and to provide a basis for determining the gross tumor target volume (GTV) for radiotherapy for BMs. MATERIALS AND METHODS: We prospectively enrolled 155 patients initially diagnosed with BMs (561 lesions >1 cm). Contrast-enhanced (CE) T1-weighted imaging scans were performed 1, 3, 5, 10, 18, and 20 min after gadolinium-based contrast agent injection and GTVs were determined as GTV-1min , GTV-3min , GTV-5min , GTV-10min , GTV-18min , and GTV-20min, respectively, which were subsequently fused in different phases...
May 18, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38768714/standard-versus-fractionated-high-dose-cisplatin-plus-radiation-for-locally-advanced-head-and-neck-cancer-results-of-the-cisfrad-gortec-2015-02-randomized-phase-ii-trial
#39
JOURNAL ARTICLE
Christian Borel, Xu-Shan Sun, Alexandre Coutte, Guillaume Bera, Christian Sire, Sylvie Zanetta, Marc Alfonsi, Guillaume Janoray, Thierry Chatellier, Muriel Garcia-Ramirez, Elisabeta Gherga, Yasser Hammoud, Mickaël Burgy, Nelly Etienne-Selloum, Adeline Pechery, Marie-Hélène Girard-Calais, Michel Velten, Jean-Pierre Pignon, Mathilde Wanneveich, Jean Bourhis
BACKGROUND: Chemoradiotherapy with high-dose cisplatin (HD-Cis: 100 mg/m2 q3w for three cycles) is the standard of care (SOC) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Cumulative delivered dose of cisplatin is prognostic of survival, even beyond 200 mg/m2 but high toxicity compromises its delivery. AIM: Cisplatin fractionation may allow, by decreasing the peak serum concentration, to decrease toxicity. To date, no direct comparison was done of HD-Cis versus fractionated high dose cisplatin (FHD-Cis)...
May 18, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38763356/generalizability-of-deep-learning-in-organ-at-risk-segmentation-a-transfer-learning-study-in-cervical-brachytherapy
#40
JOURNAL ARTICLE
Ruiyan Ni, Kathy Han, Benjamin Haibe-Kains, Alexandra Rink
PURPOSE: Deep learning can automate delineation in radiation therapy, reducing time and variability. Yet, its efficacy varies across different institutions, scanners, or settings, emphasizing the need for adaptable and robust models in clinical environments. Our study demonstrates the effectiveness of the transfer learning (TL) approach in enhancing the generalizability of deep learning models for auto-segmentation of organs-at-risk (OARs) in cervical brachytherapy. METHODS: A pre-trained model was developed using 120 scans with ring and tandem applicator on a 3 T magnetic resonance (MR) scanner (RT3)...
May 17, 2024: Radiotherapy and Oncology
journal
journal
20234
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.