journal
https://read.qxmd.com/read/36934896/validation-of-prediction-models-for-radiation-induced-late-rectal-bleeding-evidence-from-a-large-pooled-population-of-prostate-cancer-patients
#1
JOURNAL ARTICLE
Alessandro Cicchetti, Claudio Fiorino, Martin A Ebert, Jacopo Iacovacci, Angel Kennedy, David J Joseph, James W Denham, Vittorio Vavassori, Gianni Fellin, Cesare Cozzarini, Claudio Degli Esposti, Pietro Gabriele, Fernando Munoz, Barbara Avuzzi, Riccardo Valdagni, Tiziana Rancati
PURPOSE: To validate published models for the risk estimate of grade≥1 (G1+), grade≥2 (G2+) and grade=3 (G3) late rectal bleeding (LRB) after radical radiotherapy for prostate cancer in a large pooled population from three prospective trials. MATERIALS AND METHODS: The external validation population included patients from Europe, and Oceanian centres enrolled between 2003 and 2014. Patients received 3DCRT or IMRT at doses between 66-80 Gy. IMRT was administered with conventional or hypofractionated schemes (2...
March 17, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36934895/outcome-prediction-models-incorporating-clinical-variables-for-head-and-neck-squamous-cell-carcinoma-a-systematic-review-of-methodological-conduct-and-risk-of-bias
#2
REVIEW
Farhannah Aly, Christian Rønn Hansen, Daniel Al Mouiee, Purnima Sundaresan, Ali Haidar, Shalini Vinod, Lois Holloway
No abstract text is available yet for this article.
March 17, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36934894/the-role-of-adaptive-planning-in-margin-reduced-mri-guided-stereotactic-body-radiotherapy-to-the-prostate-bed-following-radical-prostatectomy-post-hoc-analysis-of-a-phase-ii-clinical-trial
#3
JOURNAL ARTICLE
John Nikitas, Lauren M Smith, Yu Gao, Ting Martin Ma, Ankush Sachdeva, Stephanie M Yoon, Tommy Jiang, Daniel A Low, Leslie K Ballas, Michael L Steinberg, Minsong Cao, Amar U Kishan
BACKGROUND AND PURPOSE: We examined the interfractional variations of clinical target volumes (CTVs), planning target volumes (PTVs), and organs-at-risk (OARs) in patients receiving MRI-guided stereotactic body radiotherapy (SBRT) to the prostate bed and evaluated the potential role of adaptive planning. MATERIALS AND METHODS: 31 patients received 30-34 Gy in five fractions to the prostate bed on a phase II clinical trial. OARs, CTVs, and PTVs were retrospectively contoured on daily pretreatment MRIs (n=155)...
March 17, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36934893/risk-factors-for-cognitive-impairment-in-radically-treated-stage-iii-nsclc-secondary-findings-of-the-nvalt-11-study
#4
JOURNAL ARTICLE
Haiyan Zeng, Lizza E L Hendriks, Willem J A Witlox, Harry J M Groen, Anne-Marie C Dingemans, John Praag, José Belderbos, Ruud Houben, Vincent van der Noort, Dirk K M De Ruysscher
AIM: To identify risk factors for self-reported cognitive impairment in radically treated stage III non-small cell lung cancer (NSCLC). METHODS: Cognitive functioning was assessed using the EORTC-QLQ-C30 at seven pre-specified time points in the phase III NVALT-11 trial (observation versus prophylactic cranial irradiation [PCI] in stage III NSCLC treated with chemo-radiotherapy±surgery). Cognition was analyzed as binary (impairment or not) and continuous outcome, respectively, using generalized estimating equation (GEE) before and after multiple imputation...
March 17, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36934892/plan-quality-association-between-dummy-run-and-individual-case-review-in-a-prospective-multi-institutional-clinical-trial-of-postoperative-cervical-cancer-patients-treated-with-intensity-modulated-radiotherapy-japan-clinical-oncology-group-study-jcog1402
#5
JOURNAL ARTICLE
Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Hiroaki Kobayashi, Masayori Ishikawa, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Satoshi Ishikura, Nobuo Yaegashi, Takashi Mizowaki, Yasumasa Nishimura, Takafumi Toita
BACKGROUND AND PURPOSE: The Japan Clinical Oncology Group (JCOG) 1402 conducted a multicenter clinical trial of postoperative intensity-modulated radiotherapy (IMRT) for high-risk uterine cervical cancer patients. We assess effectiveness of the quality assurance (QA) program in central review through dummy runs (DRs) performed before patient enrollment and post-treatment individual case review (ICR), and clarify the pitfalls in treatment planning. MATERIAL AND METHODS: The ICRs were conducted using the same QA program as the DR for 214 plans...
March 17, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36921767/prognosis-prediction-for-glioblastoma-multiforme-patients-using-machine-learning-approaches-development-of-the-clinically-applicable-model
#6
JOURNAL ARTICLE
Yeseul Kim, Kyung Hwan Kim, Junyoung Park, Hong In Yoon, Wonmo Sung
BACKGROUND AND PURPOSE: We aimed to develop a clinically applicable prognosis prediction model predicting overall survival (OS) and progression-free survival (PFS) for glioblastoma multiforme (GBM) patients. MATERIALS AND METHODS: All 467 patients treated with concurrent chemoradiotherapy at Yonsei Cancer Center from 2016 to 2020 were included in this study. We developed a conventional linear regression, Cox proportional hazards (COX), and non-linear machine learning algorithms, random survival forest (RSF) and survival support vector machine (SVM) based on 16 clinical variables...
March 13, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36921766/five-year-overall-survival-with-ipilimumab-and-stereotactic-ablative-radiotherapy-for-metastatic-disease
#7
JOURNAL ARTICLE
Kewen He, David S Hong, Chad Tang, Duygu Sezen, Livia Cox, Aurian Maleki, Genevieve Bertolet, Quynh-Nhu Nguyen, Nathan I Comeaux, Lily Schuda, Dawei Chen, James W Welsh
PURPOSE: Ipilimumab plus stereotactic ablative radiotherapy (SABR) demonstrate satisfactory short-term clinical benefit and low toxicities in metastatic cancers. Here, we report the 5-year overall survival (OS) rates for patients with metastatic disease treated with this combined-modality therapy in a phase II trial (NCT02239900). METHODS AND MATERIALS: SABR was delivered to patients with metastatic lesions in the liver and lung either during the first dose (concurrent) or 1 week after the second dose (sequential) of ipilimumab (every 3 weeks for 4 cycles)...
March 13, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36898583/voluntary-versus-mechanically-induced-deep-inspiration-breath-hold-for-left-breast-cancer-a-randomized-controlled-trial
#8
JOURNAL ARTICLE
Vander Veken Loïc, Van Ooteghem Geneviève, Razavi Ariane, Da Rita Quaresma Sergio, Longton Eleonore, Kirkove Carine, Ledoux Benjamin, Vandermeulen Ad, Abdel Massih Christel, Henderickx Pascale, Gabriels Mortimer, Delvaux Céline, Salah Faycal, Vaandering Aude, Geets Xavier
BACKGROUND AND PURPOSE: Deep inspiration breath-hold (DIBH) protects critical organs-at-risk (OARs) for adjuvant breast radiotherapy. Guidance systems e.g. surface guided radiation therapy (SGRT) improve the positional breast reproducibility and stability during DIBH. In parallel, OARs sparing with DIBH is enhanced through different techniques e.g. prone position, continuous positive airway pressure (CPAP). By inducing repeated DIBH with the same level of positive pressure, mechanically-assisted and non-invasive ventilation (MANIV) could potentially combine these DIBH optimizations...
March 8, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889598/financial-toxicity-in-cancer-patients-undergoing-radiotherapy-in-a-universal-health-care-system-a-prospective-multicenter-study-of-1075-patients
#9
JOURNAL ARTICLE
Alexander Fabian, Alexander Rühle, Justus Domschikowski, Maike Trommer, Simone Wegen, Jan-Niklas Becker, Georg Wurschi, Simon Boeke, Mathias Sonnhoff, Christoph A Fink, Lukas Käsmann, Melanie Schneider, Elodie Bockelmann, Martin Treppner, David Krug, Nils H Nicolay
PURPOSE: To establish and confirm prevalence as well as risk factors of financial toxicity in a large national cohort of cancer patients undergoing radiotherapy in a universal health care system. METHODS: We conducted a prospective cross-sectional study offering a patient-reported questionnaire to all eligible cancer patients treated with radiotherapy in 11 centers in Germany during 60 consecutive days. The four-point subjective financial distress question of the EORTC QLQ-C30 was used as a surrogate for financial toxicity...
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889597/recurrence-analysis-of-glioblastoma-cases-based-on-distance-and-dose-information
#10
JOURNAL ARTICLE
Marco Langhans, Ilinca Popp, Anca-L Grosu, Nadya Shusharina, Harald Binder, Dimos Baltas, Thomas Bortfeld
BACKGROUND AND PURPOSE: Radiation therapy for glioblastoma (GBM) typically involves large target volumes. The aim of this study was to examine the recurrence pattern of GBM following modern radiochemotherapy according to EORTC guidelines and provide dose and distance information for the choice of optimal target volume margins. MATERIALS AND METHODS: In this study, the recurrences of 97 GBM patients, treated with radiochemotherapy from 2013 to 2017 at the Medical Center- University of Freiburg, Germany were analysed...
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889596/radiotherapy-dosimetry-at-multiple-levels-to-improve-precision-development-and-understanding-of-treatment
#11
EDITORIAL
Dietmar Georg, Marianne C Aznar, Uulke van der Heide, David Thwaites
No abstract text is available yet for this article.
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889595/knowledge-based-adaptive-planning-quality-assurance-using-dosimetric-indicators-for-stereotactic-adaptive-radiotherapy-for-pancreatic-cancer
#12
JOURNAL ARTICLE
Farnoush Forghani, John S Ginn, Joshua P Schiff, Tong Zhu, Luke Marut, Eric Laugeman, Borna Maraghechi, Shahed N Badiyan, Pamela P Samson, Huyan Kim, Clifford G Robinson, Geoff D Hugo, Lauren E Henke, Alex T Price
INTRODUCTION: We aimed to develop knowledge-based tools for robust adaptive radiotherapy (ART) planning to determine on-table adaptive DVH metric variations or planning process errors for stereotactic pancreatic ART. We developed volume-based dosimetric identifiers to identify deviations of ART plans from simulation plans. MATERIALS AND METHODS: Two patient cohorts who were treated on MR-Linac for pancreas cancer were included in this retrospective study; a training cohort and a validation cohort...
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889594/a-systematic-literature-review-of-definitions-and-classification-systems-for-radiotherapy-innovation-a-first-step-towards-building-a-value-based-assessment-tool-for-radiation-oncology
#13
JOURNAL ARTICLE
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
INTRODUCTION: Timely access to radiotherapy innovations remains suboptimal, partly because there is no commonly agreed appraisal system suitable for the broad range of radiotherapy interventions. The Health Economics in Radiation Oncology (HERO) programme of ESTRO therefore engaged in building a radiotherapy-specific value-based framework. We report on a first step towards that aim, documenting the available definitions and classification systems for radiotherapy interventions. METHODS: A systematic literature search was carried out in Pubmed and Embase, following PRISMA methodology and using search terms on 'innovation', 'radiotherapy', 'definition' and 'classification'...
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36889593/outcomes-after-pd-103-versus-i-125-for-low-dose-rate-prostate-brachytherapy-monotherapy-an-international-multi-institutional-study
#14
JOURNAL ARTICLE
Chad Tang, Jeremiah Sanders, Howard Thames, David M Swanson, Juanita M Crook, Teresa Bruno, Pierre Blanchard, Jay Ciezki, Mira Keyes, Daniel Song, Tanmay Singh, Gregory Merrick, Richard Stock, Francis J Sullivan, Henry Mok, Jeremy Millar, Steven J Frank
BACKGROUND AND PURPOSE: Pd-103 and I-125 are commonly used in low dose rate (LDR) brachytherapy for prostate cancer. Comparisons of outcomes by isotope type are limited, but Pd-103 has distinct radiobiologic advantages over I-125 despite its lesser availability outside the United States. We evaluated oncologic outcomes after Pd-103 vs I-125 LDR monotherapy for prostate cancer. MATERIALS AND METHODS: We retrospectively analyzed databases at 8 institutions for men who received definitive LDR monotherapy with Pd-103 (n=1,597) or I-125 (n=7,504) for prostate cancer...
March 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870610/radiotherapy-for-mediastinal-lymphoma-in-breath-hold-using-surface-monitoring-and-nasal-high-flow-oxygen-clinical-experiences-and-breath-hold-stability
#15
JOURNAL ARTICLE
Richard Canters, Femke Vaassen, Indra Lubken, Maud Cobben, Lars Murrer, Stephanie Peeters, Maaike Berbee, Bastiaan Ta
PURPOSE: In this study we describe the clinical introduction and evaluation of radiotherapy in mediastinal lymphoma in breath hold using surface monitoring combined with nasal high flow therapy (NHFT) to prolong breath hold duration. MATERIALS AND METHODS: 11 Patients with mediastinal lymphoma were evaluated. 6 Patients received NHFT, 5 patients were treated in breath hold without NHFT. Breath hold stability as measured by a surface scanning system was evaluated, as well as internal movement based on cone beam computed tomography (CBCT) before and after treatment...
March 2, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870609/machine-learning-with-region-level-radiomic-and-dosimetric-features-for-predicting-radiotherapy-induced-rectal-toxicities-in-prostate-cancer-patients
#16
JOURNAL ARTICLE
Zhuolin Yang, David J Noble, Leila Shelley, Thomas Berger, Raj Jena, Duncan B McLaren, Neil G Burnet, William H Nailon
BACKGROUND AND PURPOSE: This study aims to build machine learning models to predict radiation-induced rectal toxicities for three clinical endpoints and explore whether the inclusion of radiomic features calculated on radiotherapy planning computerised tomography (CT) scans combined with dosimetric features can enhance the prediction performance. MATERIALS AND METHODS: 183 patients recruited to the VoxTox study (UK-CRN-ID-13716) were included. Toxicity scores were prospectively collected after 2 years with grade ≥ 1 proctitis, haemorrhage (CTCAEv4...
March 2, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870608/first-in-human-technique-translation-of-oxygen-enhanced-mri-to-an-mr-linac-system-in-patients-with-head-and-neck-cancer
#17
JOURNAL ARTICLE
Michael J Dubec, David L Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J McHugh, Nuria Porta, Ross A Little, Susan Cheung, Christina Hague, Cynthia L Eccles, Peter J Hoskin, Robert G Bristow, Julian C Matthews, Marcel van Herk, Ananya Choudhury, Geoff Jm Parker, Andrew McPartlin, James Pb O'Connor
BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system. MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants...
March 2, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870607/on-the-implant-stability-in-adaptive-multi-catheter-breast-brachytherapy-establishment-of-a-decision-tree-for-treatment-re-planning
#18
JOURNAL ARTICLE
Andre Karius, Juliane Szkitsak, Vratislav Strnad, Michael Lotter, Stephan Kreppner, Philipp Schubert, Rainer Fietkau, Christoph Bert
BACKGROUND AND PURPOSE: To assess implant stability and identify causes of implant variations during high-dose-rate multi-catheter breast brachytherapy. MATERIALS AND METHODS: Planning-CTs were compared to control-CTs acquired halfway through the treatment for 100 patients. For assessing geometric stability, Fréchet-distance and button-to-button distance changes of all catheters as well as variations of Euclidean distances and convex hulls of all dwell positions were determined...
March 2, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870606/characteristics-of-local-extension-based-on-tumor-distribution-in-nasopharyngeal-carcinoma-and-proposed-clinical-target-volume-delineation
#19
JOURNAL ARTICLE
Zheng Wu, Bin Qi, Fei-Fei Lin, Lin Zhang, Qian He, Fei-Ping Li, Hui Wang, Ya-Qian Han, Wen-Jing Yin
OBJECTIVES: To summarize the characteristics of local extension of eccentric and central nasopharyngeal carcinoma (NPC) by magnetic resonance imaging (MRI) and to improve clinical target volume (CTV) delineation. METHODS: MRI of 870 newly diagnosed NPC patients were reviewed. According to tumor distribution features, the NPCs were divided into eccentric and central lesions. RESULTS: All local invasions presented as continuous invasion from gross lesions and structures adjacent to the nasopharynx were more likely to be invaded...
March 2, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/36870605/methodological-concerns-for-ultra-hypofractionated-neoadjuvant-radiation-therapy-in-soft-tissue-sarcoma
#20
LETTER
Shu-Wei Hsu, Yung-Shuo Kao
No abstract text is available yet for this article.
March 2, 2023: Radiotherapy and Oncology
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