Michael J Dubec, David L Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J McHugh, Nuria Porta, Ross A Little, Susan Cheung, Christina Hague, Cynthia L Eccles, Peter J Hoskin, Robert G Bristow, Julian C Matthews, Marcel van Herk, Ananya Choudhury, Geoff Jm Parker, Andrew McPartlin, James Pb O'Connor
BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system. MATERIALS AND METHODS: MRI sequences were developed in phantoms and 15 healthy participants...
March 2, 2023: Radiotherapy and Oncology