journal
https://read.qxmd.com/read/38763356/generalizability-of-deep-learning-in-organ-at-risk-segmentation-a-transfer-learning-study-in-cervical-brachytherapy
#1
JOURNAL ARTICLE
Ruiyan Ni, Kathy Han, Benjamin Haibe-Kains, Alexandra Rink
PURPOSE: Deep learning can automate delineation in radiation therapy, reducing time and variability. Yet, its efficacy varies across different institutions, scanners, or settings, emphasizing the need for adaptable and robust models in clinical environments. Our study demonstrates the effectiveness of the transfer learning (TL) approach in enhancing the generalizability of deep learning models for auto-segmentation of organs-at-risk (OARs) in cervical brachytherapy. METHODS: A pre-trained model was developed using 120 scans with ring and tandem applicator on a 3 T magnetic resonance (MR) scanner (RT3)...
May 17, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38761884/mri-radiomics-nomogram-integrating-postoperative-adjuvant-treatments-in-recurrence-risk-prediction-for-patients-with-early-stage-cervical-cancer
#2
JOURNAL ARTICLE
Yao Ai, Xiaoyang Zhu, Yu Zhang, Wenlong Li, Heng Li, Zeshuo Zhao, Jicheng Zhang, Boda Ning, Chenyu Li, Qiao Zheng, Ji Zhang, Juebin Jin, Yiran Li, Congying Xie, Xiance Jin
BACKGROUND AND PURPOSE: Adjuvant treatments are valuable to decrease the recurrence rate and improve survival for early-stage cervical cancer patients (ESCC), Therefore, recurrence risk evaluation is critical for the choice of postoperative treatment. A magnetic resonance imaging (MRI) based radiomics nomogram integrating postoperative adjuvant treatments was constructed and validated externally to improve the recurrence risk prediction for ESCC. MATERIAL AND METHODS: 212 ESCC patients underwent surgery and adjuvant treatments from three centers were enrolled and divided into the training, internal validation, and external validation cohorts...
May 16, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38740091/biomarkers-associated-with-pulmonary-exacerbations-in-a-randomized-trial-of-nintedanib-for-radiation-pneumonitis
#3
JOURNAL ARTICLE
Zachary R Moore, Xiaojing Huang, Stephanie Lobaugh, Zhigang Zhang, Phillip Wong, Alexander Geyer, Andrew Pagano, Charles M Rudin, David R Jones, Daniel R Gomez, Joseph O Deasy, Raymond Mak, Adam M Schmitt, Paul K Paik, Andreas Rimner
BACKGROUND AND PURPOSE: Radiation pneumonitis (RP) is a common side effect of thoracic radiotherapy and often has a long course characterized by acute exacerbations and progression to permanent lung fibrosis. There are no validated biomarkers of prognosis in patients diagnosed with RP. MATERIALS AND METHODS: We analyzed a time course of serum chemokines, cytokines, and other proteins from patients with grade 2+ RP in a randomized clinical trial of a steroid taper plus nintedanib, a multiple tyrosine kinase inhibitor, versus placebo plus a steroid taper for the treatment of RP...
May 11, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38740090/response-to-comments-on-radiotherapy-alone-versus-concurrent-chemoradiotherapy-in-patients-with-stage-ii-and-t3n0-nasopharyngeal-carcinoma-with-adverse-features-a-propensity-score-matched-cohort-study
#4
LETTER
https://read.qxmd.com/read/38735537/anxiety-and-depression-in-nasopharyngeal-carcinoma-patients-and-network-analysis-to-identify-central-symptoms-a-cross-sectional-study-from-a-high-incidence-area
#5
JOURNAL ARTICLE
Ze-Jiang Zhan, Hao-Yang Huang, Yan-Hua Xiao, Yu-Ping Zhao, Xun Cao, Zhuo-Chen Cai, Ying-Ying Huang, Xi Chen, Ying Deng, Jia-Yu Zhou, Lu-Lu Zhang, Zhuo-Ying Luo, Wen-Ze Qiu, Tai-Ze Yuan, Wen Hu, Yu-Ying Fan, Hai-Qiang Mai, Yuan Yang, Xiang Guo, Xing Lv
PURPOSE: To determine the prevalence of anxiety and depression in patients with nasopharyngeal carcinoma (NPC) and to identify central symptoms and bridge symptoms among psychiatric disorders. METHODS: This cross-sectional study recruited patients with NPC in Guangzhou, China from May 2022, to October 2022. The General Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) were used for screening anxiety and depression, respectively. Network analysis was conducted to evaluate the centrality and connectivity of the symptoms of anxiety, depression, quality of life (QoL) and insomnia...
May 10, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38735536/detection-of-flash-radiotherapy-tissue-sparing-in-a-3d-spheroid-model-using-dna-damage-response-markers
#6
JOURNAL ARTICLE
Alastair H Kyle, Tania Karan, Jennifer H E Baker, Judit Püspöky Banáth, Taixiang Wang, Anam Liu, Claudia Mendez, M Peter Petric, Cheryl Duzenli, Andrew I Minchinton
PURPOSE: The oxygen depletion hypothesis has been proposed as a rationale to explain the observed phenomenon of FLASH-radiotherapy (FLASH-RT) sparing normal tissues while simultaneously maintaining tumor control. In this study we examined the distribution of DNA Damage Response (DDR) markers in irradiated 3D multicellular spheroids to explore the relationship between FLASH-RT protection and radiolytic-oxygen-consumption (ROC) in tissues. METHODS: Studies were performed using a Varian Truebeam linear accelerator delivering 10 MeV electrons with an average dose rate above 50 Gy/s...
May 10, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38734145/accuracy-of-machine-learning-in-preoperative-identification-of-genetic-mutation-status-in-lung-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Jinzhan Chen, Ayun Chen, Shuwen Yang, Jiaxin Liu, Congyi Xie, Hongni Jiang
BACKGROUND AND PURPOSE: We performed this systematic review and meta-analysis to investigate the performance of ML in detecting genetic mutation status in NSCLC patients. MATERIALS AND METHODS: We conducted a systematic search of PubMed, Cochrane, Embase, and Web of Science up until July 2023. We discussed the genetic mutation status of EGFR, ALK, KRAS, and BRAF, as well as the mutation status at different sites of EGFR. RESULTS: We included a total of 128 original studies, of which 114 constructed ML models based on radiomic features mainly extracted from CT, MRI, and PET-CT data...
May 10, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38734144/potential-predictive-value-of-ivim-mr-for-xerostomia-in-nasopharyngeal-carcinoma
#8
JOURNAL ARTICLE
Mingjun Shen, Xiangying Lin, Chaolin Yang, Ziyan Zhou, Sixia Chen, Yuanxiu Yin, Liling Long, Lixuan Huang, Zongxiang Yang, Rensheng Wang, Min Kang
BACKGROUND AND PURPOSE: Xerostomia, caused by radiation-induced parotid damage, is the most commonly reported radiotherapy (RT) complication for nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the value of intravoxel incoherent motion (IVIM) MR in monitoring radiation-induced parotid gland damage and predicting the risk of xerostomia. METHODS: Fifty-four NPC patients were enrolled and underwent at least three IVIM MR scans: before (pre-RT), after 5 fractions of (5th-RT), halfway through (mid-RT), and after RT (post-RT)...
May 9, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38702015/treatment-planning-and-delivery-practice-of-lung-sbrt-results-of-the-2022-estro-physics-survey
#9
JOURNAL ARTICLE
Antony Carver, Alessandro Scaggion, Diego Jurado-Bruggeman, Oliver Blanck, Emmy Dalqvist, Francesca Romana Giglioli, Aljasa Jenko, Kristin Karlsson, Vanya Staykova, Ans Swinnnen, Samantha Warren, Pietro Mancosu, Nuria Jornet
BACKGROUND AND PURPOSE: The use of Stereotactic Body Radiation Therapy (SBRT) in lung cancer is increasing. However, there is no consensus on the most appropriate treatment planning and delivery practice for lung SBRT. To gauge the range of practice, quantify its variability and identify where consensus might be achieved, ESTRO surveyed the medical physics community. MATERIALS AND METHODS: An online survey was distributed to ESTRO's physicist membership in 2022, covering experience, dose and fractionation, target delineation, dose calculation and planning practice, imaging protocols, and quality assurance...
May 1, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38702014/late-xerostomia-prediction-model-based-on-18-f-fdg-pet-image-biomarkers-of-the-main-salivary-glands
#10
JOURNAL ARTICLE
Yan Li, Maria Irene van Rijn-Dekker, Suzanne Petronella Maria de Vette, Arjen van der Schaaf, Lisa van den Bosch, Johannes Albertus Langendijk, Lisanne Vania van Dijk, Nanna Maria Sijtsema
BACKGROUND AND PURPOSE: Recently, a comprehensive xerostomia prediction model was published, based on baseline xerostomia, mean dose to parotid glands (PG) and submandibular glands (SMG). Previously, PET imaging biomarkers (IBMs) of PG were shown to improve xerostomia prediction. Therefore, this study aimed to explore the potential improvement of the additional PET-IBMs from both PG and SMG to the recent comprehensive xerostomia prediction model (i.e., the reference model). MATERIALS AND METHODS: Totally, 540 head and neck cancer patients were split into training and validation cohorts...
May 1, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38688359/the-cardiac-effects-of-postoperative-radiotherapy-in-patients-with-non-small-cell-lung-cancer-warrants-further-evaluation
#11
LETTER
Zeliang Ma, Qian Liu, Zhouguang Hui
No abstract text is available yet for this article.
April 28, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38679202/chest-wall-pain-after-single-fraction-thoracic-stereotactic-ablative-radiotherapy-dosimetric-analysis-from-the-isabr-trial
#12
JOURNAL ARTICLE
Brianna Lau, Yufan F Wu, Sunan Cui, Jie Fu, Scott Jackson, Daniel Pham, Piotr Dubrowski, Shaila Eswarappa, Lawrie Skinner, Hiroki Shirato, Hiroshi Taguchi, Michael F Gensheimer, Harriet Gee, Alexander L Chin, Maximilian Diehn, Billy W Loo, Vitali Moiseenko, Lucas K Vitzthum
BACKGROUND AND PURPOSE: Concerns over chest wall toxicity has led to debates on treating tumors adjacent to the chest wall with single-fraction stereotactic ablative radiotherapy (SABR). We performed a secondary analysis of patients treated on the prospective iSABR trial to determine the incidence and grade of chest wall pain and modeled dose-response to guide radiation planning and estimate risk. MATERIALS AND METHODS: This analysis included 99 tumors in 92 patients that were treated with 25 Gy in one fraction on the iSABR trial which individualized dose by tumor size and location...
April 26, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38679201/neoadjuvant-low-dose-radiotherapy-plus-durvalumab-and-chemotherapy-for-potentially-resectable-stage-iii-nsclc-a-phase-ib-dose-escalation-study
#13
JOURNAL ARTICLE
Juan Li, Shun Lu, Yuke Tian, Lan Jiang, Lu Li, Shao-Hua Xie, Qiang Li
BACKGROUND AND PURPOSE: This phase Ib study was designed to assess the safety/tolerability and preliminary antitumor activity of neoadjuvant low-dose radiotherapy (LDRT) plus durvalumab and chemotherapy for potentially resectable stage III non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: Eligible patients received dose-escalated radiotherapy (10 Gy in 5 fractions [cohort 1], 20 Gy in 10 fractions [cohort 2], and 30 Gy in 15 fractions [cohort 3]) according to a 3 + 3 design, with concurrent durvalumab plus standard chemotherapy for two cycles...
April 26, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38677330/lexicographic-optimization-based-planning-for-stereotactic-radiosurgery-of-brain-metastases
#14
JOURNAL ARTICLE
Sara Trivellato, Paolo Caricato, Roberto Pellegrini, Martina Camilla Daniotti, Sofia Bianchi, Bianca Bordigoni, Stefano Carminati, Valeria Faccenda, Denis Panizza, Gianluca Montanari, Stefano Arcangeli, Elena De Ponti
AIM: To validate a fully-automated lexicographic optimization-planning system (mCycle, Elekta) for single-(SL) and multiple-(ML, up to 4 metastases) lesions in intracranial stereotactic radiosurgery (SRS, 21 Gy, single fraction). METHODS: A pre-determined priority list, Wish-List (WL), represents a dialogue between planner and clinician, establishing strict constraints and pursuing objectives. In order to satisfy the clinical protocol without manual intervention, four patients were required to tweak and fine-tune each WL (SLp, MLp) for coplanar arcs...
April 25, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38677329/randomized-self-controlled-study-comparing-open-face-vs-closed-immobilization-masks-in-fractionated-cranial-radiotherapy
#15
JOURNAL ARTICLE
Michèle Keane, Nienke Weitkamp, Indira Madani, Jonathan Day, Riccardo Dal Bello, Mariangela Zamburlini, Antonia Schiess, Amanda Moreira, Sophie Perryck, Katja Tomuschat, Marilyn Spencer, Stephanie Tanadini-Lang, Matthias Guckenberger, Michelle Brown
PURPOSE: To compare patient discomfort and immobilisation performance of open-face and closed immobilization masks in cranial radiotherapy. MATERIAL AND METHODS: This was a single-center randomized self-controlled clinical trial. At CT simulation, an open-face and closed mask was made for each patient and treatment plans with identical dose prescription were generated for each mask. Patients were randomised to start treatment with an open-face or closed mask. Masks were switched halfway through the treatment course; every patient was their own control...
April 25, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38677328/linc00313-suppresses-autophagy-and-promotes-stemness-of-nasopharyngeal-carcinoma-cells-through-ptbp1-stim1-axis
#16
JOURNAL ARTICLE
Lina Xu, Sile Liu, Yang Yang, Lu Shu, Yi Sun
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a kind of malignant head and neck tumor with high mortality. lncRNAs are valuable diagnostic biomarkers and therapeutic targets for various tumors. This study investigated the effects and mechanism of LINC00313 in nasopharyngeal carcinoma. METHODS: Cell Counting Kit-8 (CCK-8) and immunohistochemistry were used for assessing cell proliferation. The levels of autophagy-related proteins, and stem cell markers were detected...
April 25, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38670266/esho-1-85-hyperthermia-as-an-adjuvant-to-radiation-therapy-in-the-treatment-of-locally-advanced-breast-carcinoma-a-randomized-multicenter-study-by-the-european-society-for-hyperthermic-oncology
#17
JOURNAL ARTICLE
Jens Overgaard, Maarten Ccm Hulshof, Olav Dahl, Giorgio Arcangeli
BACKGROUND: The ESHO protocol 1-85 is a multicenter randomized trial initiated by the European Society for Hyperthermic Oncology with the aim to investigate the value of hyperthermia (HT) as an adjuvant to radiotherapy (RT) in treatment of locally advanced breast carcinoma. The trial is one of the largest studies of hyperthermia in radiotherapy but has not been previously published. PATIENTS AND METHODS: Between February 1987 and November 1993, 155 tumors in 151 patients were included...
April 24, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38670265/image-guided-radiotherapy-in-curative-treatment-for-prostate-cancer-5-year-results-from-a-randomized-controlled-trial-ric-trial
#18
JOURNAL ARTICLE
Jo-Åsmund Lund, Stian Lydersen, Bjørg Aksnessæther, Arne Solberg, Anne Wanderås, Christoffer Lervåg, Stein Kaasa, Hanne Tøndel
BACKGROUND: Between 2012 and 2015 we conducted a randomized controlled trial in prostate cancer patients comparing weekly 2-D portal imaging versus daily 3-D verification. AIM: To evaluate the clinical outcomes of image guided radiotherapy by presenting rectal and urinary side effects, health related quality of life and progression free survival after 5-years follow up of a randomized controlled trial. METHODS: We randomized 260 men with intermediate or high-risk prostate cancer to weekly 2-D portal imaging with 15 mm margin from CTV to PTV (Arm A) or daily 3-D cone-beam computer tomography with 7 mm margins (Arm B)...
April 24, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38670264/a-joint-physics-and-radiobiology-dream-team-vision-towards-better-response-prediction-models-to-advance-radiotherapy
#19
REVIEW
C Vens, P van Luijk, R I Vogelius, I El Naqa, L Humbert-Vidan, C von Neubeck, N Gomez-Roman, E Bahn, L Brualla, T T Böhlen, S Ecker, R Koch, A Handeland, S Pereira, L Possenti, T Rancati, D Todor, B Vanderstraeten, M Van Heerden, W Ullrich, M Jackson, M Alber, L Marignol
Radiotherapy developed empirically through experience balancing tumour control and normal tissue toxicities. Early simple mathematical models formalized this practical knowledge and enabled effective cancer treatment to date. Remarkable advances in technology, computing, and experimental biology now create opportunities to incorporate this knowledge into enhanced computational models. The ESTRO DREAM (Dose Response, Experiment, Analysis, Modelling) workshop brought together experts across disciplines to pursue the vision of personalized radiotherapy for optimal outcomes through advanced modelling...
April 24, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38670263/efficacy-of-metastatic-lesion-radiotherapy-in-patients-with-metastatic-nasopharyngeal-carcinoma-a-multicenter-retrospective-study
#20
JOURNAL ARTICLE
Yang Liu, Jie Ma, Xiao-Yi Zeng, Zhi-Chao Zuo, Rui-Zhong Chen, Xiao-Yu Li, Zhong-Guo Liang, Kai-Hua Chen, Xin-Bin Pan, Su Pei, Bin-Bin Yu, Ling Li, Song Qu, Yun-Li Yang, Xiao-Dong Zhu
OBJECTIVE: We investigated the efficacy of metastatic lesion radiotherapy (MLRT) in patients with metastatic nasopharyngeal carcinoma (mNPC). MATERIALS AND METHODS: Patients with mNPC from three institutions were included in this study. Propensity score matching (PSM) was employed to ensure comparability between patient groups. Overall survival (OS) rates were assessed using the Kaplan-Meier method and compared using the log-rank test. Prognostic factors were identified using univariate and multivariate Cox hazard analyses...
April 24, 2024: Radiotherapy and Oncology
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