journal
https://read.qxmd.com/read/37739319/the-health-related-quality-of-life-of-sarcoma-patients-treated-with-neoadjuvant-versus-adjuvant-radiotherapy-results-of-a-multi-center-observational-study
#1
JOURNAL ARTICLE
Susanne Singer, Sabine Semrau, Henriette Golcher, Katja Fechner, Annett Kallies, Sergio Zapata Bonilla, Robert Grützmann, Rainer Fietkau, Torsten Kluba, Christina Jentsch, Dimosthenis Andreou, Martin Bornhäuser, Jochen Schmitt, Markus K Schuler, Martin Eichler
AIM: The sequence of radiotherapy and resection in patients with soft tissue sarcomas is usually discussed on an individual basis. Better understanding of potential differences of health-related quality of life (QoL) between patients undergoing adjuvant (ART) versus neoadjuvant radiotherapy (NART) is therefore helpful for clinical decision making. METHODS: Adult sarcoma patients from 39 hospitals completed the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30)...
September 20, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37739318/stereotactic-body-radiation-therapy-versus-conventional-external-beam-radiotherapy-for-spinal-metastases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Henry C Y Wong, Shing Fung Lee, Adrian Wai Chan, Saverio Caini, Peter Hoskin, Charles B Simone Ii, Peter Johnstone, Yvette van der Linden, Joanne M van der Velden, Emily Martin, Sara Alcorn, Candice Johnstone, J Isabelle Choi, Gustavo Nader Marta, Eva Oldenburger, Srinivas Raman, Agata Rembielak, Vassilios Vassiliou, Pierluigi Bonomo, Quynh-Nhu Nguyen, Edward Chow, Samuel Ryu
INTRODUCTION: This study aimed to compare SBRT and cEBRT for treating spinal metastases through a systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: PubMed, EMBASE and Cochrane Library were searched up to 6 May 2023 for RCTs comparing SBRT and cEBRT for spinal metastases. Overall and complete pain response, local progression, overall survival, quality of life and adverse events were extracted. Data were pooled using random-effects models...
September 20, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37739317/impact-of-consensus-guidelines-on-delineation-of-primary-tumor-clinical-target-volume-ctvp-for-head-and-neck-cancer-results-of-a-national-review-project
#3
JOURNAL ARTICLE
Heleen Bollen, Akos Gulyban, Sandra Nuyts
BACKGROUND AND PURPOSE: A significant interobserver variability (IOV) for clinical target volume of the primary tumor (CTVp) delineation was shown in a previous national review project. Since then, international expert consensus guidelines (CG) for the delineation of CTVp were published. The aim of this follow-up study was to 1) objectify the extent of implementation of the CG, 2) assess its impact on delineation quality and consistency, 3) identify any remaining ambiguities. MATERIALS AND METHODS: All Belgian RT departments were invited to complete an online survey and submit CTVp for 5 reference cases...
September 20, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37739316/favourable-outcomes-with-an-initial-active-surveillance-strategy-for-asymptomatic-radiation-induced-meningiomas-in-long-term-survivors-of-paediatric-and-young-adult-malignancies
#4
JOURNAL ARTICLE
Mary Xu, Arian Lasocki, Mathias Bressel, Natalie Goroncy, Greg Wheeler, Mary Dwyer, Kirsty Wiltshire, John F Seymour, Neda Haghighi, Kylie Mason, Damien Tange, Belinda A Campbell
PURPOSE: Radiation-induced meningiomas (RIM) are the most common secondary neoplasm post-cranial radiotherapy, yet optimal surveillance and treatment strategies remain contentious. Herein, we report the clinical outcomes and radiological growth rate of RIM, diagnosed in a cohort of survivors undergoing MRI screening, with the objective of informing clinical guidelines and practice. MATERIALS AND METHODS: Long-term survivors of paediatric or young-adult malignancies, diagnosed with RIM between 1990-2015, were identified...
September 20, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37739315/a-prospective-registry-study-of-stereotactic-magnetic-resonance-guided-radiotherapy-mrgrt-for-primary-liver-tumors
#5
JOURNAL ARTICLE
Karl Bordeau, Morgan Michalet, Valérie Dorion, Aïcha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaillé, Roxana Draghici, Marc Ychou, Eric Assenat, Marta Jarlier, Sophie Gourgou, Boris Guiu, José Ursic-Bedoya, Norbert Aillères, Pascal Fenoglietto, David Azria, Olivier Riou
BACKGROUND AND PURPOSE: Stereotactic body radiation therapy (SBRT) has demonstrated safe and effective results for primary liver tumors. Magnetic Resonance guided Radiotherapy (MRgRT) is an innovative radiotherapy modality for abdominal tumors. The aim of this study is to report on acute and late toxicities and initial oncological results for primary liver tumors treated with MRgRT. MATERIALS AND METHODS: We prospectively included in our cohort all patients treated by MRgRT for a primary liver tumor at the Montpellier Cancer Institute...
September 20, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37709053/development-and-validation-of-a-machine-learning-model-of-radiation-induced-hypothyroidism-with-clinical-and-dose-volume-features
#6
JOURNAL ARTICLE
Mu-Hung Tsai, Joseph T C Chang, Hsi-Huei Lu, Yuan-Hua Wu, Tzu-Hui Pao, Yung-Jen Cheng, Wen-Yen Zheng, Chen-Yu Chou, Jing-Han Lin, Tsung Yu, Jung-Hsien Chiang
BACKGROUND AND PURPOSE: Radiation-induced hypothyroidism (RIHT) is a common but underestimated late effect in head and neck cancers. However, no consensus exists regarding risk prediction or dose constraints in RIHT. We aimed to develop a machine learning model for the accurate risk prediction of RIHT based on clinical and dose-volume features and to evaluate its performance internally and externally. MATERIALS AND METHODS: We retrospectively searched two institutions for patients aged >20 years treated with definitive radiotherapy for nasopharyngeal or oropharyngeal cancer, and extracted their clinical information and dose-volume features...
September 12, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37709052/stereotactic-arrhythmia-radioablation-a-multicenter-pre-post-intervention-safety-evaluation-of-the-implantable-cardioverter-defibrillator-function
#7
JOURNAL ARTICLE
Martijn H van der Ree, Wiert F Hoeksema, Adrian Luca, Jorrit Visser, Brian V Balgobind, Michiel Zumbrink, Raymond Spier, Claudia Herrera-Siklody, Justin Lee, Matthew Bates, Jim Daniel DClinSci, Clive Peedell, Judit Boda-Heggemann, Boris Rudic, Roland Merten, Edith M Dieleman, Cristopher A Rinaldi, Shahreen Ahmad, John Whitaker, Pranav Bhagirath, Matthew Q Hatton, Stephen Riley, Melanie Grehn, Luis Schiappacasse, Oliver Blanck, Stephan Hohmann, Etienne Pruvot, Pieter G Postema
BACKGROUND: Stereotactic arrhythmia radioablation (STAR) appears to be beneficial in selected patients with therapy-refractory ventricular tachycardia (VT). However, high-dose radiotherapy used for STAR-treatment may affect functioning of the patients' implantable cardioverter defibrillator (ICD) by direct effects of radiation on ICD components or cardiac tissue. Currently, the effect of STAR on ICD functioning remains unknown. METHODS: A retrospective pre-post multicenter study evaluating ICD functioning in the 12-month before and after STAR was performed...
September 12, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37699447/are-7-5gy%C3%A3-2-fractions-more-efficient-than-6gy%C3%A3-3-in-exclusive-postoperative-endometrial-cancer-brachytherapy-a-clinical-and-dosimetrical-analysis
#8
JOURNAL ARTICLE
Faegheh Noorian, Rosa Abellana, Yaowen Zhang, Antonio Herreros, Clara Baltrons, Vallentina Lancellota, Luca Tagliaferri, Sebastia Sabater, Aureli Torne, Angeles Rovirosa
PURPOSE: To compare two vaginal brachytherapy (VBT) schedules in postoperative endometrial carcinoma (PEC) patients considering vaginal-cuff relapses (VCR), late toxicities, dosimetry analysis and vaginal dilator use. MATERIAL AND METHODS: 110 PEC patients were treated with exclusive high-dose-rate VBT using two schedules. Group-1:44-patients received 6Gy×3fractions (September-2011-April-2014); Group-2:66-patients were treated with 7.5Gy×2fractions with a dose limit of equivalent total doses in 2-Gy fr (EQD2(α/β=3) ) of 68Gy in the most exposed 2cm3 of clinical target volume (CTV) (July-2015-November-2021)...
September 10, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37690668/flash-rt-does-not-affect-chromosome-translocations-and-junction-structures-beyond-that-of-conv-rt-dose-rates
#9
JOURNAL ARTICLE
Paul G Barghouth, Stavros Melemenidis, Pierre Montay-Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik G Jorge, Luis A Soto, Brianna C Lau, Cheyenne Sadeghi, Anushka Edlabadkar, Richard Zhang, Ning Ru, Janet E Baulch, Rakesh Manjappa, Jinghui Wang, Marie Le Bouteiller, Murat Surucu, Amy Yu, Karl Bush, Lawrie Skinner, Peter G Maxim, Billy W Loo, Charles L Limoli, Marie-Catherine Vozenin, Richard L Frock
BACKGROUND AND PURPOSE: The impact of radiotherapy (RT) at ultra high vs conventional dose rate (FLASH vs CONV) on the generation and repair of DNA double strand breaks (DSBs) is an important question that remains to be investigated. Here, we tested the hypothesis as to whether FLASH-RT generates decreased chromosomal translocations compared to CONV-RT. MATERIALS AND METHODS: We used two FLASH validated electron beams and high-throughput rejoin and genome-wide translocation sequencing (HTGTS-JoinT-seq), employing S...
September 8, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37690667/moderate-adverse-events-and-regional-differences-in-cdk4-6-inhibitor-treatment-combined-with-palliative-radiotherapy
#10
LETTER
Terufumi Kawamoto, Tetsuo Saito, Naoki Nakamura, Naoto Shikama
No abstract text is available yet for this article.
September 8, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37690666/moderate-adverse-events-and-regional-differences-in-cdk4-6-inhibitor-treatment-combined-with-palliative-radiotherapy
#11
LETTER
Marcin Kubeczko, Michał Jarząb, Dorota Gabryś, Aleksandra Krzywon, Alexander J Cortez, Amy J Xu
No abstract text is available yet for this article.
September 8, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37690665/response-to-the-letters-to-the-editor-of-s-benkhaled-et-al-and-c-h-rim-regarding-the-article-stereotactic-radiosurgery-versus-whole-brain-radiotherapy-in-patients-with-4-10-brain-metastases-a-nonrandomized-controlled-trial-by-bodensohn-et-al
#12
LETTER
https://read.qxmd.com/read/37683811/voxel-based-analysis-roadmap-for-clinical-translation
#13
REVIEW
Alan McWilliam, Giuseppe Palma, Azadeh Abravan, Oscar Acosta, Ane Appelt, Marianne Aznar, Serena Monti, Eva Onjukka, Vanessa Panettieri, Lorenzo Placidi, Tiziana Rancati, Eliana Vasquez Osorio, Marnix Witte, Laura Cella
Voxel-based analysis (VBA) allows the full, 3-dimensional, dose distribution to be considered in radiotherapy outcome analysis. This provides new insights into anatomical variability of pathophysiology and radiosensitivity by removing the need for a priori definition of organs assumed to drive the dose response associated with patient outcomes. This approach may offer powerful biological insights demonstrating the heterogeneity of the radiobiology across tissues and potential associations of the radiotherapy dose with further factors...
September 6, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37678624/prognostic-significance-of-mri-defined-sarcopenia-in-patients-with-nasopharyngeal-carcinoma-a-propensity-score-matched-analysis-of-real-world-data
#14
JOURNAL ARTICLE
Shuyi Liu, Yujian Zou, Minying Zhong, Ting Li, Yaxian Cao, Rui Wang, Jingjing You, Shuixing Zhang, Bin Zhang
BACKGROUND AND PURPOSE: Image-defined sarcopenia is linked to increased mortality among patients with cancer. Nevertheless, its effect on patients with nasopharyngeal carcinoma (NPC) is incompletely established. This study's aim was to investigate the prognostic significance of MRI-defined sarcopenia on the survival of patients undergoing concurrent chemoradiotherapy (CCRT) ± inducing chemotherapy (IC) for NPC treatment. METHODS: 1,307 patients with stage II-IVa NPC were included in this retrospective study...
September 5, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37678623/identifying-core-mri-sequences-for-reliable-automatic-brain-metastasis-segmentation
#15
JOURNAL ARTICLE
Josef A Buchner, Jan C Peeken, Lucas Etzel, Ivan Ezhov, Michael Mayinger, Sebastian M Christ, Thomas B Brunner, Andrea Wittig, Björn Menze, Claus Zimmer, Bernhard Meyer, Matthias Guckenberger, Nicolaus Andratschke, Rami A El Shafie, Jürgen Debus, Susanne Rogers, Oliver Riesterer, Katrin Schulze, Horst J Feldmann, Oliver Blanck, Constantinos Zamboglou, Konstantinos Ferentinos, Angelika Bilger, Anca L Grosu, Robert Wolff, Jan S Kirschke, Kerstin A Eitz, Stephanie E Combs, Denise Bernhardt, Daniel Rueckert, Marie Piraud, Benedikt Wiestler, Florian Kofler
BACKGROUND: Many automatic approaches to brain tumor segmentation employ multiple magnetic resonance imaging (MRI) sequences. The goal of this project was to compare different combinations of input sequences to determine which MRI sequences are needed for effective automated brain metastasis (BM) segmentation. METHODS: We analyzed preoperative imaging (T1-weighted sequence ± contrast-enhancement (T1/T1-CE), T2-weighted sequence (T2), and T2 fluid-attenuated inversion recovery (T2-FLAIR) sequence) from 339 patients with BMs from seven centers...
September 5, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37678622/decreased-lymphoma-related-deaths-and-improved-long-term-relative-survival-with-radiotherapy-for-early-stage-diffuse-large-b-cell-lymphoma-in-the-rituximab-era
#16
JOURNAL ARTICLE
Xin Wang, Xin Liu, Qiu-Zi Zhong, Tao Wu, Yun-Peng Wu, Yong Yang, Bo Chen, Hao Jing, Yuan Tang, Jing Jin, Yue-Ping Liu, Yong-Wen Song, Hui Fang, Ning-Ning Lu, Ning Li, Yi-Rui Zhai, Wen-Wen Zhang, Shu-Lian Wang, Fan Chen, Shu-Nan Qi, Ye-Xiong Li
BACKGROUND: We aimed to investigate the incidence of lymphoma-related death (LRD) and the long-term net survival benefit of radiotherapy (RT) for early-stage diffuse large B-cell lymphoma (DLBCL) in the rituximab era. METHODS: 10,841 adults diagnosed with early-stage DLBCL between 2002-2015 were retrospectively analyzed using data from the Surveillance, Epidemiology, and End Results database. Primary therapy was categorized into combined-modality treatment (CMT, n = 3,631) and chemotherapy alone (n = 7,210)...
September 5, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37678621/induction-chemotherapy-plus-re-irradiation-versus-re-irradiation-alone-in-locally-recurrent-nasopharyngeal-carcinoma-a-model-based-analysis
#17
JOURNAL ARTICLE
Wenbin Yan, Ting Liu, Meilin He, Junlin Yi, Linquan Tang, Xiaomin Ou, Chaosu Hu
OBJECTIVE: To investigate the role of additional induction chemotherapy (IC) prior to re-irradiation in locally recurrent nasopharyngeal carcinoma (lrNPC). METHODS: A total of 480 patients from three cancer treatment centers who received re-irradiation between 2012 and 2020 were retrospectively analyzed. Overall survival (OS) was determined using the Kaplan-Meier method and compared with log-rank method. Inverse probability of treatment weighting (IPTW) was performed to match the patients in pairwise treatment groups...
September 5, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37678620/prognostic-impact-of-post-treatment-fdg-pet-ct-in-anal-canal-cancer-a-prospective-study
#18
JOURNAL ARTICLE
Caroline Bailleux, Colette Zwarthoed, Ludovic Evesque, David Baron, Cyrielle Scouarnec, Karen Benezery, David Chardin, Claire Jaraudias, Yann Chateau, Jocelyn Gal, Eric François
No abstract text is available yet for this article.
September 5, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37660753/improving-prognosis-and-assessing-adjuvant-chemotherapy-benefit-in-locally-advanced-rectal-cancer-with-deep-learning-for-mri-a-retrospective-multi-cohort-study
#19
JOURNAL ARTICLE
Song Zhang, Guoxiang Cai, Peiyi Xie, Caixia Sun, Bao Li, Weixing Dai, Xiangyu Liu, Qi Qiu, Yang Du, Zhenhui Li, Zhenyu Liu, Jie Tian
PURPOSE: Adjuvant therapy is recommended to minimize the risk of distant metastasis (DM) and local recurrence (LR) in patients with locally advanced rectal cancer (LARC). However, its role is controversial. We aimed to develop a pretreatment MRI-based deep learning model to predict LR, DM, and overall survival (OS) over 5 years after surgery and to identify patients benefitting from adjuvant chemotherapy (AC). MATERIALS AND METHODS: The multi-survival tasks network (MuST) model was developed in a primary cohort (n=308) and validated using two external cohorts (n=247, 245)...
September 1, 2023: Radiotherapy and Oncology
https://read.qxmd.com/read/37660752/eosinophil-dynamics-during-chemo-radiotherapy-correlate-to-clinical-outcome-in-stage-%C3%A2-%C3%A2-a-nasopharyngeal-carcinoma-patients-results-from-a-large-cohort-study
#20
JOURNAL ARTICLE
Dan Li, Li-Na Yang, Jie-Yi Lin, Yong-Zhong Wu, Zheng Tang, Hong-Lei Tu, Xin Zhang, Yun-Chang Liu, Meng-Qi Yang, Nuo-Han Wang, Jiang-Dong Sui, Hai-Qiang Mai, Ying Wang
BACKGROUND AND PURPOSE: We investigated the dynamics of eosinophil depletion during definitive concurrent chemo-radiotherapy (CCRT) and their association with the prognosis of stage Ⅱ-Ⅳa nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: Fuzzy C-means algorithm (FCMA) assessed longitudinal trends in circulating eosinophil counts (CECs) of 1225 patients throughout the period of radical radiotherapy. The prognostic impact on patients' survival was evaluated with Kaplan-Meier analysis and Cox proportional risk model was used to determine the hazard ratio for adverse prognostic effects in grades of eosinophil depletion...
September 1, 2023: Radiotherapy and Oncology
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