journal
https://read.qxmd.com/read/38570213/variability-in-perfusion-conditions-and-set-up-parameters-used-in-ex-vivo-human-placenta-models-a-literature-review
#21
JOURNAL ARTICLE
S C Glättli, F A Elzinga, W van der Bijl, H G D Leuvenink, J R Prins, H van Goor, S J Gordijn, P Olinga, D J Touw, P Mian
The ex vivo human placenta perfusion model has proven to be clinically relevant to study transfer- and fetal exposure of various drugs. Although the method has existed for a long period, the setup of the perfusion model has not been generalized yet. This review aims to summarize the setups of ex vivo placental perfusion models used to examine drug transfer across the placenta to identify generalized properties and differences across setups. A literature search was carried out in PubMed September 26, 2022. Studies were labeled as relevant when information was reported, between 2000 and 2022, on the setups of ex vivo placental perfusion models used to study drug transfer across the placenta...
March 23, 2024: Placenta
https://read.qxmd.com/read/38537412/high-throughput-mrna-sequencing-of-human-placenta-shows-sex-differences-across-gestation
#22
JOURNAL ARTICLE
Amy E Flowers, Tania L Gonzalez, Yizhou Wang, Chintda Santiskulvong, Ekaterina L Clark, Allynson Novoa, Caroline A Jefferies, Kate Lawrenson, Jessica L Chan, Nikhil V Joshi, Yazhen Zhu, Hsian-Rong Tseng, Erica T Wang, Mariko Ishimori, S Ananth Karumanchi, John Williams, Margareta D Pisarska
INTRODUCTION: Fetal sex affects fetal and maternal health outcomes in pregnancy, but this connection remains poorly understood. As the placenta is the route of fetomaternal communication and derives from the fetal genome, placental gene expression sex differences may explain these outcomes. OBJECTIVES: We utilized next generation sequencing to study the normal human placenta in both sexes in first and third trimester to generate a normative transcriptome based on sex and gestation...
March 21, 2024: Placenta
https://read.qxmd.com/read/38537411/paternal-age-and-first-trimester-placental-size-and-growth-the-rotterdam-periconceptional-cohort
#23
JOURNAL ARTICLE
M M Van Vliet, S Schoenmakers, B Haug, S Willemsen, R P M Steegers-Theunissen
INTRODUCTION: Despite a noticeable trend of delayed fatherhood, less is known about the impact of paternal age on the paternally programmed placenta. We hypothesize that paternal aging affects seminal quality and as such induces ageing-related epigenetic alterations that influence placental growth. Our main aim is to investigate associations between paternal age and first trimester (vascular) placental growth trajectories. METHODS: Pregnant women were enrolled before 10 weeks of gestation in the Rotterdam Periconceptional Cohort (Predict study)...
March 21, 2024: Placenta
https://read.qxmd.com/read/38531214/fetal-anemia-causes-placental-and-maternal-cellular-damage-a-lesson-from-fetal-hemoglobin-bart-s-disease
#24
JOURNAL ARTICLE
Suchaya Luewan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn Chattipakorn, Theera Tongsong
INTRODUCTION: The studies about effect of fetal anemia on placental and maternal molecular changes have rarely been published. This study aimed to compare oxidative stress levels and mitochondrial function in the placenta and maternal peripheral blood mononuclear cell (PMBCs) between anemic fetuses (using fetal Hb Bart's disease as a study model) and non-anemic fetuses. METHODS: A cross-sectional study was conducted on pregnancies affected by Hb Bart's disease and non-anemic fetuses between 16 and 22 weeks of gestation...
March 21, 2024: Placenta
https://read.qxmd.com/read/38527377/effects-of-sars-cov-2-mrna-vaccine-on-placental-histopathology-comparison-of-a-population-of-uncomplicated-covid-19-positive-pregnant-women
#25
JOURNAL ARTICLE
Silvio Tartaglia, Chiara Di Ilio, Federica Romanzi, Sascia Moresi, Eleonora Nardi, Elisa Bevilacqua, Vincenzo Arena, Antonio Lanzone
UNLABELLED: 1. INTRODUCTION: This study investigates the impact of SARS-CoV-2 infection on placental histopathology in pregnant women, comparing outcomes between vaccinated and non-vaccinated individuals. Despite known adverse pregnancy outcomes linked to SARS-CoV-2 infection, the specific effects on the placenta remain unclear. Although vaccination has demonstrated a substantial reduction in infection severity, its impact on placental health requires more insight...
March 14, 2024: Placenta
https://read.qxmd.com/read/38514278/beyond-2d-novel-biomaterial-approaches-for-modeling-the-placenta
#26
JOURNAL ARTICLE
Samantha G Zambuto, Adrienne K Scott, Michelle L Oyen
This review considers fully three-dimensional biomaterial environments of varying complexity as these pertain to research on the placenta. The developments in placental cell sources are first considered, along with the corresponding maternal cells with which the trophoblast interact. We consider biomaterial sources, including hybrid and composite biomaterials. Properties and characterization of biomaterials are discussed in the context of material design for specific placental applications. The development of increasingly complicated three-dimensional structures includes examples of advanced fabrication methods such as microfluidic device fabrication and 3D bioprinting, as utilized in a placenta context...
March 14, 2024: Placenta
https://read.qxmd.com/read/38492472/hla-g-isoforms-hla-c-allotype-and-their-expressions-differ-between-early-abortus-and-placenta-in-relation-to-spontaneous-abortions
#27
JOURNAL ARTICLE
Mayuri Bora, Sushmita Singha, Taruna Madan, Gitanjali Deka, Sumita Gogoi Hazarika, Shashi Baruah
INTRODUCTION: Spontaneous abortion (SAB) affects approximately 10% of clinically recognized pregnancies. Fetal trophobalst invasion and remodeling of maternal spiral arteries is reported to be dependent on crosstalk between HLA-C/HLA-G expressed on extra villous trophoblast (EVTs)and Killer cell Immunoglobin like receptors (KIRs) of decidual NK (dNK). Immune dysfunction in decidua contributes to early miscarriage. METHODOLOGY: The study used mother neonate paired cord blood and term placenta samples (n = 46), elective abortus (n = 17,gestational age = 10-12 weeks of pregnancy) and SAB abortus (n = 24, gestational age = 12-15 weeks of pregnancy) for HLA-G, KIR2D and HLA-C...
March 11, 2024: Placenta
https://read.qxmd.com/read/38490095/a-longitudinal-and-cross-sectional-study-of-placental-circulation-between-normal-and-placental-insufficiency-pregnancies
#28
JOURNAL ARTICLE
J Y Chen, B L Yu, X J Wu, Y F Li, L Y Zhong, M Chen
INTRODUCTION: To longitudinally and cross-sectionally study the differences in the uterine artery pulsatility index (UTPI), umbilical artery pulsatility index (UAPI) and placental vascularization indices (PVIs, derived from 3-dimensional power Doppler) between normal and placental insufficiency pregnancies throughout gestation. METHODS: UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11 to 13+6 weeks-36 weeks. Preeclampsia (PE) and fetal growth restriction (FGR) were defined as placental insufficiency...
March 11, 2024: Placenta
https://read.qxmd.com/read/38490094/n-linked-%C3%AE-2-6-sialylation-of-integrin-%C3%AE-1-by-the-sialyltransferase-st6gal1-promotes-cell-proliferation-and-stemness-in-gestational-trophoblastic-disease
#29
JOURNAL ARTICLE
Jianwei Liu, Xinyue Dong, Ru Xie, Ying Tang, Aline M Thomas, Shen Li, Shuai Liu, Ming Yu, Huamin Qin
INTRODUCTION: Gestational trophoblastic disease (GTD) encompasses a spectrum of rare pre-malignant and malignant entities originating from trophoblastic tissue, including partial hydatidiform mole, complete hydatidiform mole and choriocarcinoma. β-galactoside α2,6 sialyltransferase 1 (ST6Gal1), the primary sialyltransferase responsible for the addition of α2,6 sialic acids, is strongly associated with the occurrence and development of several tumor types. However, the role of ST6Gal1/α2,6 -sialylation of trophoblast cells in GTD is still not well understood...
March 11, 2024: Placenta
https://read.qxmd.com/read/38518389/pfas-alters-placental-arterial-vasculature-in-term-human-placentae-a-prospective-pregnancy-cohort-study
#30
JOURNAL ARTICLE
Sadia Firoza Chowdhury, Nashae Prout, Zorimar Rivera-Núñez, Emily Barrett, Jessica Brunner, Zoe Duberstein, Kurunthachalam Kannan, Carolyn M Salafia, Ruchit Shah, Richard K Miller, Thomas G O'Connor
INTRODUCTION: Perfluoroalkyl substances (PFAS) are synthetic chemicals used in industrial and consumer goods that are widely detected in human populations and are associated with adverse health outcomes, including perinatal health risks and child health. One mechanism of influence may be the impact of PFAS exposure on placental structure and function. OBJECTIVES: The objective of this study is to investigate the relationship between maternal prenatal exposure to PFAS and measures of placental vascularization, and to assess whether changes in vascularization play a role in mediating the impact of PFAS on birth outcomes...
March 9, 2024: Placenta
https://read.qxmd.com/read/38484495/whole-exome-sequencing-of-placental-chorangioma
#31
JOURNAL ARTICLE
Rachelle P Mendoza, Kristina Doytcheva, Minhaz Ud Dean, Kyla M Jorgenson, Donghyuk Choi, Jeremy Segal, Peng Wang, Ricardo R Lastra
INTRODUCTION: Placental chorangioma is a benign non-trophoblastic vascular proliferation of the placental chorion favored to represent hamartoma-like or hyperplastic capillary lesions. As the exact pathophysiology has not been established, we investigated the molecular characteristics of placental chorangiomas using exploratory whole exome sequencing. METHODS: Three cases were retrospectively selected and whole exome sequencing was performed on macrodissected lesions...
March 8, 2024: Placenta
https://read.qxmd.com/read/38452718/two-dimensional-2d-placental-ultrasound-measurements-the-correlation-with-placental-volume-measured-by-magnetic-resonance-imaging-mri
#32
JOURNAL ARTICLE
Karianne Sagberg, Anne Eskild, Silje Sommerfelt, Tuva K Halle, Vigdis Hillestad, Camilla Haavaldsen
INTRODUCTION: Information about placental size in ongoing pregnancies may aid the identification of pregnancies with increased risk of adverse outcome. Placental volume can be measured using magnetic resonance imaging (MRI). However, this method is not universally available in antenatal care. Ultrasound is the diagnostic tool of choice in pregnancy. Therefore, we studied whether simple two-dimensional (2D) ultrasound placental measurements were correlated with placental volume measured by MRI...
February 28, 2024: Placenta
https://read.qxmd.com/read/38492471/placentae-of-small-appropriately-grown-for-gestational-age-neonates-exhibit-sexually-dimorphic-transcriptomic-changes-representative-of-placental-insufficiency
#33
JOURNAL ARTICLE
Adam Ewing, Jessica L O'Callaghan, Sharon McCracken, Stacy Ellery, Martha Lappas, Olivia J Holland, Anthony Perkins, Zarqa Saif, Vicki L Clifton
INTRODUCTION: Previous studies have reported that neonates less than the 25th BWC especially if they were male, were more likely to be associated with birth complications suggesting small neonates often identified as appropriately grown are at risk of adverse outcomes. We have questioned whether smaller neonates not typically categorized as "small for gestational age" may not reach their genetically determined growth due to placental insufficiency. METHODS: RNA-Seq was performed on the Illumina NovaSeq 600 using term placentae from neonates that were less than the 10th birthweight centile (BWC) (n = 39), between the 10th and the 30th BWC (n = 15) or greater than the 30th BWC (n = 23)...
February 23, 2024: Placenta
https://read.qxmd.com/read/38458919/ifpa-joan-hunt-senior-award-in-placentology-lecture-extracellular-vesicle-signalling-and-pregnancy
#34
JOURNAL ARTICLE
Gregory E Rice, Carlos Salomon
The field of extracellular vesicle (EV) signalling has the potential to transform our understanding of maternal-fetal communication and affords new opportunities for non-invasive prenatal testing and therapeutic intervention. EVs have been implicated in implantation, placentation, maternal adaptation to pregnancy and complications of pregnancy, being detectable in maternal circulation as early as 6 weeks of pregnancy. EVs of differing biogenic origin, composition and bioactivity are released by cells to maintain homoeostasis...
February 23, 2024: Placenta
https://read.qxmd.com/read/38417305/association-between-corin-promoter-methylation-and-hypertensive-disorders-of-pregnancy-a-nested-case-control-study
#35
JOURNAL ARTICLE
Wenxiu Fan, Yuanyuan Mao, Lei Wu, Pei Feng, Xueyang Zhang, Jianwei Hu, Yibing Jin, Xiangdong Yang, Hongmei Li, Qin Liu, Hao Peng
INTRODUCTION: Corin protein and its coding gene variants have been associated with hypertensive disorders of pregnancy (HDP), but the underlying mechanisms are unclear. As a mediator linking fixed genome with the dynamic environment, DNA methylation at the CORIN gene may link corin with HDP but not has been studied. This study aimed to examine whether CORIN promoter methylation and HDP in Chinese pregnant women. METHODS: Based on a cohort of Chinese pregnant women, we designed a nested case-control study including 196 cases with HDP and 200 healthy controls...
February 23, 2024: Placenta
https://read.qxmd.com/read/38448351/engineering-placental-trophoblast-fusion-a-potential-role-for-biomechanics-in-syncytialization
#36
JOURNAL ARTICLE
Prabu Karthick Parameshwar, Cathy Vaillancourt, Christopher Moraes
The process by which placental trophoblasts fuse to form the syncytiotrophoblast around the chorionic villi is not fully understood. Mechanical features of the in vivo and in vitro culture environments have recently emerged as having the potential to influence fusion efficiency, and considering these mechanical cues may ultimately allow predictive control of trophoblast syncytialization. Here, we review recent studies that suggest that biomechanical factors such as shear stress, tissue stiffness, and dimensionally-related stresses affect villous trophoblast fusion efficiency...
February 21, 2024: Placenta
https://read.qxmd.com/read/38593637/sociodemographic-factor-associations-with-maternal-and-placental-outcomes-a-cluster-and-partial-least-squares-regression-analysis
#37
JOURNAL ARTICLE
Shevaun M Teo, Ricardo Segurado, John Mehegan, Alexander Douglass, Celine M Murrin, Martina Cronin, Cecily C Kelleher, Fionnuala M McAuliffe, Catherine M Phillips
INTRODUCTION: Maternal social disadvantage adversely affects maternal and offspring health, with limited research on placental outcomes. Therefore, we examined maternal sociodemographic factor associations with placental and birth outcomes in general (Lifeways Cross-Generation Cohort) and at-risk (PEARS Study of mothers with overweight or obesity) populations of pregnant women. METHODS: TwoStep cluster analysis profiled Lifeways mothers (n = 250) based on their age, parity, marital status, household income, private healthcare insurance, homeowner status, and education...
May 2024: Placenta
https://read.qxmd.com/read/38430682/improved-neonatal-outcomes-in-pregnancies-with-coexisting-gestational-diabetes-and-preeclampsia-in-normal-birthweight-neonates-insights-from-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Liat Mor, Liliya Tamayev, Barak Laxer, Ella Toledano, Letizia Schreiber, Yael Ganor Paz, Giulia Barda, Michal Levy, Eran Weiner
INTRODUCTION: We aimed to assess neonatal and maternal outcomes in appropriate-for-gestational-weight (AGA) neonates of mothers with both gestational diabetes mellitus (GDM) and preeclampsia (PET). METHODS: Medical records of women diagnosed with GDM or PET were reviewed. Women with AGA neonates were divided into three groups- GDM, PET, and GDM + PET and maternal neonatal and placental outcomes were compared. The primary outcome was a composite of adverse neonatal outcomes, including intensive care unit admission (NICU), neurological morbidity, hypoglycemia, ventilation, respiratory distress syndrome (RDS), phototherapy, sepsis, blood transfusion, and neonatal death...
April 2024: Placenta
https://read.qxmd.com/read/38417304/placental-weight-surface-area-shape-and-thickness-relations-with-maternal-ethnicity-and-cardio-metabolic-factors-during-pregnancy
#39
JOURNAL ARTICLE
Line Sletner, Chittaranjan S Yajnik, Gitta Turowski, Trond M Michelsen, Christine Sommer, Kåre I Birkeland, Borghild Roald, Anne Karen Jenum
INTRODUCTION: A better understanding of the determinants of placental growth is needed. Our primary aim was to explore associations between maternal ethnic origin and cardio-metabolic factors during pregnancy, and placental weight, surface area, shape and thickness. METHODS: A multi-ethnic population-based cohort study of 474 pregnant women examined at mean 15 and 28 weeks' gestation. Placentas were inspected after birth by a placental pathologist. Outcome measures were trimmed placental weight and three uncorrelated placental components; surface area, shape (oval vs round) and thickness, created through a principal components analysis...
March 25, 2024: Placenta
https://read.qxmd.com/read/38359600/covid-19-vaccination-protects-infected-pregnant-women-from-developing-sars-cov-2-placentitis-and-decreases-the-risk-for-stillbirth
#40
JOURNAL ARTICLE
Gitte Zels, Cecile Colpaert, Dorien Leenaerts, Heleen Nailis, Magali Verheecke, Luc De Catte, Jute Richter, Marcella Baldewijns
INTRODUCTION: The impact of COVID-19 infection in pregnant women remained unclear for a long time. Previous research showed that SARS-CoV-2 virus is able to infect the placenta, potentially causing significant lesions leading to placental insufficiency. The impact of maternal vaccination status on the prevalence of SARS-CoV-2 placentitis remains unclear. We characterized placental lesions in SARS-CoV-2 infected pregnant women and studied the impact of vaccination on placental involvement...
March 25, 2024: Placenta
journal
journal
20230
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.