journal
https://read.qxmd.com/read/38528753/histopathology-mrna-expression-profile-and-donor-derived-cell-free-dna-for-assessment-of-rejection-in-pediatric-heart-transplantation
#1
JOURNAL ARTICLE
Conor P O'Halloran, Paul Tannous, Nicoleta C Arva, Philip T Thrush, Michael Monge, Anna Joong, Defne A Magnetta
BACKGROUND: The relationship between histopathologic and molecular ("MMDx"®) assessments of endomyocardial biopsy (EMB) and serum donor-derived cell-free DNA (ddcfDNA) in acute rejection (AR) assessment following pediatric heart transplantation (HT) is unknown. METHODS: EMB sent for MMDx and histopathology from November 2021 to September 2022 were reviewed. MMDx and histopathology results were compared. DdcfDNA obtained ≤1 week prior to EMB were compared with histopathology and MMDx results...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38450793/leflunomide-as-adjunct-therapy-for-bk-viremia-management-in-pediatric-kidney-transplant-recipients
#2
JOURNAL ARTICLE
Alexandra Aldieri, Mary Chandran, Debora Matossian, Aparna Hariprasad, Bliss Magella, Danielle Lazear, Eliza Blanchette, Eric Benz, Margret Bock
BACKGROUND: BK viremia after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy and impacts graft survival. Conventional treatment involves reduction of immunosuppression, which in turn may increase risk for rejection. To address this dilemma, use of anti-viral therapy with immunosuppressive properties such as leflunomide is an attractive option. METHODS: We performed a multi-center, retrospective chart review to report tolerability and effectiveness of leflunomide use for the eradication of BK viremia and prevention of BK virus-associated nephropathy in pediatric KT recipients...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436533/antibody-mediated-rejection-amr-in-pediatric-lung-transplantation-current-state-and-future-directions
#3
JOURNAL ARTICLE
Christian Benden, Kathryn A Wikenheiser-Brokamp
Lung transplantation is considered as the ultimate therapy for children with advanced pulmonary disease. International data show a median conditional 1-year post-transplantation survival of 9.1 years. Recently, antibody-mediated rejection (AMR) has increasingly been recognized as an important cause of allograft dysfunction although pediatric reports are still scarce. Donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are known to play a role in AMR development post-transplant but AMR pathogenesis is still poorly understood...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436520/ten-year-follow-up-of-cavoportal-hemitransposition-in-pediatric-liver-transplantation-for-complete-portomesenteric-venous-thrombosis-a-case-report-and-literature-review
#4
REVIEW
John O Barron, Kadakkal Radhakrishnan, Christopher Coppa, Deborah Goldman, Vera Hupertz, Mike Leonis, Bijan Eghtesad, Koji Hashimoto
BACKGROUND: Portal vein thrombosis is a potentially devastating complication following pediatric liver transplantation. In rare instances of complete portomesenteric thrombosis, cavoportal hemitransposition may provide graft inflow. Here we describe long-term results following a case of pediatric cavoportal hemitransposition during liver transplantation and review the current pediatric literature. METHODS: A 9-month-old female with a history of biliary atresia and failed Kasai portoenterostomy underwent living donor liver transplantation, which was complicated by portomesenteric venous thrombosis...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436213/unlocking-the-key-delving-into-implicit-bias-in-pediatric-heart-transplantation
#5
EDITORIAL
Carmel Bogle
No abstract text is available yet for this article.
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436145/kidney-adolescent-and-young-adult-clinic-a-transition-model-in-africa
#6
REVIEW
Zibya Barday, Bianca Davidson, Paul Harden, Zakira Mukuddem-Sablay, Nicola Wearne, Erika S W Jones, Daley Cross, Mignon McCulloch
Adolescents and Young Adults (AYAs) with chronic kidney disease (CKD) have challenges unique to this developmental period, with increased rates of high-risk behavior and non-adherence to therapy which may impact the progression of kidney disease and their requirement for kidney replacement therapy (KRT). Successful transition of AYA patients are particularly important in low- and middle-income countries (LMICs) where KRT is limited, rationed or not available. Kidney AYA transition clinics have the potential to improve clinical outcomes but there is a paucity of data on the clinical translational impact of these clinics in Africa...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38436099/biodegradable-biliary-stents-placement-using-a-kissing-stent-technique-for-management-of-a-recalcitrant-stricture-post-live-donor-liver-transplant
#7
Aleena Malik, Vicky L Ng, Blayne A Sayed, Asad Siddiqui, Dimitri A Parra
BACKGROUND: Biliary complications are common in pediatric liver transplant. Strictures resistant to interventional radiology procedures can be extremely challenging to manage and may result in the need of surgery or retransplantation. METHODS: This case report illustrates the use of biodegradable stents post left lateral segment live donor liver transplant in a pediatric patient with a recalcitrant chronic stricture of the biliary-enteric anastomosis. The patient developed a high stricture requiring multiple interventions and eventual access of both the segment II and segment III ducts of the graft...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433649/determining-analgesic-efficacy-and-clinical-benefits-of-bilateral-continuous-erector-spinae-plane-blocks-after-pediatric-liver-transplantation
#8
LETTER
Cheng-Wen Li, Nong He, Fu-Shan Xue
No abstract text is available yet for this article.
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433619/liver-transplant-for-primary-biliary-tract-neuroendocrine-tumor-in-a-nine-year-old-girl
#9
Anjali Rai, Lauren Sproule, Tatianna Larman, Kiyoko Oshima, Daniel Rhee, Kenneth Ng, Elizabeth King, Douglas Mogul, Kathryn Lemberg
BACKGROUND: Neuroendocrine tumors (NETs) are rare epithelial neoplasms that arise most commonly from the gastrointestinal tract. In pediatrics, the most common site of origin is in the appendix, with the liver being the most common site of metastasis. Neuroendocrine tumors arising from the biliary tract are extremely rare. METHODS: We describe a case of a nine-year-old girl who presented with obstructive cholestasis and was found to have multiple liver masses identified on biopsy as well-differentiated neuroendocrine tumor with an unknown primary tumor site...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433611/should-urinary-cxcl10-creatinine-be-measured-for-kidney-transplantation
#10
EDITORIAL
Guido Filler, Ajay P Sharma
No abstract text is available yet for this article.
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433601/management-of-pediatric-patients-with-a-failing-kidney-transplant-a-survey-of-uk-based-renal-units
#11
LETTER
Matthew Letts, Zainab Arslan, Lucy Plumb, Pippa Bailey, Siân Griffin, Jelena Stojanovic
No abstract text is available yet for this article.
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433587/applications-of-motivational-interviewing-in-adolescent-solid-organ-transplant
#12
REVIEW
Julie M Gettings, Debra S Lefkowitz
BACKGROUND: Adolescence is a developmental period that is known for the highest risk of difficulties with adoption and maintenance of health behaviors for successful transplant. Motivational interviewing (MI) has been demonstrated to be an effective strategy in the management of modifiable factors impacting adherence in both adult transplant and analogous pediatric chronic illness populations. AIMS: This paper describes MI and its applicability to adolescent transplant, providing examples of its potential use at each stage of the transplant journey...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433570/survival-does-not-differ-by-annual-center-transplant-volume-a-pediatric-heart-transplant-society-registry-study
#13
JOURNAL ARTICLE
A Marion Ybarra, Alicia M Kamsheh, Matthew J O'Connor, Seth A Hollander, Maria Bano, Michelle Ploutz, Gabrielle Vaughn, Andrea Lambert, Michael Wallendorf, James Kirklin, Charles E Canter
BACKGROUND: There are conflicting data regarding the relationship between center volume and outcomes in pediatric heart transplantation. Previous studies have not fully accounted for differences in case mix, particularly in high-risk congenital heart disease (CHD) groups. We aimed to evaluate the relationship between center volume and outcomes using the Pediatric Heart Transplant Society (PHTS) Registry and explore how case mix may affect outcomes. METHODS: A retrospective cohort study of all pediatric patients in the PHTS Registry who received a heart transplant from 2009 to 2018 was performed...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433569/living-donor-liver-transplantation-for-methylmalonic-acidemia-patient-with-hepatocellular-carcinoma-a-case-report-and-literature-review
#14
REVIEW
Harunori Deguchi, Seisuke Sakamoto, Seiichi Shimizu, Akinari Fukuda, Hajime Uchida, Yusuke Yanagi, Toshimasa Nakao, Tasuku Kodama, Ryuji Komine, Kentaro Nishi, Koichi Kamei, Chizuko Haga, Takako Yoshioka, Kimikazu Matsumoto, Reiko Horikawa, Mureo Kasahara
BACKGROUND: Methylmalonic acidemia (MMA) is an autosomal recessive disorder caused by defects in propionyl-CoA (P-CoA) catabolism; of note, liver neoplasms rarely occur as a long-term complication of the disorder. Herein, we report the case of a patient with MMA and hepatocellular carcinoma (HCC) who was successfully treated with a living-donor liver transplant (LDLT) following prior kidney transplantation. CASE REPORT: A 25-year-old male patient with MMA underwent LDLT with a left lobe graft because of metabolic instability and liver neoplasms...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433565/the-effect-of-socioeconomic-status-on-pediatric-heart-transplant-outcomes-at-a-single-institution-between-2013-and%C3%A2-2022
#15
JOURNAL ARTICLE
Allison Armstrong, Jane W Liang, Danton Char, Seth A Hollander, Kimberly A Pyke-Grimm
BACKGROUND: Disparities in pediatric heart transplant outcomes based on socioeconomic status (SES) have been previously observed. However, there is a need to reevaluate these associations in contemporary settings with advancements in transplant therapies and increased awareness of health disparities. This retrospective study aims to investigate the relationship between SES and outcomes for pediatric heart transplant patients. METHODS: Data were collected through a chart review of 176 pediatric patients who underwent first orthotopic heart transplantation (OHT) at a single center from 2013 to 2021...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433343/good-outcomes-after-repeated-pediatric-liver-retransplantations-a-justified-procedure-even-in-times-of-organ-shortage
#16
JOURNAL ARTICLE
Henrik Junger, Birgit Knoppke, Leonhard Schurr, Frank W Brennfleck, Dirk Grothues, Michael Melter, Edward K Geissler, Hans J Schlitt, Stefan M Brunner, Markus Goetz
BACKGROUND: Pediatric liver transplantations generally represent advanced surgery for selected patients. In case of acute or chronic graft failure, biliary or vessel complications, a retransplantation (reLT) can be necessary. In these situations massive adhesions, critical patient condition or lack of good vessels for anastomosis often are problematic. METHODS: Between 2008 and 2021, 208 pediatric patients received a liver transplantation at our center. Retrospectively, all cases with at least one retransplantation were identified and stored in a database...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433342/mtor-inhibition-within-the-first-days-after-pediatric-heart-transplantation-is-a-potentially-safe-option-to-prevent-cardiac-allograft-vasculopathy
#17
JOURNAL ARTICLE
Hannah Kreienbaum, Brigitte Stiller, Rouven Kubicki, Alexej Bobrowski, Johannes Kroll, Thilo Fleck
BACKGROUND: Immunosuppression after heart transplantation (HTX) with mammalian target of rapamycin (mTOR) inhibitors serves as a prophylaxis against rejection and to treat coronary vascular injury. However, there is little data on the early, preventive use of everolimus after pediatric HTX. METHODS: Retrospective study of 61 pediatric HTX patients (48 cardiomyopathy and 13 congenital heart disease), 28 females, median age 10.1 (range 0.1-17.9) years transplanted between 2008 and 2020...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433334/pharmacokinetics-of-envarsus-in-pediatric-kidney-transplant-recipients-phase-1-pilot-conversion-study
#18
JOURNAL ARTICLE
Jon Jin Kim, Laura Lawless, David Marshall, Andrew Maxted, Andrew Lunn, Meeta Mallik, Alun Williams
INTRODUCTION: Tacrolimus is the standard immunosuppressant for pediatric kidney transplants and is routinely administered twice daily (BD-tac). Envarsus (LCP-tac), an extended-release formulation, is approved for adults but not for pediatric patients. METHODS: We conducted a pilot open-label phase 1 study in stable pediatric kidney transplant recipients (age < 18 at the time of study). Our primary objective was to compare the pharmacokinetics (Pk) of LCP-tac versus BD-tac...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38420725/how-to-choose-a-best-kidney-for-pediatric-kidney-transplant-recipients
#19
EDITORIAL
Asha Moudgil, Amy Bobrowski
No abstract text is available yet for this article.
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38420722/evaluation-of-valganciclovir-s-neutropenia-risk-in-pediatric-solid-organ-transplant-recipients-utilizing-two-dosing-regimens
#20
JOURNAL ARTICLE
Avani Patel, Kevin Le, Natalia Panek
BACKGROUND: Valganciclovir is approved for cytomegalovirus prophylaxis in pediatrics using the Pescovitz algorithm. There are reports of valganciclovir overdoses in children with low body surface area and overestimated creatinine clearance utilizing this algorithm. This study compared the incidence of neutropenia and cytomegalovirus infection between the Pescovitz and weight-based dosing algorithms. METHODS: A single-center retrospective chart review from January 2010 to September 2018 was performed on pediatric heart, liver, and kidney transplant recipients, who received valganciclovir...
March 2024: Pediatric Transplantation
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