journal
https://read.qxmd.com/read/38613159/small-for-size-liver-graft-syndrome-not-everything-is-what-it-seems-to-be-even-salt-looks-like-sugar
#1
EDITORIAL
Jean de Ville de Goyet
No abstract text is available yet for this article.
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38613151/biliary-strictures-post-pediatric-liver-transplantation-incidence-and-risk-factors-in-a-single-tertiary-referral-transplant-center
#2
JOURNAL ARTICLE
Odelia Vingrovich, Shiri Cooper, Michael Gurevich, Aenov Cohen, Yael Mozer-Glassberg, Michal Rosenfeld Bar-Lev, Raanan Shamir, Orith Waisbourd-Zinman
BACKGROUND: Biliary strictures are a significant cause of morbidity and graft loss in pediatric liver transplant recipients. Risk factors for the development of biliary strictures are not fully established. We aimed to evaluate the incidence of biliary strictures and treatment modalities outcomes and to identify potential risk factors for occurrence. METHODS: Pediatric patients who underwent liver transplantation in the single tertiary pediatric liver transplant center in Israel were evaluated...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38613143/pediatric-donor-heart-utilization-variability-among-organ-procurement-organizations
#3
JOURNAL ARTICLE
Firezer Haregu, R Jerome Dixon, Michael Porter, Michael McCulloch
BACKGROUND: Organ procurement organizations (OPOs) are responsible for the medical management of organ donors. Given the variability in pediatric donor heart utilization among OPOs, we examined factors that may explain this variability, including differences in donor medical management, organ quality, and candidate factors. METHODS: The Organ Procurement and Transplant Network database was queried for pediatric (<18 years) heart donors and candidates receiving pediatric donor heart offers from 2010 to 2019...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38602290/a-new-method-to-predict-venous-complications-in-pediatric-liver-transplantation-evaluation-of-splenic-parameters-by-ultrasonography
#4
JOURNAL ARTICLE
Jin Jieyang, Liao Mei, Liu Kunying, Wu Tao, Jin Ling, Yang Yang, Yi Shuhong, Lv Yan, Ren Jie
BACKGROUND: Venous complications after pediatric liver transplantation seriously affect the survival rate of patients and grafts. At present, the diagnostic indicators have not been unified. Venous complications may cause portal hypertension, which may lead to splenomegaly and splenic vein dilatation. Therefore, the changes in spleen may be closely related to the venous complications. The purpose of this study was to explore the relationship between ultrasonic splenic parameters and venous complications and to study whether these splenic parameters can be used for the diagnosis of venous complications...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38602219/postoperative-outcomes-of-acute-on-chronic-liver-failure-in-infants-and-children-with-biliary-atresia
#5
JOURNAL ARTICLE
Buria Naeem, Adil Ayub, Jorge Coss-Bu, Muhammad Umair M Mian, Ruben Hernaez, Thomas P Fogarty, Kirby Deshotels, Curt Kennedy, John Goss, Moreshwar S Desai
INTRODUCTION: Acute-on-chronic liver failure (ACLF) is associated with increased mortality and morbidity in patients with biliary atresia (BA). Data on impact of ACLF on postoperative outcomes, however, are sparse. METHOD: We performed a retrospective analysis of patients with BA aged <18 years who underwent LT between 2011 and 2021 at our institution. ACLF was defined using the pediatric ACLF criteria: ≥1 extra-hepatic organ failure in children with decompensated cirrhosis...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38602171/antibody-mediated-rejection-in-pediatric-kidney-transplant-recipients-a-report-from-the-pediatric-nephrology-research-consortium
#6
REVIEW
Isa F Ashoor, Rachel M Engen, Dechu Puliyanda, Nicole Hayde, Caitlin G Peterson, Rima S Zahr, Sonia Solomon, Mahmoud Kallash, Rouba Garro, Amrish Jain, Lyndsay A Harshman, Scott T McEwen, Asifhusen Mansuri, Mathew J Gregoski, Katherine E Twombley
BACKGROUND: Antibody-mediated rejection (AMR) is a major cause of kidney allograft loss. There is a paucity of large-scale pediatric-specific data regarding AMR treatment outcomes. METHODS: Data were obtained from 14 centers within the Pediatric Nephrology Research Consortium. Kidney transplant recipients aged 1-18 years at transplant with biopsy-proven AMR between 2009 and 2019 and at least 12 months of follow-up were included. The primary outcome was graft failure or an eGFR <20 mL/min/1...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38602169/haploidentical-hematopoietic-stem-cell-transplantation-with-busulfan-cyclophosphamide-and-fludarabine-conditioning-for-x-linked-adrenal-cerebral-leukodystrophy
#7
JOURNAL ARTICLE
Yao Chen, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Kai-Yan Liu, Jiong Qing, Yan-Ling Yang, Xiao-Jun Huang
OBJECTIVE: We investigated the safety and efficacy of haploidentical stem cell transplantation (SCT) in pediatric patients with X-linked adrenoleukodystrophy (ALD). METHODS: A retrospective analysis of transplantation data from 29 cases of ALD, treated between December 2014 and April 2022, was conducted. Neurologic function scores (NFS) were assessed. The conditioning regimen was busulfan 9.6 mg/kg, cyclophosphamide 200 mg/kg, and fludarabine 90 mg/m2 (BFC)...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38602156/let-s-get-physical-aerobic-capacity-muscle-strength-and-muscle-endurance-after-pediatric-heart-transplantation
#8
JOURNAL ARTICLE
Amanda R Krysler, Chantal J Allan, Ingrid Larsen, Sunita Mathur, Catherine Morgan, Steven C Greenway, Tom Blydt-Hansen, Michael Khoury, Lori J West, Simon Urschel
BACKGROUND: Pediatric heart (HTx) and kidney transplant (KTx) recipients may have lower physical fitness than healthy children. This study sought to quantify fitness levels in transplant recipients, investigate associations to clinical factors and quality of life, and identify whether a quick, simple wall-sit test is feasible as a surrogate for overall fitness for longitudinal assessment. METHODS: Aerobic capacity (6-min walk test, 6MWT), normalized muscle strength, muscle endurance, physical activity questionnaire (PAQ), and quality of life (PedsQL™) were prospectively assessed in transplanted children and matched healthy controls...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38600717/impact-of-prophylactic-echinocandin-on-the-development-of-neurological-complications-in-patients-receiving-busulfan-containing-conditioning-regimens-for-stem-cell-transplantation-a-single-center-retrospective-study
#9
JOURNAL ARTICLE
Shogo Horikawa, Kenji Kishimoto, Suguru Uemura, Sayaka Hyodo, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Daiichiro Hasegawa, Yoshiyuki Kosaka
BACKGROUND: Although neurotoxicity is a major adverse event associated with busulfan, little information is available regarding the association between drug interactions and neurological symptoms during busulfan-based regimens. This study evaluated the association between prophylactic echinocandins and neurological complications in patients receiving busulfan-containing conditioning regimens for stem cell transplantation. METHODS: We retrospectively included consecutive patients who administered intravenous busulfan as a conditioning regimen at our facility between 2007 and 2022...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38566341/kidney-transplant-in-pediatric-gut-transplant-recipients-technical-challenges-and-outcomes
#10
JOURNAL ARTICLE
Arpit Amin, Bishoy Emmanuel, Vikram Raghu, Ajai Khanna, Kyle Soltys, Rakesh Sindhi, Amit Tevar, Michael L Moritz, Abhinav Humar, George Mazariegos, Armando Ganoza
BACKGROUND: There is limited data in the literature about pediatric kidney transplant (KT) following gut transplant (GT). The purpose of this study is to highlight the technical challenges and outcomes of KT in pediatric gut recipients who developed kidney failure (KF). METHODS: A retrospective single-center study of pediatric GT recipients from January 2000 to December 2019 was performed. In total, 14 (7%) out of 206 pediatric GT recipients developed KF and were listed for KT...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38566336/effect-of-pre-emptive-rituximab-on-ebv-dna-levels-and-prevention-of-post-transplant-lymphoproliferative-disorder-in-pediatric-kidney-transplant-recipients-a-case-series-from-the-pediatric-nephrology-research-consortium
#11
JOURNAL ARTICLE
Isa F Ashoor, Samhar Al-Akash, Sarah Kizilbash, Asha Moudgil, Dechu Puliyanda, Saritha Ranabothu, Yi Shi, Vikas Dharnidharka
BACKGROUND: There are scant data on the effect of rituximab on EBV DNA levels and prevention of post-transplant lymphoproliferative disorder (PTLD) in pediatric kidney transplant recipients with EBV DNAemia. METHODS: Kidney transplant recipients with EBV DNAemia treated with rituximab to prevent PTLD between 7/1999 and 7/2019 at five pediatric centers were included. Those with confirmed PTLD at the onset of rituximab were excluded. Primary outcomes included percentage change in EBV DNAemia and occurrence of PTLD post rituximab...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38566335/semilunar-valve-growth-and-function-10%C3%A2-years-after-infant-heart-transplantation-predicting-long-term-outcomes-of-partial-heart-transplants
#12
JOURNAL ARTICLE
Taufiek K Rajab, Mohamed Abdelrahman, Elridge J Schwartzenburg, Berk Aykut, Joseph W Turek, Deani H McVadon
INTRODUCTION: Partial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short-term outcomes of partial heart transplants are excellent, but long-term outcomes are unknown. In order to predict the long-term outcomes of partial heart transplants, we evaluated long-term growth and function of semilunar heart valves transplanted in infancy as part of a heart transplant. METHODS: All children who underwent infant heart transplantation at a single center from 1997 to 2014 were included in this study...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38566317/sexual-and-reproductive-health-screening-and-counseling-in-adolescent-and-young-adult-transplant-recipients
#13
REVIEW
Paula Cody
Adolescents and young adults with and without chronic illnesses partake in risk-taking behavior. Clinicians in transplant clinics should be aware of the prevalence of risk-taking behavior in their adolescent and young adult solid organ transplant patients in order to provide complete care. Creating an environment where teens and young adults feel comfortable discussing risky behavior is important and includes creating a privacy policy and increasing comfort of the healthcare provider in asking sensitive questions...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553822/post-traumatic-growth-among-pediatric-transplant-recipients-and-their-caregivers-a-scoping-review
#14
REVIEW
Mikela A Murphy, Rachel A Annunziato
BACKGROUND: Pediatric transplantation can be a stressful process for patients and caregivers. Some individuals may experience post-traumatic stress symptoms (PTSS) and post-traumatic growth (PTG) as a result. Although post-traumatic stress disorder (PTSD) has been well-studied in this population, the purpose of the present scoping review is to provide a first synthesis of the existing literature on PTG in pediatric transplant populations. METHODS: We conducted a literature search of PsycINFO and Scopus in May 2023...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553820/utilization-of-immediate-extubation-in-a-multidisciplinary-pathway-for-pediatric-liver-transplantation-associated-with-improved-postoperative-outcomes
#15
JOURNAL ARTICLE
Matthew A Goldstein, Joelle Karlik, Pradip P Kamat, Denise J Lo, Katie Liu, Laura E Gilbertson
BACKGROUND: Immediate extubation is becoming more common in liver transplantation. However, limited data exist on how to identify pediatric patients with potential for successful immediate extubation and how this intervention may affect recovery. METHODS: This retrospective review evaluated patients who underwent liver transplantation from 2015 to 2021 at Children's Healthcare of Atlanta. Preoperative status and intraoperative management were evaluated and compared...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553819/efficacy-and-safety-of-single-dose-anti-thymocyte-globulin-versus-basiliximab-induction-therapy-in-pediatric-kidney-transplant-recipients-a-retrospective-comparative-cohort-study
#16
JOURNAL ARTICLE
Luciana de Fatima Porini Custodio, Suelen Bianca Stopa Martins, Laila Almeida Viana, Marina Pontello Cristelli, Lucio Requião-Moura, Charles Yea Zen Chow, Suzana Friedlander Del Nero Camargo, Monica Rika Nakamura, Renato Demarchi Foresto, Helio Tedesco-Silva, Jose Medina-Pestana
BACKGROUND: This study aimed to compare the efficacy and safety of basiliximab (BAS) versus a single dose of anti-thymocyte globulin (r-ATG) induction therapy in pediatric kidney transplant recipients (KTRs). METHODS: This single-center retrospective comparative cohort study included all pediatric KTRs from May 2013 to April 2018 and followed up to 12 months. In the first period, all recipients received BAS, while from May 2016, a single 3 mg/kg dose of r-ATG was instituted...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553815/optimizing-the-approach-to-monitoring-allograft-inflammation-using-serial-urinary-cxcl10-creatinine-testing-in-pediatric-kidney-transplant-recipients
#17
JOURNAL ARTICLE
Ella Barrett-Chan, Li Wang, Jeffrey Bone, Amy Thachil, Kevin Vytlingam, Tom Blydt-Hansen
BACKGROUND: Urinary CXCL10/creatinine (uCXCL10/Cr) is proposed as an effective biomarker of subclinical rejection in pediatric kidney transplant recipients. This study objective was to model implementation in the clinical setting. METHODS: Banked urine samples at a single center were tested for uCXCL10/Cr to validate published thresholds for rejection diagnosis (>80% specificity). The positive predictive value (PPV) for rejection diagnosis for uCXCL10/Cr-indicated biopsy was modeled with first-positive versus two-test-positive approaches, with accounting for changes associated with urinary tract infection (UTI), BK and CMV viremia, and subsequent recovery...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553813/the-power-of-it-will-be-okay
#18
JOURNAL ARTICLE
Christina J VanderPluym
As caregivers for critically ill children and their families, there are moments when we find ourselves unsure of how best to offer support. The magnitude of the medical experience can cloud our communication with patients and their families. With years of counseling families through some of their most challenging and darkest hours, I aim to emphasize the profound impact of thoughtful and well-informed reassurance; how we can provide hope in hopeless situations.
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553812/evaluating-threshold-for-donor-fraction-cell-free-dna-using-clinically-available-assay-for-rejection-in-pediatric-and-adult-heart-transplantation
#19
JOURNAL ARTICLE
Shriprasad R Deshpande, Steven D Zangwill, Marc E Richmond, Steven J Kindel, Jacob N Schroder, Nunzio Gaglianello, David P Bichell, Mark A Wigger, Kenneth R Knecht, Phillip T Thrush, William T Mahle, Paula E North, Pippa M Simpson, Liyun Zhang, Mahua Dasgupta, Aoy Tomita-Mitchell, Michael E Mitchell
BACKGROUND: The aims of the study were to assess the performance of a clinically available cell-free DNA (cfDNA) assay in a large cohort of pediatric and adult heart transplant recipients and to evaluate performance at specific cut points in detection of rejection. METHODS: Observational, non-interventional, prospective study enrolled pediatric and adult heart transplant recipients from seven centers. Biopsy-associated plasma samples were used for cfDNA measurements...
May 2024: Pediatric Transplantation
https://read.qxmd.com/read/38553805/pediatric-en-bloc-kidney-transplant-from-donors-15%C3%A2-kg-an-excellent-approach-to-expand-the-pediatric-deceased-donor-pool
#20
JOURNAL ARTICLE
Ahmad Azzam, Mansour Tawfeeq, Mahmoud Obeid, Iftikhar Khan, Mohammed Almaghrabi, Mohammed AlQahtani, Alanoud Alshami
INTRODUCTION: Most kidneys from small pediatric donors are transplanted to adult recipients because of the perceived risk of surgical complications and graft thrombosis. In this study, we aim to demonstrate our favorable outcomes in transplanting pediatric kidneys from donors <15 k into pediatric recipients. METHODS: This study retrospectively analyzes the outcomes of seven pediatric recipients of en block kidney transplants from pediatric donors weighing <15 kg performed at King Fahad Specialist Hospital-Dammam from December 2014 to January 2018...
May 2024: Pediatric Transplantation
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