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Pediatric Surgery International

Robert J Vandewalle, Julia K Peceny, Jodi L Raymond, Thomas M Rouse
PURPOSE: Trending the pediatric-adjusted shock index (SIPA) after admission has been described for children suffering severe blunt injuries (i.e., injury severity score (ISS) ≥ 15). We propose that following SIPA in children with moderate blunt injuries, as defined by ISS 10-14, has similar utility. METHODS: The trauma registry at a single institution was queried over a 7 year period. Patients were included if they were between 4 and 16 years old at the time of admission, sustained a blunt injury with an ISS 10-14, and were admitted less than 12 h after their injury (n = 501)...
March 20, 2019: Pediatric Surgery International
Atsuki Naoe, Tomonori Tsuchiya, Yasuhiro Kondo, Naoko Uga, Shunsuke Watanabe, Toshihiro Yasui, Fujio Hara, Tatsuya Suzuki
PURPOSE: Arctigenin has been shown to have anti-tumor effects in various types of cancers. This study was conducted to verify these effects in the human-derived hepatoblastoma cell line, HUH-6 clone 5 (hereinafter, HUH-6). METHODS: Arctigenin was added to cultured HUH-6 cells, and cellular activity was evaluated by MTS assay. To determine the relationship between reduced cellular activity and apoptosis, we measured the activities of caspase 3/7, 8, and 9 and conducted flow cytometry with Annexin V/PI staining...
March 19, 2019: Pediatric Surgery International
Lingling Zhao, Shaoguang Feng, Peng Wu, Xin-He Lai, Chengjie Lv, Guorong Chen
BACKGROUND: Intussusception secondary to pathologic lead points (PLPs) is a potential surgical emergency and almost all cases need surgery. The aim of this study was to evaluate the clinical manifestations, physical examinations and surgical outcomes of secondary intussusception (SI) caused by PLPs, as well as to improve the diagnosis and treatment of PLPs in children and infants. MATERIALS AND METHODS: We retrospectively reviewed the records of 83 children and infants who were diagnosed with intussusception secondary to PLPs in our institution...
March 14, 2019: Pediatric Surgery International
Adil A Shah, Mikael Petrosyan, Ashanti L Franklin, Alfred A Chahine, Clarivet Torres, Anthony D Sandler
PURPOSE: To review the effectiveness of the longitudinal intestinal lengthening and tailoring (LILT) and serial transverse enteroplasty (STEP) operations in a cohort of patients with short bowel syndrome (SBS). METHODS: We conducted a retrospective analysis of children with SBS treated at our institution from 2004 until 2014. Children aged 0 days to 18 years with SBS who underwent autologous intestinal reconstruction were included in the study. RESULTS: Twenty-two SBS patients underwent 31 different lengthening procedures (LP)...
March 13, 2019: Pediatric Surgery International
Hisako Kuyama, Sadashige Uemura, Atsushi Yoshida, Mayumi Yamamoto
PURPOSE: The aim of this study was to clarify the relationship between the length of the round ligament and the presence of a patent processus vaginalis (PV) based on the hypothesis that a short round ligament is the cause of ovarian inguinal hernia in female infants. METHODS: Between April 2011 and March 2017, 132 girls underwent laparoscopic surgery for inguinal hernia. Before surgery, the presence of ovarian prolapse was diagnosed. We observed the internal inguinal ring laparoscopically and examined the diameter of the PV orifice as well as the round ligament length...
March 12, 2019: Pediatric Surgery International
Sharmila Babu, Malavika Prasad, Malki Miller, Mark Morrissey, Alok Bhutada, Mary Rojas, Shantanu Rastogi
PURPOSE: Necrotizing enterocolitis (NEC), a leading cause of mortality and morbidity in preterm neonates, lacks a reliable biomarker. Citrulline is primarily produced by enterocytes and correlates with intestinal function. Serum citrulline concentration (CIT) is routinely measured in routine newborn screening (NBS). The purpose of the study is to test if CIT from NBS may predict the occurrence of NEC and whether it correlates with the time to full feeds (TTFF) and length of stay (LOS), serving as a biomarker of NEC and intestinal health...
March 9, 2019: Pediatric Surgery International
Satoshi Obata, Satoshi Ieiri, Takashi Akiyama, Naoto Urushihara, Hisayoshi Kawahara, Masayuki Kubota, Miyuki Kono, Yuji Nirasawa, Shohei Honda, Masaki Nio, Tomoaki Taguchi
PURPOSE: Hirschsprung's disease-related short bowel syndrome (HDSBS) is characterized by aganglionosis that extends orally to 75 cm from Treitz's band. The condition is reported be associated with a high mortality rate of 50-80%. This retrospective study aimed to survey the current trends in HDSBS treatment in Japan. METHODS: Patient data were extracted from the results of a nationwide survey we conducted, resulting in the retrospective collection of the data of 1087 HD patients from 2008 to 2012 in Japan...
March 7, 2019: Pediatric Surgery International
Ancuta Muntean, Ionica Stoica, Suzanne Victoria McMahon, Alan Mortell, John Gillick, Brian Terence Sweeney
OBJECTIVES: Few studies have reported on the utility and efficacy of laparoscopic colectomy in the paediatric population. We aim to compare the characteristics and outcomes of children with inflammatory bowel disease (IBD) who underwent open vs laparoscopic treatment at our centre. METHODS: A 10-year retrospective review was performed. Collected data included demographics, indication for surgery, operative characteristics, histopathology results, post-operative course and peri-operative complications...
March 7, 2019: Pediatric Surgery International
Masahiro Zenitani, Hiroshi Hosoda, Tasuku Kodama, Ryuta Saka, Yuichi Takama, Takehisa Ueno, Yuko Tazuke, Kenji Kangawa, Takaharu Oue, Hiroomi Okuyama
PURPOSE: Ghrelin was recently reported to promote recovery from hepatic injury. We hypothesized that it could also be associated with clinical recovery of the transplanted liver from ischemia and reperfusion injury. Our aims were to investigate perioperative ghrelin changes following pediatric living donor liver transplantation (LDLT) and to analyze the association of these changes with postoperative hepatic function. METHODS: We measured plasma acyl ghrelin (AG) concentrations before surgery, at the end of surgery and on postoperative days (PODs) 1, 3 and 7 in 12 children who underwent LDLTs, and, as controls, pre- and post-operatively and on POD1 in 7 children who underwent benign abdominal mass resection...
March 5, 2019: Pediatric Surgery International
Rajay Rampersad, Michael Singh, Dakshesh Parikh
BACKGROUND: Foregut duplication cysts (FD) with a common muscular wall with the oesophagus are well recognised. Our case series highlights the existence of a common wall between superior mediastinal FD and the tracheo-bronchial tree. MATERIALS AND METHODS: Over the last 15 years, we have thoracoscopically resected 41 FD. Five cases were identified to have a common wall with the tracheo-bronchial tree at operation. The clinical history, radiology, findings at operation and pathology were evaluated to highlight learning points...
March 5, 2019: Pediatric Surgery International
Charlene Dekonenko, Joseph A Sujka, Katrina Weaver, Susan W Sharp, Katherine Gonzalez, Shawn D St Peter
PURPOSE: Intestinal malrotation is often diagnosed in infancy. The true incidence of malrotation outside of this age is unknown. These patients can present atypically or be asymptomatic and diagnosed incidentally. We evaluate the incidence, clinical presentation, ideal imaging, and intra-operative findings of patients with malrotation over 1 year of age. METHODS: Retrospective review was conducted in patients older than 1 year, treated for malrotation at a single pediatric tertiary care center from 2000 to 2015...
February 27, 2019: Pediatric Surgery International
M Sarrami, W Ridley, S Nightingale, T Wright, R Kumar
BACKGROUND AND AIM: Currently, there is a paucity of the literature describing the natural history of cholelithiasis (CL) and choledocholithiasis (CDL) in adolescent children. This study aims to analyse the changing demographics of paediatric and adolescent gallstones. METHODOLOGY: Retrospective review of all children (Age 0-18 years) presenting with symptomatic gallstones over the last 15 years (2002-2017) at a single tertiary institution. Demographics, diagnostic and therapeutic information were collected, with a 5-year median follow-up...
February 26, 2019: Pediatric Surgery International
Chunlei Jiao, Kechi Yu, Dandan Li, Kang Fu, Pei Wang, Ying He, Jiexiong Feng
OBJECTIVE: To study the ideal Kasai portoenterostomy (KPE) time for preterm infants with biliary atresia (BA) through evaluation of the postoperative effects. METHODS: Retrospectively, 34 preterm infants with BA from 2012 to 2016 were recruited in the present study. The following three groups were established according to their chronological and corrected age at the time of KPE operation: chronological age ≤ 90 days, chronological age > 90 days and corrected age ≤ 90 days, and corrected age > 90 days...
February 25, 2019: Pediatric Surgery International
Michael D Traynor, Matthew C Hernandez, Omair Shariq, Wanda Bekker, John L Bruce, Elizabeth B Habermann, Amy E Glasgow, Grant L Laing, Victor Y Kong, Johan J P Buitendag, Denise B Klinkner, Christopher Moir, Damian L Clarke, Martin D Zielinski, Stephanie F Polites
PURPOSE: There is a lack of data-driven, risk-adjusted mortality estimates for injured children outside of high-income countries (HIC). To inform injury prevention and quality improvement efforts, an upper middle-income country (UMIC) pediatric trauma registry was compared to that of a HIC. METHODS: Clinical data, injury details, and mortality of injured children (< 18 years) hospitalized in two centers (USA and South African (SA)) from 2013 to 2017 were abstracted...
February 21, 2019: Pediatric Surgery International
Insu Kawahara, Kosaku Maeda, Yoshitomo Samejima, Keisuke Kajihara, Kotaro Uemura, Kozo Nomura, Kaori Isono, Keiichi Morita, Hiroaki Fukuzawa, Makoto Nakao, Akiko Yokoi
PURPOSE: A type IV laryngotracheoesophageal cleft (LTEC) is a very rare congenital malformation. Type IV LTEC that extends to the carina have poor prognosis and are difficult to manage. We present our experience with surgical repair in such a case using extracorporeal membranous oxygenation (ECMO). METHODS: A male infant, who was diagnosed with Goldenhar syndrome, showed severe dyspnea and dysphagia. Laryngoscopy indicated the presence of LTEC. The patient was transferred to our institute for radical operation 26 days after birth...
February 19, 2019: Pediatric Surgery International
Changkai Deng, Qiang Peng, Xianliang Hu, Li Gao, Juan Xu, Jing Su, Xue Xia, Feng Liu, Maoxian Li
PURPOSE: Based on previously two meta-analyses, urinary nerve growth factor (NGF) has emerged as one potentially noninvasive biomarker for overactive bladder (OAB) in adults. We performed this systematic review to explore if NGF is a biomarker for OAB in children. METHODS: A literature search was conducted in PubMed, Embase, Web of science and Cochrane Library. Copies of all relevant articles were retrieved for quality assessment and data abstraction by two reviewers...
February 19, 2019: Pediatric Surgery International
Alice Louise Mears, May Bisharat, Feilim Murphy, Chandrasen K Sinha
PURPOSE: Following a previously published 1 year audit of readmissions, this is a reaudit of our readmission rate (ReAd) in paediatric surgery, asking: is ReAd reproducible, can it be an indicator of quality of care in paediatric surgery, and can it be improved? METHOD: Prospectively collected Hospital Episode statistics were used to identify readmissions over 1 year. Patients were subdivided into emergency vs elective regarding the first admission and outcomes compared including with our previously published ReAd data...
February 18, 2019: Pediatric Surgery International
Ryota Souzaki, Naonori Kawakubo, Toshiharu Matsuura, Koichiro Yoshimaru, Yuhki Koga, Junkichi Takemoto, Yuichi Shibui, Kenichi Kohashi, Makoto Hayashida, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi
BACKGROUND: Technology for detecting liver tumors and identifying the bile ducts using indocyanine green (ICG) has recently been developed. However, the usefulness and limitations of ICG navigation surgery for hepatoblastoma (HB) have not been fully clarified. We herein report our experiences with surgical navigation using ICG for in HB patients. METHODS: In 5 HB patients, 10 ICG navigation surgeries were performed using a 10-mm infrared fluorescence imaging scope after the injection of 0...
February 16, 2019: Pediatric Surgery International
R Sueyoshi, S Shibuya, T Ochi, M Okawada, G Miyano, H Koga, G J Lane, A Yamataka
PURPOSE: We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM). METHODS: 53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the neonatal period; n = 13) and group S > neo: (symptomatic after the neonatal period; n = 40) were compared for type of CPAM, affected lobes, types of symptoms/infections, treatment, duration of follow-up, and histopathology...
February 16, 2019: Pediatric Surgery International
Edward C Dee, Nathan H Varady, Jeffrey N Katz, Terry L Buchmiller
BACKGROUND: Although the quality of online health information (OHI) for adult surgical conditions is well described, the availability of quality OHI for pediatric surgical conditions, and the comparison to that of adult surgical OHI, remains undefined. METHODS: Medical and lay terms for 15 pediatric and 15 adult surgical conditions were searched using Google in English. The Health on the Net Foundation, a non-governmental OHI accreditation body, designates approval for quality websites...
February 15, 2019: Pediatric Surgery International
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