journal
https://read.qxmd.com/read/36929867/severe-asthma-guidelines-in-children-and-adolescents-a-practical-document-for-physicians
#1
REVIEW
Federica Porcaro, Nicola Ullmann, Antonio Di Marco, Annalisa Allegorico, Claudio Cherchi, Maria Giovanna Paglietti, Renato Cutrera
Asthma is a common disease in childhood with a minority of affected children suffering from severe asthma. Patients with severe asthma require high dose inhaled glucocorticoids plus a second controller and/or systemic corticosteroids to be well-controlled or remain uncontrolled despite such treatment. Although only a small subset of children and adolescents falls in this category, the management of affected patients represents a major concern for pediatricians. Guidelines and recommendations have been designed to guide the management of this group of patients...
March 17, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36929864/dexamethasone-versus-methylprednisolone-for-critical-asthma-a-single-center-open-label-parallel-group-clinical-trial
#2
JOURNAL ARTICLE
Meghan R Roddy, Austin R Sellers, Kristina K Darville, Beatriz Teppa-Sanchez, Scott D McKinley, Meghan Martin, Neil A Goldenberg, Thomas A Nakagawa, Anthony A Sochet
BACKGROUND: Evidence for the use of dexamethasone for pediatric critical asthma is limited. We sought to compare the clinical efficacy and safety of dexamethasone versus methylprednisolone among children hospitalized in the pediatric intensive care unit (PICU) for critical asthma. METHODS: A prospective, single center, open-label, two-arm, parallel-group, nonrandomized trial among children ages 5-17 years hospitalized within the PICU from April 2019 to December 2021 for critical asthma consented to receive methylprednisolone (standard care) or dexamethasone (intervention) at a 2:1 allocation ratio, respectively...
March 17, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36929859/the-impact-of-elexacaftor-tezacaftor-ivacaftor-on-body-composition-in-a-small-cohort-of-youth-with-cystic-fibrosis
#3
LETTER
Andrea Granados, Christine L Chan, Amir Moheet, Timothy Vigers, Ana María Arbeláez, Katie Larson Ode
BACKGROUND: The effects of elexacaftor-tezacaftor-ivacaftor (ETI) on body composition in people with CF (pwCF) are unknown. METHODS: Dual-energy X-ray absorptiometry fat-free mass and fat mass adjusted for height (FMI) as well as oral glucose tolerance test derived measures of insulin secretion and sensitivity were compared before and after ETI initiation in eight pwCF. RESULTS: Patients median age: 22 years interquartile range (IQR: 16-28), 87...
March 17, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36929855/synchronized-intermittent-mandatory-ventilation-with-volume-guarantee-and-pressure-support-in-neonates-detailed-analysis-of-ventilator-parameters
#4
JOURNAL ARTICLE
Andras Balajthy, Gergely Balazs, Tamas Kovacs, Gusztav Belteki
OBJECTIVE: To analyse the relationship between peak inflating pressure, expired tidal volume, respiratory rate, and inspiratory time of volume-guaranteed ventilator inflations and pressure-supported spontaneous breaths during synchronized intermittent positive pressure mode with volume guarantee and pressure support (SIMV-VG-PS) in neonates. METHODS: Ventilator parameters were downloaded every second from 16 babies ventilated with SIMV-VG-PS mode using Dräger Babylog VN500 ventilators over 137 days...
March 17, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36920233/corrigendum
#5
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36920053/ductus-arteriosus-flow-predicts-outcome-in-neonates-with-congecsion
#6
JOURNAL ARTICLE
Bartolomeo Bo, Flaminia Pugnaloni, Amelia Licari, Neil Patel, Brigitte Strizek, Lotte Lemloh, Judith Leyens, Andreas Mueller, Florian Kipfmueller
OBJECTIVE: To investigate whether the pattern of flow through the ductus arteriosus (DA) is associated with the need for extracorporeal membrane oxygenation support (ECMO) or death in neonates with congenital diaphragmatic hernia (CDH). DESIGN: Retrospective observational study. SETTING: German level III Neonatal Intensive Care Unit. PARTICIPANTS: One hundred and nine CDH neonates were born between March 2009 and May 2021...
March 15, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36919525/underlying-causes-and-outcomes-of-recurrent-pneumonia-in-hospitalized-children
#7
JOURNAL ARTICLE
Mei Mei, Dan Dai, Zhuoyao Guo, Congcong Zhang, Jing Liu, Yuanyuan Qi, Xiaochuan Wang, Libo Wang, Liling Qian
OBJECTIVES: To describe the clinical characteristics and underlying causes of recurrent pneumonia (RP) among hospitalized children, and to identify risk factors associated with adverse outcomes. METHODS: We reviewed the medical records of hospitalized children diagnosed with RP at the Children's Hospital of Fudan University from January 2016 to January 2021 and then described clinical characteristics and underlying causes. The associations between factors and adverse outcomes were assessed using logistic regression...
March 15, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36858451/high-deductible-insurance-plans-impart-economic-burden-for-people-with-cystic-fibrosis
#8
LETTER
Ryan C Perkins, Gregory S Sawicki
The cost of cystic fibrosis (CF) care is high with a mean annual expenditure of $131,000 and is driven largely by medications and hospital utilization This article is protected by copyright. All rights reserved.
March 1, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36856268/depression-anxiety-and-sleep-quality-of-caregivers-of-children-with-spinal-muscular-atrophy
#9
JOURNAL ARTICLE
Almala Pinar Ergenekon, Zeynep Gümüş, Cansu Yilmaz Yegit, Muruvvet Cenk, Aynur Gulieva, Mine Kalyoncu, Merve Selcuk, Seyda Karabulut, Gulten Ozturk, Ela Erdem Eralp, Olcay Unver, Bulent Karadag, Yasemin Gokdemir
BACKGROUND: The aim of this study was to evaluate the prevalence of anxiety, depression, sleep, and associated factors in caregivers of children with spinal muscular atrophy (SMA). MATERIALS AND METHODS: Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory-State (STAI-S), the State-Trait Anxiety Inventory-Trait (STAI-T), and Pittsburgh Sleep Quality Index (PSQI) were used to assess the anxiety, depression, and sleep quality of the caregivers of children with SMA...
March 1, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36855907/learning-to-make-a-difference-for-child-value-creation-through-network-collaboration-and-team-science
#10
JOURNAL ARTICLE
Lauren McKnight, André Schultz, Nada Vidic, Elizabeth E Palmer, Adam Jaffe
Addressing the recognized challenges and inequalities in providing high quality healthcare for rare diseases such as children's interstitial lung disease (chILD) requires collaboration across institutional, geographical, discipline, and system boundaries. The Children's Interstitial Lung Disease Respiratory Network of Australia and New Zealand (chILDRANZ) is an example of a clinical network that brings together multidisciplinary health professionals for collaboration, peer learning, and advocacy with the goal of improving the diagnosis and management of this group of rare and ultra-rare conditions...
March 1, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36852622/congenital-lobar-emphysema-a-rare-cause-of-respiratory-failure-in-neonates
#11
JOURNAL ARTICLE
Paul Rose, Saim Rana, Cassie Abbey, Seth Deskins, Saif Al-Qatarneh
Congenital lobar overinflation, also known as congenital lobar emphysema (CLE), is an uncommon (1/20,000-30,000 live births) abnormality characterized by hyperinflation of one or more pulmonary lobes, usually with contralateral displacement of the mediastinum [1]. While the etiology of most cases of CLE is poorly understood and labeled idiopathic, some cases are thought to be due to an intrinsic or extrinsic bronchial wall abnormality causing a ball valve mechanism with resultant hyperinflation of the affected lobe [2]...
February 28, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36852547/obstructive-sleep-apnea-screening-in-children-with-asthma
#12
JOURNAL ARTICLE
Mudiaga O Sowho, Rachelle Koehl, Rebecca Shade, Eliza Judge, Han Woo, Tianshi David Wu, Emily P Brigham, Nadia N Hansel, Jody Tversky, Laura M Sterni, Meredith C McCormack
RATIONALE: Obstructive sleep apnea is highly prevalent in children with asthma, particularly in obese children. The sleep-related breathing disorder screening questionnaire has low screening accuracy for obstructive sleep apnea in children with asthma. Our goal was to identify the questions on the sleep-related breathing disorder survey associated with obstructive sleep apnea in children with asthma. METHODS: Participants completed the survey, underwent polysomnography and their body mass index z-score was measured...
February 28, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36852449/incidence-of-ultrasonographic-signs-of-pneumothorax-in-asymptomatic-neonates
#13
JOURNAL ARTICLE
Jon Montero Gato, Pablo Andrés Sacristán, Nerea López Vázquez, Mónica de Las Heras Martín, Ana Gutiérrez Amorós, Lorena Rodeño Fernández
INTRODUCTION: Pneumothorax in neonates can be life-threatening. In neonates without respiratory distress, spontaneous pneumothorax can also develop under certain conditions. OBJECTIVES: To determine the incidence of ultrasonographic signs of pneumothorax in asymptomatic neonates using lung ultrasound as the diagnostic tool. METHODS: This was an observational prospective study conducted at the Basurto University Hospital (Bilbao, Spain) between January 2018 and December 2020...
February 27, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36850051/the-bridging-bronchus-and-pulmonary-artery-sling
#14
JOURNAL ARTICLE
Furkan Ufuk, Hakki Peker, Munevver Yılmaz, Dolunay Gurses
No abstract text is available yet for this article.
February 27, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36843306/diaphragm-excursion-correlates-with-performance-and-ventilation-on-the-6-min-walk-test-in-children-with-sickle-cell-disease
#15
JOURNAL ARTICLE
Simon Ho, Kelly Rock, Victoria Marchese
INTRODUCTION: Diaphragm function may be impaired in children with sickle cell disease (SCD). We hypothesized that diaphragm function is related to performance and ventilation on the 6-min walk test (6MWT). METHODS: Respiratory muscle testing, diaphragm ultrasonography, and the 6MWT with portable gas analysis were performed on children with SCD and age- and sex-matched controls. RESULTS: Fourteen children with SCD were enrolled. Comparisons were made between nine children with SCD (9...
February 26, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36840405/beyond-the-nicu-comprehensive-management-of-infants-with-bronchopulmonary-dysplasia-in-the-picu
#16
LETTER
Carolyn A Stickney, Philip T Levy, Leah Abecassis, Jonathan C Levin
No abstract text is available yet for this article.
February 24, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36825385/the-association-of-objectively-measured-sedentary-time-with-asthma-in-us-youth-a-glimpse-into-the-connection-between-obesity-and-asthma
#17
JOURNAL ARTICLE
Jacob Hartz, Emily Bucholz, Wanda Phipatanakul, Sarah de Ferranti, Tiffany Powell-Wiley
BACKGROUND: Evidence suggests that asthma and obesity may share a common pathway, possibly through an increase in inflammation. Sedentary time is thought to promote both inflammation and obesity and previous studies have found a relationship between self-reported sedentary and asthma. However, the relationship between objectively measured sedentary time and asthma is not well described. We hypothesized that the association between asthma and sedentary time would not be present when physical activity was measured objectively, nor would objectively-measured sedentary time play an important role in the relationship between asthma and obesity...
February 24, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36825306/the-long-term-outcomes-of-symptomatic-congenital-lobar-emphysema-patients
#18
JOURNAL ARTICLE
Dvir Gatt, Eveline Lapidus-Krol, Priscilla P L Chiu
INTRODUCTION: Surgical (OP) management for symptomatic congenital lobar emphysema (CLE) is the standard of care with non-operative (NOP) approach applied for asymptomatic cases. The aim of this study is to report the outcomes for NOP approach to the care of symptomatic CLE infants. METHODS: A retrospective study of CLE patients treated 2000-2021 at a single institution. Patients with CLE and respiratory symptoms were included. RESULTS: Overall, 23 children had symptomatic CLE, and 12 had NOP management...
February 23, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36815645/minimally-invasive-resection-of-symptomatic-bifid-intrathoracic-rib
#19
JOURNAL ARTICLE
Carlos Delgado-Miguel, Pablo Fernández, Antonio Muñoz-Serrano, Pablo Aguado, Ennio Fuentes, Ricardo Díez
Intrathoracic ribs are rare congenital anomalies where a supra- or normonumerary rib follows an abnormal course within the thorax (1). Less than 10 cases have been reported in children, being commonly asymptomatic and usually found incidentally (2). Surgical treatment is seldom necessary due to the benign and asymptomatic presentation. However, in symptomatic cases, little is known about optimal treatment strategy. We report a unique case of a symptomatic intrathoracic rib that required surgical treatment by minimally invasive approach This article is protected by copyright...
February 23, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/36815622/cepacia-syndrome-in-cystic-fibrosis-a-systematic-review-of-the-literature-and-possible-new-perspectives-in-treatment
#20
REVIEW
Valeria Daccò, Gianfranco Alicandro, Alessandra Consales, Chiara Rosazza, Calogero Sathia Sciarrabba, Lisa Cariani, Carla Colombo
BACKGROUND: Cepacia syndrome (CS) is an acute, necrotizing pneumonia with a high mortality rate, occurring in patients with cystic fibrosis (CF) infected with Burkholderia cepacia complex (BCC). Due to its low incidence, data on this condition are limited. METHODS: We conducted a systematic review of the reported cases of CS by searching MEDLINE, Embase and the Cochrane Library to improve knowledge on this rare but potentially lethal condition. RESULTS: We included 15 eligible articles, describing 18 cases (9 females) of CS...
February 23, 2023: Pediatric Pulmonology
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