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Pediatric Neurology

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https://read.qxmd.com/read/30770270/vacuum-extraction-in-preterm-deliveries-and-long-term-neurological-outcome-of-the-offspring
#1
Polina Schwarzman, Eyal Sheiner, Tamar Wainstock, Salvatore Andrea Mastrolia, Idit Segal, Daniella Landau, Asnat Walfisch
BACKGROUND: Concern exists regarding a possible harmful impact of vacuum extraction on the preterm newborn. We aimed to evaluate the long-term pediatric neurodevelopmental outcomes of the preterm offspring after vacuum extraction. METHODS: A population-based cohort analysis was performed comparing the risk for long-term neurological morbidity (up to age 18 years) in preterm (less than 37 completed weeks of gestation) children born via following three delivery modes: vacuum extraction, spontaneous delivery, and cesarean delivery performed during the second stage of labor...
January 15, 2019: Pediatric Neurology
https://read.qxmd.com/read/30765136/children-with-severe-traumatic-brain-injury-intracranial-pressure-cerebral-perfusion-pressure-what-does-it-mean-a-review-of-the-literature
#2
REVIEW
Marlina E Lovett, Nicole F O'Brien, Jeffrey R Leonard
Severe traumatic brain injury is a leading cause of morbidity and mortality in children. In 2003 the Brain Trauma Foundation released guidelines that have since been updated (2010) and have helped standardize and improve care. One area of care that remains controversial is whether the placement of an intracranial pressure monitor is advantageous in the management of traumatic brain injury. Another aspect of care that is widely debated is whether management after traumatic brain injury should be based on intracranial pressure-directed therapy, cerebral perfusion pressure-directed therapy, or a combination of the two...
January 11, 2019: Pediatric Neurology
https://read.qxmd.com/read/30770271/genotypic-spectrum-and-natural-history-of-cavitating-leukoencephalopathies-in-childhood
#3
Jie Zhang, Ming Liu, Zhongbin Zhang, Ling Zhou, Weijing Kong, Yuwu Jiang, Jingmin Wang, Jiangxi Xiao, Ye Wu
BACKGROUND: We aimed to delineate the pattern of natural course, neuroimaging features, and the genotypic spectrum of cavitating leukoencephalopathies. METHODS: Children (age of onset ≤16 years) who met the criteria for cavitating leukoencephalopathies from January 2009 to October 2018 were identified. Whole-exome sequencing and prospective follow-up study of the natural history and brain magnetic resonance imaging (MRI) were performed. RESULTS: Thirty-seven children were clinically diagnosed with cavitating leukoencephalopathies...
January 8, 2019: Pediatric Neurology
https://read.qxmd.com/read/30718162/cerebral-hemodynamics-during-neonatal-cerebrospinal-fluid-removal
#4
Stefano Bembich, Gabriele Cont, Jenny Bua, Giulia Paviotti, Sergio Demarini
BACKGROUND: Standard treatment of neonatal posthemorrhagic hydrocephalus is cerebrospinal fluid removal. The aim of this study was to assess how much cerebrospinal fluid volume removal, by ventricular reservoir taps, is needed to improve cerebral hemodynamics and oxygenation in neonatal posthemorrhagic hydrocephalus. METHODS: Cerebral hemodynamics and oxygenation were continuously monitored by near-infrared spectroscopy in four newborns (one term and three preterm) during 28 ventricular reservoir taps...
January 8, 2019: Pediatric Neurology
https://read.qxmd.com/read/30704868/ketogenic-diet-in-epilepsy-of-infancy-with-migrating-focal-seizures
#5
LETTER
Priyanka Madaan, Prashant Jauhari, Biswaroop Chakrabarty, Sheffali Gulati
No abstract text is available yet for this article.
January 7, 2019: Pediatric Neurology
https://read.qxmd.com/read/30770272/macroglossia-dry-skin-developmental-delay-and-stippled-epiphysis-a-treatable-condition
#6
Indar Kumar Sharawat, Lesa Dawman
No abstract text is available yet for this article.
January 4, 2019: Pediatric Neurology
https://read.qxmd.com/read/30683500/nerve-transfers-in-acute-flaccid-myelitis-a-beacon-of-hope
#7
LETTER
Priyanka Madaan, Lokesh Saini
No abstract text is available yet for this article.
December 29, 2018: Pediatric Neurology
https://read.qxmd.com/read/30691779/prognostic-value-of-electroencephalography-in-hypothermia-treated-neonates-with-hypoxic-ischemic-encephalopathy-a-meta-analysis
#8
Ye Han, Na Fu, Wenjie Chen, Jingjing Liang, Yanan Cui, Ying Zhang, Jiong Qin
BACKGROUND: Electroencephalography (EEG) background activity is associated with neurological outcome in neonates with hypoxic-ischemic encephalopathy. There is uncertainty about the prognostic value of EEG background activity after hypothermia was introduced. METHODS: Searches were made on Pubmed, Embase, and the Cochrane Library, from inception to March 1, 2018. Pooled sensitivities and specificities were calculated to assess the diagnostic power of burst suppression, low voltage, and flat trace background activities in the prediction of an adverse neurological outcome in the follow-up period in hypothermia-treated neonates with hypoxic-ischemic encephalopathy...
December 28, 2018: Pediatric Neurology
https://read.qxmd.com/read/30686628/cntnap1-related-congenital-hypomyelinating-neuropathy
#9
Harry Lesmana, Marissa Vawter Lee, Seyed Ali Hosseini, T Andrew Burrow, Barbara Hallinan, Kevin Bove, Mark Schapiro, Robert J Hopkin
BACKGROUND: Congenital hypomyelinating neuropathy is a rare form of hereditary peripheral neuropathy characterized by nonprogressive weakness, areflexia, hypotonia, severely reduced nerve conduction velocities, and hypomyelination. Mutations in contactin-associated protein 1 (CNTNAP1) were recently described as a cause of congenital hypomyelinating neuropathy. CNTNAP1-associated congenital hypomyelinating neuropathy is characterized by severe hypotonia, multiple distal joint contractures, and high mortality in the first few months of life...
December 28, 2018: Pediatric Neurology
https://read.qxmd.com/read/30683501/jeavons-syndrome-an-overlooked-epilepsy-syndrome
#10
LETTER
Priyanka Madaan, Prashant Jauhari, Biswaroop Chakrabarty, Sheffali Gulati
No abstract text is available yet for this article.
December 28, 2018: Pediatric Neurology
https://read.qxmd.com/read/30704869/pediatric-epilepsy-readmissions-the-who-when-and-why
#11
Marissa Vawter-Lee, Alexandria Lutley, Sharon W Lake, Shirley Fledderjohn, Anna King, Paul S Horn, Kristen R Wesselkamper
BACKGROUND: Prior studies have demonstrated a pediatric epilepsy readmission rate of 6% to 10% but have not described details of the readmitted patients. We report the characteristics of pediatric patients admitted for epilepsy who were readmitted to the hospital within 30 days of discharge. METHODS: An interdisciplinary team was established to individually review and characterize the 30-day readmissions of patients admitted for epilepsy from May 2014 to October 2016...
December 25, 2018: Pediatric Neurology
https://read.qxmd.com/read/30770273/arrest-of-fetal-brain-development-in-alg11-congenital-disorder-of-glycosylation
#12
Sarah B Mulkey, Bobby G Ng, Gilbert L Vezina, Dorothy I Bulas, Lynne A Wolfe, Hudson H Freeze, Carlos R Ferreira
BACKGROUND: Arrest of fetal brain development and the fetal brain disruption sequence describe a severe phenotype involving microcephaly, occipital bone prominence, and scalp rugae. Congenital disorders of glycosylation are a heterogeneous group of inherited disorders involved in glycoprotein and glycolipid biosynthesis, which can cause microcephaly and severe neurodevelopmental disability. METHODS: We report an example of fetal microcephaly diagnosed at 36 weeks' gestation with a history of normal fetal biometry at 20 weeks' gestation...
December 24, 2018: Pediatric Neurology
https://read.qxmd.com/read/30686629/cerebral-infarction-in-cars2-mutation
#13
LETTER
Debopam Samanta
No abstract text is available yet for this article.
December 24, 2018: Pediatric Neurology
https://read.qxmd.com/read/30686626/protocols-and-guidelines-for-stroke-in-children-point-and-counterpoint
#14
Adam Kirton, Michael Dowling
No abstract text is available yet for this article.
December 24, 2018: Pediatric Neurology
https://read.qxmd.com/read/30765137/where-to-from-here
#15
Nomazulu Dlamini
No abstract text is available yet for this article.
December 20, 2018: Pediatric Neurology
https://read.qxmd.com/read/30704867/use-of-venous-pco-2-in-determination-of-death-by-neurological-criteria-in-children
#16
Alireza Fathi, Jean L Lake
BACKGROUND: Compare the increase in partial pressure of carbon dioxide (Pco2 ) from venous blood samples with that of arterial blood samples during apnea challenge test in determination of death by neurological criteria. METHODS: Prospective nonrandomized cohort study in tertiary care pediatric intensive care unit. Patients older than 37 week's gestation admitted to PICU with irreversible brain injury at the time when attending physician will perform apnea challenge test as part of brain death examination from October 2015 till September 2017...
December 19, 2018: Pediatric Neurology
https://read.qxmd.com/read/30686625/expanding-the-phenotypic-spectrum-of-cacna1h-mutations
#17
Nitish Chourasia, Henry Ossó-Rivera, Ankita Ghosh, Gretchen Von Allmen, Mary Kay Koenig
BACKGROUND: The CACNA1H gene mutations encoding the α1H subunit of Cav3.2 T-type calcium channels have been associated with generalized epilepsy. Focal or multifocal epilepsy and systemic (immunologic and gastrointestinal) involvement associated with these mutations have not been described previously. We detail the clinical characteristics of five patients with CACNA1H mutations and expand its phenotypic spectrum. METHODS: A case series of five patients with pathogenic CACNA1H mutations was evaluated...
December 19, 2018: Pediatric Neurology
https://read.qxmd.com/read/30639248/infant-botulism-with-asymmetric-cranial-nerve-palsies
#18
Ariel Maia Lyons-Warren, Sarah R Risen, Gary Clark
No abstract text is available yet for this article.
November 30, 2018: Pediatric Neurology
https://read.qxmd.com/read/30591236/multiple-intracranial-cystic-brain-lesions-a-diagnostic-dilemma
#19
Ashutosh Gupta, Sandeep Singh, Dyutima Madan
No abstract text is available yet for this article.
November 30, 2018: Pediatric Neurology
https://read.qxmd.com/read/30686630/reply-to-finsterer-regarding-lethal-nars2-related-disorder-associated-with-rapidly-progressive-intractable-epilepsy-and-global-brain-atrophy
#20
LETTER
Laurie H Seaver, Steven DeRoos, Brad Betz, Surender Rajasekaran
No abstract text is available yet for this article.
November 28, 2018: Pediatric Neurology
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