Cemal Karakas, Isabella Herman, Stephen F Kralik, Troy A Webber, Danielle S Takacs, Saleh Bhar, Davut Pehlivan
BACKGROUND: To analyze the clinical and neuroimaging features, risk factors, treatment choices, and long-term clinical outcomes in children with cerebral sinus venous thrombosis (CSVT). METHODS: This is a retrospective cohort study of children diagnosed with CSVT between 2002 and 2018 at Texas Children's Hospital. RESULTS: A total of 183 children (male: 62.3%) with CSVT were included. The average presenting age was 7.7 years (S.D.: 5...
March 26, 2024: Pediatric Neurology
Zahra Shekari, Razieh Sadeghian Afarani, Saeid Fatorehchy, Enayatollah Bakhshi, Soheila Shahshahani, Elahe Mousavi
BACKGROUND: Primary symptoms of cerebral palsy (CP), such as spasm and weakness, can lead to secondary musculoskeletal problems. Exploring the interplay and impact of secondary symptoms is essential in CP management. METHODS: A total of 56 children (32 males and 24 females) aged eight to 12 years in level I to III of Gross Motor Function Classification System (GMFCS) completed The Pediatric Balance Scale and Wong-Baker Faces Scale and the Posture and Postural Ability Scale...
March 24, 2024: Pediatric Neurology
Lindsay Berg, Davide Martino, Z Paige L'Erario, Tamara Pringsheim
BACKGROUND: We performed this study to improve understanding of the relationship between functional tic-like behaviors (FTLBs) and quality of life, loneliness, family functioning, anxiety, depression, and suicidality. METHOD: This cross-sectional study assessed self-reported quality of life, disability, loneliness, depression, anxiety, family functioning, tic severity, and suicide risk in age- and birth-sex matched youth with FTLBs, Tourette syndrome (TS), and neurotypical controls...
March 22, 2024: Pediatric Neurology
Nicole M McDonald, Sydney Jacobs, Carly Hyde, Connie Kasari, Shafali S Jeste
BACKGROUND: The TAND (Tuberous Sclerosis Complex [TSC]-Associated Neuropsychiatric Disorders) Checklist was developed as a clinical screener for neurodevelopmental disorders in TSC. Most studies have described patterns in older children and adults. This study sought to better understand behavioral concerns as measured by the TAND Checklist in young children with TSC. METHODS: We examined patterns of caregiver responses to the TAND Checklist in 90 toddlers with TSC (12 to 23 months n = 60; 24 to 36 months n = 30) through data collected during baseline visits across two TSC early intervention studies...
March 22, 2024: Pediatric Neurology
Amaar Marefi, Nafisa Husein, Mary Dunbar, Deborah Dewey, Nicole Letourneau, Maryam Oskoui, Adam Kirton, Michael Shevell
BACKGROUND: To identify if a predetermined set of potential risk factors are associated with spastic diplegic cerebral palsy (SDCP) in term-born children. METHODS: This is a case-control study with cases (n = 134) extracted from the Canadian Cerebral Palsy Registry (CCPR) and controls (n = 1950) from the Alberta Pregnancy Outcomes and Nutrition (APrON) study. Our primary variable was the SDCP phenotype in term-born children. Possible risk factors were selected a priori and include extreme maternal age (<19 or >35 years), pregnancy complications, maternal disease, substance use, perinatal infection, mode of delivery, perinatal adversity (i...
March 20, 2024: Pediatric Neurology
Marija Babunovska, Tatjana Cepreganova Cangovska, Igor Kuzmanovski, Predrag Noveski, Dijana Plaseska-Karanfilska, Emilija Cvetkovska
No abstract text is available yet for this article.
March 16, 2024: Pediatric Neurology
Varun Sampat, John Whitinger, Katherine Flynn-O'Brien, Irene Kim, Binod Balakrishnan, Niyati Mehta, Rachel Sawdy, Namrata D Patel, Rupa Nallamothu, Liyun Zhang, Ke Yan, Kimberley Zvara, Raquel Farias-Moeller
BACKGROUND: Children with severe traumatic brain injury (sTBI) are at risk for neurological sequelae impacting function. Clinicians are tasked with neuroprognostication to assist in decision-making. We describe a single-center study assessing clinicians' neuroprognostication accuracy. METHODS: Clinicians of various specialties caring for children with sTBI were asked to predict their patients' functioning three to six months postinjury. Clinicians were asked to participate in the study if their patient had survived but not returned to baseline between day 4 and 7 postinjury...
March 16, 2024: Pediatric Neurology
Yuki Kawashima, Shohei Ariji, Rui Aoyagi, Masahiro Noda, Kunihiro Oba, Masashi Ogasawara
No abstract text is available yet for this article.
March 16, 2024: Pediatric Neurology
Carmen Palma-Milla, Aina Prat-Planas, Emma Soengas-Gonda, Mónica Centeno-Pla, Jaime Sánchez-Pozo, Irene Lazaro-Rodriguez, Juan F Quesada-Espinosa, Ana Arteche-Lopez, Jonathan Olival, Marta Pacio-Miguez, María Palomares-Bralo, Fernando Santos-Simarro, Ramón Cancho-Candela, María Vázquez-López, Veronica Seidel, Antonio F Martinez-Monseny, Didac Casas-Alba, Daniel Grinberg, Susanna Balcells, Mercedes Serrano, Raquel Rabionet, Miguel A Martin, Roser Urreizti
BACKGROUND: TRAF7-related cardiac, facial, and digital anomalies with developmental delay (CAFDADD), a multisystemic neurodevelopmental disorder caused by germline missense variants in the TRAF7 gene, exhibits heterogeneous clinical presentations. METHODS: We present a detailed description of 11 new TRAF7-related CAFDADD cases, featuring eight distinct variants, including a novel one. RESULTS: Phenotypic analysis and a comprehensive review of the 58 previously reported cases outline consistent clinical presentations, emphasizing dysmorphic features, developmental delay, endocrine manifestations, and cardiac defects...
March 14, 2024: Pediatric Neurology
Moninder Kaur, Levon Utidjian, Nicholas S Abend, Kimberley Dickinson, Robert Roebling, Jill McDonald, Mitchell G Maltenfort, Nadia Foskett, Sami Elmoufti, Rejean M Guerriero, Badal G Jain, Nathan M Pajor, Suchitra Rao, Renée A Shellhaas, Laurel Slaughter, Christopher B Forrest
BACKGROUND: There is growing evidence supporting the safety and effectiveness of lacosamide in older children. However, minimal data are available for neonates. We aimed to determine the incidence of adverse events associated with lacosamide use and explore the electroencephalographic seizure response to lacosamide in neonates. METHODS: A retrospective cohort study was conducted using data from seven pediatric hospitals from January 2009 to February 2020. For safety outcomes, neonates were followed for ≤30 days from index date...
March 13, 2024: Pediatric Neurology
Arpan Saha, Shristi Das, Samragni De, Tithi Dutta, Shubhrajit Roy, Atanu Biswas, Mainak Sengupta
BACKGROUND: Wilson disease (WD) is a rare autosomal recessive disorder of copper metabolism caused due to mutations in the copper transporter ATP7B. There is often a striking variability of clinical manifestations among patients with ATP7B mutations, including in siblings. This phenomenon may be caused by individual differences in copper accumulation in hepatocytes and intolerance to copper toxicity as governed by genetic variations in copper metabolism genes acting as modifier loci to the disease...
March 8, 2024: Pediatric Neurology
Sho Narahara, Nobuhiko Ochi, Yuji Ito, Tadashi Ito, Hajime Narita, Koji Noritake, Hiroyuki Kidokoro, Jun Natsume
BACKGROUND: GTP-cyclohydrolase 1-deficient dopa-responsive dystonia (GTPCH1-deficient DRD) typically presents in childhood with dystonic posture of the lower extremities, gait impairment, and a significant response to levodopa. We performed three-dimensional gait analysis (3DGA) to quantitatively assess the gait characteristics and changes associated with levodopa treatment in patients with GTPCH1-deficient DRD. METHODS: Three levodopa-treated patients with GTPCH1-deficient DRD underwent 3DGA twice, longitudinally...
March 8, 2024: Pediatric Neurology
Zhongling Wu, Xiaolei Li, Yuanxin Huang, Kailing Huang, Bo Xiao, Yunfang Chi, Li Feng, Haojun Yang
BACKGROUND: This study aimed to evaluate the effects of a nurse-led cognitive behavioral intervention for parents of children with epilepsy (CWE). METHODS: The study recruited 238 CWE from the neurology ward of Xiangya Hospital from March 2019 to August 2022. According to the interventions after discharge, the children and their parents were randomly divided into 117 parent-child dyads in the intervention group and 121 parent-child dyads in the control group. The seizure severity and treatment compliance in CWE as well as the parents' psychological states and satisfaction with the care provided by nurses were compared before and after intervention...
March 7, 2024: Pediatric Neurology
Hanan Azouz, Wafaa Muhammed, Marwa Abd Elmaksoud
BACKGROUND: Identifying the cause of headaches in pediatric emergency departments (PEDs) can be challenging due to the lack of comprehensive research. This study aims to identify the frequency, characteristics, and unnecessary diagnostic procedures of patients with headaches in the PED setting. METHODS: A six-month cross-sectional study was conducted at the PED of Alexandria University Children's Hospital, including all children with headaches. Children were classified as having primary headache (PH), secondary benign headache (SBH), and secondary serious headache (SSH) according to predetermined criteria...
March 5, 2024: Pediatric Neurology
Marisela E Dy-Hollins, Samuel J Carr, Angela Essa, Lisa Osiecki, Daniel T Lackland, Jenifer H Voeks, Nicte I Mejia, Nutan Sharma, Cathy L Budman, Danielle C Cath, Marco A Grados, Robert A King, Gholson J Lyon, Guy A Rouleau, Paul Sandor, Harvey S Singer, Lori B Chibnik, Carol A Mathews, Jeremiah M Scharf
BACKGROUND: To examine the association between race, ethnicity, and parental educational attainment on tic-related outcomes among Tourette Syndrome (TS) participants in the Tourette Association of America International Consortium for Genetics (TAAICG) database. METHODS: 723 participants in the TAAICG dataset aged ≤21 years were included. The relationships between tic-related outcomes and race and ethnicity were examined using linear and logistic regressions...
March 1, 2024: Pediatric Neurology
Matthew O'Neal, Ines Noher de Halac, Shawn C Aylward, Vedat Yildiz, Bianca Zapanta, Nicolas Abreu, Emily de Los Reyes
BACKGROUND: Mutations in the CLN6 gene cause late infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disease of childhood onset. Clinically, individuals present with progressive motor and cognitive regression, ataxia, and early death. The aim of this study is to establish natural history data of individuals with classic, late-infantile-onset (age less than five years) CLN6 disease. METHODS: We analyzed the natural history of 25 patients with late-infantile-onset CLN6, utilizing the Hamburg motor-language scale to measure disease progression...
March 1, 2024: Pediatric Neurology
Shimaa A M Anwar, Elham E Elsakka, Mona Khalil, Afaf A G Ibrahim, Ahmed ElBeheiry, Sohair Farouk Mohammed, Tarek E I Omar, Yasser S Amer
No abstract text is available yet for this article.
February 21, 2024: Pediatric Neurology
Adriana S Morell, Sarah E Monsell, Marie-Coralie Cornet, Jessica L Wisnowski, Robert C McKinstry, Amit M Mathur, Yi Li, Hannah C Glass, Fernando F Gonzalez, Dennis E Mayock, Kristen L Benninger, Krisa P Van Meurs, Andrea L Lampland, Tai-Wei Wu, David Riley, Ulrike Mietzsch, Lina Chalak, John Flibotte, Joern-Hendrick Weitkamp, Kaashif A Ahmad, Toby D Yanowitz, Mariana Baserga, Stephanie Merhar, Rakesh Rao, Gregory M Sokol, Bryan A Comstock, Patrick J Heagerty, Sandra E Juul, Yvonne W Wu
BACKGROUND: Infants with hypoxic ischemic encephalopathy (HIE) may have underlying conditions predisposing them to hypoxic-ischemic injury during labor and delivery. It is unclear how genetic and congenital anomalies impact outcomes of HIE. METHODS: Infants with HIE enrolled in a phase III trial underwent genetic testing when clinically indicated. Infants with known genetic or congenital anomalies were excluded. The primary outcome, i.e., death or neurodevelopmental impairment (NDI), was determined at age two years by a standardized neurological examination, Bayley Scales of Infant Development, Third Edition (BSID-III), and the Gross Motor Function Classification Scales...
February 20, 2024: Pediatric Neurology
Amira Masri, Nosaiba Al Ryalat, Azmy Hadidy, Ashjan Ahmad Al-Shakkah, Majd Ali, Mira Al Jaberi, Raghad Shihadat, Abdallah Rayyan, Mohammad AlMasri, Lina Abunameh
BACKGROUND: This cross-sectional study aimed to report all neuroimaging findings suggestive of raised intracranial pressure in children with pseudotumor cerebri syndrome (PTCS), before and after re-review by two neuroradiologists. METHODS: We included 48 children aged <18 years diagnosed with PTCS between 2016 and 2021. Clinical and radiological data were obtained from their medical files. Two neuroradiologists independently re-reviewed all neuroimages, and the average of their assessments was compared with the initial neuroimaging reports; an additional review was done to analyze inter- and intraclass correlation...
February 18, 2024: Pediatric Neurology
Brandon Morgan, Pedro Weisleder, Anup D Patel, William Parker, Megan Rose, Catherine Butz
BACKGROUND: Tic disorders in children often co-occur with other disorders that can significantly impact functioning. Screening for quality of life (QoL) can help identify optimal treatment paths. This quality improvement (QI) study describes implementation of a QoL measure in a busy neurology clinic to help guide psychological intervention for patients with tics. METHODS: Using QI methodology outlined by the Institute for Healthcare Improvement, this study implemented the PedsQL Generic Core (4...
February 17, 2024: Pediatric Neurology
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