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Pediatric Nephrology: Journal of the International Pediatric Nephrology Association

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https://read.qxmd.com/read/30904930/treatment-of-nephrotic-syndrome-going-beyond-immunosuppressive-therapy
#1
REVIEW
Jinghong Zhao, Zhihong Liu
It is indisputable that immunosuppressive therapy and pathological diagnosis of renal biopsy have greatly improved the prognosis of childhood nephrotic syndrome. Unfortunately, there is no "one-size-fits-all" approach for precise patient stratification and treatment when facing the huge challenges posed by steroid-resistant nephrotic syndrome (SRNS). But genomic medicine has brought a glimmer of light, and the cognition of SRNS has entered a new stage. Based on this, identification of single genetic variants of SRNS has recognized the key role of podocyte injury in its pathogenesis...
March 23, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30903375/cardiovascular-disease-risk-among-children-with-focal-segmental-glomerulosclerosis-a-report-from-the-chronic-kidney-disease-in-children-study
#2
Christine B Sethna, Derek K Ng, Shuai Jiang, Jeff Saland, Bradley A Warady, Susan Furth, Kevin E Meyers
BACKGROUND: The aims were to compare the cardiovascular disease (CVD) risk among children with chronic kidney disease (CKD) secondary to focal segmental glomerulosclerosis (FSGS) with the CVD risk of children with CKD due to other diagnoses. METHODS: Casual blood pressure (BP), ambulatory blood pressure monitoring (APBM), echocardiogram, lipids, carotid intima medial thickness (cIMT), and uric acid obtained from participants in the Chronic Kidney Disease in Children (CKiD) cohort were analyzed longitudinally...
March 22, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30903374/mild-hypotonia-and-recurrent-seizures-in-an-8-month-old-boy-answers
#3
Sare Gülfem Özlü, Cigdem Seher Kasapkara, Serdar Ceylaner, Meryem Erat Nergız, Başak Alan, Songül Yılmaz, Ayşegül Neşe Çıtak Kurt
No abstract text is available yet for this article.
March 22, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30903373/mild-hypotonia-and-recurrent-seizures-in-an-8-month-old-boy-questions
#4
Sare Gülfem Özlü, Cigdem Seher Kasapkara, Serdar Ceylaner, Meryem Erat Nergız, Başak Alan, Songül Yılmaz, Ayşegül Neşe Çıtak Kurt
Hypomagnesemia with secondary hypocalcemia is a rare autosomal recessive disorder which manifests in early infancy with generalized seizures, other symptoms of neuromuscular irritability, and growth disturbances. Homozygous mutations in the magnesium transporter gene, transient receptor potential melastatin 6 (TRPM6), cause the disease. Here, we present an 8-month-old Turkish boy with a novel mutation of TRPM6. The patient, son of first-degree cousins, was hospitalized because of recurrent seizures and mild hypotonia...
March 22, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30895368/using-urine-nitrite-sticks-to-test-for-urinary-tract-infection-in-children-aged-2-years-a-meta-analysis
#5
Malcolm G Coulthard
BACKGROUND: This study aimed to determine whether nitrite sticks are as sensitive at detecting urinary tract infection (UTI) in children <2 years as they are in older children. METHODS: I reanalysed data on using nitrite sticks to detect UTIs for children aged either < 2 or 2-18 years. For sensitivity, evidence of a UTI was defined as level 1 when a single uropathogen grew ≥ 105 colony forming units/ml (cfu/ml) in two urine samples, level 2 when just one sample was cultured or a threshold of < 105  cfu/ml was used, and level 3 if mixed growths or Staphylococcus albus was considered to be positive...
March 20, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30895367/psychosocial-considerations-and-recommendations-for-care-of-pediatric-patients-on-dialysis
#6
Michelle A Clementi, Cortney Taylor Zimmerman
Dialysis treatment has evolved to enable children to live longer and transition to adulthood. Thus, the focus of care shifts to a consideration of pediatric patients' quality of life and psychosocial functioning across childhood, adolescence, and young adulthood. Despite well-documented concerns in various domains (including depression/anxiety, self-esteem and social functioning, behavior problems, and academic and cognitive functioning), limited literature exists regarding psychosocial guidelines for children and adolescents undergoing dialysis...
March 20, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30887110/predictors-of-rituximab-related-neutropenia-in-japanese-children-with-steroid-dependent-nephrotic-syndrome
#7
LETTER
Shuichiro Fujinaga, Yuji Tomii
No abstract text is available yet for this article.
March 18, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30887109/dialysis-modalities-for-the-management-of-pediatric-acute-kidney-injury
#8
Lara de Galasso, Stefano Picca, Isabella Guzzo
Acute kidney injury (AKI) is an increasingly frequent complication among hospitalized children. It is associated with high morbidity and mortality, especially in neonates and children requiring dialysis. The different renal replacement therapy (RRT) options for AKI have expanded from peritoneal dialysis (PD) and intermittent hemodialysis (HD) to continuous RRT (CRRT) and hybrid modalities. Recent advances in the provision of RRT in children allow a higher standard of care for increasingly ill and young patients...
March 18, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30874941/clinical-course-of-hantavirus-induced-nephropathia-epidemica-in-children-compared-to-adults-in-germany-analysis-of-317-patients
#9
Fabian Echterdiek, Daniel Kitterer, M Dominik Alscher, Vedat Schwenger, Bettina Ruckenbrod, Martin Bald, Joerg Latus
BACKGROUND: Hantavirus infections are endemic worldwide, and its incidence in Europe has been steadily increasing. In Western Europe, hantavirus infections are typically caused by Puumala hantavirus and cause nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. Up to now, there is only little data about the course of acute NE in children, but it has been suggested that hantavirus infections take a lighter course in children when compared to adults. We performed a retrospective analysis of adults and children diagnosed with acute NE in two counties in South-Western Germany to investigate if there are differences in the course of the disease...
March 14, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30863911/nephrotic-syndrome-and-mitochondrial-disorders-answers
#10
Julie Bernardor, Camille Faudeux, Anabelle Chaussenot, Corinne Antignac, Alice Goldenberg, Marie Claire Gubler, Nicole Wagner, Etienne Bérard
No abstract text is available yet for this article.
March 12, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30863910/nephrotic-syndrome-and-mitochondrial-disorders-questions
#11
Julie Bernardor, Camille Faudeux, Anabelle Chaussenot, Corinne Antignac, Alice Goldenberg, Marie Claire Gubler, Nicole Wagner, Etienne Bérard
No abstract text is available yet for this article.
March 12, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30852663/prevalence-of-low-molecular-weight-proteinuria-and-dent-disease-1-clcn5-mutations-in-proteinuric-cohorts
#12
Lada Beara-Lasic, Andrea Cogal, Kristin Mara, Felicity Enders, Ramila A Mehta, Zejfa Haskic, Susan L Furth, Howard Trachtman, Steven J Scheinman, Dawn S Milliner, David S Goldfarb, Peter C Harris, John C Lieske
BACKGROUND: Dent disease type 1 (DD1) is a rare X-linked disorder caused mainly by CLCN5 mutations. Patients may present with nephrotic-range proteinuria leading to erroneous diagnosis of focal segmental glomerulosclerosis (FSGS) and unnecessary immunosuppressive treatments. METHODS: The following cohorts were screened for CLCN5 mutations: Chronic Kidney Disease in Children (CKiD; n = 112); Multicenter FSGS-Clinical Trial (FSGS-CT) (n = 96), and Novel Therapies for Resistant FSGS Trial (FONT) (n = 30)...
March 10, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30847554/the-pathogenesis-and-management-of-renal-scarring-in-children-with-vesicoureteric-reflux-and-pyelonephritis
#13
REVIEW
Vasikar Murugapoopathy, Christine McCusker, Indra R Gupta
Bacterial urinary tract infections (UTIs) are one of the most common reasons for children to be admitted to hospital. Bacteria infect and invade the bladder (the lower urinary tract) and if the infection disseminates to the upper urinary tract, significant inflammation in the kidneys may arise. Inflammation is a double-edged sword: it is needed to clear bacteria, but if excessive, kidney tissue is injured. During injury, nephrons are destroyed and replaced with deposition of extracellular matrix and a renal scar...
March 7, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843115/clostridium-difficile-infection-after-pediatric-solid-organ-transplantation-a-practical-single-center-experience
#14
Christian Breuer, Sabrina Döring, Holger Rohde, Stefan Rutkowski, Ingo Müller, Jun Oh
BACKGROUND: During the last two decades, there has been a worldwide increase in frequency and severity of infections with Clostridium difficile (CDI). Solid organ transplant (SOT) recipients receiving immunosuppressing medications are especially at risk. METHODS: We collected data from immunocompromised pediatric patients, including kidney and liver transplant recipients, at our tertiary pediatric care center in Germany. For this, we performed a retrospective review of institutional databases and analyzed data from all children who underwent diagnostic tests for CDI in a 3-year study period...
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843114/feeding-modality-is-a-barrier-to-adequate-protein-provision-in-children-receiving-continuous-renal-replacement-therapy-crrt
#15
Molly Wong Vega, Marisa Juarez Calderon, Naile Tufan Pekkucuksen, Poyyapakkam Srivaths, Ayse Akcan Arikan
BACKGROUND: Critically ill children have a high prevalence of malnutrition. Children with acute kidney injury experience high rates of protein debt. Previous research has indicated that protein provision is positively associated with survival. METHODS: This was a prospective observational study of all patients receiving CRRT for greater than 48 h at our tertiary care institution. Patients with inborn errors of metabolism were excluded. Data collection included energy, protein, and fluid volume intakes, anthropometrics, feeding modality, and route of nutrition intake...
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843113/glomerular-disease-patients-have-higher-odds-not-to-reach-quality-targets-in-chronic-dialysis-compared-with-cakut-patients-analyses-from-a-nationwide-german-paediatric-dialysis-registry
#16
Katrin Lübbe, Eva Nüsken, Katherine Rascher, Gero von Gersdorff, Heyke Cramer, Christina Samel, Claudia Barth, Dieter Bach, Lutz T Weber, Jörg Dötsch
BACKGROUND: Paediatric dialysis patients still suffer from high morbidity rates. To improve this, quality assurance programs like the German QiNKid (Quality in Nephrology for Children)-Registry have been developed. In our study, the significance of underlying renal disease on a range of clinical and laboratory parameters impacting morbidity and mortality was analysed. Our aim was to evaluate whether or not disease-specific dialysis strategies should be considered in planning dialysis for a patient...
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843112/an-adolescent-patient-presenting-with-hyponatremic-seizure-answers
#17
Meral Torun Bayram, Gizem Yıldız, Alper Soylu, Salih Kavukçu
No abstract text is available yet for this article.
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843111/proteinuria-in-a-patient-with-graves-disease-answers
#18
Aydilek Dagdeviren Cakir, Nur Canpolat, Seha Saygili, Isin Kilicaslan, Hande Turan, Oya Ercan, Olcay Evliyaoglu
No abstract text is available yet for this article.
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843110/transitioning-adolescents-to-adult-nephrology-care-a-systematic-review-of-the-experiences-of-adolescents-parents-and-health-professionals
#19
REVIEW
Kimberley Crawford, Cath Wilson, Jac Kee Low, Elizabeth Manias, Allison Williams
A challenging phase for adolescents with chronic kidney disease (CKD) is the transition from a pediatric to an adult health service. Failure to adequately prepare adolescents for transfer to adult care can lead to a decline in attendance to the adult clinic and an increase in the rate of non-adherence to medical treatment. The aim of this systematic review was to analyze studies exploring the experiences of adolescents, parents, and health professionals regarding the transition process of adolescents with CKD...
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30843109/proteinuria-in-a-patient-with-graves-disease-questions
#20
Aydilek Dagdeviren Cakir, Nur Canpolat, Seha Saygili, Isin Kilicaslan, Hande Turan, Oya Ercan, Olcay Evliyaoglu
No abstract text is available yet for this article.
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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