journal
https://read.qxmd.com/read/36952039/what-is-circulating-factor-disease-and-how-is-it-currently-explained
#1
REVIEW
Samantha Hayward, Kevon Parmesar, Moin A Saleem
Nephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous group of disease processes with different underlying drivers. The existence of circulating factor disease (CFD) as a driver of NS has been epitomised by a subset of patients who exhibit disease recurrence after transplantation, alongside laboratory work. Several circulating factors have been proposed and studied, broadly grouped into protease components such as soluble urokinase-type plasminogen activator (suPAR), hemopexin (Hx) and calcium/calmodulin-serine protease kinase (CASK), and other circulating proteases, and immune components such as TNF-α, CD40 and cardiotrophin-like cytokine-1 (CLC-1)...
March 23, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36943469/nsaid-associated-acute-kidney-injury-in-hospitalized-children-a-prospective-pediatric-nephrology-research-consortium-study
#2
JOURNAL ARTICLE
Jason M Misurac, Matthew M Grinsell, JoAnn Hansen Narus, Sherene Mason, Mahmoud Kallash, Sharon P Andreoli
BACKGROUND: Acute kidney injury (AKI) in children has serious short-term and long-term consequences. We sought 1) to prospectively describe NSAID-associated AKI in hospitalized children; 2) to determine if NSAID-associated AKI was more severe in younger children < 5 years; and 3) to follow outcomes after hospitalization for NSAID-associated AKI. METHODS: This was a prospective, multi-center study in hospitalized children 1 month to 18 years...
March 21, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36943468/the-efficacy-and-safety-of-corticosteroids-in-pediatric-kidney-scar-prevention-after-urinary-tract-infection-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#3
REVIEW
Nikolaos Gkiourtzis, Agni Glava, Maria Moutafi, Theopisti Vasileiadou, Theodora Delaporta, Panagiota Michou, Nikoleta Printza, Kali Makedou, Despoina Tramma
BACKGROUND: Acute pyelonephritis (APN) in pediatric patients may lead to kidney scarring and is one of the main causes of permanent kidney damage. The incidence of kidney scarring after one febrile urinary tract infection (UTI) is reported to range from 2.8 to 15%, with the percentage rising to 28.6% after ≥ 3 febrile UTIs. Corticosteroids may have a role in the reduction of kidney scar formation and urine cytokine levels. The possible benefit of adjuvant corticosteroid administration in the reduction of kidney scar formation in children with APN has been recently examined in randomized controlled trials (RCTs)...
March 21, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36943467/daily-serum-phosphate-increase-as-early-and-reliable-indicator-of-kidney-injury-in-children-with-leukemia-and-lymphoma-developing-tumor-lysis-syndrome
#4
JOURNAL ARTICLE
Erika Biró, Dániel Erdélyi, Petra Varga, Mária Sinkó, Katalin Bartyik, Gábor Kovács, Gábor Ottóffy, Ferenc Vincze, István Szegedi, Csongor Kiss, Tamás Szabó
BACKGROUND: Tumor lysis syndrome (TLS) and its most serious complication, acute kidney injury (AKI) are one of the emergency conditions in onco-hematology. It is difficult to predict the degree of kidney involvement. Therefore, we studied children with leukemia and lymphoma treated in four Hungarian tertiary centers (inpatient university clinics) retrospectively (2006-2016) from a nephrological aspect. METHOD: Data of 31 pediatric patients were obtained from electronic- and paper-based medical records...
March 21, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36943466/new-onset-pediatric-idiopathic-nephrotic-syndrome-secondary-to-covid-19
#5
LETTER
Yuhi Takagi, Shigemi Yoshihara
No abstract text is available yet for this article.
March 21, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36941486/world-kidney-day-2023-preparing-for-the-unexpected-supporting-the-vulnerable
#6
EDITORIAL
Ankana Daga, Erica C Bjornstad, Florencio McCarthy, Melvin Bonilla-Felix
No abstract text is available yet for this article.
March 20, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36939917/low-agreement-between-various-egfr-formulae-in-pediatric-and-young-adult-adpkd-patients
#7
JOURNAL ARTICLE
Pieter Schellekens, Marcelien Verjans, Peter Janssens, Angélique Dachy, Stéphanie De Rechter, Luc Breysem, Karel Allegaert, Bert Bammens, Rudi Vennekens, Pieter Vermeersch, Hans Pottel, Djalila Mekahli
BACKGROUND: Young autosomal dominant polycystic kidney disease (ADPKD) patients are becoming the new target population for the development of new treatment options. Determination of a reliable equation for estimated glomerular filtration rate (eGFR) from early stages is needed with the promising potential interventional therapies. METHODS: Prospective and longitudinal study on a cohort of 68 genotyped ADPKD patients (age range 0-23 years) with long-term follow-up...
March 20, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36939916/serum-renin-and-prorenin-concentrations-predict-severe-persistent-acute-kidney-injury-and-mortality-in-pediatric-septic-shock
#8
JOURNAL ARTICLE
Natalja L Stanski, Naomi Pode Shakked, Bin Zhang, Natalie Z Cvijanovich, Julie C Fitzgerald, Parag N Jain, Adam J Schwarz, Jeffrey Nowak, Scott L Weiss, Geoffrey L Allen, Neal J Thomas, Bereketeab Haileselassie, Stuart L Goldstein
BACKGROUND: Studies in critically ill adults demonstrate associations between serum renin concentrations (a proposed surrogate for renin-angiotensin-aldosterone system dysregulation) and poor outcomes, but data in critically ill children are lacking. We assessed serum renin + prorenin concentrations in children with septic shock to determine their predictive ability for acute kidney injury (AKI) and mortality. METHODS: We conducted a secondary analysis of a multicenter observational study of children aged 1 week to 18 years admitted to 14 pediatric intensive care units (PICUs) with septic shock and residual serum available for renin + prorenin measurement...
March 20, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36939915/hyperkalemia-in-pediatric-chronic-kidney-disease
#9
JOURNAL ARTICLE
Katherine L Kurzinski, Yunwen Xu, Derek K Ng, Susan L Furth, George J Schwartz, Bradley A Warady
BACKGROUND: While hyperkalemia is well described in adult chronic kidney disease (CKD), large studies evaluating potassium trends and risk factors for hyperkalemia in pediatric CKD are lacking. This study aimed to characterize hyperkalemia prevalence and risk factors in pediatric CKD. METHODS: Cross-sectional analysis of Chronic Kidney Disease in Children (CKiD) study data evaluated median potassium levels and percentage of visits with hyperkalemia (K ≥5...
March 20, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36939914/nutritional-management-of-children-with-acute-kidney-injury-clinical-practice-recommendations-from-the-pediatric-renal-nutrition-taskforce
#10
REVIEW
Molly R Wong Vega, Dana Cerminara, An Desloovere, Fabio Paglialonga, José Renken-Terhaerdt, Johan Vande Walle, Vanessa Shaw, Stella Stabouli, Caroline Elizabeth Anderson, Dieter Haffner, Christina L Nelms, Nonnie Polderman, Leila Qizalbash, Jetta Tuokkola, Bradley A Warady, Rukshana Shroff, Larry A Greenbaum
The nutritional management of children with acute kidney injury (AKI) is complex. The dynamic nature of AKI necessitates frequent nutritional assessments and adjustments in management. Dietitians providing medical nutrition therapies to this patient population must consider the interaction of medical treatments and AKI status to effectively support both the nutrition status of patients with AKI as well as limit adverse metabolic derangements associated with inappropriately prescribed nutrition support. The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric renal dietitians and pediatric nephrologists, has developed clinical practice recommendations (CPR) for the nutritional management of children with AKI...
March 20, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36929388/predictors-of-rapidly-progressive-glomerulonephritis-in-acute-poststreptococcal-glomerulonephritis
#11
JOURNAL ARTICLE
Deniz Karakaya, Tülin Güngör, Evrim Kargın Çakıcı, Fatma Yazılıtaş, Evra Çelikkaya, Sait Can Yücebaş, Mehmet Bülbül
BACKGROUND: Acute post-streptococcal glomerulonephritis (APSGN) is an immune-mediated inflammatory respsonse in the kidneys caused by nephritogenic strains of group A β-hemolytic streptococcus (GAS). The present study aimed to present a large patient cohort of APSGN patients to determine the factors that can be used for predicting the prognosis and progression to rapidly progressive glomerulonephritis (RPGN). METHODS: The study included 153 children with APSGN that were seen between January 2010 and January 2022...
March 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36929387/deceased-donor-kidney-transplanted-in-childhood-functioning-well-after-52%C3%A2-years
#12
JOURNAL ARTICLE
Giuseppina Spartà, Karine Hadaya, Luc Paunier, Eric Girardin, Ernst Leumann
BACKGROUND: Kidney transplantation in children in 1970 was considered by many to be unethical, as long-term survival was minimal. It was therefore risky at the time to offer transplantation to a child. CASE DIAGNOSIS/TREATMENT: A 6-year-old boy with kidney failure due to haemolytic uraemic syndrome received 4 months of intermittent peritoneal dialysis followed by 6 months of haemodialysis until at 6 years and 10 months, he underwent bilateral nephrectomy and received a kidney transplant from a deceased 18-year-old donor...
March 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36929386/outcomes-associated-with-unrecognized-acute-kidney-injury-in-postoperative-pediatric-cardiac-patients
#13
JOURNAL ARTICLE
Satoshi Kimura, Kazuyoshi Shimizu, Tatsuo Iwasaki, Tomoyuki Kanazawa, Takashi Morimatsu, Takeru Hatano, Hiroshi Morimatsu
BACKGROUND: The present retrospective study was carried out to determine the incidence of unrecognized cardiac surgery-associated acute kidney injury (CSA-AKI) due to infrequency of serum creatinine (SCr) measurements in pediatric cardiac patients and to assess the association between unrecognized CSA-AKI and clinical outcomes. METHODS: This study was a single-center, retrospective study of pediatric patients who underwent cardiac surgery. Patients were diagnosed with CSA-AKI based on SCr measurements, and unrecognized CSA-AKI was defined under the assumptions that there had been only one or two SCr measurements within 48 h after surgery: CSA-AKI unrecognized by one SCr measurement (AKI-URone), CSA-AKI unrecognized by two SCr measurements (AKI-URtwo), and CSA-AKI recognized by one and two SCr measurements (AKI-R)...
March 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36929385/illness-related-parental-stress-and-quality-of-life-in-children-with-kidney-diseases
#14
JOURNAL ARTICLE
Elke De Bruyne, Lore Willem, Koen Van Hoeck, Sarah Reynaert, Sylvie Vankerckhove, Brigitte Adams, Stéphanie Leroi, Laure Collard, Aline Michaux, Nathalie Godefroid, Djalila Mekahli, Noël Knops, Sunny Eloot, Ann Raes, Johan Vande Walle, Eline Van Hoecke, Evelien Snauwaert, Elena Levtchenko
BACKGROUND: This cross-sectional study investigated quality of life (QoL) and illness-related parental stress in children with kidney diseases by (1) comparing mean levels of these two variables between several kidney disease categories; (2) exploring correlations between QoL and parental stress; and (3) describing which disease category reports lowest QoL and highest parental stress. METHODS: We included 295 patients with a kidney disease (0-18 years) and their parents, followed at 6 reference centers for pediatric nephrology...
March 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36929384/gravity-assisted-continuous-flow-peritoneal-dialysis-technique-use-in-acute-kidney-injury-in-children-a-randomized-crossover-clinical-trial
#15
JOURNAL ARTICLE
Peter Nourse, Mignon McCulloch, Ashton Coetzee, Tim Bunchman, Stefano Picca, Jody Rusch, Andre Brooks, Hilton Heydenrych, Brenda Morrow
BACKGROUND: Our previously demonstrated continuous flow peritoneal dialysis (CFPD) technique in children with acute kidney injury (AKI), although effective, was manpower heavy and expensive due to the high-volume pumps required. The aim of this study was to develop and test a novel gravity-driven CFPD technique in children using readily available, inexpensive equipment and to compare this technique to conventional PD. METHODS: After development and initial in vitro testing, a randomised crossover clinical trial was conducted in 15 children with AKI requiring dialysis...
March 16, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36920569/antenatally-detected-urinary-tract-dilatation-long-term-outcome
#16
REVIEW
Maria Herthelius
This review provides updated knowledge on the long-term outcomes among children with antenatally diagnosed urinary tract dilatation (UTD), previously often referred to as antenatal hydronephrosis. Different definitions of UTD exist, which makes comparison between studies and generalized conclusions difficult. Roughly, one-third of antenatally diagnosed UTD, defined as a renal pelvis anterior posterior diameter (APD) of ≥ 4 mm in the second trimester and/or ≥ 7 mm in the third trimester, will resolve before birth, another third will resolve within the first years of life, and in the remaining cases, UTD will persist or a congenital abnormality (CAKUT) will be diagnosed postnatally...
March 15, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36917294/abnormal-teeth-and-renal-calcifications-questions
#17
JOURNAL ARTICLE
Lore Therssen, Loes Lambrecht, Griet Vansteenkiste, Noël Knops
No abstract text is available yet for this article.
March 14, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36917293/primary-hyperoxaluria-type-1-in-children-clinical-and-laboratory-manifestations-and-outcome
#18
JOURNAL ARTICLE
Hala Wannous
BACKGROUND: Primary hyperoxaluria (PH) results from genetic mutations in different genes of glyoxylate metabolism, which cause significant increases in production of oxalate by the liver. This study aimed to report clinical and laboratory manifestations and outcome of PH type 1 in children in our center. METHODS: A single-center observational cohort study was conducted at Children's University Hospital in Damascus, and included all patients admitted from 2018 to 2020, with a diagnosis of hyperoxaluria (urinary oxalate excretion > 45 mg/1...
March 14, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36917292/abnormal-teeth-and-renal-calcifications-answers
#19
JOURNAL ARTICLE
Lore Therssen, Loes Lambrecht, Griet Vansteenkiste, Noël Knops
No abstract text is available yet for this article.
March 14, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36884075/utilizing-therapeutic-drug-monitoring-to-optimize-therapy-with-eculizumab-and-mycophenolate-mofetil-in-a-child-with-c3-glomerulonephritis
#20
JOURNAL ARTICLE
Magdalena Riedl Khursigara, Erin Chung, James Tjon, Damien Noone, Rose Chami, Christoph Licht, Chia Wei Teoh
BACKGROUND: C3 glomerulonephritis (C3GN) can be a devastating disease with poor response to immunosuppressive therapy. Complement inhibition with eculizumab has had equivocal results in patients with C3GN. CASE-DIAGNOSIS/TREATMENT: We report a case of a 6-year-old boy with C3GN presenting with nephrotic syndrome, severe hypertension and impaired kidney function. He did not respond to initial treatment with prednisone and mycophenolate (mofetil and sodium), and subsequent treatment with standard dosing of eculizumab...
March 8, 2023: Pediatric Nephrology
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