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Pediatric Blood & Cancer

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https://read.qxmd.com/read/30786169/abbreviated-breast-magnetic-resonance-imaging-fast-mri-a-novel-approach-to-breast-cancer-screening-in-patients-with-previous-hodgkin-lymphoma
#1
LETTER
Cristiana Indolfi, Salvatore Cappabianca, Francesca Rossi, Silverio Perrotta, Eugenio Procaccini, Elvira Pota, Martina Di Martino, Daniela Di Pinto, Fiorina Casale, Paolo Indolfi
No abstract text is available yet for this article.
February 20, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30786168/disparities-in-the-delivery-of-pediatric-oncology-nursing-care-by-country-income-classification-international-survey-results
#2
Lisa Morrissey, Megan Lurvey, Courtney Sullivan, Julia Challinor, Peter W Forbes, Linda Abramovitz, Glenn M Afungchwi, Rachel Hollis, Sara Day
BACKGROUND: In 2014, a task force of the International Society of Paediatric Oncology (SIOP) Paediatric Oncology in Developing Countries Nursing Workgroup published six baseline standards to provide a framework for pediatric oncology nursing care in low- and lower-middle income countries (L/LMIC). We conducted an international survey in 2016-2017 to examine the association between country income level and nurses' resporting of conformity to the standards at their respective institutions...
February 20, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30786157/phase-i-dose-finding-study-for-melatonin-in-pediatric-oncology-patients-with-relapsed-solid-tumors
#3
Donna L Johnston, Susan Zupanec, Darcy Nicksy, Daniel Morgenstern, Aru Narendran, Rebecca J Deyell, Yvan Samson, Bing Wu, Sylvain Baruchel
BACKGROUND: Melatonin is a natural health product used for sleep disturbances. In preliminary studies of adults with advanced cancer, 20 mg of melatonin daily was associated with reduction in anorexia and weight loss-symptoms that also impact pediatric oncology patients. High doses of melatonin have not been studied in pediatrics. METHODS: This was a multicenter single-arm phase I dose-escalation study utilizing a 3 + 3 design to determine the safety and tolerability of escalating doses of melatonin in pediatric oncology patients with relapsed solid tumors...
February 20, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30773805/agreement-between-clinicoradiological-signs-at-diagnosis-and-radiohistological-analysis-after-neoadjuvant-chemotherapy-of-suspected-wilms-tumor-rupture-consequences-on-therapeutic-choices
#4
Marie-Amelyne Le Rouzic, Ludovic Mansuy, Marie-Agnès Galloy, Jacqueline Champigneulle, Valérie Bernier, Pascal Chastagner
INTRODUCTION: According to SIOP criteria, every patient presenting with preoperative Wilms tumor (WT) rupture must receive abdominal radiotherapy. Neoadjuvant chemotherapy reduces tumor volume and is responsible for the development of peritumoral capsule formation, which can mask tumor rupture on histological analysis, while it was clinically or radiologically obvious at diagnosis. Yet, there are no protocol recommendations for this particular presentation. OBJECTIVES: Study the agreement between clinicoradiological signs and histological confirmation after neoadjuvant chemotherapy of suspected WT rupture and describe the therapeutic choices arising in consequence...
February 17, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30767415/critical-review-of-the-management-of-primary-central-nervous-nongerminomatous-germ-cell-tumors
#5
REVIEW
Mohammad H Abu Arja, Eric Bouffet, Jonathan L Finlay, Mohamed S AbdelBaki
Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor...
February 15, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30767382/fundamental-problems-with-pediatric-adaptive-dosing-of-carboplatin-using-nuclear-medicine-based-estimates-of-renal-function
#6
Peter C Adamson, Gareth J Veal, Richard B Womer, Holly J Meany, M Brooke Bernhardt, A Lindsay Frazier, Frank M Balis
BACKGROUND: Carboplatin is often adaptively dosed based on glomerular filtration rate (GFR), usually estimated by nuclear medicine tests. At least five pediatric adaptive dosing formulas have been developed. In an effort to standardize dosing in Children's Oncology Group protocols, we explored methodologic variation in GFR estimation and adaptive-dosing formula performance. PROCEDURE: Nuclear medicine GFR data from published series of ≥100 children with cancer were compared...
February 15, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30767372/a-qualitative-study-of-sexual-and-reproductive-health-communication-with-adolescent-and-young-adult-oncology-patients
#7
Natasha N Frederick, Anna Revette, Alexis Michaud, Sharon L Bober
BACKGROUND: Adolescent and young adult patients with cancer (AYAs) identify sexual and reproductive health (SRH) as an important but often neglected aspect of their comprehensive cancer care. The purpose of this study was to explore AYA perceptions and experiences of SRH communication with oncology clinicians. METHODS: Twenty-three AYA patients and survivors ages 15-25 years from a large academic oncology center participated in semistructured qualitative interviews investigating their experiences discussing SRH issues, including specific topics discussed, conversation barriers and facilitators, suggestions for clinicians on how to improve conversations, and education and resource needs...
February 15, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30767367/comment-on-ketogenic-diet-treatment-in-recurrent-diffuse-intrinsic-pontine-glioma-in-children-a-safety-and-feasibility-study
#8
LETTER
Alexandre Perez, Laura Merlini, Moatasem El-Ayadi, Christian Korff, Marc Ansari, André O von Bueren
No abstract text is available yet for this article.
February 15, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30762284/aspirin-in-childhood-acute-ischemic-stroke-the-evidence-for-treatment-and-efficacy-testing
#9
REVIEW
Alexander A Boucher, J Michael Taylor, Lori Luchtman-Jones
Aspirin is the most commonly prescribed antiplatelet agent worldwide, but evidence supporting its use varies by age and disease process. Despite its frequent use in childhood acute ischemic stroke prevention and management, major knowledge gaps exist about optimal pediatric aspirin use, particularly in this setting, where high-quality clinical trials are urgently needed. This review focuses upon the evidence for aspirin use in childhood acute ischemic stroke, includes a summary of aspirin pharmacology to highlight misconceptions and common clinical situations which may limit its efficacy, and discusses the techniques and potential role of laboratory monitoring of aspirin efficacy in children...
February 14, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30762282/rhabdomyosarcoma-diagnosed-in-the-first-year-of-life-localized-metastatic-and-relapsed-disease-outcome-data-from-five-trials-and-one-registry-of-the-cooperative-weichteilsarkom-studiengruppe-cws
#10
Monika Sparber-Sauer, Sabine Stegmaier, Christian Vokuhl, Guido Seitz, Thekla von Kalle, Monika Scheer, Marc Münter, Stefan S Bielack, Jadwiga Weclawek-Tompol, Ruth Ladenstein, Felix Niggli, Gustaf Ljungman, Joerg Fuchs, Simone Hettmer, Ewa Koscielniak, Thomas Klingebiel
BACKGROUND: Rhabdomyosarcoma (RMS) diagnosed during the first year of life is reported to have poor outcome. Little is known about treatment and outcome data of relapsed disease (RD). METHODS: Characteristics, treatment, and outcome of 155 patients ≤ 12 months registered within the Cooperative Weichteilsarkom Studiengruppe (CWS) between 1981 and 2016 were evaluated. RESULTS: Localized disease (LD) was diagnosed in 144 patients and metastatic disease (MD) in 11...
February 14, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30761727/the-diagnostic-accuracy-and-clinical-utility-of-pediatric-renal-tumor-biopsy-report-of-the-uk-experience-in-the-siop-uk-wt-2001-trial
#11
Thomas J Jackson, Richard D Williams, Jesper Brok, Tanzina Chowdhury, Milind Ronghe, Mark Powis, Kathy Pritchard-Jones, Gordan M Vujanić
INTRODUCTION: The International Society of Paediatric Oncology (SIOP) protocols recommend preoperative chemotherapy appropriate for Wilms tumors (WTs) in children with renal tumors aged ≥6 months, reserving biopsy for "atypical" cases. The Children's Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation. METHOD: Retrospective study of concordance between locally reported renal tumor biopsies and central pathology review nephrectomy diagnoses of children enrolled by CCLG centers in the SIOP-WT-2001 study...
February 13, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30758124/bloodstream-infections-exacerbate-incidence-and-severity-of-symptomatic-glucocorticoid-induced-osteonecrosis
#12
Emily R Finch, Laura J Janke, Colton A Smith, Seth E Karol, Deqing Pei, Cheng Cheng, Sue C Kaste, Hiroto Inaba, Ching-Hon Pui, Joshua Wolf, Mary V Relling
BACKGROUND: Osteonecrosis is a common toxicity associated with glucocorticoid (e.g., dexamethasone and prednisone) treatment of children with acute lymphoblastic leukemia (ALL), but risk factors are incompletely defined. Infections are also a common complication of ALL therapy. Lipopolysaccharide (LPS) is used experimentally to mimic infection-related systemic effects. To our knowledge, the contribution of systemic infections to the risk of glucocorticoid-induced osteonecrosis has not been investigated...
February 13, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30756484/understanding-measuring-and-addressing-the-financial-impact-of-cancer-on-adolescents-and-young-adults
#13
REVIEW
John M Salsman, Kristin Bingen, Ronald D Barr, David R Freyer
The financial impact of cancer treatment among adolescents and young adults (AYAs, 15-39 years) is deep and long lasting. Compared with other age groups, because of their life stage, AYAs are particularly vulnerable to the adverse economic effects of cancer treatment, also known as financial toxicity. Clinical manifestations of cancer-related financial toxicity include interrupted work and income loss, accumulated debt, treatment nonadherence, avoidance of medical care, and social isolation. Effective clinical interventions should include efforts to increase financial self-efficacy as well as direct support...
February 12, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30746839/indications-and-results-of-diagnostic-biopsy-in-pediatric-renal-tumors-a-retrospective-analysis-of-317-patients-with-critical-review-of-siop-guidelines
#14
Yvan de la Monneraye, J Michon, H Pacquement, I Aerts, Daniel Orbach, F Doz, F Bourdeaut, S Sarnacki, P Philippe-Chomette, G Audry, A Coulomb, P Fréneaux, J Klijanienko, D Berrebi, J-M Zucker, G Schleiermacher, H J Brisse
OBJECTIVES: According to the Renal Tumor Study Group (RTSG) of the International Society of Paediatric Oncology (SIOP), diagnostic biopsy of renal tumors prior to neoadjuvant chemotherapy is not mandatory unless the presentation is atypical for a Wilms tumor (WT). This study addresses the relevance of this strategy as well as the accuracy and safety of image-guided needle biopsy. METHODS: Clinical, radiological, and pathological data from 317 children (141 males/176 females, mean age: 4 years, range, 0-17...
February 12, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740900/low-risk-factors-for-severe-bacterial-infection-and-acute-chest-syndrome-in-children-with-sickle-cell-disease
#15
Elena María Rincón-López, María Luisa Navarro Gómez, Teresa Hernández-Sampelayo Matos, Jesús Saavedra-Lozano, Yurena Aguilar de la Red, Belén Hernández Rupérez, Elena Cela de Julián
INTRODUCTION: The rate of bacterial infections in children with sickle cell disease (SCD) has decreased in recent years, mainly due to penicillin prophylaxis and vaccination. OBJECTIVES: To determine the rate of severe bacterial infection (SBI) in a cohort of children with SCD and to describe low-risk factors for confirmed SBI (CSBI) and acute chest syndrome (ACS). METHODS: This 11-year retrospective cohort study included children with febrile SCD admitted to a reference hospital in Spain...
February 10, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740898/malignant-transformation-of-presacral-mass-in-currarino-syndrome
#16
LETTER
Julien Rod, Celia Cretolle, Laurence Faivre, Caroline Jacquot, Ossama Yacoub, Philippe Ravasse, Nicolas Cheynel, Sabine Sarnacki
No abstract text is available yet for this article.
February 10, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740885/piperacillin-pharmacokinetics-and-target-attainment-in-children-with-cancer-and-fever-can-we-optimize-our-dosing-strategy
#17
Sabine F Maarbjerg, Anders Thorsted, Anders Kristoffersson, Lena E Friberg, Elisabet I Nielsen, Mikala Wang, Birgitte Brock, Henrik Schrøder
BACKGROUND: Data on piperacillin-tazobactam pharmacokinetics and optimal dosing in children with cancer and fever are limited. Our objective was to investigate piperacillin pharmacokinetics and the probability of target attainment (PTA) with standard intermittent administration (IA), and to simulate PTA in other dosing regimens. PROCEDURE: This prospective pharmacokinetic study was conducted from April 2016 to January 2018. Children with cancer receiving empiric piperacillin-tazobactam to treat infections were included...
February 10, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740874/initial-presentation-with-dengue-infection-masking-the-diagnosis-of-acute-lymphoblastic-leukemia
#18
LETTER
Esmee C M Kooijmans, Martine F Raphael
No abstract text is available yet for this article.
February 10, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740866/multimorbidity-and-healthcare-utilization-among-early-survivors-of-pediatric-cancer
#19
Rachel L Harrington, Dima M Qato, James W Antoon, Rachel N Caskey, Glen T Schumock, Todd A Lee
Early survivors of pediatric cancer are at increased risk of experiencing chronic conditions; however, little is known about the morbidity burden in this population. In this observational cohort study of commercially insured pediatric cancer survivors in the United States (2009-2014), we find that 22.5% of survivors had one chronic condition, and 36.3% had multiple. Compared with survivors without chronic conditions, the presence of multiple conditions significantly increased the odds of an emergency department visit by 70% (odds ratios [OR], 1...
February 10, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30740860/in-hospital-mortality-of-hematopoietic-stem-cell-transplantation-among-children-with-nonmalignancies-a-nationwide-study-in-the-united-states-from-2000-to-2012
#20
Takuto Takahashi, Maria A Pereda, Natasha Bala, Sairaman Nagarajan
BACKGROUND: Hematopoietic stem cell transplant (HSCT) can cure or alleviate a wide range of nonmalignant childhood conditions. However, few studies have examined longitudinal national trends of frequency or short-term complications of HSCT before 2006 when an HSCT became a reportable procedure by US law. By using a US nationally representative database, we conducted nationwide longitudinal analyses on demographics, in-hospital mortality, and short-term complications in nonmalignant HSCT from 2000 to 2012...
February 10, 2019: Pediatric Blood & Cancer
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