journal
https://read.qxmd.com/read/36975201/gene-therapy-in-sickle-cell-disease-attitudes-and-informational-needs-of-patients-and-caregivers
#1
JOURNAL ARTICLE
Akshay Sharma, Amanda Young, Yvonne Carroll, Himani Darji, Yimei Li, Belinda N Mandrell, Marquita N Nelson, Curtis L Owens, Mary Irvine, Mary Caples, Lauren P Jerkins, Yoram Unguru, Jane S Hankins, Liza-Marie Johnson
BACKGROUND: Sickle cell disease (SCD) is an inherited blood disorder that results in serious morbidity and early mortality. Novel therapies for SCD, most notably genetic therapies (GTs) and HLA-mismatched donor hematopoietic cell transplantation, are in clinical trials. While potentially curative, these interventions are some of the most intensive treatments for SCD and are associated with serious and life-altering side effects, which may manifest several years after treatment. Little is known about knowledge, beliefs, and attitudes of individuals with SCD, or their caregivers, toward existing and these emerging therapies...
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975184/anthracyclines-for-acute-promyelocytic-leukemia-in-a-female-with-congenital-long-qt-syndrome
#2
LETTER
Miku Kamimura, Takuro Nishikawa, Yoshihiro Takahashi, Jun Nagahama, Shunsuke Nakagawa, Yumiko Ninomiya, Masao Yoshinaga, Yasuhiro Okamoto
No abstract text is available yet for this article.
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975177/a-male-with-ganglioneuroblastoma-cerebrospinal-hemorrhages-cardiomyopathy-and-retinopathy-due-to-severe-hypertension
#3
LETTER
Takuma Deguchi, Hiroko Fukushima, Ryoko Suzuki, Yuni Yamaki, Takumi Ishiodori, Mai Tanaka, Shinichi Fukuda, Kentaro Shirai, Noriaki Sakamoto, Kouji Masumoto, Hidetoshi Takada
No abstract text is available yet for this article.
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975174/the-effects-of-lactocare-synbiotic-administration-on-chemotherapy-induced-nausea-vomiting-diarrhea-and-constipation-in-children-with-all-a-double-blind-randomized-clinical-trial
#4
JOURNAL ARTICLE
Aziz Eghbali, Kazem Ghaffari, Atefeh Khalilpour, Roghayeh Rahimi Afzal, Aygin Eghbali, Ali Ghasemi
BACKGROUND: Synbiotics are supplements containing probiotics and prebiotics and potentially have a stronger effect in modulating the gut microbiota than probiotics or prebiotics alone. The aim of this study was to determine the effects of LactoCare synbiotic administration on chemotherapy-induced diarrhea (CID), nausea, vomiting, and constipation in children with acute lymphoblastic leukemia (ALL) who receiving maintenance chemotherapy. METHODS: This double-blind clinical trial was performed on 113 children with ALL...
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975166/survival-effect-of-complete-surgical-resection-of-the-primary-tumor-in-patients-with-metastatic-high-risk-neuroblastoma-in-a-large-canadian-cohort
#5
JOURNAL ARTICLE
Natashia M Seemann, Craig Erker, Meredith S Irwin, Steven R Lopushinsky, Ketan Kulkarni, Conrad V Fernandez, Rodrigo L P Romao
PURPOSE: To determine whether extent of surgical resection of the primary tumor correlates with survival in patients with International Neuroblastoma Staging System (INSS) stage 4, high-risk neuroblastoma. METHODS: Data were extracted for patients with newly diagnosed INSS stage 4, high-risk neuroblastoma between 2001 and 2019 from the national Cancer in Young People in Canada (CYPC) database. Complete resection was defined as gross total resection of primary tumor based on operative reports...
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975157/a-simple-procedure-to-identify-children-with-b-lineage-acute-lymphoblastic-leukemia-who-can-be-successfully-treated-with-low-or-moderate-intensity-sequential-versus-single-point-minimal-residual-disease-measurement
#6
JOURNAL ARTICLE
Alexander Popov, Guenter Henze, Julia Roumiantseva, Oleg Budanov, Mikhail Belevtsev, Tatiana Verzhbitskaya, Elena Boyakova, Liudmila Movchan, Grigory Tsaur, Maria Fadeeva, Svetlana Lagoyko, Liudmila Zharikova, Natalia Miakova, Dmitry Litvinov, Olga Khlebnikova, Olga Streneva, Elena Stolyarova, Natalia Ponomareva, Galina Novichkova, Larisa Fechina, Olga Aleinikova, Alexander Karachunskiy
Sequential monitoring of minimal residual disease (MRD) by molecular techniques or multicolor flow cytometry (MFC) has emerged over the past two decades as the primary tool to optimize treatment in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The aim of our study was to compare the prognostic power of repeated MFC-MRD measurement with single-point MRD assessment in children with BCP-ALL treated with the reduced-intensity protocol ALL-MB 2008. Data from consecutive MFC-MRD at day 15 and day 36 (end of induction, EOI) were available for 507 children with Philadelphia-negative BCP-ALL...
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975155/severe-autoimmune-lymphoproliferative-syndrome-phenotype-in-a-pediatric-patient-with-a-germline-fas-gene-variant
#7
LETTER
Alexandra Dreyzin, Jinjun Cheng, David Leitenberg, Yaser Diab
No abstract text is available yet for this article.
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36975152/use-of-stereotactic-radiosurgery-in-treatment-of-brain-metastases-from-pediatric-extracranial-solid-tumors
#8
LETTER
Suzanne Xu, Allison Campbell, Veronica Chiang, Ranjit Bindra, Juan Vasquez, Farzana Pashankar
No abstract text is available yet for this article.
March 28, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36973999/prognostic-value-of-xenograft-engraftment-in-patients-with-metastatic-high-risk-neuroblastoma
#9
JOURNAL ARTICLE
Rosario Aschero, Helena Castillo-Ecija, Merce Baulenas-Farres, Claudia Resa-Pares, Ana Jimenez-Cabaco, Eva Rodriguez, Carles Monterrubio, Sara Perez-Jaume, Mariona Suñol, Guillermo L Chantada, Cinzia Lavarino, Jaume Mora, Angel M Carcaboso
BACKGROUND: Successful engraftment of human cancer biopsies in immunodeficient mice correlates with the poor prognosis of patients. This was reported 30 years ago for children with neuroblastoma, but the standard of care treatment evolved significantly during the last 15 years, leading to improved survival of these patients. Here, we evaluated the association of patient-derived xenograft (PDX) engraftment and prognosis in patients receiving up-to-date treatments for cancers classified as metastatic (stage M) high-risk neuroblastoma (HR-NB) by the International Neuroblastoma Risk Group Staging System (INRGSS)...
March 27, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36971444/the-prognostic-value-of-ikzf1-plus-in-b-cell-progenitor-acute-lymphoblastic-leukemia-results-from-the-eortc-58951-trial
#10
JOURNAL ARTICLE
Michal Kicinski, Chloé Arfeuille, Nathalie Grardel, Marleen Bakkus, Aurélie Caye-Eude, Geneviève Plat, Alina Ferster, Anne Uyttebroeck, Barbara De Moerloose, Pierre Rohrlich, Stefan Suciu, Yves Bertrand, Hélène Cavé
BACKGROUND: IKZF1 gene deletion is an indicator of poor prognosis in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The AEIOP/BFM group proposed that the prognostic strength of IKZF1 deletion could be remarkably improved by taking into account additional genetic deletions and reported that among patients with an IKZF1 deletion those with deletions in CDKN2A/2B, PAX5, or PAR1 in the absence of ERG deletion, grouped as IKZF1plus , had the worst outcome. PROCEDURE: Between 1998 and 2008, 1636 patients under 18 years of age with previously untreated BCP-ALL were registered in the EORTC 58951 trial...
March 27, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965193/acute-lymphoblastic-leukemia-with-pancreatic-infiltration-atypical-presentation-of-a-common-disease-in-a-3-month-old-infant-a-case-report
#11
LETTER
Laila Alkhouli, Naser Al Zein
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965191/significant-response-to-targeted-treatment-with-alectinib-for-intramedullary-pediatric-spinal-high-grade-glioma-with-alk-fusion
#12
LETTER
Amit Ringel, Ronit Elhasid, Shlomi Constantini, Jonathan Roth, Rina Dvir
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965190/multifocal-bone-marrow-disease-in-a-young-female-with-myeloid-sarcoma
#13
LETTER
Kritika Patel, Loretta S Li
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965188/a-rare-case-of-hepatoblastoma-in-a-syndromic-child-with-a-de-novo-germline-jag1-mutation
#14
LETTER
Gustavo Dib Dangoni, Anne Caroline Barbosa Teixeira, Talita Ferreira Aguiar, Sofia Mizuho Miura Sugayama, Vicente Odone Filho, Débora Romeo Bertola, Ana Cristina Victorino Krepischi
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965185/supportive-care-in-paediatric-oncology-during-the-pandemic-lessons-from-a-nationwide-survey-in-india
#15
LETTER
Maya Prasad, Nirmalya Roy Moulik
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36965174/combined-treatment-with-venetoclax-dasatinib-and-flt3-inhibitors-for-nup98-nsd1-flt3-itd-acute-myeloid-leukemia-a-pediatric-case-report
#16
LETTER
Xiaojia Wen, Ying Wu, Pengli Huang, Huyong Zheng
No abstract text is available yet for this article.
March 25, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36951413/psychosocial-impact-of-covid-19-on-caregivers-and-adolescents-and-young-adult-survivors-of-childhood-cancer
#17
JOURNAL ARTICLE
Sara King-Dowling, Shannon N Hammer, Haley Faust, Rebecca Madden, Sarah Drake, Annisa Ahmed, May Albee, Janet A Deatrick, Lauren Daniel, Ahna Pai, David Freyer, Alexandra M Psihogios, Lamia P Barakat, Lisa A Schwartz
BACKGROUND: Caregivers and adolescents and young adult (AYA) cancer survivors may be at greater psychosocial risk from the COVID-19 pandemic than healthy peers due to complex and traumatic medical histories. This study describes COVID-19-related event exposures, impact, and distress among a large sample of caregivers and AYA cancer survivors and the relationship of these variables to demographic and cancer characteristics. PROCEDURE: From May 2020 to December 2021, 422 caregivers and 531 AYA survivors completed the COVID-19 Exposures and Family Impact Survey (CEFIS) and CEFIS-AYA, respectively...
March 23, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36945123/children-s-oncology-group-kidscare-smartphone-application-for-parents-of-children-with-cancer
#18
JOURNAL ARTICLE
Wendy Landier, Paula D Campos Gonzalez, Harrison Henneberg, Jocelyn M York, Aman Wadhwa, Kandice Adams, Avi Madan-Swain, Julie Anna Wolfson, Beth Benton, Cindi Seidel, Valencia Slater, Kim Snuggs, Amy Folsom, Jeneane Miller, Kathryn Tomlinson, Susan Zupanec, Smita Bhatia
BACKGROUND: Parents of children with cancer must learn and retain crucial information necessary to provide safe care for their child. Smartphone applications (apps) provide a significant opportunity to meet the informational needs of these parents. We aimed to develop, refine, and evaluate a smartphone app, informed by the Children's Oncology Group (COG) expert consensus recommendations, to support the informational needs of parents of children with cancer. PROCEDURE: We employed a user-centered iterative mixed-methods approach in two phases (prototype development/refinement and pilot testing)...
March 21, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36939061/sweet-syndrome-masquerading-as-a-disseminated-and-pulmonary-fungal-disease-in-a-child-with-acute-myeloid-leukemia-case-report-and-review-of-the-literature
#19
LETTER
Shannon Hamilton, Karen Trevino, Muayad Alali
No abstract text is available yet for this article.
March 20, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/36939038/stand-with-ukraine
#20
LETTER
Stefan S Bielack
No abstract text is available yet for this article.
March 20, 2023: Pediatric Blood & Cancer
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