Lorenzo Subissi, Paola Stefanelli, Giovanni Rezza
The eradication of smallpox and the cessation of vaccination have led to the growth of the susceptible human population to poxviruses. This has led to the increasing detection of zoonotic orthopoxviruses. Among those viruses, monkeypox virus (MPV) is the most commonly detected in Western and Central African regions. Since 2022, MPV is causing local transmission in newly affected countries all over the world. While the virus causing the current outbreak remains part of clade II (historically referred to as West African clade), it has a significant number of mutations as compared to other clade II sequences and is therefore referred to as clade IIb...
September 16, 2023: Pathogens and Global Health
Safae El Mazouri, Abdelmounim Essabbar, Tarik Aanniz, Rachid Eljaoudi, Lahcen Belyamani, Azeddine Ibrahimi, Mouna Ouadghiri
Among the numerous variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that have been reported worldwide, the emergence of the Omicron variant has drastically changed the landscape of the coronavirus disease (COVID-19) pandemic. Here, we analyzed the genetic diversity of Moroccan SARS-CoV-2 genomes with a focus on Omicron variant after one year of its detection in Morocco in order to understand its genomic dynamics, features and its potential introduction sources. From 937 Omicron genomes, we identified a total of 999 non-unique mutations distributed across 92 Omicron lineages, of which 13 were specific to the country...
August 27, 2023: Pathogens and Global Health
Gianpiero Tebano, Elisa Vanino, Paolo Muratori, Francesco Cristini
Neglected tropical diseases (NTDs) are a group of diseases mainly affecting people in low- and middle-income Countries. The aim of this study was to perform a bibliometric analysis of the scientific literature on NTDs. Using the MeSH database, we quantified the number of publications on MEDLINE targeting each NTD, which were published from 1 January 1999 to 31 January 2019. In order to weight the number of publications targeting a given NTD according to the total number of publications/year, we calculated a Yearly Publication Index (YPI) for each NTD/year...
August 22, 2023: Pathogens and Global Health
Bianca Conrad Bohm, Maria Helena Franco Morais, Maria da Consolação Magalhães Cunha, Nádia Campos Pereira Bruhn, Waleska Teixeira Caiaffa, Fábio Raphael Pascoti Bruhn
Dengue is a viral infection transmitted by the Aedes aegypti mosquito. This study aimed to assess the distribution of cases and deaths from dengue and severe dengue, and its relationship with social vulnerability in Belo Horizonte, State of Minas Gerais, Brazil, from 2010 to 2018. The incidence and lethality rates of dengue and their relationship with sex, age, education, skin color, and social vulnerability were studied using chi-square tests, Ordinary Least Squares (OLS), and Geographically Weighted Regression (GWR) analyses...
August 21, 2023: Pathogens and Global Health
Ankita Agarwal, Ruchi Ganvir, Dipesh Kale, Deepti Chaurasia, Garima Kapoor
Central India faced major dengue outbreaks in 2019 and 2021. In the present study, we aimed to identify the dengue virus serotypes and genotypes circulating in Central India during the COVID pre-pandemic year (2019) and ongoing-pandemic year (2021). For this purpose, the suspected cases were first tested by serological assays. Sero-positive samples were then subjected to molecular diagnosis by RT-PCR and semi-nested PCR. The serotypes obtained were confirmed by nucleotide sequencing. A phylogenetic analysis of serotypes was performed to identify the circulating genotypes...
August 13, 2023: Pathogens and Global Health
Ronga Luigi, Stolfa Stefania, Indraccolo Francesca, Romanelli Federica, Bavaro Davide Fiore, Saracino Annalisa, Di Gennaro Francesco, Milano Eugenio, Manuela Mandorino, Mosca Adriana, Sparapano Eleonora, De Carlo Carmela, Nisi Lucia, Ranieri Enrica, Mastria Michele, Montagna Maria Teresa, Del Prete Raffaele
Human papillomavirus (HPV) is considered the commonest viral cause of sexually transmitted infections. The impact of social distance measures due to Covid-19 pandemic on HPV spread is unknown. Therefore, this study has analyzed the seven-year trend of HPV prevalence in all patients tested for HPV DNA at the Microbiology and Virology Unit at Bari Policlinico. Moreover, the HPV prevalence in 2020 has been compared with the previous year ones in order to evaluate the consequences of lockdown and social distancing measures on transmission risks...
August 2, 2023: Pathogens and Global Health
María Asunción Pérez-Jacoiste Asín, Marta De Castro, Begoña De Dios, Ana Pérez-Ayala, Antonio Lalueza, Ana García-Reyne, Irene Losada, Juan María Herrero-Martínez, Pilar Hernández Jiménez, Carlos Lumbreras, Manuel Lizasoain, Francisco López Medrano
Strongyloides stercoralis hyperinfection syndrome has been observed in immunosuppressed coronavirus disease 2019 (COVID-19) patients. Detecting and treating asymptomatic Strongyloides infection in individuals from endemic areas can effectively prevent hyperinfection. Unfortunately, many clinicians are unaware of this neglected infection. Therefore, we aimed to evaluate whether including Strongyloides screening in COVID-19 management protocols would encourage this practice. To accomplish this, we conducted a retrospective single-center study at 'Hospital Universitario 12 de Octubre' in Madrid, Spain, comparing two consecutive cohorts...
July 31, 2023: Pathogens and Global Health
Asmaa R Ellakany, Hanan El Baz, Zeinab S Shoheib, Mohamed Elzallat, Dalia S Ashour, Nabila A Yassen
Schistosomiasis is a neglected tropical disease. Egg-induced granuloma formation and tissue fibrosis are the main causes of the high morbidity and mortality of schistosomiasis. Mesenchymal stem cells (MSCs)-derived exosomes play an important role with a superior safety profile than MSCs in the treatment of liver fibrosis. Therefore, the aim of this study was to investigate the potential therapeutic effect of MSCs-derived exosomes on schistosomal hepatic fibrosis. Exosomes were isolated from bone marrow MSCs and characterized...
July 30, 2023: Pathogens and Global Health
Tony Haykal, Jonathan Mina, Mohamad Fleifel, Hani Dimassi, Janane Nasr, Ahmad Mahdi, Ranime Harb, Ghida El Hout, Elissar Franjieh, Jacques Mokhbat, Anna Farra, Mariana Helou, Rola Husni
This study aims to describe COVID-19 patients characteristics, laboratory and imaging results, and the different outcomes of patients admitted to the Lebanese American University Medical Center-Rizk Hospital over a period of 9 months. In this observational retrospective study, data were obtained from electronic medical records of 491 male and female patients from the ages of 17 to 97. Analysis of the patients was performed in 3 periods: August 2020 to October 20 November 202020 to January 2021 and February 2021 to April 2021 corresponding with 3 waves of newly diagnosed cases during this period...
July 23, 2023: Pathogens and Global Health
Parisa Sadeghi, Karim Mahnam, Azhar Salari-Jazi, Ashok Aspatwar, Jamshid Faghri
Pseudomonas aeruginosa has different antibiotic resistance pathways, such as broad-spectrum lactamases and metallo-β-lactamases (MBL), penicillin-binding protein (PBP) alteration, and active efflux pumps. Polymerase chain reaction (PCR) and sequencing methods were applied for double-locus sequence typing (DLST) and New Delhi metallo-β-lactamase (NDM) typing. We deduced the evolutionary pathways for DLST and NDM genes of P. aeruginosa using phylogenetic network. Among the analyzed isolates, 62.50% of the P...
July 18, 2023: Pathogens and Global Health
Alexandra Martín Ramírez, Lourdes Barón Argos, Marta Lanza Suárez, Claudia Carmona Rubio, Ana Pérez-Ayala, Shamilah R Hisam, José M Rubio
Malaria is a parasitic disease distributed in tropical areas but with a high number of imported cases in non-endemic countries. The most specific and sensitive malaria diagnostic methods are PCR and LAMP. However, both require specific equipment, extraction procedures and a cold chain. This study aims to solve some limitations of LAMP method with the optimization and validation of six LAMP assays, genus and species-specific, using an easy and fast extraction method, the incorporation of a reaction control assay, two ways (Dual) of result reading and reagent lyophilization...
July 6, 2023: Pathogens and Global Health
Ngoc-Ha Tran, Nguyen Khoi Quan, Van Phu Tran, Dang Nguyen, Ngoc Phuong Hong Tao, Nguyen Ngoc Hoang Linh, Nguyen Tien Huy
No abstract text is available yet for this article.
July 3, 2023: Pathogens and Global Health
Alyexandra Arienzo, Valentina Gallo, Federica Tomassetti, Nicoletta Pitaro, Michele Pitaro, Giovanni Antonini
The Coronavirus disease 19 (COVID-19) pandemics, caused by severe acute respiratory syndrome coronaviruses, SARS-CoV-2, represent an unprecedented public health challenge. Beside person-to-person contagion via airborne droplets and aerosol, which is the main SARS-CoV-2's route of transmission, alternative modes, including transmission via fomites, food and food packaging, have been investigated for their potential impact on SARS-CoV-2 diffusion. In this context, several studies have demonstrated the persistence of SARS-CoV-2 RNA and, in some cases, of infectious particles on exposed fomites, food and water samples, confirming their possible role as sources of contamination and transmission...
June 23, 2023: Pathogens and Global Health
Francesco Branda, Sandra Mazzoli
No abstract text is available yet for this article.
June 20, 2023: Pathogens and Global Health
Rawan Masarwa, Yaniv Yonai, Merav Ben-Natan, Yaron Berkovich
In 2022, the Mpox viral outbreak signaled a global public health emergency. Infectious disease management and prevention are crucial tasks for healthcare workers. In their line of work, orthopedic surgeons could come across cases of the Mpox virus. The aim of the present study was to explore orthopedic surgeons' knowledge of the Mpox virus, their conspiracy beliefs regarding emerging viral infections, and their self-confidence in managing the Mpox virus. In this cross-sectional survey, 137 orthopedic surgeons completed an online questionnaire...
June 20, 2023: Pathogens and Global Health
Héctor Serrano-Coll, Mónica Muñoz, Juan Camilo Beltrán, Nora Cardona-Castro
INTRODUCTION: Leprosy is a chronic infectious disease caused by two mycobacteria (Mycobacterium leprae and Mycobacterium lepromatosis). The household contacts (HHC) of leprosy index cases are at higher risk of being infected with these mycobacteria. Therefore, serological testing in HHC would be an effective strategy to eliminate leprosy in Colombia. OBJECTIVE: To determine the seroprevalence and factors associated with the infection by M. leprae in HHC. METHODS: An observational study was conducted in 428 HHC located in the Colombian Caribbean, Andean, Pacific, and Amazonian regions...
May 25, 2023: Pathogens and Global Health
Carly Ching, Muhammad H Zaman
No abstract text is available yet for this article.
May 23, 2023: Pathogens and Global Health
Maryam Akbari, Hossein Heli, Ahmad Oryan, Gholamreza Hatam
The visceral form of leishmaniasis (VL), due to infection by Leishmania infantum , is a neglected tropical disease. The accessible therapeutic options are limited. Artemisinin is an efficient antileishmanial product with poor biological availability that requires high repetition of therapeutic doses in VL. Solid lipid nanoparticles (SLNs) provide targeted delivery, increase bioavailability and reduce toxicity of the traditional therapeutic strategy. The spherical shape artemisinin-loaded SLNs were prepared in a particle diameter of 222...
May 15, 2023: Pathogens and Global Health
Chigozie A Ogwara, Jennifer W Ronberg, Sierra M Cox, Briana M Wagner, Jacqueline W Stotts, Gerardo Chowell, Anne C Spaulding, Isaac Chun-Hai Fung
To study the SARS-CoV-2 transmission potential in Rhode Island (RI) and its association with policy changes and mobility changes, the time-varying reproduction number, Rt , was estimated. The daily incident case counts (16 March 2020, through 30 November 2021) were bootstrapped within a 15-day sliding window and multiplied by Poisson-distributed multipliers (λ = 4, sensitivity analysis: 11) to generate 1000 estimated infection counts, to which EpiEstim was applied to generate Rt time series...
April 19, 2023: Pathogens and Global Health
Abhi Mallick, Abhiparna Roy, Soma Sarkar, Keshab Ch Mondal, Surojit Das
The acute crisis of carbapenem resistance impedes the empirical use of carbapenems in medical emergencies, especially, bloodstream infections. Carbapenemase-producing carbapenem-resistant organisms (CP-CROs) attribute high case-fatality, necessitating rapid diagnostics to initiate early targeted antibiotics. Expensive diagnostics are the major driver of antibiotic misuse, neglecting evidence-based treatment in India. One in-house molecular diagnostics assay was customized for rapid detection of CP-CROs using positive blood-culture (BC) broths at a low-cost...
April 17, 2023: Pathogens and Global Health
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