journal
https://read.qxmd.com/read/38354848/obesity-and-body-mass-index-past-and-future-considerations-in-osteoarthritis-research
#21
REVIEW
Kristine Godziuk, Gillian A Hawker
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties and limitations. These include an inability to discern fat and muscle mass, account for sex-differences in fat distribution, or identify adiposityrelated health impairments. A focus on BMI in OA research may influence weight bias in clinical practice and impact disparities in access to effective OA treatments. To ensure that our understanding and approaches to improve health outcomes for individuals with or at risk for OA continues to advance in the next decade, future research will need to consider alternative measures beyond BMI for obesity identification and align with evolving obesity science...
February 12, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38354847/changing-the-narrative-on-osteoarthritis-a-call-for-global-action
#22
EDITORIAL
C Jinks, A Botto-van Bemden, J Bowden, S Bunzli, J Eyles, T Egerton, N E Foster, E L Healey, J Maddison, D O'Brien, E Parry, J G Quicke, D Schiphof, M J Thomas, M A Holden
No abstract text is available yet for this article.
February 12, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38331162/30-years-of-mri-based-cartilage-bone-morphometry-in-knee-osteoarthritis-from-correlation-to-clinical-trials
#23
REVIEW
Felix Eckstein, Anita E Wluka, Wolfgang Wirth, Flavia Cicuttini
OBJECTIVE: The first publication on morphometric analysis of articular cartilage using magnetic resonance imaging (MRI) in 1994 set the scene for a game change in osteoarthritis (OA) research. The current review highlights milestones in cartilage and bone morphometry, summarizing the rapid progress made in imaging, its application to understanding joint (patho-)physiology, and its use in interventional clinical trials. METHODS: Based on a Pubmed search of articles from 1994 to 2023, the authors subjectively selected representative work illustrating important steps in the development or application of MR-based cartilage and bone morphometry, with a focus on studies in humans, and on the knee...
February 6, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38325599/adoption-of-core-outcome-sets-in-osteoarthritis-clinical-trials-still-a-long-way-to-go
#24
EDITORIAL
Toby O Smith
No abstract text is available yet for this article.
February 5, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38311107/associations-of-inflammatory-and-metabolic-biomarkers-with-incident-erosive-hand-osteoarthritis-in-the-osteoarthritis-initiative-cohort
#25
JOURNAL ARTICLE
Timothy E McAlindon, Jennifer L Hunnicutt, Mary B Roberts, Ida K Haugen, Lena F Schaefer, Jeffrey B Driban, Bing Lu, Jeffrey Duryea, Stacy E Smith, Sarah L Booth, Gayle A Petty, Alexander Mathiessen, Li Zeng, Charles Eaton
OBJECTIVE: Erosive hand osteoarthritis (eHOA) is a subtype of hand OA that develops in finger joints with pre-existing osteoarthritis and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. METHOD: This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline and 48-months, and biospecimens collected at baseline...
February 2, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38244717/molecular-pathogenesis-of-oa-pain-past-present-and-future
#26
JOURNAL ARTICLE
Tonia L Vincent, Rachel E Miller
OBJECTIVE: To provide a historical perspective and narrative review on research into the molecular pathogenesis of osteoarthritis pain. DESIGN: PubMed databases were searched for combinations of "osteoarthritis", "pain" and "animal models" for papers that represented key phases in the history of osteoarthritis pain discovery research including epidemiology, pathology, imaging, preclinical modelling and clinical trials. RESULTS: The possible anatomical sources of osteoarthritis pain were identified over 50 years ago, but relatively slow progress has been made in understanding the apparent disconnect between structural changes captured by radiography and symptom severity...
January 18, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38242313/assessing-the-association-of-epigenetic-age-acceleration-with-osteoarthritis-in-the-multicenter-osteoarthritis-study-most
#27
JOURNAL ARTICLE
Michelle S Yau, Paul C Okoro, Ida K Haugen, John A Lynch, Michael C Nevitt, Cora E Lewis, James C Torner, David T Felson
PURPOSE: Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. METHODS: We analyzed data from the Multicenter Osteoarthritis Study in a subset of 671 participants ages 45-69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina Infinium MethylationEPIC 850K array. We calculated predicted epigenetic age according to Hannum, Horvath, PhenoAge, and GrimAge epigenetic clocks, then regressed epigenetic age on chronological age to obtain the residuals...
January 17, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38242312/anaphylatoxins-and-their-corresponding-receptors-as-potential-drivers-in-cartilage-calcification-during-osteoarthritis-progression
#28
JOURNAL ARTICLE
Leonie Ruths, Markus Huber-Lang, Gundula Schulze-Tanzil, Jana Riegger
OBJECTIVE: The complement cascade as major fluid phase innate immune system is activated during progression of osteoarthritis (OA). Generated anaphylatoxins and the corresponding receptors C3aR and C5aR1 are associated with the calcification of blood vessels and involved in osteogenic differentiation. This study aims on elucidating whether complement activation products contribute to cartilage calcification of OA cartilage. METHOD: Human articular chondrocytes were osteogenically differentiated in vitro in the presence or absence of C3a, C5a, and bone morphogenetic protein (BMP) 2...
January 17, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38237761/looking-back-on-30-years-of-the-johnston-county-osteoarthritis-project-while-looking-forward-with-the-johnston-county-health-study-a-narrative-review
#29
JOURNAL ARTICLE
Yvonne M Golightly, Jordan B Renner, Charles G Helmick, Joanne M Jordan, Amanda E Nelson
Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and Osteoarthritis and Cartilage has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding prevalence, incidence, and progression of OA, as well as its risk factors, in a predominantly rural population of Black and White adults 45+ years old in a county in the southeastern United States...
January 17, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38237760/optimising-the-implementation-of-evidence-based-osteoarthritis-guidelines-in-primary-care-development-of-a-knowledge-mobilisation-toolkit
#30
JOURNAL ARTICLE
Laura Swaithes, Zoe Paskins, Andrew Finney, Nicola Walsh, Magdalena Skrybant, Christian Mallen, Krysia Dziedzic
OBJECTIVE: Implementing clinical guidelines for osteoarthritis in primary care is complex. Whilst international guidelines detail what best practice for osteoarthritis looks like, little is known about how this is best implemented. Limited resources are available to guideline developers, practitioners, researchers, or the public to facilitate implementation. Set in the context of a larger research project which sought to understand the factors that influence knowledge mobilisation (KM) in implementation for osteoarthritis guidelines, this study reports the development of a toolkit to optimise KM for the implementation of evidence-based osteoarthritis guidelines in primary care...
January 16, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38218227/efficacy-and-safety-of-collagen-derivatives-for-osteoarthritis-a-trial-sequential-meta-analysis
#31
JOURNAL ARTICLE
Chun-Wei Liang, Hsiao-Yi Cheng, Yu-Hao Lee, Chun-De Liao, Shih-Wei Huang
OBJECTIVE: To investigate the efficacy and safety of collagen derivatives for osteoarthritis. DESIGN: PubMed, Embase, and Cochrane Library were searched till June 2023 for randomized controlled trials (RCTs) investigating collagen derivatives for treating osteoarthritis. Data were independently extracted by two authors. The risk of bias was assessed using the RoB 2 tool. A random-effects meta-analysis was performed within a frequentist framework. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations approach...
January 11, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38211810/a-perspective-on-the-evolution-of-semi-quantitative-mri-assessment-of-osteoarthritis-past-present-and-future
#32
JOURNAL ARTICLE
Frank W Roemer, Mohamed Jarraya, Daichi Hayashi, Michel D Crema, Ida K Haugen, David J Hunter, Ali Guermazi
OBJECTIVE: This perspective describes the evolution of semi-quantitative (SQ) magnetic resonance imaging (MRI) in characterizing structural tissue pathologies in osteoarthritis (OA) imaging research over the last 30 years. METHODS: Authors selected representative articles from a PubMed search to illustrate key steps in SQ MRI development, validation, and application. Topics include main scoring systems, reading techniques, responsiveness, reliability, technical considerations, and potential impact of artificial intelligence (AI)...
January 10, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38199296/the-evolving-landscape-of-gene-therapy-strategies-for-the-treatment-of-osteoarthritis
#33
JOURNAL ARTICLE
Matthew W Grol
OBJECTIVES: Significant advances have been made in our understanding of osteoarthritis (OA) pathogenesis; however, no disease-modifying therapies have been identified. This review will summarize the gene therapy landscape, its initial successes for OA, and possible challenges using recent studies and examples of gene therapies in clinical trials. DESIGN: This narrative review has three major sections: 1) vector systems for OA gene therapy, 2) current and emerging targets for OA gene therapy, and 3) considerations and future directions...
January 8, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38190960/mitonuclear-epistasis-involving-tp63-and-haplogroup-uk-risk-of-rapid-progression-of-knee-oa-in-patients-from-the-oai
#34
JOURNAL ARTICLE
Alejandro Durán-Sotuela, Natividad Oreiro, Mercedes Fernández-Moreno, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To investigate genetic interactions between mitochondrial deoxyribonucleic acid (mtDNA) haplogroups and nuclear single nucleotide polymorphisms (nSNPs) to analyze their impact on the development of the rapid progression of knee osteoarthritis (OA). DESIGN: A total of 1095 subjects from the Osteoarthritis Initiative, with a follow-up time of at least 48-months, were included. Appropriate statistical approaches were performed, including generalized estimating equations adjusting for age, gender, body mass index, contralateral knee OA, Western Ontario and McMaster Universities Osteoarthritis Index pain, previous injury in target knee and the presence of the mtDNA variant m...
January 6, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38160744/is-rankl-a-potential-molecular-target-in-osteoarthritis
#35
REVIEW
Dzenita Muratovic, Gerald J Atkins, David M Findlay
OBJECTIVE: Osteoarthritis (OA) is a disease of joints, in which the bone under the articular cartilage undergoes increased remodelling activity. The question is whether a better understanding of the causes and mechanisms of bone remodelling can predict disease-modifying treatments. DESIGN: This review summarises the current understanding of the aetiology of OA, with an emphasis on events in the subchondral bone (SCB), and the cells and cytokines involved, to seek an answer to this question...
December 30, 2023: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38128875/biomarkers-have-to-make-sense
#36
EDITORIAL
André Struglics
No abstract text is available yet for this article.
March 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38035975/osteoarthritis-year-in-review-2023-epidemiology-therapy
#37
REVIEW
Anthony V Perruccio, James J Young, Jessica M Wilfong, J Denise Power, Mayilee Canizares, Elizabeth M Badley
OBJECTIVE: To highlight some important findings from osteoarthritis (OA) epidemiology and therapy research undertaken over the past year. METHODS: Search of MEDLINE and EMBASE databases between April 1, 2022 to March 3, 2023 using "exp *Osteoarthritis/" as the preliminary search term. The search was limited to articles published in English and including human subjects. Final inclusions were based on perceived importance and results that may inform improved identification of risk factors or OA treatments, as well as OA subgroups of potential relevance to risk factors or treatment approaches...
February 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/37944663/osteoarthritis-year-in-review-2023-biology
#38
REVIEW
Anke J Roelofs, Cosimo De Bari
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from the end of April 2022 to the end of April 2023. The selected articles have been arranged in themes. These include 1) molecular regulation of articular cartilage and implications for OA, 2) mechanisms of subchondral bone remodelling, 3) role of synovium and inflammation, 4) role of age-related changes including cartilage matrix stiffening, cellular senescence, mitochondrial dysfunction, metabolic dysfunction, and impaired autophagy, and 5) peripheral mechanisms of OA pain...
February 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/37805005/counsel-and-weight-loss-in-knee-hip-osteoarthritis
#39
EDITORIAL
Henning Bliddal
No abstract text is available yet for this article.
January 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/37648149/kr%C3%A3-ppel-like-factor-15-deficiency-exacerbates-osteoarthritis-through-reduced-expression-of-peroxisome-proliferator-activated-receptor-gamma-signaling-in-mice
#40
JOURNAL ARTICLE
Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda
OBJECTIVE: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). METHODS: 0Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining were performed...
January 2024: Osteoarthritis and Cartilage
journal
journal
20209
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.