Read by QxMD icon Read

Osteoarthritis and Cartilage

Jos Runhaar, Daniel P Beavers, Gary D Miller, Barbara Nicklas, Richard Loeser, Sita Bierma-Zeinstra, Stephen Messier
OBJECTIVE: Diet restriction and exercise form key treatments for osteoarthritis (OA) related symptoms in overweight and obese individuals. Although both interventions are known to influence systemic low-grade inflammation, which is related to pain levels and functional limitations, little is known about the potential changes in systemic inflammation as a working mechanism of diet restriction and exercise in knee OA. DESIGN: Data from the Arthritis, Diet, and Activity Promotion Trial (ADAPT) were used...
April 19, 2019: Osteoarthritis and Cartilage
Nicole Hecht, Brian Johnstone, Peter Angele, Tilman Walker, Wiltrud Richter
OBJECTIVE: Elucidation of whether miRs are involved in mechanotransduction pathways by which cartilage is maintained or disturbed has a particular importance in our understanding of osteoarthritis (OA) pathophysiology. The aim was to investigate whether mechanical loading influences global miR-expression in human chondrocytes and to identify mechanosensitive miRs responding to beneficial and non-beneficial loading regimes as potential to obtain valuable diagnostic or therapeutic targets to advance OA-treatment...
April 19, 2019: Osteoarthritis and Cartilage
Anna Cronström, Leif E Dahlberg, Håkan Nero, Catharina Sjödahl Hammarlund
OBJECTIVE: To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA). DESIGN: Nineteen patients with hip or knee OA were interviewed after finishing their first six weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed using a systematic text condensation method...
April 16, 2019: Osteoarthritis and Cartilage
Sebastian Wangler, Ursula Menzel, Zhen Li, Junxuan Ma, Sven Hoppe, Lorin M Benneker, Mauro Alini, Sibylle Grad, Marianna Peroglio
OBJECTIVE: This study aimed to characterize the mesenchymal stem cell (MSC) subpopulation migrating towards a degenerated intervertebral disc (IVD) and to assess its regenerative potential. DESIGN: Based on initial screening for migration towards chemokine ligand 5 (CCL5), the migration potential of CD146+ and CD146- MSCs was evaluated in vitro and in a degenerated organ culture model (degeneration by high-frequency loading in a bioreactor). Discogenic differentiation potential of CD146+ and CD146- MSCs was investigated by in vitro pellet culture assay with supplementation of growth and differentiation factor-6 (GDF6)...
April 16, 2019: Osteoarthritis and Cartilage
Amanda E Nelson, Fuhui Fang, Liubov Arbeeva, Rebecca J Cleveland, Todd A Schwartz, Leigh F Callahan, J S Marron, Richard F Loeser
OBJECTIVE: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping in order to define progression phenotypes that are potentially more responsive to interventions. DESIGN: We used publicly available data from the FNIH OA Biomarkers Consortium, where radiographic (medial joint space narrowing of ≥0.7mm), and pain progression (increase of ≥9 WOMAC points) were defined at 48 months, as four mutually exclusive outcome groups (none, both, pain only, radiographic only), along with an extensive set of covariates...
April 16, 2019: Osteoarthritis and Cartilage
Stefan Kluzek, Tobias A Mattei
No abstract text is available yet for this article.
April 16, 2019: Osteoarthritis and Cartilage
Emma Parry, Reuben Ogollah, George Peat
OBJECTIVE: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures. DESIGN: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects)...
April 14, 2019: Osteoarthritis and Cartilage
C A Zurmühle, F Schmaranzer, K Nuss, N Wolfer, M K Ryan, G Zheng, B von Rechenberg, M Tannast
OBJECTIVE: In ovine hips chondrolabral damage as seen in cam-type femoroacetabular impingement (FAI) can be induced via an intertrochanteric varus osteotomy. However, it is yet to proven whether the observed cartilage damage is caused by a dynamic cam type impingement. Thus we asked, (1) whether actual cartilage damage observed after FAI induction in ovine hips occurs at the predicted, computed zone of FAI; (2) whether the extent of cartilage damage increases with ambulation time in this animal model? DESIGN: In this experimental, controlled, comparative study 20 sheep underwent unilateral FAI induction through an intertrochanteric varus osteotomy...
April 13, 2019: Osteoarthritis and Cartilage
S van Beest, W Damman, R Liu, M Reijnierse, F R Rosendaal, M Kloppenburg
OBJECTIVE: To investigate determinants of decrease and increase in joint pain in symptomatic finger osteoarthritis (OA) on magnetic resonance (MR) imaging over two years. DESIGN: Eighty-five patients (81.2% women, mean age 59.2 years) with primary hand OA (89.4% fulfilling ACR classification criteria) from a rheumatology outpatient clinic received contrast-enhanced MR imaging (1.5T) and physical examination of the right interphalangeal finger joints 2-5 at baseline and at follow-up two years later...
April 9, 2019: Osteoarthritis and Cartilage
Satoshi Miyamura, Kunihiro Oka, Takashi Sakai, Hiroyuki Tanaka, Ryoya Shiode, Shoichi Shimada, Tatsuo Mae, Kazuomi Sugamoto, Hideki Yoshikawa, Tsuyoshi Murase
OBJECTIVE: The present quantitative study aimed to assess the three-dimensional (3-D) cartilage wear patterns of the first metacarpal and trapezium in the advanced stage of osteoarthritis (OA) and compare cartilage measurements with radiographic severity. DESIGN: Using 19 cadaveric trapeziometacarpal (TMC) joints, 3-D cartilage surface models of the first metacarpal and trapezium were created with a laser scanner, and 3-D bone surface model counterparts were similarly created after dissolving the cartilage...
April 4, 2019: Osteoarthritis and Cartilage
Laura R Swaithes, Krysia S Dziedzic, Elizabeth Cottrell, Jonathan G Quicke
No abstract text is available yet for this article.
March 29, 2019: Osteoarthritis and Cartilage
Su Fu Md, Clare L Thompson PhD, Ahmed Ali, Wen Wang PhD, Paul Chapple PhD, Hannah M Mitchison Phd, Phil L Beales, Angus K Wann PhD, Martin M Knight PhD
OBJECTIVE: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and associated intraflagellar transport (IFT) in the mechanical regulation of interleukin-1β (IL-1β) signalling. DESIGN: Isolated chondrocytes and cartilage explants were subjected to cyclic mechanical loading in the presence and absence of the cytokine IL-1β...
March 25, 2019: Osteoarthritis and Cartilage
J H Salmon, A C Rat, H Achit, W Ngueyon-Sime, C Gard, F Guillemin, D Jolly, B Fautrel
BACKGROUND: Data on the economic consequences of hip and knee osteoarthritis (OA) are scarce. We aimed to estimate the annual direct and indirect costs for patients followed for hip and/or knee OA in the KHOALA cohort. METHODS: The KHOALA cohort, set up from 2007 to 2009, is a French multicenter study of 878 individuals with symptomatic knee/hip OA who were 40 to 75 years old. Resources used were collected annually for 5 years. Costs were assigned by using official sources and expressed in 2018 euros per patient...
March 25, 2019: Osteoarthritis and Cartilage
Jae-Man Kwak, Erica Kholinne, Yucheng Sun, Adel Mohammed Alhazmi, Kyoung-Hwan Koh, In-Ho Jeon
OBJECTIVES: To develop a staging system that could better reflect symptoms by the spurs quantification in the fossa and joint space narrowing using computed tomography (CT) for elbow arthritis and to evaluate its reproducibility with multiple readers. METHODS: This retrospective study evaluated 81 cases of primary elbow osteoarthritis using both plain radiography and CT. Qualitative and quantitative analyses were independently performed by four orthopedic surgeons using previous and newly proposed staging systems...
March 25, 2019: Osteoarthritis and Cartilage
Valentina Pedoia, Jinhee Lee, Berk Norman, Thomas M Link, Sharmila Majumdar
OBJECTIVE: we aim to study to what extent conventional and deep-learning-based T2 relaxometry patterns are able to distinguish between knees with and without radiographic OA. METHODS: T2 relaxation time maps were analyzed for 4,384 subjects from the baseline Osteoarthritis Initiative Dataset. Voxel Based Relaxometry was used for automatic quantification and voxel-based analysis of the differences in T2 between subjects with and without radiographic OA. A Densely Connected Convolutional Neural Network (DenseNet) was trained to diagnose OA from T2 data...
March 21, 2019: Osteoarthritis and Cartilage
Ying-Ying Leung, Mohammad Talaei, Li-Wei Ang, Jian-Min Yuan, Woon-Puay Koh
OBJECTIVES: Knee osteoarthritis (OA) is more common in women, and may be related to reproductive or hormonal factors. We evaluated these factors with the risk of total knee replacement (TKR) for severe knee OA among women. METHODS: The Singapore Chinese Health Study recruited 63,257 Chinese aged 45-74 years from 1993 to 1998, and among them, 35,298 were women. Information on height, weight, lifestyle factors, number of biological children, ages at menarche and menopause, and use of hormonal therapies was collected through interviews...
March 19, 2019: Osteoarthritis and Cartilage
Philip Conaghan
No abstract text is available yet for this article.
March 18, 2019: Osteoarthritis and Cartilage
S M Robbins, M Morelli, P A Martineau, N St-Onge, M Boily, R Dimentberg, J Antoniou
OBJECTIVE: The objective was to compare muscle activation and knee mechanics during gait between participants with non-traumatic knee osteoarthritis (OA), post-traumatic knee OA, and healthy adults. DESIGN: Participants with non-traumatic knee OA (n = 22), post-traumatic knee OA (n = 19), and healthy adults (n = 22) completed gait trials for this observational, cross-sectional study. Post-traumatic OA group had a history of traumatic anterior cruciate ligament (ACL) rupture...
March 18, 2019: Osteoarthritis and Cartilage
Andreas Berlin, David Simon, Koray Tascilar, Camille Figureido, Sara Bayat, Stephanie Finzel, Engelke Klaus, Juergen Rech, Axel J Hueber, Arnd Kleyer, Georg Schett
OBJECTIVE: To analyze the age-related changes of the physiological hand joint architecture. METHOD: To address this concept, healthy individuals (each 10 women and 10 men in 6 different age decades spanning from 21-80 years) were recruited through a field campaign, investigated for the absence of rheumatic diseases and other comorbidities and received high-resolution quantitative computed tomography (HR-pQCT) examination of the hand joints. Number and extent of erosions and osteophytes were quantified across the ages and different sexes...
March 16, 2019: Osteoarthritis and Cartilage
Ikufumi Takahashi, Taro Matsuzaki, Hiroshi Kuroki, Masahiro Hoso
OBJECTIVE: The aim of the study was to examine how mechanical unloading affects articular cartilage degeneration in the patellofemoral (PF) and tibiofemoral (TF) joints of a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis (OA). DESIGN: The study involved 60 male rats. Osteoarthritis was induced by intra-articular injecting MIA into both knee joints. All animals were equally divided into two groups: sedentary (SE) and hindlimb unloading (HU) groups...
March 16, 2019: Osteoarthritis and Cartilage
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"