Ophthalmology

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PURPOSE: To review the published literature on the diagnostic capabilities of the newest generation of corneal imaging devices for the identification of keratoconus. METHODS: Corneal imaging devices studied included tomographic platforms (Scheimpflug photography, OCT) and functional biomechanical devices (imaging an air impulse on the cornea). A literature search in the PubMed database for English language studies was last conducted in February 2023. The search yielded 469 citations, which were reviewed in abstract form...

PURPOSE: To assess risk factors for worse visual acuity (VA) outcomes after intraocular lens (IOL) exchange, and the most common postsurgical complications. DESIGN: Retrospective cohort study. SUBJECTS: Eyes from patients aged 18 years and older in the IRIS® Registry (Intelligent Research in Sight) that underwent IOL exchange in the United States between 2013 and 2019. METHODS: VA improvement compared to baseline was determined at 1-year postoperatively...

PURPOSE: To assess the web accessibility and readability of patient-oriented educational websites for cataract surgery. DESIGN: Cross-sectional electronic survey. SUBJECTS: Websites with information dedicated to educating patients about cataract surgery. METHODS: An incognito search for "cataract surgery" was performed using a popular search engine. The top 100 patient-oriented cataract surgery websites that came up were included and categorized as institutional, private practice, or medical organization according to authorship...

OBJECTIVE: To compare population demographics with the geographic distribution of oculofacial plastic surgeons (OPS) in the United States (US). DESIGN: A cross-sectional study design was employed to investigate demographic differences between counties with one or more OPS and counties with zero OPS. PARTICIPANTS: The number of OPS were identified in each US County using online public databases - American Society of Ophthalmic Plastic and Reconstructive Surgeons; American Academy of Ophthalmology...

PURPOSE: To assess the duration, incidence, reversibility, and severity of adverse events (AEs) in patients with thyroid eye disease (TED) treated with teprotumumab. DESIGN: Multi-center retrospective observational cohort study. PARTICIPANTS: Patients with TED of all stages and activity levels treated with at least 4 infusions of teprotumumab. METHODS: Patients were treated with teprotumumab between February 2020 and October 2022 at 6 tertiary centers...

We describe the results of two surveys about diagnostic odyssey assessing over 1000 patients with inherited retinal diseases. Younger patients, those who attended multiple visits, and those given different diagnoses, faced longer diagnostic delay.

PURPOSE: To characterize focal biomechanical alterations in subclinical keratoconus (SKC) using motion tracking (MT) Brillouin microscopy and evaluate the ability of MT Brillouin metrics to differentiate SKC eyes from normal controls. DESIGN: Prospective cross-sectional study PARTICIPANTS: Thirty eyes from 30 patients were evaluated, including 15 eyes from 15 bilaterally normal patients and 15 SKC eyes from 15 patients. METHODS: All patients underwent Scheimpflug tomography and MT Brillouin microscopy imaging using a custom-built device...

PURPOSE: Glaucoma is a heterogeneous group of optic neuropathies that potentially may be associated with other cerebral neurodegenerative processes leading to dementia. However, prior studies have been inconsistent. We examined dementia risks following glaucoma diagnosis in a large population-based cohort. DESIGN: National matched cohort study. PARTICIPANTS: 324,730 persons diagnosed with glaucoma during 1995-2017 in Sweden and 3,247,300 age- and sex-matched population-based controls without prior dementia...

PURPOSE: To describe the clinical presentation and treatment outcomes of children diagnosed with retinoblastoma (RB) in the year 2017, throughout Asia. DESIGN: Multi-national prospective study including treatment-naïve patients diagnosed with retinoblastoma in Asia during 2017 and followed up thereafter. PARTICIPANTS: A total of 2112 patients (2797 eyes) from 96 RB treatment centers in 33 Asian countries. INTERVENTION: Chemotherapy, radiotherapy, enucleation, orbital exenteration MAIN OUTCOME MEASURES: Enucleation and death RESULTS: Within the cohort, 1021 (48%) patients were from South Asia (SA), 503 (24%) from East Asia (EA), 310 (15%) from South-East Asia (SEA), 218 (10%) from West Asia (WA) and 60 (3%) from Central Asia (CA)...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

PURPOSE: To assess the risk of dementia in individuals with newly diagnosed ocular motor cranial neuropathy (OMCN). DESIGN: A nationwide, population-based cohort study using authenticated data from the Korean National Health Insurance Service (KNHIS). SUBJECTS: This study included 60,781 OMCN patients diagnosed between 2010 and 2017 and followed through 2018, with an average follow-up of 3.37 (SD, 2.21) years with a one-year lag. After excluding patients with disease related to oculomotor dysfunction preceding the OMCN diagnosis (e...

We classified drug-induced uveitis related to Immune Checkpoint inhibitors (ICIs) and MAP-kinase pathway inhibitors (MAPKi), including BRAF-inhibitors (BRAFi) and MEK-inhibitors (MEKi), according ophthalmological examination. Cases were retrieved from the French pharmacovigilance database (FPVD) which included all adverse drug reactions (ADR) registred by the French Regional Pharmacovigilance Network. We collected 113 cases of drug-induced uveitis (46 ICI-related and 67 MAPKi-related). The classification analysis identified four clusters...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVES: To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml) + propamidine 0.1% (1 mg/ml) [PHMB 0.02%+propamidine] to PHMB 0.08% (0.8 mg/ml) with placebo [PHMB 0.08%] for Acanthamoeba keratitis (AK) treatment. DESIGN: Prospective randomized, double-masked, active-controlled, multicentre, Phase3 study (ClinicalTrials.gov NCT03274895). PARTICIPANTS: 135 at six European centres between 08/17/2017 to 06/18/2021. METHODS: Principal inclusion criteria: ≥12 years old; in vivo confocal microscopy (IVCM) with clinical findings consistent with AK...

PURPOSE: Private equity (PE) firms are increasingly acquiring ophthalmology practices; little is known of their influence on care utilization and spending. We studied changes in utilization and Medicare spending after PE acquisition. DESIGN: Retrospective cohort study. PARTICIPANTS: 762 clinicians in 123 practices acquired by PE between 2017 and 2018; 34,807 clinicians in 20,549 never-acquired practices. METHODS: We analyzed Medicare fee-for-service claims (2012-2019) combined with a novel national database of PE acquisitions of ophthalmology practices using a difference-in-differences method within an event study framework to compare changes after a practice was acquired to changes in practices that were not acquired...