Ophthalmology

PURPOSE: To analyze ARMS2/HTRA1 as a risk factor for faster geographic atrophy (GA) enlargement according to (i) GA area and (ii) contiguous enlargement versus progression to multifocality. DESIGN: Post hoc analysis of a cohort within the Age-Related Eye Disease Study 2 (AREDS2) clinical trial. PARTICIPANTS: 546 eyes (406 participants, mean age 73.8 years) with GA. METHODS: GA area was measured from color fundus photographs at annual visits...

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PURPOSE: Housing and food insecurity are social risk factors that can impact eye health outcomes. This study investigated the association of these social risk factors with vision and ophthalmic pathology. DESIGN: Cross-sectional study from July 28, 2020 - July 27, 2021 for the Free Clinic and January 27, 2021 - January 26, 2022 for the Federally Qualified Health Center. Subjects, Participants, and/or Controls: Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program first year participants...

OBJECTIVE: To determine early endophthalmitis incidence and risk factors following glaucoma surgeries in the Medicare population. DESIGN: Retrospective, longitudinal study. SUBJECTS AND PARTICIPANTS: Eyes that had glaucoma surgery among Medicare Fee-For-Service and Medicare Advantage beneficiaries in the US aged 65 years or older. METHODS: Medicare Fee-For-Service and Medicare Advantage claims were used to identify all patients who underwent glaucoma surgery, combined cataract/glaucoma surgery, and cataract surgery alone from 2016 to 2019...

PURPOSE: To review the current published literature for high-quality studies on the use of selective laser trabeculoplasty (SLT) for the treatment of glaucoma. This is an update of the Ophthalmic Technology Assessment titled, "Laser Trabeculoplasty for Open-Angle Glaucoma," published in November 2011. METHODS: Literature searches in the PubMed database in March 2020, September 2021, August 2022, and March 2023 yielded 110 articles. The abstracts of these articles were examined to include those written since November 2011 and to exclude reviews and non-English articles...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: To assess the impact of baseline data on psychophysical and morphological outcomes of subretinal Voretigene Neparvovec (VN, Luxturna®) treatment. DESIGN: Single center, retrospective, longitudinal, consecutive case series. PARTICIPANTS: Patients with RPE65-IRD treated by one surgeon (FGH) between 02-2020 and 03-2022 with VN and oral immunosuppression according to the manufacturer´s recommendation. METHODS: Retrospective analysis of surgical and clinical records, ancillary testing and retinal imaging following VN therapy for RPE65-IRD...

OBJECTIVE: To report 8-year outcomes from a randomized controlled trial (RCT) comparing bilateral lateral rectus muscle recessions (BLRc) with unilateral recess-resect (R&R) for childhood intermittent exotropia (IXT). DESIGN: Eight-year follow-up of RCT cohort PARTICIPANTS: 123 of 197 randomized participants agreed to continue follow-up after the 3-year outcome visit (baseline age 3 to <11 years with basic-type IXT 15-40 prism diopters (Δ) by prism and alternate cover test (PACT), baseline stereoacuity of 400 arcsec or better, no prior surgery) METHODS: Following the RCT primary outcome at 3 years, annual follow-up from 4 through 8 years with treatment at investigator discretion...

TOPIC: This review summarizes existing evidence on the impact of vision impairment and ocular morbidity and their treatment on children's quality of life (QoL). CLINICAL RELEVANCE: Myopia and strabismus are associated with reduced QoL among children. Surgical treatment of strabismus significantly improves affected children's QoL. METHODS: We conducted a systematic review and meta-analysis by screening articles in any language in nine databases published from inception through August 22, 2022, for publications addressing the impact of vision impairment, ocular morbidity and their treatment on QoL in children...

PURPOSE: To explore prevalence and causes of loss of visual acuity and visual field in highly myopic eyes. DESIGN: Population-based study. PARTICIPANTS: The participants (n=4439) of the Beijing Eye Study underwent an ophthalmological and systemic examination including frequency doubling technology perimetry (FDT). METHODS: High myopia was defined by a refractive error of ≤-6Dpt or axial length >26.0 mm. MAIN OUTCOME PARAMETERS: Prevalence of vision impairment causes...

PURPOSE: To report on macular hole repair in macular telangiectasia type 2 (MacTel). DESIGN: Global, multicenter, retrospective case series. PARTICIPANTS: Patients with surgery for MacTel-associated full thickness macular hole (MTMH). METHODS: A standardized data collection sheet was distributed to all surgeons. MAIN OUTCOME MEASURES: Anatomic closure and visual outcomes of MTMH RESULTS: Sixty-three surgeries in 47 patients with MTMH were included from 30 surgeons...

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PURPOSE: To review the literature on the adjuvant use of mitomycin C (MMC) during dacryocystorhinostomy (DCR) in adults with primary nasolacrimal duct obstructions (NLDOs) to determine the efficacy in improving functional and anatomic outcomes with an acceptable level of risk. METHODS: A literature search conducted in November 2020 and updated in November 2022 yielded 137 articles. Twenty-four articles met the inclusion criteria and were rated for level of evidence by the panel methodologist...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

PURPOSE: To review the published literature on the use of levodopa/carbidopa to augment the treatment of amblyopia. METHODS: Literature searches for English language studies were last conducted in October 2022 in the PubMed database with no date restrictions. The combined searches yielded 55 articles, of which 23 were reviewed in full text. Twelve of these were considered appropriate for inclusion in this assessment and were assigned a level of evidence rating by the panel methodologist...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

PURPOSE: To review the literature to determine the efficacy and safety of thermal pulsation technologies in improving signs or symptoms of meibomian gland dysfunction (MGD) and dry eye compared with no therapy or with conventional warm compress therapy or eyelid hygiene. METHODS: A literature search was conducted in the PubMed database in June 2022 and again in March 2023 to identify all studies in the English language on the use of thermal pulsation to treat MGD or dry eye...