Ophthalmology

TOPIC: We provide global estimates of the prevalence of corneal blindness and vision impairment in adults 40 years and older and examine the burden by age, gender, and geographic region from 1984-2020. CLINICAL RELEVANCE: Corneal opacities (CO) are among the top five causes of blindness worldwide, yet the global prevalence, regional differences, and risk factors are unclear. METHODS: Abstracted data from the published literature and surveys were obtained from the Global Burden of Disease Vision Loss Expert Group...

OBJECTIVE: Increased disease-specific mortality has been observed among patients with local recurrence (LR) from uveal melanoma, but the underlying mechanism is unknown. The purpose of this study was to determine if copy number alterations of chromosomes 3 and 8q, at the time of diagnosis, increase the incidence of LR and if disease-specific mortality among patients with LR depends on the chromosome status of the primary tumor. STUDY DESIGN: Retrospective cohort study SUBJECTS: The study included 239 consecutive patients with primary uveal melanoma (choroidal or ciliary body) treated with Ru-106 brachytherapy, from January 2009 to December 2019 at a single national referral center...

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No abstract text is available yet for this article.

PURPOSE: To estimate incidence and evaluate demographic risk factors and visual acuity (VA) outcomes of open globe injuries requiring surgical repair in the IRIS® Registry (Intelligent Research in Sight). DESIGN: Retrospective cohort study. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Patients with open globe injury repairs (OGR) were identified by Current Procedural Terminology codes (65275, 65280, 65285, 65286, 65235, 65260, 65265) from 2014 to 2018 in the IRIS Registry...

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TOPIC: Understanding approaches to sustainability in cataract surgery and their risks and benefits CLINICAL RELEVANCE: In the United States, healthcare is responsible for approximately 8.5% of greenhouse gas (GHG), and cataract surgery is one of the most commonly performed surgical procedures. Ophthalmologists can contribute to reducing GHG emissions, which lead to a steadily increasing list of health concerns ranging from trauma to food instability. METHODS: We conducted a literature review to identify the benefits and risks of sustainability interventions...

PURPOSE: To report 2-year results from the Archway clinical trial of the Port Delivery System with ranibizumab (PDS) for treatment of neovascular age-related macular degeneration (nAMD). DESIGN: Phase 3, randomized, multicenter, open-label, active-comparator trial. PARTICIPANTS: Patients with previously treated nAMD diagnosed within 9 months of screening and responsive to anti-vascular endothelial growth factor therapy. METHODS: Patients were randomized 3:2 to PDS with ranibizumab 100 mg/ml with fixed refill-exchanges every 24 weeks (PDS Q24W) or intravitreal ranibizumab 0...

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OBJECTIVE: To determine the incidence of loss to follow up (LTFU) and nonpersistence in patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF) injections in the United States. DESIGN: Retrospective cohort study using IRIS (Intelligent Research in Sight) Registry data. SUBJECTS: 156,327 treatment-naïve neovascular AMD patients who were subsequently treated with anti-VEGF therapy from 2013 to 2015 and followed through 2019...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

Adolescent Hispanic children were more likely to report vision impairment, while adolescent non-Hispanic Black children were more likely to report unmet vision needs compared to non-Hispanic White children. These disparities persisted across socioeconomic levels and were exacerbated by the COVID-19 pandemic.

PURPOSE: To analyze demographic and ophthalmologic data in patients with and without chorioretinal atrophy after voretigene neparvovec-rzyl (VN) in order to identify possible causes for this phenomenon. DESIGN: Retrospective cohort study with longitudinal follow-up. SUBJECTS: 71 eyes of 38 patients aged 2 to 44 years with RPE65-mediated retinal dystrophy treated with VN across two large gene therapy centers in the USA and Germany. METHODS: VN-treated patients who developed atrophy were compared to those who did not...

PURPOSE: To investigate the risk of dementia in participants with newly diagnosed glaucoma. DESIGN: A nationwide cohort study using authorized data provided by the Korean National Health Insurance Service (NHIS). PARTICIPANTS: A total of 788,961 participants aged ≥ 45 years in 2006, who did not have dementia or glaucoma between 2002 and 2005, were included. METHODS: Data were collected from a nationwide population-based retrospective cohort study using the Korean NHIS database...

PURPOSE: Genetic variants in regions that include the mitochondrial genes TXNRD2 and ME3 are associated with primary open-angle glaucoma (POAG) in genome-wide association studies (GWAS). To assess their clinical impact, we investigated whether TXNRD2 and ME3 genetic risk scores (GRSs) are associated with specific glaucoma phenotypes. DESIGN: Cross-sectional study PARTICIPANTS: 2617 POAG cases and 2634 controls from the NEIGHBORHOOD consortium. METHODS: All POAG-associated single nucleotide polymorphisms (SNPs) in the TXNRD2 and ME3 loci were identified using GWAS data (p<0...

PURPOSE: To examine the frequency and risk factors for ocular pain after laser assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). METHODS: Prospective study of individuals undergoing refractive surgery at two different centers. Participants rated their ocular pain on a 0 - 10 Numerical Rating Scale (NRS) pre-surgery and 1 day, 3 months, and 6 months post-surgery. A clinical examination focused on ocular surface health was performed 3- and 6-months post-surgery...

Ocular complications of mpox infection have a prevalence of 1% in the current outbreak. Although conjunctivitis is the most common presentation, corneal involvement may occur. Tecovirimat is recommended for severe ocular mpox involvement.

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