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Scott R Lambert, Vinay K Aakalu, Amy K Hutchinson, Stacy L Pineles, Jennifer A Galvin, Gena Heidary, Gil Binenbaum, Deborah K VanderVeen
PURPOSE: To compare the visual outcomes and adverse events associated with optical correction using an intraocular lens (IOL), contact lenses, or spectacles after cataract surgery in children 2 years of age or younger. METHODS: Literature searches were conducted in PubMed, the Cochrane Library, and the databases of clinical trials in February 2019, without date or language restrictions. The search resulted in 194 potentially relevant citations, and 34 were selected for full-text review...
June 20, 2019: Ophthalmology
Sarah E Eppley, Steven L Mansberger, Saras Ramanathan, Eugene A Lowry
PURPOSE: To identify the characteristics that are associated with adherence to annual diabetic eye exams and patient awareness of retinopathy using a nationally representative sample from the United States. DESIGN: Cross-sectional, secondary analysis. PARTICIPANTS: National Health and Nutrition Examination Survey (NHANES) participants from 2005 to 2016 aged 20 years and older with diabetes mellitus. METHODS: The NHANES collected surveys every 2 years from 2005 to 2016, which contained demographic information, clinical information, and time to last dilated eye exam...
June 15, 2019: Ophthalmology
Koji M Nishiguchi, Yasuhiro Ikeda, Kosuke Fujita, Hiroshi Kunikata, Makoto Akiho, Kazuki Hashimoto, Katsuhiro Hosono, Kentaro Kurata, Yoshito Koyanagi, Masato Akiyama, Takefumi Suzuki, Ryo Kawasaki, Yuko Wada, Yoshihiro Hotta, Koh-Hei Sonoda, Akira Murakami, Mitsuru Nakazawa, Toru Nakazawa, Toshiaki Abe
PURPOSE: To present phenotypic features of 22 patients with S-antigen (SAG) mutations. DESIGN: Retrospective cohort study. PARTICIPANTS: Twenty-one Japanese patients from 16 families with a homozygous c.924delA mutation and 1 patient with a homozygous c.636delT mutation in the SAG gene. METHODS: Clinical records on symptoms; best-corrected visual acuity; and Goldmann perimetry, fundus photography, fundus autofluorescence (FAF), OCT, and electroretinography results were reviewed...
June 6, 2019: Ophthalmology
Jaemin Son, Joo Young Shin, Hoon Dong Kim, Kyu-Hwan Jung, Kyu Hyung Park, Sang Jun Park
PURPOSE: To develop and evaluate deep learning models that screen multiple abnormal findings in retinal fundus images. DESIGN: Cross-sectional study. PARTICIPANTS: For the development and testing of deep learning models, 309 786 readings from 103 262 images were used. Two additional external datasets (the Indian Diabetic Retinopathy Image Dataset and e-ophtha) were used for testing. A third external dataset (Messidor) was used for comparison of the models with human experts...
May 31, 2019: Ophthalmology
Marco Nassisi, Jianqin Lei, Nizar Saleh Abdelfattah, Ayesha Karamat, Siva Balasubramanian, Wenying Fan, Akihito Uji, Kenneth M Marion, Kirstie Baker, Xiwen Huang, Elizabeth Morgenthien, Srinivas R Sadda
PURPOSE: To evaluate the relationship between OCT features and progression to late age related-macular degeneration (AMD) in the fellow eyes of patients enrolled in the Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular AMD (HARBOR) ( identifier, NCT00891735). DESIGN: Post hoc analysis of a phase 3 multicenter, prospective, randomized, double-masked, active treatment-controlled clinical trial...
May 29, 2019: Ophthalmology
Dan Gong, Jonathan S Chang, Miriam Barbany, Borja F Corcostegui, Mehmet Fatih Kağan Değirmenci, Hiroto Ishikawa, Zaid Mammo, Emin Ozmert, Tommaso Rossi, Stanley Chang
PURPOSE: To compare United States and international drug pricing for commonly prescribed intravitreal and topical ophthalmic medications. DESIGN: Cross-sectional observational study. METHODS: For 25 commonly used ophthalmic medications (3 intravitreal, 22 topical), we obtained 2017 third quarter United States average wholesale price (AWP), drug acquisition cost, or consumer pricing through United States government health insurance plans (Veterans Affairs [VA], Medicaid, Medicare Part B, and Medicare Part D) and commercial drug plans (CVS Caremark and Navitus Health Solutions), online pricing without insurance through a large United States warehouse retailer (Costco), and international drug pricing through government-sponsored health plans in Italy, Spain, Turkey, Canada, and Japan...
May 27, 2019: Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
PURPOSE: To determine whether the presence of glaucoma is associated significantly with nighttime blood pressure (BP) and dipping pattern. DESIGN: Observational, cross-sectional study. PARTICIPANTS: We assessed 109 glaucoma patients (mean age, 71.0 years) from the Longitudinal Study of Biological Circadian Rhythms in Glaucoma Patients: Home Testing of Circadian Intraocular Pressure and Biological Parameters (LIGHT) study and 708 healthy control participants without glaucoma (mean age, 70...
May 25, 2019: Ophthalmology
Chandrakumar Balaratnasingam, Dong An, K Bailey Freund, Ashley Francke, Dao-Yi Yu
No abstract text is available yet for this article.
May 23, 2019: Ophthalmology
Liangbo L Shen, Mengyuan Sun, Holly K Grossetta Nardini, Lucian V Del Priore
TOPIC: Systematic review and meta-analysis of the natural history of autosomal recessive Stargardt disease (STGD1). CLINICAL RELEVANCE: Controversy exists regarding the progression pattern of atrophic lesions secondary to STGD1, and the reported growth rates vary widely among studies. METHODS: We searched in 6 literature databases up through March 15, 2019, to identify studies that monitored atrophy progression by fundus autofluorescence in untreated eyes with STGD1 for 6 months or more...
May 17, 2019: Ophthalmology
Samantha S Y Lee, Nigel McArdle, Paul G Sanfilippo, Seyhan Yazar, Peter R Eastwood, Alex W Hewitt, Qiang Li, David A Mackey
PURPOSE: Obstructive sleep apnea (OSA) is linked to increased glaucoma risk in middle-aged and older adults. However, little is known about associations between OSA and glaucoma-related optic disc parameters in young adults. We explored associations between overnight polysomnography-derived measures of OSA and the optic disc in young adults. DESIGN: Cross-sectional cohort study. PARTICIPANTS: Eight hundred forty-eight adults 19 to 22 years of age...
May 17, 2019: Ophthalmology
Kaveh Vahdani, Geoffrey E Rose
No abstract text is available yet for this article.
May 16, 2019: Ophthalmology
Jordan W Winegar, Grant A Justin, Matthew C Caldwell, Christopher J Calvano, John B Cason, Elizabeth M Hofmeister, Travis C Frazier, Robert A Mazzoli, Marcus H Colyer, Brett W Davies
No abstract text is available yet for this article.
May 9, 2019: Ophthalmology
Hitoshi Ishikawa, Takeshi Kezuka, Keigo Shikishima, Akiko Yamagami, Miki Hiraoka, Hideki Chuman, Makoto Nakamura, Keika Hoshi, Toshiaki Goseki, Kimiyo Mashimo, Osamu Mimura, Takeshi Yoshitomi, Keiko Tanaka
PURPOSE: To elucidate the clinical and epidemiologic characteristics of optic neuritis in Japan. DESIGN: Multicenter cross-sectional, observational cohort study. PARTICIPANTS: A total of 531 cases of unilateral or bilateral noninfectious optic neuritis identified in 33 institutions nationwide in Japan. METHODS: Serum samples from patients with optic neuritis were tested for anti-aquaporin-4 antibodies (AQP4-Abs) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) using a cell-based assay and were correlated with the clinical findings...
May 6, 2019: Ophthalmology
George B Bartley
No abstract text is available yet for this article.
May 6, 2019: Ophthalmology
George A Williams, David W Parke
No abstract text is available yet for this article.
May 5, 2019: Ophthalmology
Feng-Juan Gao, Jian-Kang Li, Han Chen, Fang-Yuan Hu, Sheng-Hai Zhang, Yu-He Qi, Ping Xu, Dan-Dan Wang, Lu-Sheng Wang, Qing Chang, Yong-Jin Zhang, Wei Liu, Wei Li, Min Wang, Fang Chen, Ge-Zhi Xu, Ji-Hong Wu
PURPOSE: To characterize the genetic landscape of patients with suspected retinitis pigmentosa (RP) in the Chinese population. DESIGN: Cohort study. PARTICIPANTS: A total of 1243 patients of Chinese origin with clinically suspected RP and their available family members (n=2701) were recruited. METHODS: All patients and available family members were screened using multigene panel testing (including 586 eye disease-associated genes), followed by clinical variant interpretation...
May 1, 2019: Ophthalmology
Philip P Storey, Maitri Pancholy, Turner D Wibbelsman, Anthony Obeid, Daniel Su, Durga Borkar, Sunir Garg, Omesh Gupta
OBJECTIVE: To report the rate, risk factors, and outcomes of rhegmatogenous retinal detachment (RRD) following intravitreal injection of anti-vascular endothelial growth factor medications. DESIGN: Single-center, retrospective, consecutive review PARTICIPANTS: All patients receiving ranibizumab, bevacizumab, or aflibercept for neovascular age-related macular degeneration or retinal vein occlusion between 10/1/2014 and 10/1/2017. METHODS: The total number of eyes and injections were determined from billing codes...
April 28, 2019: Ophthalmology
Iqbal Ike K Ahmed, Antonio Fea, Leon Au, Robert E Ang, Paul Harasymowycz, Henry Jampel, Thomas W Samuelson, David F Chang, Douglas J Rhee
PURPOSE: To compare the efficacy of different microinvasive glaucoma surgery (MIGS) devices for reducing intraocular pressure (IOP) and medications in open-angle glaucoma (OAG). DESIGN: Prospective, multicenter, randomized clinical trial. PARTICIPANTS: One hundred fifty-two eyes from 152 patients aged 45 to 84 years with OAG, Shaffer angle grade III-IV, best-corrected visual acuity (BCVA) 20/30 or better, and IOP 23 to 39 mmHg after washout of all hypotensive medications...
April 26, 2019: Ophthalmology
Albert S Li, Donna MacKay, Howard Chen, Rithwick Rajagopal, Rajendra S Apte
No abstract text is available yet for this article.
April 24, 2019: Ophthalmology
Anurag Garg, Victoria Vickerstaff, Neil Nathwani, David Garway-Heath, Evgenia Konstantakopoulou, Gareth Ambler, Catey Bunce, Richard Wormald, Keith Barton, Gus Gazzard
PURPOSE: To report clinical efficacy, predictors of success and safety of primary selective laser trabeculoplasty (SLT) used in treatment-naïve open-angle glaucoma (OAG) or ocular hypertension (OHT) patients. DESIGN: Post-hoc analysis of a multicentre prospective randomized-controlled-trial. PARTICIPANTS: Treatment-naïve OAG or OHT patients. METHODS: Patients randomized to SLT or topical medication and treated to pre-defined target IOPs requiring ≥20% IOP reduction from baseline for all disease severity levels...
April 24, 2019: Ophthalmology
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