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Adam M Hanif, Rachel Shah, Jiong Yan, Jithin S Varghese, Shivani A Patel, Blaine E Cribbs, Ghazala O'Keefe, Andrew M Hendrick, Jessica G Shantha, G Baker Hubbard, Purnima S Patel, Prethy Rao, Steven Yeh, Nieraj Jain
In this retrospective study of 219 patients with interstitial cystitis at a single institution, pentosan polysulfate exposure was the sole predictor of a newly described maculopathy. All 14 affected patients had exposure to the drug.
April 17, 2019: Ophthalmology
Crandall E Peeler, Catherine M Villani, Marissa G Fiorello, Hyunjoo Lee, Manju L Subramanian
PURPOSE: To determine whether patient satisfaction with oral sedation is non-inferior to intravenous (IV) sedation for cataract surgery. DESIGN: A prospective, randomized, double-masked clinical trial. SUBJECTS: A volunteer sample of patients age 18 or older from diverse ethnic, racial, and socioeconomic backgrounds scheduled for cataract surgery. Patients were excluded if they were allergic to benzodiazepines, over the age of 70 and failed a delirium screening questionnaire, pregnant or nursing, using a medication inhibiting cytochrome 450 3A, or intoxicated on the day of surgery...
April 16, 2019: Ophthalmology
Stephanie N Kletke, Zhao Xun Feng, Lili-Naz Hazrati, Brenda L Gallie, Sameh E Soliman
OBJECTIVE: Attempted eye salvage for unilateral (cT2b/Group D) retinoblastoma may increase risk of tumor spread compared to primary enucleation. Identification of clinical features predictive of low histopathologic risk would support safe trial salvage. DESIGN: Retrospective, non-comparative single-institutional observational case series PARTICIPANTS: Children with unilateral cT2b/Group D retinoblastoma (January 2008-February 2018) managed with primary enucleation at the Hospital for Sick Children (SickKids), Toronto, Canada...
April 12, 2019: Ophthalmology
Pravin U Dugel, Adrian Koh, Yuichiro Ogura, Glenn Jaffe, Ursula Schmidt-Erfurth, David Brown, Andre V Gomes, James Warburton, Andreas Weichselberger, Frank G Holz
OBJECTIVE: Two similarly designed, phase 3 trials (HAWK and HARRIER) compared brolucizumab, a single-chain antibody fragment that inhibits vascular endothelial growth factor-A, with aflibercept to treat neovascular age-related macular degeneration (AMD). DESIGN: Double-masked, multicenter, active-controlled, randomized trials. PATIENTS: Patients (N = 1817) with untreated, active choroidal neovascularization due to AMD in the study eye. INTERVENTION: Patients were randomized to intravitreal brolucizumab 3 mg (HAWK only) or 6 mg or aflibercept 2 mg...
April 12, 2019: Ophthalmology
D Vail, S Pershing, M G Reeves, A R Afshar
OBJECTIVE: To evaluate geographic variation and characterize the relative contributions of patient characteristics, physician practice, and geographic region on variation in primary rhegmatogenous retinal detachment (RRD) management. DESIGN: Retrospective claims-based analysis PARTICIPANTS: 12,779 commercially-insured patients with incident RRD diagnosed between 2008 and 2016. METHODS: We determined whether patients underwent primary RRD repair within 60 days of diagnosis, and identified type of repair performed...
April 12, 2019: Ophthalmology
Zala Lužnik, Silke Oellerich, Karin Roesch, Jia Yin, Markus Zumbansen, Lars Franken, Gerrit R J Melles, Reza Dana
No abstract text is available yet for this article.
April 11, 2019: Ophthalmology
Michael S Deiner, Stephen D McLeod, Jessica Wong, James Chodosh, Thomas M Lietman, Travis C Porco
PURPOSE: and Objective: Epidemic and seasonal infectious conjunctivitis outbreaks can adversely impact education, workforce and economy. Yet conjunctivitis is typically not a reportable disease, potentially delaying mitigating intervention. Our study objective was to determine if conjunctivitis epidemics could be identified using Google Trends search data. DESIGN: Search data for conjunctivitis-related and control search terms from 5 years and countries worldwide were obtained...
April 11, 2019: Ophthalmology
Ronald B Melles, Jack X Kane, Thomas Olsen, William J Chang
In a study published last year we showed the Barrett was the single most accurate IOL formula overall. Herein we report on the outcomes of new or updated formulas when run against the same datasets. Achievement of a target refractive outcome has become an integral part of cataract surgery. Fortunately, the advent of optical biometry and introduction of newer generation intraocular lens (IOL) calculation formulas has improved our ability to accurately predict cataract surgery refractive outcomes, as we showed in a study published in Ophthalmology last year...
April 10, 2019: Ophthalmology
Jacob T Cox, Ganesh Subburaman, Beatriz Munoz, David S Friedman, Ravilla D Ravindran
OBJECTIVE: Primary objective was to assess associations between annual surgeon case volume and visual acuity outcomes following cataract surgery. Secondary objectives included (i) assessing for associations between other case and patient characteristics and post-operative visual acuity outcomes and (ii) assessing for associations between annual surgeon case volume and complication rates. DESIGN: Database study. PARTICIPANTS: All adult eyes that underwent small-incision or phacoemulsification cataract surgery with intraocular lens placement at the Aravind Eye Hospital in Madurai, India during calendar year 2015...
April 8, 2019: Ophthalmology
Damien F Goldberg, Ranjan P Malhotra, Barry A Schechter, Angela Justice, Sidney L Weiss, John D Sheppard
OBJECTIVE: Evaluate the safety and efficacy of OTX-101, a novel aqueous nanomicellar formulation of cyclosporine (0.09%), in the treatment of subjects with dry eye disease (DED). DESIGN: A randomized, multicenter, vehicle-controlled, double-masked, phase 3 clinical trial. PARTICIPANTS: Adults (18-90 years of age) with a history and clinical diagnosis of DED, a global symptom score ≥40 (0-100 range), and a lissamine green conjunctival staining score of ≥3 and ≤9 (0-12 range) in at least 1 eye...
April 6, 2019: Ophthalmology
Peizeng Yang, Shulin Liu, Zhenyu Zhong, Liping Du, Zi Ye, Wenjun Zhou, Aize Kijlstra
PURPOSE: To characterize the clinical features of Sympathetic ophthalmia (SO) and make a comparison between SO and Vogt-Koyanagi-Harada (VKH) disease in Chinese patients. DESIGN: Retrospective case series. PARTICIPANTS: A total of 131 consecutive SO and 500 VKH patients randomly selected out of those referred to our uveitis center from April 2008 to June 2018. METHODS: The history, extraocular and ocular findings, best corrected visual acuity (BCVA), auxiliary examination findings, complications and therapeutic effects were analyzed retrospectively in SO and VKH patients...
April 5, 2019: Ophthalmology
Yuan-Yao Fan, Yu-Shu Huang, Chung-Ying Huang, Jen-Fu Hsu, Chia-Pang Shih, Yih-Shiou Hwang, Tsung-Chieh Yao, Chi-Chun Lai, Wei-Chi Wu
OBJECTIVE: To evaluate the neurodevelopmental and ocular developmental outcomes in premature children who have undergone intravitreal bevacizumab injection (IVB) for treatment of type 1 retinopathy of prematurity (ROP) DESIGN: Prospective case-control study SUBJECTS: We enrolled 3 groups of premature patients: premature children who had no history of ROP (Group 0), premature children with history of ROP without treatment (Group 1), and premature children who had received a single IVB (0...
April 4, 2019: Ophthalmology
Prajna Lalitha, Gerami D Seitzman, Ritesh Kotecha, Armin Hinterwirth, Cindi Chen, Lina Zhong, Susie Cummings, Elodie Lebas, Malaya K Sahoo, Benjamin A Pinsky, Thomas M Lietman, Thuy Doan
PURPOSE: The etiology of conjunctivitis is often misdiagnosed. An ideal diagnostic test would identify all possible infectious causes. In this study, we apply unbiased metagenomic RNA deep sequencing (MDS) to identify pathogens causing conjunctivitis. DESIGN: Molecular study of prospectively collected conjunctival swabs from patients with presumed infectious conjunctivitis. PARTICIPANTS: Patients with presumed acute infectious conjunctivitis...
April 3, 2019: Ophthalmology
Hana L Takusagawa, Ambika Hoguet, Anna K Junk, Kouros Nouri-Mahdavi, Sunita Radhakrishnan, Teresa C Chen
OBJECTIVE: To review the published literature on the use of swept-source optical coherence tomography (SS-OCT) for evaluating the lamina cribrosa in glaucoma. METHODS: A PubMed and Cochrane Library literature search initially conducted on March 3, 2017 and updated on June 26, 2018 yielded a total of 64 articles. Articles that were reviews or that were not published in English were excluded, and 29 were found to fit the inclusion criteria. The panel methodologist then assigned a level of evidence rating to each study...
April 3, 2019: Ophthalmology
Edward J Wladis, Vinay K Aakalu, Jeremiah P Tao, Rachel K Sobel, Suzanne K Freitag, Jill A Foster, Louise A Mawn
PURPOSE: To determine the efficacy and complication rates of monocanalicular stents in the setting of canalicular lacerations. METHODS: A literature search was performed in May 2018 in the PubMed database to identify all English-language reports of monocanalicular stenting to address canalicular lacerations. Studies that did not include at least 10 patients with at least 3 months of follow-up evaluation after surgery were excluded. Ninety-nine articles were identified, and 15 of these met criteria for data abstraction and were included in this assessment...
April 3, 2019: Ophthalmology
Peter A Campochiaro, Dennis M Marcus, Carl C Awh, Carl Regillo, Anthony P Adamis, Vladimir Bantseev, Yawen Chiang, Jason S Ehrlich, Signe Erickson, William D Hanley, Joshua Horvath, Katie F Maass, Natasha Singh, Fan Tang, Giulio Barteselli
PURPOSE: To evaluate the safety and efficacy of the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) treatment. DESIGN: Phase 2, multicenter, randomized, active treatment-controlled clinical trial. PARTICIPANTS: Patients diagnosed with nAMD within 9 months who had received ≥ 2 prior anti-vascular endothelial growth factor intravitreal injections and were responsive to treatment. METHODS: Patients were randomized 3:3:3:2 to receive the PDS filled with ranibizumab 10 mg/mL, 40 mg/mL, and 100 mg/mL formulations or monthly intravitreal ranibizumab 0...
April 1, 2019: Ophthalmology
Charles C Wykoff, Chirag Shah, Dilsher Dhoot, Hanna Rodriguez Coleman, Desmond Thompson, Weiming Du, Keith Baker, Robert Vitti, Alyson J Berliner, Carola Metzig, Namrata Saroj
PURPOSE: To evaluate changes in retinal perfusion status with intravitreal aflibercept injection (IAI) and laser treatment in the phase 3 VISTA study of patients with diabetic macular edema (DME). DESIGN: Post-hoc analysis of a double-masked, randomized, active-controlled, phase 3 trial. PARTICIPANTS: Patients with center-involved DME in the study eye. METHODS: VISTA randomized 466 patients to laser, intravitreal aflibercept injection (IAI) 2 mg q4 weeks (2q4), or IAI 2 mg q8 weeks following five monthly doses (2q8)...
April 1, 2019: Ophthalmology
Daniel A Brill, Taylor S Fields, Steven P Dunn, Michael D Ober
PURPOSE: To report a case of retinal necrosis after Depo-MedrolTM injection during complicated cataract surgery. METHODS: Interventional case report. A PubMed search was conducted using the search terms "methylprednisolone acetate" and "intraocular" as well as "methylprednisolone acetate" and "cataract surgery." All articles retrieved by this method were reviewed. RESULTS: A 68-year-old man complained of vision loss in the left eye immediately following cataract surgery...
March 28, 2019: Ophthalmology
Henry N Marshall, Nicholas H Andrew, Mark Hassall, Ayub Qassim, Emmanuelle Souzeau, Bronwyn Ridge, Thi Nguyen, Jude Fitzgerald, Mona S Awadalla, Kathryn P Burdon, Paul R Healey, Ashish Agar, Anna Galanopoulos, Alex W Hewitt, Stuart L Graham, John Landers, Robert J Casson, Jamie E Craig
PURPOSE: To investigate which clinical measures influence whether an individual demonstrates earliest glaucomatous structural progression on peripapillary retinal nerve fibre layer (pRNFL) or macular ganglion cell-inner plexiform layer (mGCIPL). DESIGN: Prospective longitudinal cohort study. PARTICIPANTS: 271 eyes from 207 individuals with statistically significant evidence of glaucomatous progression on optical coherence tomography (OCT)-Guided Progression Analysis (GPA) software were drawn from a total of 1271 eyes from 686 individuals categorized as glaucoma suspect or having early manifest glaucoma undergoing glaucoma surveillance...
March 22, 2019: Ophthalmology
Rachel L Taylor, James A Poulter, Susan M Downes, Martin McKibbin, Kamron N Khan, Chris F Inglehearn, Andrew R Webster, Alison J Hardcastle, Michel Michaelides, Paul N Bishop, Simon J Clark, Graeme C Black
PURPOSE: To characterise the molecular mechanism underpinning early-onset macular drusen (EOMD), a phenotypically severe sub-type of age-related macular degeneration (AMD), in a sub-group of patients. DESIGN: Multi-centre case series, in vitro experimentation and retrospective analysis of previously reported variants. PARTICIPANTS: Seven families with apparently autosomal dominant EOMD. METHODS: Patients underwent comprehensive ophthalmic assessment...
March 21, 2019: Ophthalmology
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