Matthew K Hoffman, Shivaprasad Goudar, Sangappa Dhaded, Lester Figueroa, Manolo Mazariegos, Nancy F Krebs, Jamie Westcott, Shiyam Sunder Tikmani, Fatima Karim, Sarah Saleem, Robert L Goldenberg, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Archana Patel, Prabir Das, Patricia Hibberd, Elwyn Chomba, Musaku Mwenchanya, Waldemar A Carlo, Marissa Trotta, Alexis Williams, Janet Moore, Tracy Nolen, Norman Goco, Elizabeth M McClure, Michele A Lobo, Andrea B Cunha, Richard J Derman
OBJECTIVE: Because low-dose aspirin is now commonly prescribed in pregnancy, we sought to assess the association between early antenatal exposure and child neurodevelopment. METHODS: We performed a noninferiority, masked, neurodevelopmental follow-up study of children between age 33 and 39 months whose mothers had been randomized to daily low-dose aspirin (81 mg) or placebo between 6 0/7 and 13 6/7 weeks of gestation through 37 weeks. Neurodevelopment was assessed with the Bayley-III (Bayley Scales of Infant and Toddler Development, 3rd Edition) and the ASQ-3 (Ages and Stages Questionnaire, 3rd Edition)...
January 23, 2024: Obstetrics and Gynecology