journal
https://read.qxmd.com/read/36928418/mpox-monkeypox-infection-during-pregnancy
#1
JOURNAL ARTICLE
Mindy M Sampson, Gray Magee, Evan A Schrader, Keerti L Dantuluri, Areej Bukhari, Catherine Passaretti, Lorene Temming, Michael Leonard, Jennifer B Philips, David Weinrib
BACKGROUND: An mpox (formerly "monkeypox") outbreak began in 2022, leading to infection in special populations, including pregnant individuals. CASE: We present a case of an individual who presented with a labial ulcer and subsequent papular rash at 31 weeks of gestation. She was diagnosed with mpox infection and was treated with tecovirimat. She had an uncomplicated induction of labor at 39 2/7 weeks of gestation and delivered a healthy neonate. The neonate had a positive immunoglobulin G test result for orthopoxvirus but did not have skin lesions or positive molecular test results suggestive of infection...
March 16, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36928334/nirmatrelvir-ritonavir-paxlovid-for-mild-coronavirus-disease-2019-covid-19-in-pregnancy-and-lactation
#2
JOURNAL ARTICLE
Christine Y Lin, Arianna G Cassidy, Lin Li, Mary K Prahl, Yarden Golan, Stephanie L Gaw
Nirmatrelvir-ritonavir (Paxlovid) is recommended to reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) in pregnancy. Data on use in pregnancy, including prescribing patterns and patient experience (adverse effects, incidence of rebound), are limited. We performed a cross-sectional study in which we surveyed a cohort of vaccinated pregnant or lactating individuals with breakthrough COVID-19. Of 35 pregnant respondents, 51.4% were prescribed and 34.3% took nirmatrelvir-ritonavir; of these, 91...
March 16, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36922376/changes-in-pregnancy-related-mortality-associated-with-the-coronavirus-disease-2019-covid-19-pandemic-in-the-united-states
#3
JOURNAL ARTICLE
Marie E Thoma, Eugene R Declercq
OBJECTIVE: To examine pregnancy-related mortality ratios before (January 2019-March 2020) and during (April 2020-December 2020 and 2021) the coronavirus disease 2019 (COVID-19) pandemic overall, by race and ethnicity, and by rural-urban classifications using vital records data. METHODS: Mortality and natality data (2019-2021) were obtained from the Centers for Disease Control and Prevention's WONDER database to estimate pregnancy-related mortality ratios, which correspond to any death during pregnancy or up to 1 year after the end of a pregnancy from causes related to the pregnancy per 100,000 live births...
March 16, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897561/universal-tetanus-diphtheria-pertussis-vaccination-during-pregnancy-a-cost-effectiveness-analysis
#4
JOURNAL ARTICLE
Rachel C Egan, Sarina R Chaiken, Kelli Derrah, Uma Doshi, Alyssa Hersh, Claire H Packer, Aaron B Caughey
OBJECTIVE: To assess the cost effectiveness of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination in pregnant patients in the United States. METHODS: A decision-analytic model in TreeAge was developed to compare universal Tdap vaccination in pregnancy with no Tdap vaccination in pregnancy using a theoretical cohort of 3.66 million pregnant individuals, the approximate number of deliveries per year in the United States. Outcomes included infant pertussis infections, infant hospitalizations, infant encephalopathy cases, infant deaths, and maternal pertussis infections...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897186/outcomes-of-menstrual-management-use-in-transgender-and-gender-diverse-adolescents
#5
JOURNAL ARTICLE
Beth I Schwartz, Benjamin Bear, Vanessa L Short, Anne E Kazak
OBJECTIVE: To describe and compare the outcomes of various menstrual-management methods, including method choice, continuation, bleeding patterns, amenorrhea rates, effect on moods and dysphoria, and side effects, in transgender and gender-diverse adolescents. METHODS: This was a retrospective chart review of all patients seen in a multidisciplinary pediatric gender program from March 2015 to December 2020 who were assigned female at birth, had achieved menarche, and used a menstrual-management method during the study period...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897185/nonoperative-management-of-pelvic-organ-prolapse
#6
JOURNAL ARTICLE
Vivian W Sung, Peter Jeppson, Annetta Madsen
Pelvic organ prolapse (POP) is defined as the descent of one or more of the anterior, posterior, or apical vagina. It is a common condition, with up to 50% of women having prolapse on examination in their lifetimes. This article provides an overview of the evaluation and discussion of nonoperative management of POP for the obstetrician-gynecologist (ob-gyn), with consideration of recommendations from the American College of Obstetricians and Gynecologists, the American Urogynecologic Society, and the International Urogynecological Association...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897180/safety-of-fezolinetant-for-vasomotor-symptoms-associated-with-menopause-a-randomized-controlled-trial
#7
JOURNAL ARTICLE
Genevieve Neal-Perry, Antonio Cano, Samuel Lederman, Rossella E Nappi, Nanette Santoro, Wendy Wolfman, Marci English, Catherine Franklin, Udaya Valluri, Faith D Ottery
OBJECTIVE: To evaluate the safety, tolerability, and effect of fezolinetant on endometrial health over 52 weeks. METHODS: We conducted a phase 3, randomized, double-blind, 52-week safety study (SKYLIGHT 4 [Study to Find Out How Safe Long-term Treatment With Fezolinetant is in Women With Hot Flashes Going Through Menopause]) of placebo, fezolinetant 30 mg, and fezolinetant 45 mg once daily (1:1:1). Participants were postmenopausal and seeking treatment for vasomotor symptoms associated with menopause...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897178/severe-maternal-morbidity-review-and-preventability-assessment-in-a-large-academic-center
#8
JOURNAL ARTICLE
Olga Grechukhina, Heather S Lipkind, Lisbet S Lundsberg, Audrey A Merriam, Cheryl Raab, Daisy Leon-Martinez, Katherine H Campbell
With the goal of identifying factors contributing to severe maternal morbidity (SMM) at our institution, we established a formal SMM review process. We performed a retrospective cohort study including all SMM cases as defined by American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine consensus criteria that were managed at Yale-New Haven Hospital over a 4-year period. Overall, 156 cases were reviewed. The SMM rate was 0.49% (95% CI 0.40-0.58). The leading causes of SMM were hemorrhage (44...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897177/postpartum-opioid-related-mortality-in-patients-with-public-insurance
#9
JOURNAL ARTICLE
Elizabeth A Suarez, Krista F Huybrechts, Loreen Straub, Sonia Hernández-Díaz, Andreea A Creanga, Hilary S Connery, Kathryn J Gray, Seanna M Vine, Hendrée E Jones, Brian T Bateman
OBJECTIVE: To assess the incidence and risk factors for postpartum opioid overdose death and describe other causes of postpartum death in individuals with opioid use disorder (OUD). METHODS: We conducted a cohort study that used health care utilization data from the Medicaid Analytic eXtract linked to the National Death Index in the United States from 2006 to 2013. All pregnant individuals with live births or stillbirths and continuous enrollment for 3 months before delivery were eligible, including 4,972,061 deliveries...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897164/crisis-pregnancy-centers
#10
JOURNAL ARTICLE
Sarah Villarreal
No abstract text is available yet for this article.
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897162/endometrial-cancer-surgery-with-or-without-concomitant-stress-urinary-incontinence-surgery
#11
JOURNAL ARTICLE
Katina Robison, Kyle Wohlrab, Chanelle J Howe, Holly E Richter, Vivian Sung, Kerri S Bevis, Christine Luis, Carolyn McCourt, Jerry Lowder, John Occhino, Gretchen Glaser, Elizabeth Lokich, Gena Dunivan, Amy Brown, Elena Tunitsky-Bitton, Stephanie Wethington, Chi Chiung Grace Chen, David Rahn, Matthew Carlson, Robin Cram, Christina Raker, Melissa A Clark
OBJECTIVE: To compare quality of life (QOL) among patients with endometrial intraepithelial neoplasia or early-stage endometrial cancer and stress urinary incontinence (SUI) who chose to have concomitant surgery with cancer surgery alone. METHODS: A multicenter, prospective cohort study was conducted across eight U.S. sites. Potentially eligible patients were screened for SUI symptoms. Those who screened positive were offered referral to urogynecology and incontinence treatment, including concomitant surgery...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897156/outcomes-of-uterine-rupture-in-the-setting-of-the-unscarred-compared-with-the-scarred-uterus
#12
JOURNAL ARTICLE
Aoife McEvoy, Gillian A Corbett, Ciara Nolan, Ronan Daly, Megan Murnane, Shane Higgins, Fergal D Malone, Michael P O'Connell, Mark P Hehir, Jennifer M Walsh
Uterine rupture is a rare obstetric complication that is associated with maternal and neonatal morbidity and mortality. The aim of this study was to examine uterine rupture and its outcomes in the setting of the unscarred compared with the scarred uterus. A retrospective observational cohort study was performed examining all cases of uterine rupture in three tertiary care hospitals in Dublin, Ireland, over a 20-year period. The primary outcome was perinatal mortality rate with uterine rupture, which was 11...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897153/preventing-postpartum-opioid-overdoses-our-patients-our-job
#13
JOURNAL ARTICLE
Marcela C Smid
No abstract text is available yet for this article.
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897148/assessing-health-care-utilization-and-feasibility-of-transurethral-catheter-self-discontinuation
#14
JOURNAL ARTICLE
Abigail Davenport, Yi Li, Emily Melvin, Arthur Arcaz, Lucie Lefbom, Cheryl B Iglesia, Alexis A Dieter
OBJECTIVE: To compare the rates of health care utilization (office messages or calls, office visits, and emergency department [ED] visits) and postoperative complications within 30 days after surgery between patients with successful voiding trials on postoperative day 0 and those with unsuccessful voiding trials on postoperative day 0 and between patients with successful and unsuccessful voiding trials on postoperative day 1. Secondary objectives were to identify risk factors for unsuccessful voiding trials on postoperative days 0 and 1 and to explore the feasibility of catheter self-discontinuation by assessing for any complications associated with at-home catheter self-discontinuation on postoperative day 1...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897147/efficacy-of-postpartum-pharmacologic-thromboprophylaxis-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Megan C Oakes, Molly Reese, Graham A Colditz, Carolyn R T Stoll, Angela Hardi, Lauren D Arnold, Antonina I Frolova
OBJECTIVE: To evaluate the effectiveness of pharmacologic venous thromboembolism (VTE) prophylaxis in postpartum patients. DATA SOURCES: On February 21, 2022, a literature search was conducted on Embase.com, Ovid-Medline All, Cochrane Library, Scopus, and ClinicalTrials.gov using terms postpartum period AND thromboprophylaxis AND antithrombin medications including heparin and low molecular weight heparin. METHODS OF STUDY SELECTION: Studies that evaluated the outcome of VTE among postpartum patients exposed to pharmacologic VTE prophylaxis with or without a comparator group were eligible for inclusion...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897146/association-between-antenatal-depression-symptom-trajectories-and-preterm-birth
#16
JOURNAL ARTICLE
Allie Sakowicz, Emma Allen, Mayán Alvarado-Goldberg, William A Grobman, Emily S Miller
OBJECTIVE: To evaluate whether, among pregnant people referred for mental health care, improvement in antenatal depression symptoms before delivery was associated with a reduction in preterm birth. METHODS: This retrospective cohort study included all pregnant people referred to a perinatal collaborative care program for mental health care who delivered between March 2016 and March 2021. Those referred to the collaborative care program had access to subspecialty mental health treatment, including psychiatric consultation, psychopharmacotherapy, and psychotherapy...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897145/adjuvant-human-papillomavirus-vaccination-after-excisional-procedure-for-cervical-intraepithelial-neoplasia-a-cost-effectiveness-analysis
#17
JOURNAL ARTICLE
Sarina R Chaiken, Amanda S Bruegl, Aaron B Caughey, Jenna Emerson, Elizabeth G Munro
OBJECTIVE: To examine the cost effectiveness of human papillomavirus (HPV) vaccination after excisional procedure compared with no vaccination. METHODS: We constructed a decision-analytic model (TreeAge Pro 2021) to compare outcomes between patients who underwent an excisional procedure followed by nonavalent HPV vaccination to those who underwent an excisional procedure without vaccination. Our theoretical cohort contained 250,000 patients, the approximate number undergoing excisional procedures annually in the United States...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897144/concurrent-surgery-for-locoregional-gynecologic-cancers-and-pelvic-floor-disorders-in-a-population-of-patients-with-medicare-insurance
#18
JOURNAL ARTICLE
Logan Corey, Randell Seaton, Julie J Ruterbusch, Carol Emi Bretschneider, Alex Vezina, Trieu Do, Deslyn Hobson, Ira Winer
OBJECTIVE: To estimate the rate of concurrent surgery for locoregional gynecologic cancer and pelvic organ prolapse-urinary incontinence (POP-UI) and to assess the rate of surgery for POP-UI within 5 years for those who did not undergo concurrent surgery. METHODS: This is a retrospective cohort study. The SEER-Medicare data set was used to identify cases of local or regional endometrial, cervical, and ovarian cancer diagnosed from 2000 to 2017. Patients were followed up for 5 years from diagnosis...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897142/initiation-and-treatment-discontinuation-of-medications-for-opioid-use-disorder-in-pregnant-people-compared-with-nonpregnant-people
#19
JOURNAL ARTICLE
Kevin Y Xu, Hendrée E Jones, Davida M Schiff, Caitlin E Martin, Jeannie C Kelly, Ebony B Carter, Laura J Bierut, Richard A Grucza
OBJECTIVE: To examine the association between pregnancy and medications for opioid use disorder (MOUD) initiation and discontinuation among reproductive-aged people receiving treatment for opioid use disorder (OUD) in the United States. METHODS: We conducted a retrospective cohort study of people with gender recorded as female, aged 18-45 years, in the MerativeTM MarketScan® Commercial and Multi-State Medicaid Databases (2006-2016). Opioid use disorder and pregnancy status were identified based on inpatient or outpatient claims for established International Classification of Diseases, Ninth and Tenth Revision diagnosis and procedure codes...
March 9, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/36897140/increased-scheduled-intravenous-ketorolac-after-cesarean-delivery-and-its-effect-on-opioid-use-a-randomized-controlled-trial
#20
JOURNAL ARTICLE
Jean Hostage, Diana Kolettis, Deanna Sverdlov, Jennifer Ludgin, Dan Drzymalski, Benjamin Sweigart, Mohak Mhatre, Michael House
OBJECTIVE: To evaluate the efficacy of scheduled ketorolac in reducing opioid use after cesarean delivery. METHODS: This was a single-center, randomized, double-blind, parallel-group trial to assess pain management after cesarean delivery with scheduled ketorolac compared with placebo. All patients undergoing cesarean delivery with neuraxial anesthesia received two doses of 30 mg intravenous ketorolac postoperatively and then were randomized to receive four doses of 30 mg of intravenous ketorolac or placebo every 6 hours...
March 9, 2023: Obstetrics and Gynecology
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