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Journals Nephrology, Dialysis, Transpla...

Nephrology, Dialysis, Transplantation

https://read.qxmd.com/read/33367854/glucocorticoid-free-treatment-of-severe-anti-neutrophil-cytoplasm-antibody-associated-vasculitis
#21
Tariq E Farrah, Maria Prendecki, Robert W Hunter, Rashmi Lahiri, Thomas D Cairns, Charles D Pusey, Stephen P McAdoo, Neeraj Dhaun
No abstract text is available yet for this article.
December 27, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367822/new-evidence-shows-it-is-time-to-stop-unnecessary-use-of-antibiotics-in-kidney-transplant-recipients-with-asymptomatic-bacteriuria
#22
Julien Coussement, Nassim Kamar, Daniel Abramowicz
No abstract text is available yet for this article.
December 27, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367807/prevention-of-venous-thromboembolism-in-nephrotic-syndrome-the-quest-towards-precision-medicine
#23
Hervé Lobbes, Sabine Mainbourg, Jean-Christophe Lega
No abstract text is available yet for this article.
December 27, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367881/association-of-lactate-dehydrogenase-with-mortality-in-incident-hemodialysis-patients
#24
Soh Young Ryu, Carola-Ellen Kleine, Jui-Ting Hsiung, Christina Park, Connie M Rhee, Hamid Moradi, Ramy Hanna, Kamyar Kalantar-Zadeh, Elani Streja
BACKGROUND: Lactate dehydrogenase (LDH) plays a role in the glucose metabolism of the human body. Higher LDH levels have been linked to mortality in various cancer types; however, the relationship between LDH and survival in incident hemodialysis (HD) patients has not yet been examined. We hypothesized that higher LDH level is associated with higher death risk in these patients. METHODS: We examined the association of baseline and time-varying serum LDH with all-cause, cardiovascular and infection-related mortality among 109 632 adult incident HD patients receiving care from a large dialysis organization in the USA during January 2007 to December 2011...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367879/association-between-thrombotic-microangiopathy-and-activated-alternative-complement-pathway-in-malignant-nephrosclerosis
#25
Ying Zhang, Chaona Yang, Xinjin Zhou, Ruimin Hu, Songxia Quan, Yali Zhou, Yuan Li, Guolan Xing
BACKGROUND: Malignant nephrosclerosis, defined as renal microangiopathy in the setting of severe hypertension, remains a critical renal emergency leading to end-stage renal disease despite aggressive anti-hypertensive treatment. Recently, activation of the complement alternative pathway (AP) has been reported to play a prominent role in the pathogenesis of malignant nephrosclerosis. However, subsequent study failed to recapitulate the findings of genetic complement abnormalities in the disease...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367877/copeptin-and-renal-function-decline-cardiovascular-events-and-mortality-in-type-1-diabetes
#26
Niels S Heinrich, Simone Theilade, Signe A Winther, Nete Tofte, Tarunveer S Ahluwalia, Jørgen L Jeppesen, Frederik Persson, Tine W Hansen, Jens P Goetze, Peter Rossing
BACKGROUND: Plasma copeptin is a surrogate of arginine vasopressin (AVP) secretion and is associated with a risk of renal and cardiovascular disease. We investigated associations between copeptin and renal events, cardiovascular events and mortality in type 1 diabetes (T1D). METHODS: We conducted a prospective cohort study on 658 individuals with T1D from Steno Diabetes Center Copenhagen. Plasma copeptin concentrations and conventional risk factors were assessed at baseline...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367818/treatment-and-long-term-outcome-in-primary-nephrogenic-diabetes-insipidus
#27
Sergio C Lopez-Garcia, Mallory L Downie, Ji Soo Kim, Olivia Boyer, Stephen B Walsh, Tom Nijenhuis, Svetlana Papizh, Pallavi Yadav, Ben C Reynolds, Stéphane Decramer, Martine Besouw, Manel Perelló Carrascosa, Claudio La Scola, Francesco Trepiccione, Gema Ariceta, Aurélie Hummel, Claire Dossier, John A Sayer, Martin Konrad, Mandy G Keijzer-Veen, Atif Awan, Biswanath Basu, Dominique Chauveau, Leire Madariaga, Linda Koster-Kamphuis, Mónica Furlano, Miriam Zacchia, Pierluigi Marzuillo, Yincent Tse, Ismail Dursun, Ayse Seda Pinarbasi, Despoina Tramma, Ewout J Hoorn, Ibrahim Gokce, Kathleen Nicholls, Loai A Eid, Lisa Sartz, Michael Riordan, Nakysa Hooman, Nikoleta Printza, Olivier Bonny, Pedro Arango Sancho, Raphael Schild, Rajiv Sinha, Stefano Guarino, Victor Martinez Jimenez, Lidia Rodríguez Peña, Hendrica Belge, Olivier Devuyst, Tanja Wlodkowski, Francesco Emma, Elena Levtchenko, Nine V A M Knoers, Daniel G Bichet, Franz Schaefer, Robert Kleta, Detlef Bockenhauer
BACKGROUND: Primary nephrogenic diabetes insipidus (NDI) is a rare disorder and little is known about treatment practices and long-term outcome. METHODS: Paediatric and adult nephrologists contacted through European professional organizations entered data in an online form. RESULTS: Data were collected on 315 patients (22 countries, male 84%, adults 35%). Mutation testing had been performed in 270 (86%); pathogenic variants were identified in 258 (96%)...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367794/kidney-transplantation-after-rescue-allocation-meticulous-selection-yields-the-chance-for-excellent-outcome
#28
Volker Assfalg, Svea Misselwitz, Lutz Renders, Norbert Hüser, Alexander Novotny, Carsten Jäger, Maike Büttner-Herold, Kerstin Amann, Christoph Schmaderer, Uwe Heemann, Ming Wen, Flora Haberfellner, Carlos Torrez, Quirin Bachmann, Stephan Kemmner
BACKGROUND: The small number of organ donors forces transplant centres to consider potentially suboptimal kidneys for transplantation. Eurotransplant established an algorithm for rescue allocation (RA) of kidneys repeatedly declined or not allocated within 5 h after procurement. Data on the outcomes and benefits of RA are scarce to date. METHODS: We conducted a retrospective 8-year analysis of transplant outcomes of RA offers based on our in-house criteria catalogue for acceptance and decline of organs and potential recipients...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367781/patient-reported-outcome-measures-for-life-participation-in-peritoneal-dialysis-a-systematic-review
#29
Karine E Manera, Angela Ju, Amanda Baumgart, Elyssa Hannan, Wenjing Qiao, Martin Howell, Melissa Nataatmadja, Martin Wilkie, Fiona Loud, Daniel Schwartz, Helen Hurst, Sarbjit Vanita Jassal, Ana Figueiredo, Rajnish Mehrotra, Jenny Shen, Rachael L Morton, Thyago Moraes, Rachael Walker, Catherine Cheung, Janine F Farragher, Jonathan Craig, David W Johnson, Allison Tong
BACKGROUND: Patients receiving peritoneal dialysis (PD) endure an ongoing regimen of daily fluid exchanges and are at risk of potentially life-threatening complications and debilitating symptoms that can limit their ability to participate in life activities. The aim of the study was to identify the characteristics, content and psychometric properties of measures for life participation used in research in PD. METHODS: We searched MEDLINE, Embase, PsychInfo, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and the Cochrane Central Register of Controlled Trials from inception to May 2020 for all studies that reported life participation in patients on PD...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367776/the-unsolved-challenge-of-implementing-sustained-reductions-of-sodium-intake-in-patients-with-chronic-kidney-disease
#30
Michel Burnier, Denis Fouque
No abstract text is available yet for this article.
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367750/development-and-validation-of-a-risk-score-for-the-prediction-of-cardiovascular-disease-in-living-donor-kidney-transplant-recipients
#31
Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kaneyasu Nakagawa, Hiroaki Tsujikawa, Kosuke Masutani, Shigeru Tanaka, Keizo Kaku, Hiroshi Noguchi, Yasuhiro Okabe, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Kazuhiko Tsuruya, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono
BACKGROUND: Cardiovascular disease (CVD) is a major cause of death in kidney transplant (KT) recipients. To improve their long-term survival, it is clinically important to estimate the risk of CVD after living donor KT via adequate pre-transplant CVD screening. METHODS: A derivation cohort containing 331 KT recipients underwent living donor KT at Kyushu University Hospital from January 2006 to December 2012. A prediction model was retrospectively developed and risk scores were investigated via a Cox proportional hazards regression model...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367746/the-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA%C3%AE-ligand-receptor-leucine-rich-repeat-containing-g-protein-coupled-receptor-4-contributes-to-parathyroid-hormone-induced-vascular-calcification
#32
Natalia Carrillo-López, Laura Martínez-Arias, Cristina Alonso-Montes, Beatriz Martín-Carro, Julia Martín-Vírgala, Marta Ruiz-Ortega, José Luis Fernández-Martín, Adriana S Dusso, Minerva Rodriguez-García, Manuel Naves-Díaz, Jorge B Cannata-Andía, Sara Panizo
BACKGROUND: In chronic kidney disease, serum phosphorus (P) elevations stimulate parathyroid hormone (PTH) production, causing severe alterations in the bone-vasculature axis. PTH is the main regulator of the receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, which is essential for bone maintenance and also plays an important role in vascular smooth muscle cell (VSMC) calcification. The discovery of a new RANKL receptor, leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), which is important for osteoblast differentiation but with an unknown role in vascular calcification (VC), led us to examine the contribution of LGR4 in high P/high PTH-driven VC...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367744/effects-of-the-chymase-inhibitor-fulacimstat-in-diabetic-kidney-disease-results-from-the-cada-dia-trial
#33
Peter Rossing, Jorma Strand, Angelo Avogaro, Michael Becka, Friederike Kanefendt, Christiane Otto
BACKGROUND: The protease chymase generates multiple factors involved in tissue remodelling including angiotensin II (Ang II) and has been implicated in the pathophysiology of diabetic kidney disease (DKD). This study investigated the effects of the chymase inhibitor fulacimstat on albuminuria in patients with Type II diabetes mellitus and a clinical diagnosis of DKD. METHODS: In this double-blind, randomized, placebo-controlled trial, patients were on the maximum tolerated dose of either an Ang II receptor blocker or an Ang-converting enzyme inhibitor since at least 3 months before the screening visit...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367720/subsequent-urinary-stone-events-are-predicted-by-the-magnitude-of-urinary-oxalate-excretion-in-enteric-hyperoxaluria
#34
Matthew R D'Costa, Annamaria T Kausz, Kevin J Carroll, Jóhann P Ingimarsson, Felicity T Enders, Kristin C Mara, Ramila A Mehta, John C Lieske
 : Data directly demonstrating the relationship between urinary oxalate (UOx) excretion and stone events in those with enteric hyperoxaluria (EH) are limited. Therefore, we assessed the relationship between UOx excretion and risk of kidney stone events in a retrospective population-based EH cohort. In all, 297 patients from Olmsted County, Minnesota were identified with EH based upon having a 24-h UOx ≥40 mg/24 h preceded by a diagnosis or procedure associated with malabsorption...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367715/relationship-between-measured-and-prescribed-dialysate-sodium-in-haemodialysis-a-systematic-review-and-meta-analysis
#35
Jack Kit-Chung Ng, Brendan Smyth, Mark R Marshall, Amy Kang, Jule Pinter, Abhinav Bassi, Rathika Krishnasamy, Patrick Rossignol, Michael V Rocco, Zuo Li, Vivekanand Jha, Carmel M Hawley, Peter G Kerr, Gian Luca DI Tanna, Mark Woodward, And Meg Jardine
BACKGROUND: Dialysate sodium (DNa) prescription policy differs between haemodialysis (HD) units, and the optimal DNa remains uncertain. We sought to summarize the evidence on the agreement between prescribed and delivered DNa, and whether the relationship varied according to prescribed DNa. METHODS: We searched MEDLINE and PubMed from inception to 26 February 2020 for studies reporting measured and prescribed DNa. We analysed results reported in aggregate with random-effects meta-analysis...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367652/association-of-circulating-cardiac-biomarkers-with-electrocardiographic-abnormalities-in-chronic-kidney-disease
#36
Alexander J Kula, Ronit Katz, Leila R Zelnick, Elsayed Soliman, Alan Go, Michael Shlipak, Rajat Deo, Bonnie Ky, Ian DeBoer, Amanda Anderson, Rob Christenson, Stephen L Seliger, Chris Defilippi, Harold I Feldman, Myles Wolf, John Kusek, Tariq Shafi, Jiang He, Nisha Bansal
BACKGROUND: Among patients with chronic kidney disease (CKD), the circulating cardiac biomarkers soluble ST2 (SST2), galectin-3, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin-T (hsTnT) possibly reflect pathophysiologic processes and are associated with clinical cardiovascular disease. Whether these biomarkers are associated with electrocardiographic findings is not known. The aim of this study was to test the association between serum cardiac biomarkers and the presence of electrocardiographic changes potentially indicative of subclinical myocardial disease in patients with CKD...
December 26, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367899/erratum-to-hematological-disorders-following-kidney-transplantation
#37
Jolanta Malyszko, Grzegorz Basak, Krzysztof Batko, Giavambatista Capasso, Anna Capasso, Joanna Drozd-Sokolowska, Katarzyna Krzanowska, Pawel Kulicki, Joanna Matuszkiewicz-Rowinska, Maria Jose Soler, Ben Sprangers, Jacek Malyszko
No abstract text is available yet for this article.
December 25, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367895/a-plea-for-renin-angiotensin-system-blockers-as-first-line-treatment-in-cases-of-severe-acute-hypertension
#38
Sébastien Rubin, Romain Boulestreau, Philippe Gosse, Christian Combe
No abstract text is available yet for this article.
December 25, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367872/renin-angiotensin-system-blocker-discontinuation-and-adverse-outcomes-in-chronic-kidney-disease
#39
Carl P Walther, Wolfgang C Winkelmayer, Peter A Richardson, Salim S Virani, Sankar D Navaneethan
BACKGROUND: Treatment with renin-angiotensin system inhibitors (RASIs), angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) is the standard of care for those with chronic kidney disease (CKD) and albuminuria. However, ACEI/ARB treatment is often discontinued for various reasons. We investigated the association of ACEI/ARB discontinuation with outcomes among US veterans with non-dialysis-dependent CKD. METHODS: We performed a retrospective cohort study of patients in the Veterans Affairs healthcare system with non-dialysis-dependent CKD who subsequently were started on ACEI/ARB therapy (new user design)...
December 25, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/33367921/measurement-of-serum-albumin-in-nephrology-we-need-to-improve
#40
Marith van Schrojenstein Lantman, Anne-Els van de Logt, Marc Thelen, Jack F Wetzels, Miranda van Berkel
Serum albumin is a widely used biomarker in clinical nephrology. Serum albumin cut-off values are used to define disease, to predict outcome, and to guide patient care. The available commercial assays to measure serum albumin rely on different analytical principles, all with their own (analytical) specifications. This paper provides an overview of the different clinical applications of serum albumin measurements in nephrology, the (dis)advantages of the available assays and the estimates of the effects of the measurement uncertainty between different assays in clinical decision making...
December 24, 2020: Nephrology, Dialysis, Transplantation
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